Methods and Compositions Involving miRNAs In Cancer Stem Cells

ABSTRACT

The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells.

This application claims priority to U.S. Provisional Patent applicationSer. No. 61/113,385 filed on Nov. 11, 2008, which is incorporated hereinby reference in its entirety.

This invention was made with government support under W81XWH-07-1-0616awarded by the Department of Defense. The government has certain rightsin the invention.

BACKGROUND OF THE INVENTION

I. Field of the Invention

The present invention relates to the fields of molecular biology andoncology. More specifically, the invention relates to methods andcompositions involving microRNA molecules (miRNAs) for the treatment ofcancer.

II. Background

Two models of tumor stem cell proliferation have been proposed. Thestochastic model postulates that oncogenic mutations occur randomly incells and that every cell within a tumor has a low but equal likelihoodof re-initiating a tumor and thus functioning as a stem cell. Incontrast, the cancer stem cell (CSC) model posits that tumors arise froma small, phenotypically distinct subset of cancer cells that cause theheterogeneous cell lineages observed in a tumor (Clarke et al., 2006).

CSCs have several properties that distinguish them from the remainder ofthe population. Most importantly, they undergo self-renewal—a uniquetype of cell division in which one or both progeny remains identical tothe parent cell. In normal adult tissues, self-renewal is displayedexclusively by adult stem cells. Like adult stem cells, CSCs sit on topof the tumor cell hierarchy and can respond to stimuli to generate cellsfurther along the differentiation spectrum, albeit in an aberrant manner(Clarke et al., 2006). CSCs are also resistant to chemotherapy andradiation therapy (Bao et al., 2006; Li et al., 2008; Hambardzumyan etal., 2008; Liu et al., 2006), which could explain why conventionaltreatments are ineffective in curing cancer and relapse occurs ingenerally more aggressive forms. Moreover, some CSCs are relativelyquiescent shielding them from drugs that target highly proliferativecells (Holyoake et al., 1999; Guan and Hogge, 2000). Finally, CSCs canmediate metastasis in some cancers (Hermann et al., 2007; Patrawala etal., 2006).

Currently, cancer treatments are based on the stochastic model of tumorcell proliferation, targeting the bulk of the tumor withoutdiscrimination. Given that CSCs are the ‘root’ of the tumor andinsensitive to most treatments, it is imperative that therapeuticmodalities are developed to specifically eradicate them.

Recently, microRNAs have been implicated in various cancers. microRNAs(miRNAs) are short RNA molecules (16-29 nucleotides in length) thatarise from longer precursors, which are transcribed from non-proteincoding genes (Carrington et al., 2003). The precursors are processed bycellular proteins to generate short double-stranded miRNA. One of themiRNA strands is incorporated into a complex of proteins and miRNAcalled the RNA-induced silencing complex (RISC). The miRNA guides theRISC complex to a target mRNA, which is then cleaved or translationallysilenced, depending on the degree of sequence complementarity of themiRNA or its target mRNA (Bagga et al., 2005; Lim et al., 2005).

Additional compositions and methods for identifying and treating thesecancer stem cells is needed.

SUMMARY OF THE INVENTION

The present invention includes compositions and methods related toidentifying and treating cancer and/or cancer stem cells. In certainembodiments, compositions and methods are directed to miRNAsdifferentially expressed in cancer stem cells. In a further embodiment,the cancer stem cells can be associated with a variety of cancers,including but not limited to bone, brain, breast, colorectal,pancreatic, ovarian, prostate, testicular, hepatic, kidney, lung, orskin. In certain aspects, miRNAs are isolated from prostate tumors andrepresent targets for therapeutic intervention or diagnostic markers inprostate cancer. In a further aspect, hsa-miR-34a, hsa-miR-126 andlet-7b are therapeutic targets or therapeutics that can inhibit cancerstem cell growth in vitro and in vivo.

The present invention provides additional compositions and methods forthe identification and/or treatment of CSCs by identifying miRNAs thatare differentially expressed or mis-regulated in CSCs. Further, theinvention describes a method for treating cancer based on administeringa molecule having an activity of selected miRNAs or miRNA inhibitors toa patient, tissue, or cells at risk of developing cancer, suspected ofhaving cancer, or having cancer.

The term “miRNA” or “miR” is used according to its ordinary and plainmeaning and refers to a microRNA molecule found in eukaryotes that isinvolved in RNA-based gene regulation. See, e.g., Carrington et al.,2003, which is hereby incorporated by reference. The term will be usedto refer to the single-stranded RNA molecule processed from a precursor.Names of miRNAs and their sequences related to the present invention areprovided herein.

miR sequences can be used to evaluate cells and/or tissue for thepossibility of a condition associated with CSCs, particularly thoseconditions that will result in the development of a disease or apathological condition associated with CSCs, namely cancer.

In certain aspects, an miRNA that is differentially expressed between aCSC and a non-CSC or normal cell is administered to a patient having orsuspected of having precancerous or cancerous condition. In certainaspects, an inhibitor of a miRNA that is differentially expressedbetween CSC and a non-CSC or a normal cell is administered to a patienthaving, suspected of having, or at risk of cancer. In certain aspectsthe cancer is prostate cancer.

Embodiments of the invention include methods of modulating cellularnucleic acids and the processing of these nucleic acids comprisingadministering to the cell, tissue, or subject an amount of an isolatednucleic acid or mimetic thereof comprising all or part of an miRNAnucleic acid sequence, mimetic, or inhibitor sequence in an amountsufficient to modulate the processing of a cellular nucleic acid bypositive or negative regulation, which includes one or more ofregulating/modulating: transcription, mRNA levels, mRNA translation,and/or protein levels in a cell, tissue, or organ. In certain aspectsthe expression of a gene or level of a gene product, such as mRNA orencoded protein, is down-regulated or up-regulated. Administration of anucleic acid or nucleic acid mimetic can result in a decrease in orcessation of growth, metabolism, or replication of a cancer stem cell.In certain aspects administration of a nucleic acid composition resultsin the death of some or all cancer stem cells.

In certain embodiments methods include treating cancer comprisingadministering to a subject in need of such therapy an effective amountof: (a) an inhibitor of hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-miR-100,hsa-miR-101, hsa-miR-105, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a,hsa-miR-125a, hsa-miR-125b, hsa-miR-127, hsa-miR-133a, hsa-miR-133b,hsa-miR-140, hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-145, hsa-miR-146a,hsa-miR-146b, hsa-miR-147, hsa-miR-148a, hsa-miR-148b, hsa-miR-15b,hsa-miR-16, hsa-miR-181 a, hsa-miR-181d, hsa-miR-183, hsa-miR-18a,hsa-miR-190, hsa-miR-192, hsa-miR-193b, hsa-miR-195, hsa-miR-196a,hsa-miR-196b, hsa-miR-19a, hsa-miR-19b, hsa-miR-203, hsa-miR-205,hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22, hsa-miR-221,hsa-miR-222, hsa-miR-223, hsa-miR-24, hsa-miR-25, hsa-miR-26b,hsa-miR-27a, hsa-miR-27b, hsa-miR-28, hsa-miR-29a, hsa-miR-29b,hsa-miR-29c, hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b,hsa-miR-30c, hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32, hsa-miR-320,hsa-miR-324-3p, hsa-miR-324-5p, hsa-miR-328, hsa-miR-33, hsa-miR-331,hsa-miR-338, hsa-miR-339, hsa-miR-345, hsa-miR-361, hsa-miR-374,hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-423, hsa-miR-425,hsa-miR-433, hsa-miR-451, hsa-miR-452, hsa-miR-500, hsa-miR-501,hsa-miR-9, and/or hsa-miR-96; or (b) a molecule having hsa-let-7a,hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-let-7i, hsa-miR-101,hsa-miR-103, hsa-miR-106a, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a,hsa-miR-125a, hsa-miR-126, hsa-miR-132, hsa-miR-133a, hsa-miR-141,hsa-miR-146a, hsa-miR-146b, hsa-miR-148a, hsa-miR-148b, hsa-miR-149,hsa-miR-151, hsa-miR-152, hsa-miR-15a, hsa-miR-15b, hsa-miR-181b,hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-191, hsa-miR-193b,hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-199a, hsa-miR-200a,hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-222, hsa-miR-24, hsa-miR-25,hsa-miR-26a, hsa-miR-27a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30a-3p,hsa-miR-30a-5p, hsa-miR-30d, hsa-miR-320, hsa-miR-324-5p, hsa-miR-328,hsa-miR-331, hsa-miR-335, hsa-miR-340, hsa-miR-342, hsa-miR-345,hsa-miR-34a, hsa-miR-362, hsa-miR-365, hsa-miR-375, hsa-miR-378,hsa-miR-422a, hsa-miR-422b, hsa-miR-425, hsa-miR-429, hsa-miR-500,hsa-miR-7, hsa-miR-9*, hsa-miR-92, hsa-miR-93, hsa-miR-98, and/orhsa-miR-99b activity.

A “therapeutic nucleic acid sequence” includes nucleic acids thatpositively or negatively modulate the processing of a cellular nucleicacid. A therapeutic nucleic may include the full length or segments ofprecursor sequence of a miRNA identified herein, or a complementthereof. In certain aspects a therapeutic nucleic acid can comprise allor part of a processed (i.e., mature) miRNA sequence or complementthereof, including 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or more nucleotides of anmiRNA described herein. In other aspects a therapeutic nucleic acid caninclude all or part of a mature miRNA sequence or complement as well as5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23,24, 25, 26, 27, 28, 29 or more nucleotides of a precursor miRNA or itsprocessed sequence, or complement thereof, including all ranges andintegers there between. In certain embodiments, the therapeutic nucleicacid sequence contains a full-length processed miRNA sequence describedherein or a complement thereof. In still further aspects, thetherapeutic nucleic acid comprises about, at least, or at most a 5, 6,7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25,50 nucleotide segment (including all ranges and integers there between)or complementary segment of a miRNA described herein that is at least75, 80, 85, 90, 95, 98, 99 or 100% identical to SEQ ID NO:1 to SEQ IDNO:119. In certain aspects, a subset of these miRNAs will be used thatinclude some but not all of the miRNA described herein. In certainaspects, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,19, 20 or more miRNAs or segments thereof (including complementarysequences) will be included with all other miRNA sequences excluded. Incertain aspects, subsets of these miRNAs will be used that include somebut not all of the listed miRNA sequences, segments, or complements.

In certain aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of an isolated (a) nucleic acid inhibitor of hsa-let-7b,hsa-let-7c, hsa-let-7e, hsa-miR-100, hsa-miR-101, hsa-miR-105,hsa-miR-10a, hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-125b,hsa-miR-127, hsa-miR-133a, hsa-miR-133b, hsa-miR-140, hsa-miR-142-3p,hsa-miR-142-5p, hsa-miR-145, hsa-miR-146a, hsa-miR-146b, hsa-miR-147,hsa-miR-148a, hsa-miR-148b, hsa-miR-15b, hsa-miR-16, hsa-miR-181a,hsa-miR-181d, hsa-miR-183, hsa-miR-18a, hsa-miR-190, hsa-miR-192,hsa-miR-193b, hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-19a,hsa-miR-19b, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-223,hsa-miR-24, hsa-miR-25, hsa-miR-26b, hsa-miR-27a, hsa-miR-27b,hsa-miR-28, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-301,hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d,hsa-miR-30e-5p, hsa-miR-32, hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p,hsa-miR-328, hsa-miR-33, hsa-miR-331, hsa-miR-338, hsa-miR-339,hsa-miR-345, hsa-miR-361, hsa-miR-374, hsa-miR-378, hsa-miR-422a,hsa-miR-422b, hsa-miR-423, hsa-miR-425, hsa-miR-433, hsa-miR-451,hsa-miR-452, hsa-miR-500, hsa-miR-501, hsa-miR-9, and/or hsa-miR-96; or(b) nucleic acid having hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e,hsa-let-7f, hsa-let-7i, hsa-miR-101, hsa-miR-103, hsa-miR-106a,hsa-miR-10a, hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-126,hsa-miR-132, hsa-miR-133a, hsa-miR-141, hsa-miR-146a, hsa-miR-146b,hsa-miR-148a, hsa-miR-148b, hsa-miR-149, hsa-miR-151, hsa-miR-152,hsa-miR-15a, hsa-miR-15b, hsa-miR-181b, hsa-miR-182, hsa-miR-183,hsa-miR-18a, hsa-miR-191, hsa-miR-193b, hsa-miR-195, hsa-miR-196a,hsa-miR-196b, hsa-miR-199a, hsa-miR-200a, hsa-miR-200c, hsa-miR-203,hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22,hsa-miR-222, hsa-miR-24, hsa-miR-25, hsa-miR-26a, hsa-miR-27a,hsa-miR-29b, hsa-miR-29c, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30d,hsa-miR-320, hsa-miR-324-5p, hsa-miR-328, hsa-miR-331, hsa-miR-335,hsa-miR-340, hsa-miR-342, hsa-miR-345, hsa-miR-34a, hsa-miR-362,hsa-miR-365, hsa-miR-375, hsa-miR-378, hsa-miR-422a, hsa-miR-422b,hsa-miR-425, hsa-miR-429, hsa-miR-500, hsa-miR-7, hsa-miR-9*,hsa-miR-92, hsa-miR-93, hsa-miR-98, and/or hsa-miR-99b activity; in anamount sufficient to treat cancer (an “*” indicates the miR is derivedfrom the opposite arm of the precursor miRNA). Typically, a cell orsubject can have, be suspected of having, or be at risk of developingcancer. In certain aspects the growth of a cancer stem cell isprevented, ameliorated, reduced, or eliminated.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of 1, 2, 3, 4, 5, 6 or more of miR-34, let-7, miR-15, mir-16,miR106, miR-10, Mir-141, miR218, mir422a, and/or miR-335 in combinationwith an isolated (a) nucleic acid inhibitor of hsa-let-7b, hsa-let-7c,hsa-let-7e, hsa-miR-100, hsa-miR-101, hsa-miR-105, hsa-miR-10a,hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-125b, hsa-miR-127,hsa-miR-133a, hsa-miR-133b, hsa-miR-140, hsa-miR-142-3p, hsa-miR-142-5p,hsa-miR-145, hsa-miR-146a, hsa-miR-146b, hsa-miR-147, hsa-miR-148a,hsa-miR-148b, hsa-miR-15b, hsa-miR-16, hsa-miR-181 a, hsa-miR-181d,hsa-miR-183, hsa-miR-18a, hsa-miR-190, hsa-miR-192, hsa-miR-193b,hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-19a, hsa-miR-19b,hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218,hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-223, hsa-miR-24,hsa-miR-25, hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-28,hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-301, hsa-miR-30a-3p,hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e-5p,hsa-miR-32, hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p, hsa-miR-328,hsa-miR-33, hsa-miR-331, hsa-miR-338, hsa-miR-339, hsa-miR-345,hsa-miR-361, hsa-miR-374, hsa-miR-378, hsa-miR-422a, hsa-miR-422b,hsa-miR-423, hsa-miR-425, hsa-miR-433, hsa-miR-451, hsa-miR-452,hsa-miR-500, hsa-miR-501, hsa-miR-9, and/or hsa-miR-96; or (b) nucleicacid having hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f,hsa-let-7i, hsa-miR-101, hsa-miR-103, hsa-miR-106a, hsa-miR-10a,hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-126, hsa-miR-132,hsa-miR-133 a, hsa-miR-141, hsa-miR-146a, hsa-miR-146b, hsa-miR-148a,hsa-miR-148b, hsa-miR-149, hsa-miR-151, hsa-miR-152, hsa-miR-15a,hsa-miR-15b, hsa-miR-181b, hsa-miR-182, hsa-miR-183, hsa-miR-18a,hsa-miR-191, hsa-miR-193b, hsa-miR-195, hsa-miR-196a, hsa-miR-196b,hsa-miR-199a, hsa-miR-200a, hsa-miR-200c, hsa-miR-203, hsa-miR-205,hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22, hsa-miR-222,hsa-miR-24, hsa-miR-25, hsa-miR-26a, hsa-miR-27a, hsa-miR-29b,hsa-miR-29c, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30d, hsa-miR-320,hsa-miR-324-5p, hsa-miR-328, hsa-miR-331, hsa-miR-335, hsa-miR-340,hsa-miR-342, hsa-miR-345, hsa-miR-34a, hsa-miR-362, hsa-miR-365,hsa-miR-375, hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-425,hsa-miR-429, hsa-miR-500, hsa-miR-7, hsa-miR-9*, hsa-miR-92, hsa-miR-93,hsa-miR-98, and/or hsa-miR-99b activity; in an amount sufficient totreat cancer (an “*” indicates the miR is derived from the opposite armof the precursor miRNA). Typically, a cell or subject can have, besuspected of having, or be at risk of developing cancer. In certainaspects the growth of a cancer stem cell is prevented, ameliorated,reduced, or eliminated.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR-34 or an inhibitorthereof sufficient to treat cancer or eliminates, prevents, ameliorates,or reduces the growth of a cancer stem cell.

In still further aspects the invention includes methods of treating acancer stem cell or associated cancer comprising administering to thecell an amount of a nucleic acid comprising a sequence of let-7 or aninhibitor thereof sufficient to treat cancer or eliminates, prevents,ameliorates, or reduces the growth of a cancer stem cell.

In certain aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR-15 or an inhibitorthereof sufficient to treat cancer or eliminates, prevents, ameliorates,or reduces the growth of a cancer stem cell.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of mir-16 or an inhibitorthereof sufficient to treat cancer or eliminates, prevents, ameliorates,or reduces the growth of a cancer stem cell.

In still further aspects the invention includes methods of treating acancer stem cell or associated cancer comprising administering to thecell an amount of a nucleic acid comprising a sequence of miR-106 or aninhibitor thereof sufficient to treat cancer or eliminates, prevents,ameliorates, or reduces the growth of a cancer stem cell.

In certain aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR-10 or an inhibitorthereof sufficient to treat cancer or eliminates, prevents, ameliorates,or reduces the growth of a cancer stem cell.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR-141 or aninhibitor thereof sufficient to treat cancer or eliminates, prevents,ameliorates, or reduces the growth of a cancer stem cell.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR-218 or aninhibitor thereof sufficient to treat cancer or eliminates, prevents,ameliorates, or reduces the growth of a cancer stem cell.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR422a or aninhibitor thereof sufficient to treat cancer or eliminates, prevents,ameliorates, or reduces the growth of a cancer stem cell.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of a nucleic acid comprising a sequence of miR-335 or aninhibitor thereof sufficient to treat cancer or eliminates, prevents,ameliorates, or reduces the growth of a cancer stem cell.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of an inhibitor of hsa-miR-125b, hsa-miR-133b, hsa-miR-142-3p,hsa-miR-181a, hsa-miR-181d, hsa-miR-205, hsa-miR-221, hsa-miR-222,hsa-miR-223, hsa-miR-29a, hsa-miR-29c, hsa-miR-301, hsa-miR-328,hsa-miR-33, hsa-miR-338, hsa-miR-374, hsa-miR-378, hsa-miR-451,hsa-miR-452, and/or hsa-miR-501. The nucleic acid can be administered inan amount sufficient to treat cancer. Typically, a cell or subject canhave, be suspected of having, or be at risk of developing cancer. Incertain aspects the growth of a cancer stem cell is prevented,ameliorated, reduced, or eliminated.

In further aspects the invention includes methods of treating a cancerstem cell or associated cancer comprising administering to the cell anamount of an nucleic acid has an activity of one or more hsa-let-7c,hsa-miR-126, hsa-miR-15a, hsa-miR-15b, hsa-miR-182, hsa-miR-183,hsa-miR-191, hsa-miR-200a, hsa-miR-200c, hsa-miR-203, hsa-miR-218,hsa-miR-27a, hsa-miR-29b, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-335,hsa-miR-340, hsa-miR-34a, hsa-miR-365, hsa-miR-375, hsa-miR-422a,hsa-miR-425, hsa-miR-92, and/or hsa-miR-93. The nucleic acid can beadministered in an amount sufficient to treat cancer. Typically, a cellor subject can have, be suspected of having, or be at risk of developingcancer. In certain aspects the growth of a cancer stem cell isprevented, ameliorated, reduced, or eliminated.

In still further aspects, a nucleic acid has an activity of ahsa-let-7b, hsa-miR-34a, hsa-miR-126, hsa-miR-141, hsa-miR-335,hsa-miR-365, and/or hsa-miR-375.

In certain aspects a nucleic acid inhibitor is an inhibitor ofhsa-miR-142-3p, hsa-miR-33, hsa-miR-301, hsa-miR-451, and/orhsa-miR-452.

In still a further aspect a hsa-miR-34a nucleic acid is administered.

In certain embodiments a therapeutic nucleic acid is a recombinantnucleic acid, such as RNA, DNA, or RNA/DNA hybrid. A recombinant nucleicacid of the invention can be comprised in a miRNA expression cassette,which can be further comprised in a nucleic acid vector such as a viralvector, or a plasmid vector. Typically a viral vector is administered ata dose of 1×10⁵ to 1×10¹⁴ viral particles per dose. A plasmid DNA vectoris typically administered at a dose of 100 mg per patient to 4000 mg perpatient.

In certain aspects the therapeutic nucleic acid is a synthetic nucleicacid. Typically a nucleic acid is administered at a dose of 0.01, 0.05,0.1, 0.5, 1, 2, 3, 4, 5, 6 mg/kg of body weight to 5, 6, 7, 8, 9, 10mg/kg of body weight, including all values and ranges there between. Thenucleic acid can be administered enterally, parenterally, topically orby other administration methods well known to those skilled in the art.In certain aspects the nucleic acid is comprised in a pharmaceuticalformulation, such as a lipid composition or a nanoparticle compositionor biocompatible and biodegradable molecule composition.

In still a further aspect, 2, 3, 4, 5, 6, or more therapeutic nucleicacids may be administered together or sequentially. Typically if thenucleic acids are administered together, they will be in a singlecomposition.

In yet still further aspects a therapy will reduce the viability of thecell, reduce proliferation of the cell, reduce metastasis of the cell,or increase the cell's sensitivity to therapy.

In yet another embodiment the invention includes methods of treating apatient diagnosed with or suspected of having or at risk of developingprostate cancer comprising the steps of: (a) administering to thepatient an amount of an isolated therapeutic nucleic acid comprising amiRNA sequence in an amount sufficient to positively or negativelyregulate a cellular pathway or treat a patient, wherein a therapeuticnucleic acid inhibitor of one or more of hsa-let-7b, hsa-let-7c,hsa-let-7e, hsa-miR-100, hsa-miR-101, hsa-miR-105, hsa-miR-10a,hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-125b, hsa-miR-127,hsa-miR-133a, hsa-miR-133b, hsa-miR-140, hsa-miR-142-3p, hsa-miR-142-5p,hsa-miR-145, hsa-miR-146a, hsa-miR-146b, hsa-miR-147, hsa-miR-148a,hsa-miR-148b, hsa-miR-15b, hsa-miR-16, hsa-miR-181 a, hsa-miR-181d,hsa-miR-183, hsa-miR-18a, hsa-miR-190, hsa-miR-192, hsa-miR-193b,hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-19a, hsa-miR-19b,hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218,hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-223, hsa-miR-24,hsa-miR-25, hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-28,hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-301, hsa-miR-30a-3p,hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e-5p,hsa-miR-32, hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p, hsa-miR-328,hsa-miR-33, hsa-miR-331, hsa-miR-338, hsa-miR-339, hsa-miR-345,hsa-miR-361, hsa-miR-374, hsa-miR-378, hsa-miR-422a, hsa-miR-422b,hsa-miR-423, hsa-miR-425, hsa-miR-433, hsa-miR-451, hsa-miR-452,hsa-miR-500, hsa-miR-501, hsa-miR-9, and/or hsa-miR-96; and/or atherapeutic nucleic acid having an activity of one or more ofhsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-let-7i,hsa-miR-101, hsa-miR-103, hsa-miR-106a, hsa-miR-10a, hsa-miR-10b,hsa-miR-124a, hsa-miR-125a, hsa-miR-126, hsa-miR-132, hsa-miR-133a,hsa-miR-141, hsa-miR-146a, hsa-miR-146b, hsa-miR-148a, hsa-miR-148b,hsa-miR-149, hsa-miR-151, hsa-miR-152, hsa-miR-15a, hsa-miR-15b,hsa-miR-181b, hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-191,hsa-miR-193b, hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-199a,hsa-miR-200a, hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-21,hsa-miR-214, hsa-miR-218, hsa-miR-22, hsa-miR-222, hsa-miR-24,hsa-miR-25, hsa-miR-26a, hsa-miR-27a, hsa-miR-29b, hsa-miR-29c,hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30d, hsa-miR-320,hsa-miR-324-5p, hsa-miR-328, hsa-miR-331, hsa-miR-335, hsa-miR-340,hsa-miR-342, hsa-miR-345, hsa-miR-34a, hsa-miR-362, hsa-miR-365,hsa-miR-375, hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-425,hsa-miR-429, hsa-miR-500, hsa-miR-7, hsa-miR-9*, hsa-miR-92, hsa-miR-93,hsa-miR-98, and/or hsa-miR-99b activity, and (b) administering a secondtherapy, wherein the regulation of the cellular pathway sensitizes thepatient to a second therapy.

In certain aspects, components or genes of a cellular pathway, which mayalso be regulated by various combinations of miRNAs include, but are notlimited to Nanog, Oct-3/4, Gli1, Smoothened, Patched-1, Wnt3A,β-catenin, Notch-1, Jagged-1, Sox2, CD133, CD44, Bmi-1, ABCG2, ABCB1,ITGA2, ITGB1, PTEN, Stat3, Sox4, ALDH1, Prostate stem cell antigen,integrin αV, NFKB1, Bcl-2, CXCR4, PAPPA, Tight Junction Protein 2,Abl-interactor-1, B-cell translocation gene 1, Interleukin-6, CASP8 andFADD-like apoptosis regulator, Smu-1, S100 calcium biding protein A3,Ras and EF-hand domain containing, Interferon gamma receptor 1, insulingrowth factor-like family member 1, Microseminoprotein beta, CEACAM5,S100 calcium binding protein A7, Hydroxyprostaglandin dehydrogenase 15,CEACAM7, Trefoil factor 1, Prolactin-induced protein, Secretagogin,SWAP70, cyclin Y, C10orf9, cell division cycle 123 homolog, alkylationrepair homolog 1, transducer of ERBB2, xenotropic and polytropicretrovirus receptor, CD59 molecule, low density lipoprotein-relatedprotein 2, proteolipid protein 2, mitogen-activated protein kinase 14,matrix metallopeptidase 7, matrix Gla protein, myeloid leukemia factor1, filaminB beta, sodium channel modifier 1, cornichon homolog 4,receptor accessory protein 5, solute carrier family 25 member 33, solutecarrier family 44 member 1, transmembrane channel-like 4, zinc fingerDHHC-type containing 2, toll-like receptor adaptor molecule 2, KDEL (SEQID NO:120) (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retentionreceptor 3, glucosamine-6-phosphate deaminase 1, thioesterasesuperfamily member 2, debranching enzyme homolog 1, solute carrierfamily 38 member 9, N-acetyltrans-ferase 10, chromosome 16 open readingframe 33, lactate dehydrogenase A, major histocompatibility complexclass I-related, leucyl-tRNA synthetase, GTP binding protein 1, proteaseserine 16, WAP four-disulfide core domain 2, aurora kinase B,3-hydroxybutyrate dehydrogenase type 2, dehydrogenase/reductase (SDRfamily) member 4, abhydrolase domain containing 14B, EF-hand calciumbinding domain 4A, enoyl coenzyme A hydratase domain containing 2, golgiautoantigen, ATPase type 13A3, prolyl endopeptidase-like, cytochromeP450, JTV1, isoprenyl-cysteine carboxyl methyltransferase, DNA(cytosine-5-)-methyltransferase 3 alpha, histamine N-methyltransferase,methyltransferase like 7A, methyltransferase like 2A, methyltransferaselike 2B, ezrin, tumor protein D52, actin related protein ⅔ complexsubunit 5 16 kDa, nucleolar protein 8, N-ehylmaleimide-sensitive factor,RAD23 homolog B, signal recognition particle 54 kDa, heat shock 70 kDaprotein 2, mediator complex subunit 1, THAP domain containing, apoptosisassociated protein 2, cold inducible RNA binding protein, small nuclearribonucleoprotein polypeptide N, superkiller viralicidic activity 2-like2, dual specificity phosphatase 10, signal sequence receptor, alpha,v-erb-a erythroblastic leukemia viral oncogene homolog 4, epithelialmembrane protein 1, low density lipoprotein receptor-related proteinassociated protein 1, SCY1-like binding protein 1, CSTF1, Kelch-like 20,DNAJC13, amyloid beta (A4) precursor-like protein 2, sorbin and SH3domain containing 2, DNAJB1, nebulette, SH3 domain binding glutamicacid-rich protein like, nudix, GABA(A) receptor-associated protein like1, microtubule-associated protein tau, DCBLD1, serine threonine kinase,protein kinase N2, CSNK2A1, paired immunoglobin-like type 2 receptorbeta, endoplasmic reticulum to nucleus signaling 1,serum/gluco-corticoid regulated kinase family, member 3, WEE1 homolog,microtubule associated serine/threonine kinase family member 4,chromosome 11 open reading frame, nucleoproin 37 kDa, CLTC, coatomerprotein complex, subunit beta 2 (beta prime), solute carrier family 25,EGFR-coamplified and overexpressed protein, phosphodiesterase 8A, signaltranducing adaptor molecule, tubulin beta, sorting nexin 6, RAB23,phospholipase A2-activating protein, stanniocalcin 2, lactotransferrin,interferon regulator factor 9, ataxin 3, GTF3C3, glycogen synthasekinase 3 beta, kruppel-like factor 10, ELL2, zinc finger and BTB domaincontaining 20, iroquois homeobox 3, v-ets erythroblastosis virus E26oncogene homolog 1, SERTA domain containing 1, transmembrane protein101, v-maf musculo-aponeurotic fibrosarcoma oncogene homolog F, SFPQ,Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminaldomain 4, CCAAT/enhancer binding protein (C/EBP) delta, eukaryotictranslation initiation factor 4E family member 2, heparan sulfate2-O-sulfotransferase 1, alkylglycerone phosphate synthase,phospho-glycerate kinase 1, 5-aminoimidazole-4-carboxamideribonucleotide formyltrans-ferase/IMP cyclohydrolase, ethanolaminekinase 1, asparagine-linked glycosylation 2 homolog,ubiquitin-conjugating enzyme E2F, membrane-associated ring finger,CCR4-NOT transcription complex, subunit, ring finger protein 8, PSMA5,AMMERCR1, integrator complex subunit 2, FAM152A, integrator complexsubunit 8, THUMP domain containing 3, centrosomal protein 350 kDa, Ewingtumor-associated antigen 1, WD repeat domain 68, viral DNApolymerase-transactivated protein 6, chromosome 7 open reading frame 25,chromosome 2 open reading frame 60, chromosome 17 open reading frame 71,chromosome 7 open reading frame 36, elongation protein 4 homolog, nudEnuclear distribution gene E homolog, chromosome 1 open reading frame 63,FAM172A, FAM53C, immediate early response 5, KIAA0146, transmembraneprotein 63A, NEDD4 binding protein 2-like 1, LY6/PLAUR domain containing6B, BEX family member 5, KIAA1217, chromosome 4 open reading frame 7,chromosome 9 open reading frame 64, Zyg-11 homolog B, FAM160B1, limbregion 1 homolog, nuclear casein kinase and cyclin-dependent kinasesubstrate 1, ankyrin repeat domain 13C, coiled-coil domain containing43, UHRF1 binding protein 1, chromosome 1 open reading frame 163, AIDA,chromosome 4 open reading frame 32, nestin, c-kit, GLI2, MCL1, IL4,MUC1, ABCA3, SHH (sonic hedgehog), IHH (Indian hedgehog) or combinationsthereof.

In still another aspect the invention includes methods of selecting amiRNA to be administered to a subject suspected of having, or having apropensity for developing cancer comprising: (a) determining anexpression profile of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, 17, 18, 19, 20 or more miRNA selected from hsa-let-7a, hsa-let-7b,hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-let-7i, hsa-miR-100,hsa-miR-101, hsa-miR-103, hsa-miR-105, hsa-miR-106a, hsa-miR-10a,hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-125b, hsa-miR-126,hsa-miR-127, hsa-miR-132, hsa-miR-133a, hsa-miR-133b, hsa-miR-140,hsa-miR-141, hsa-miR-142-3p, hsa-miR-142-5p hsa-miR-145, hsa-miR-146a,hsa-miR-146b, hsa-miR-147, hsa-miR-148a, hsa-miR-148b, hsa-miR-149,hsa-miR-151, hsa-miR-152, hsa-miR-15a, hsa-miR-15b, hsa-miR-16,hsa-miR-181a, hsa-miR-181b, hsa-miR-181d, hsa-miR-182, hsa-miR-183,hsa-miR-18a, hsa-miR-190, hsa-miR-191, hsa-miR-192, hsa-miR-193b,hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-199a, hsa-miR-19a,hsa-miR-19b, hsa-miR-200a, hsa-miR-200c, hsa-miR-203, hsa-miR-205,hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22, hsa-miR-221,hsa-miR-222, hsa-miR-223, hsa-miR-24, hsa-miR-25, hsa-miR-26a,hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-28, hsa-miR-29a,hsa-miR-29b, hsa-miR-29c, hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p,hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32,hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p, hsa-miR-328, hsa-miR-33,hsa-miR-331, hsa-miR-335, hsa-miR-338, hsa-miR-339, hsa-miR-340,hsa-miR-342, hsa-miR-345, hsa-miR-34a, hsa-miR-361, hsa-miR-362,hsa-miR-365, hsa-miR-374, hsa-miR-375, hsa-miR-378, hsa-miR-422a,hsa-miR-422b, hsa-miR-423, hsa-miR-425, hsa-miR-429, hsa-miR-433,hsa-miR-451, hsa-miR-452, hsa-miR-500, hsa-miR-501, hsa-miR-7,hsa-miR-9, hsa-miR-9*, hsa-miR-92, hsa-miR-93, hsa-miR-96, hsa-miR-98,and/or hsa-miR-99b; and (b) administering a second therapy, wherein theregulation of the cellular pathway sensitizes the patient to a secondtherapy; and (b) assessing the sensitivity of the subject to atherapeutic nucleic acid based on an expression profile; and (c)selecting one or more therapeutic nucleic acid for administration to thepatient based on the assessed sensitivity. The method can furthercomprise treating the subject with 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, ormore therapeutic nucleic acids administered individually, or in one ormore combinations.

Corresponding miRNA sequences that can be used in the context of theinvention include, but are not limited to, all or a portion of thosesequences in the sequence listing provided herein, as well as the miRNAprecursor sequence, or complement of one or more of these miRNAs. Anyone or subset of these sequences can be specifically excluded from theclaimed invention.

In some embodiments, it may be useful to know whether a cell expresses aparticular miRNA endogenously or whether such expression is affectedunder particular conditions or when it is in a particular disease state,e.g., cancer. Thus, in some embodiments of the invention, methodsinclude assaying a cell or a sample containing a cell for the presenceof one or more miRNA. In certain aspects, the miRNAs evaluated includethose differentially expressed when the cell is a CSC. Consequently, insome embodiments, methods include a step of generating a miRNA profilefor a sample. The term “miRNA profile” refers to data regarding theexpression pattern of miRNAs in the sample (e.g., one or more miRNA fromTable 1). It is contemplated that the miRNA profile can be obtainedusing a set of miRNAs, using for example nucleic acid amplification orhybridization techniques well know to one of ordinary skill in the art.In certain embodiments, expression of one or more miRNA of SEQ ID NO:1to SEQ ID NO:119 is evaluated prior to or after administration of atherapeutic miRNA.

In some embodiments of the invention, an miRNA profile is generated bysteps that include one or more of: (a) labeling miRNA in the sample; (b)hybridizing miRNA to a number of probes, or amplifying a number ofmiRNA, and/or (c) determining miRNA hybridization to the probes ordetecting miRNA amplification products, wherein a miRNA expression isevaluated. See U.S. patent application Ser. Nos. 11/141,707 and11/855,792, all of which are hereby incorporated by reference.

It is specifically contemplated that miRNA profiles for patients,particularly those suspected of having a particular disease orcondition, such as cancer, can be generated by evaluating one or moremiRNA or set of miRNAs discussed in this application. The miRNA profilethat is generated from the patient will be one that provides informationregarding the particular disease, condition, or therapeutic target. Incertain aspects, a party evaluating miRNA expression may prepare arecommendation, report and/or summary conveying processed or raw data toa diagnosing physician. In certain aspects, a miRNA profile can be usedin conjunction with other diagnostic tests or therapies.

Still a further embodiment includes methods of treating a patient with apathological condition related to the presence of CSCs comprising one ormore of step of (a) administering to the patient an amount of atherapeutic nucleic acid comprising all or part of a miRNA nucleic acidsequence or complement thereof in an amount sufficient to modulate theexpression of one or more genes, mRNA, and/or protein expression; and,alternatively, (b) administering a second therapy, wherein themodulation of one or more genes, mRNA, and/or protein sensitizes thepatient to the second therapy. A second therapy can includeadministration of a second therapeutic nucleic acid, or may includevarious standard therapies, chemotherapy, radiation therapy, drugtherapy, immunotherapy, surgery, and the like.

Embodiments of the invention may also include the determination orassessment of a gene expression or miRNA profile for the selection of anappropriate therapy. A physician may choose to treat a cancer usingtherapeutic nucleic acids of the invention in combination with standardtreatment such as chemotherapy, radiation therapy, and/or surgery (e.g.,freezing with liquid nitrogen (cryotherapy), electrocautery, surgicalexcision, laser treatments) and/or other methods.

Certain aspects of the invention include methods of treating a subjectwith a condition related to cancer comprising one or more of the stepsof (a) determining an expression profile of one or more miRNA selectedfrom those miRNA described herein (b) assessing the sensitivity oramenability of the subject to therapy based on the expression profile;(c) selecting a therapy based on the assessment of the patient in lightof the miRNA profile; and (d) treating the subject using one or moreselected therapy.

Because “cancer” refers to a class of diseases, it is unlikely thatthere will be a single treatment. Aspects of the invention can be usedto determine which treatment will be most effective or most harmful, andprovide a guide for the physician in evaluating, assessing, andformulating a treatment strategy for a patient.

Therapeutic nucleic acids may also include various heterologous nucleicacid sequences, i.e., those sequences not typically found operativelycoupled with miRNA in nature, such as promoters, enhancers, and thelike. The therapeutic nucleic acid can be a recombinant nucleic acid,and can be a ribonucleic acid and/or a deoxyribonucleic acid. Therecombinant nucleic acid may comprise a therapeutic nucleic acidexpression cassette, i.e., a nucleic acid segment that expresses atherapeutic nucleic acid when introduce into an environment containingcomponents for nucleic acid synthesis. In a further aspect, theexpression cassette is comprised in a viral vector, or plasmid DNAvector or other therapeutic nucleic acid vector or delivery vehicle,including liposomes and the like. In certain aspects, viral vectors canbe administered at 1×10², 1×10³, 1×10⁴ 1×10⁵, 1×10⁶, 1×10⁷, 1×10⁸,1×10⁹, 1×10¹⁰, 1×10¹¹, 1×10¹², 1×10¹³, 1×10¹⁴ pfu or viral particle(vp). In still further aspects, a therapeutic nucleic acid or a DNAcomprising a therapeutic nucleic acid of the invention can beadministered at 0.001, 0.01, 0.1, 1, 10, 20, 30, 40, 50, 100, 200, 400,600, 800, 1000, 2000, to 4000 ng, μg, or mg, including all values andranges there between.

In certain aspects, the therapeutic nucleic acid is a synthetic nucleicacid. Moreover, nucleic acids of the invention may be fully or partiallysynthetic. In yet a further aspect, nucleic acids of the invention,including synthetic nucleic acid, can be administered at 0.001, 0.01,0.1, 1, 10, 20, 30, 40, 50, 100, to 200 ng, μg, or mg per kilogram (kg)of body weight. Each of the amounts described herein may be administeredover a period of time, including 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,minutes, hours, days, weeks, months or years, including all values andranges there between.

In certain embodiments, administration of the composition(s) can beenteral or parenteral. In certain aspects, enteral administration isoral. In further aspects, parenteral administration is intralesional,intravascular, intracranial, intrapleural, intratumoral,intraperitoneal, intramuscular, intralymphatic, intraglandular,subcutaneous, topical, intrabronchial, intratracheal, intranasal,inhaled, or instilled. Compositions of the invention may be administeredregionally or locally and not necessarily directly into a lesion.

A further embodiment of the invention includes methods of detectingcancer or CSCs in a biological sample comprising evaluating expressionlevels of 1, 2, 3, 4, 5, 6, 7, 8 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,19, 20, or more of hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e,hsa-let-7f, hsa-let-7i, hsa-miR-100, hsa-miR-101, hsa-miR-103,hsa-miR-105, hsa-miR-106a, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a,hsa-miR-125a, hsa-miR-125b, hsa-miR-126, hsa-miR-127, hsa-miR-132,hsa-miR-133a, hsa-miR-133b, hsa-miR-140, hsa-miR-141, hsa-miR-142-3p,hsa-miR-142-5p, hsa-miR-145, hsa-miR-146a, hsa-miR-146b, hsa-miR-147,hsa-miR-148a, hsa-miR-148b, hsa-miR-149, hsa-miR-151, hsa-miR-152,hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-181a, hsa-miR-181b,hsa-miR-181d, hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-190,hsa-miR-191, hsa-miR-192, hsa-miR-193b, hsa-miR-195, hsa-miR-196a,hsa-miR-196b, hsa-miR-199a, hsa-miR-19a, hsa-miR-19b, hsa-miR-200a,hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-223,hsa-miR-24, hsa-miR-25, hsa-miR-26a, hsa-miR-26b, hsa-miR-27a,hsa-miR-27b, hsa-miR-28, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c,hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c,hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32, hsa-miR-320, hsa-miR-324-3p,hsa-miR-324-5p, hsa-miR-328, hsa-miR-33, hsa-miR-331, hsa-miR-335,hsa-miR-338, hsa-miR-339, hsa-miR-340, hsa-miR-342, hsa-miR-345,hsa-miR-34a, hsa-miR-361, hsa-miR-362, hsa-miR-365, hsa-miR-374,hsa-miR-375, hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-423,hsa-miR-425, hsa-miR-429, hsa-miR-433, hsa-miR-451, hsa-miR-452,hsa-miR-500, hsa-miR-501, hsa-miR-7, hsa-miR-9, hsa-miR-9*, hsa-miR-92,hsa-miR-93, hsa-miR-96, hsa-miR-98, hsa-miR-99b or combinations thereof.

An increase in the level of hsa-let-7b, hsa-let-7c, hsa-let-7e,hsa-miR-100, hsa-miR-101, hsa-miR-105, hsa-miR-10a, hsa-miR-10b,hsa-miR-124a, hsa-miR-125a, hsa-miR-125b, hsa-miR-127, hsa-miR-133a,hsa-miR-133b, hsa-miR-140, hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-145,hsa-miR-146a, hsa-miR-146b, hsa-miR-147, hsa-miR-148a, hsa-miR-148b,hsa-miR-15b, hsa-miR-16, hsa-miR-181a, hsa-miR-181d, hsa-miR-183,hsa-miR-18a, hsa-miR-190, hsa-miR-192, hsa-miR-193b, hsa-miR-195,hsa-miR-196a, hsa-miR-196b, hsa-miR-19a, hsa-miR-19b, hsa-miR-203,hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22,hsa-miR-221, hsa-miR-222, hsa-miR-223, hsa-miR-24, hsa-miR-25,hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-28, hsa-miR-29a,hsa-miR-29b, hsa-miR-29c, hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p,hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32,hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p, hsa-miR-328, hsa-miR-33,hsa-miR-331, hsa-miR-338, hsa-miR-339, hsa-miR-345, hsa-miR-361,hsa-miR-374, hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-423,hsa-miR-425, hsa-miR-433, hsa-miR-451, hsa-miR-452, hsa-miR-500,hsa-miR-501, hsa-miR-9, and/or hsa-miR-96 expression is indicative ofcancer or CSCs. A decrease in the level of hsa-let-7a, hsa-let-7b,hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-let-7i, hsa-miR-101,hsa-miR-103, hsa-miR-106a, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a,hsa-miR-125a, hsa-miR-126, hsa-miR-132, hsa-miR-133a, hsa-miR-141,hsa-miR-146a, hsa-miR-146b, hsa-miR-148a, hsa-miR-148b, hsa-miR-149,hsa-miR-151, hsa-miR-152, hsa-miR-15a, hsa-miR-15b, hsa-miR-181b,hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-191, hsa-miR-193b,hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-199a, hsa-miR-200a,hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-222, hsa-miR-24, hsa-miR-25,hsa-miR-26a, hsa-miR-27a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30a-3p,hsa-miR-30a-5p, hsa-miR-30d, hsa-miR-320, hsa-miR-324-5p, hsa-miR-328,hsa-miR-331, hsa-miR-335, hsa-miR-340, hsa-miR-342, hsa-miR-345,hsa-miR-34a, hsa-miR-362, hsa-miR-365, hsa-miR-375, hsa-miR-378,hsa-miR-422a, hsa-miR-422b, hsa-miR-425, hsa-miR-429, hsa-miR-500,hsa-miR-7, hsa-miR-9*, hsa-miR-92, hsa-miR-93, hsa-miR-98, and/orhsa-miR-99b expression is indicative of cancer or CSCs.

The present invention also concerns kits containing compositions of theinvention or compositions to implement methods of the invention. In someembodiments, kits can be used to administer one or more therapeuticnucleic acid molecules. In certain embodiments, a kit contains at leastor contains at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33,34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 ormore therapeutic nucleic acids related to miRNAs described herein andinclude all or part of an miRNA and/or synthetic miRNA molecules and/ormiRNA inhibitors, or any range and combination derivable therein. Insome embodiments, there are kits for evaluating miRNA activity in a celland assessing the effectiveness of nucleic acid therapy.

Kits may comprise components, which may be individually packaged orplaced in a container, such as a tube, bottle, vial, syringe, or othersuitable container means.

Individual components may also be provided in a kit in concentratedamounts; in some embodiments, a component is provided individually inthe same concentration as it would be in a solution with othercomponents. Concentrations of components may be provided as 1×, 2×, 5×,10×, or 20× or more.

Kits for using therapeutic nucleic acids and/or miRNA inhibitors of theinvention for therapeutic applications are included as part of theinvention. Specifically contemplated are any such moleculescorresponding to any miRNA effective against cancer or CSCs, such asthose discussed herein.

It is contemplated that any method or composition described herein canbe implemented with respect to any other method or composition describedherein and that different embodiments may be combined. It isspecifically contemplated that any methods and compositions discussedherein with respect to therapeutic nucleic acids, miRNA molecules,and/or miRNA inhibitors may be implemented with respect to syntheticmiRNAs. Nucleic acids may be exposed to conditions that allow it tobecome processed under physiological circumstances. The claimsoriginally filed are contemplated to cover claims that are multiplydependent on any filed claim or combination of filed claims.

Any embodiment of the invention involving specific miRNAs by name iscontemplated also to cover embodiments involving miRNAs whose sequencesare at least 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,95, 96, 97, 98, 99% identical to the mature sequence or precursorsequence of a specified miRNA(s). In other aspects miRNA of theinvention may include additional nucleotides at the 5′,3′, or both 5′and 3′ ends of at least, at most or about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10or more nucleotides.

Embodiments of the invention include kits for analysis of a pathologicalsample by assessing miRNA profile for a sample comprising, in suitablecontainer means, two or more miRNA probes and/or amplification primers,wherein the miRNA probes detect or primer amplify one or more miRNAdescribed herein. The kit can further comprise reagents for labelingmiRNA in the sample. The kit may also include the labeling reagentsinclude at least one amine-modified nucleotide, poly(A) polymerase, andpoly(A) polymerase buffer. Labeling reagents can include anamine-reactive dye.

The use of the word “a” or “an” when used in conjunction with the term“comprising” in the claims and/or the specification may mean “one,” butit is also consistent with the meaning of “one or more,” “at least one,”and “one or more than one.”

It is contemplated that any embodiment discussed herein can beimplemented with respect to any method or composition of the invention,and vice versa. Furthermore, compositions and kits of the invention canbe used to achieve methods of the invention.

Throughout this application, the term “about” may be used to indicatethat a value includes the standard deviation of error for the device ormethod being employed to determine the value.

The use of the term “or” in the claims is used to mean “and/or” unlessexplicitly indicated to refer to alternatives only or the alternativesare mutually exclusive, although the disclosure supports a definitionthat refers to only alternatives and “and/or.”

As used in this specification and claim(s), the words “comprising” (andany form of comprising, such as “comprise” and “comprises”), “having”(and any form of having, such as “have” and “has”), “including” (and anyform of including, such as “includes” and “include”) or “containing”(and any form of containing, such as “contains” and “contain”) areinclusive or open-ended and do not exclude additional, unrecitedelements or method steps.

Other objects, features and advantages of the present invention willbecome apparent from the following detailed description. It should beunderstood, however, that the detailed description and the specificexamples, while indicating specific embodiments of the invention, aregiven by way of illustration only, since various changes andmodifications within the spirit and scope of the invention will becomeapparent to those skilled in the art from this detailed description.

DESCRIPTION OF THE DRAWINGS

The following drawings form part of the present specification and areincluded to further demonstrate certain aspects of the presentinvention. The invention may be better understood by reference to one ormore of these drawings in combination with the detailed description ofspecific embodiments presented herein.

FIG. 1 illustrates differential expression of miRNAs in CD44⁺ CSCsderived from freshly isolated human prostate tumor samples. Expressionof miRNAs in CSCs was normalized to the expression of miRNAs in theCD44⁻ cancer cells (100%). Each vertical bar represents miRNA expressionin a single human prostate tumor sample.

FIG. 2 illustrates effects of hsa-miR-34a on tumor growth of prostatecancer stem cells. Purified CD44+ Du145 prostate cancer cells wereinfected with lentivirus carrying hsa-miR-34a (miR-34a) or negativecontrol miRNA (ctl). Each 10⁴ cells were injected into the dorsalprostate of NOD/SCID mice. Mice injected with miR-34 treated LAPC9 cellsdid not develop tumors.

FIG. 3 illustrates LAPC9 prostate cancer tumors from eight mice,forty-eight days following transfection of anti-miR-34a or negativecontrol miRNA (anti-miR-NC) into LAPC9 cells and subsequent injection of10⁵ cells into the dorsal prostate of NOD/SCID mice.

FIG. 4 illustrates long-term effects of hsa-miR-34a on cultured humanPPC-1, PC3 and Du145 prostate cancer cells. Equal numbers cells wereelectroporated with 1.6 μM hsa-miR-34a (white squares) or negativecontrol miRNA (NC, black diamonds), seeded and propagated in regulargrowth medium. When the control cells reached confluence (days 4 and 11for PPC-1, days 7 and 14 for PC3 and Du145), cells were harvested,counted and electroporated again with the respective miRNAs. Thepopulation doubling and cumulative cell counts was calculated andplotted on a linear scale. Arrows represent electroporation days.Experiments with PC3 and Du145 cells were carried out in triplicates.Standard deviations are shown in the graphs. Abbreviation: miR-34a,hsa-miR-34a; NC, negative control miRNA.

FIG. 5 illustrates the average tumor volumes in groups of seven (n=7)mice carrying human PPC-1 prostate cancer xenografts. Human PPC-1prostate tumor cells were treated with hsa-miR-34a (white squares) orwith a negative control miRNA (NC, black diamonds) on days 0, 7, 13, 20,and 25 (arrows). Tumor growth was determined by caliper measurements for32 days. Standard deviations are shown in the graph. All data pointsyielded p values<0.01. The p value obtained from data on day 22 isindicated by a circle. Abbreviation: miR-34a, hsa-miR-34a; NC, negativecontrol miRNA.

FIG. 6 illustrates the histology of tumors that developed from PPC-1prostate cancer cells treated with negative control miRNA (right) orhsa-miR-34a (left). Images show tumors stained with hematoxylin andeosin. The arrow indicates a pocket with seemingly viable cells.Abbreviation: miR-34a, hsa-miR-34a; NC, negative control miRNA.

FIG. 7 illustrates immunohistochemistry of PPC-1 tumors treated withnegative control miRNA (top panels) or hsa-miR-34a (bottom panels). Forhsa-miR-34a-treated tumors, the analysis is limited to areas withseemingly viable cells as shown in FIG. 8. Left images show tumor cellsstained with hematoxylin and eosin (H&E); center images show animmunohistochemistry analysis using antibodies against the Ki-67 antigen(dark spotted areas); right images show an immunohistochemistry analysisusing antibodies against caspase 3. Areas with increased apoptoticactivity are exemplarily denoted by arrows. Abbreviation: miR-34a,hsa-miR-34a; NC, negative control miRNA.

FIG. 8 Survival curve. LAPC9-GFP cells (500,000) were orthotopicallyimplanted in the dorsal prostate of male NOD/SCID mice. Twenty-one dayslater, animals were divided into four groups (n=7 for each group) andinjected, via tail vein, with PBS (diamonds); vehicle control,(circles); miR-NC (triangles); and hsa-miR-34a (squares) on day 0.Injections were repeated on days 2, 4, 6, 8, and 10. Survival wastracked and plotted for 13 days.

FIG. 9 illustrates the long-term effects of hsa-miR-34a on culturedhuman H226 lung cancer cell numbers. Equal numbers of H226 cells wereelectroporated with 1.6 μM hsa-miR-34a (white squares) or negativecontrol miRNA (NC, black diamonds), seeded and propagated in regulargrowth medium. When the control cells reached confluence (days 6, 17 and25), cells were harvested, counted and electroporated again with therespective miRNAs. The population doubling and cumulative cell countswas calculated and plotted on a linear scale. Arrows representelectroporation days. Abbreviation: miR-34a, hsa-miR-34a; NC, negativecontrol miRNA.

FIG. 10 illustrates average tumor volumes in groups of six (n=6) micecarrying human H460 lung cancer xenografts. Palpable tumors were treatedwith hsa-miR-34a (white squares) or with a negative control miRNA (NC,black diamonds) on days 11, 14, and 17 (arrows). Standard deviations areshown in the graph. Data points with p values<0.1, <0.05 and <0.01 areindicated by a cross, an asterisk or circles, respectively.Abbreviation: miR-34a, hsa-miR-34a; NC, negative control miRNA.

FIG. 11 illustrates the average tumor volumes in groups of seven (n=7)mice carrying human PPC-1 prostate cancer xenografts. Human PPC-1prostate tumor cells were treated with hsa-miR-126 (white squares) orwith a negative control miRNA (NC, black diamonds) on days 0, 7, 13 and20 (arrows). Tumor growth was determined by caliper measurements for 22days. Standard deviations are shown in the graph. Data points with pvalues<0.01 are indicated by a circle. Abbreviation: miR-126,hsa-miR-126; NC, negative control miRNA.

FIG. 12 illustrates average tumor volumes in groups of six (n=6) micecarrying human H460 lung cancer xenografts. Palpable tumors were treatedwith hsa-miR-126 (white squares) or with a negative control miRNA (NC,black diamonds) on days 11, 14, and 17 (arrows). Standard deviations areshown in the graph. Data points with p values<0.05 and <0.01 areindicated by an asterisk or circles, respectively. Abbreviation:miR-126, hsa-miR-126; NC, negative control miRNA.

FIG. 13 illustrates average tumor volumes in groups of six (n=6) micecarrying human H460 lung cancer xenografts. Palpable tumors were treatedwith hsa-let-7b (white squares) or with a negative control miRNA (NC,black diamonds) on days 11, 14, and 17 (arrows). Standard deviations areshown in the graph. Data points with p values<0.01 are indicatedcircles. Abbreviation: let-7b, hsa-let-7b; NC, negative control miRNA.

DETAILED DESCRIPTION OF THE INVENTION

The present invention is directed to compositions and methods relatingto preparation and characterization of miRNAs, as well as use of miRNAsfor therapeutic, prognostic, and diagnostic applications, particularlythose methods and compositions related to assessing and/or identifyingcancer, CSCs and related conditions or diseases. In certain aspects thecancer is prostate cancer. In certain aspects the cancer is lung cancer.Other conditions amenable to the methods described herein include benignprostatic hyperplasia (BPH).

I. Identification and Isolation of Stem Cells and CSCs

The most common method of identifying CSCs in a tumor is through theidentification of cell surface markers that also identify normal stemcells in the tissue of origin. For instance, leukemic stem cells (LSCs)express the CD34 surface marker and lack the CD38 surface antigen, as isthe case for normal (i.e., non-leukemic) hematopoietic stem cells(Bonnet and Dick, 1997). Prostate CSCs are positive for the CD133 andCD44 surface antigens (CD133⁺CD44⁺) and thus exhibit the sameCD133⁺/CD44⁺ phenotype as normal prostate stem cells (Collins et al.,2005; Richardson et al., 2004). CSCs identified by cell surface markerexpression can be purified by methods such as fluorescence-activatedcell sorting (FACS).

Besides cell surface marker expression, functional assays are alsofrequently used to identify and isolate CSCs. Normal stem cells and CSCspreferentially express ATP-binding cassette (ABC) transporters, membraneprotein complexes that enable the cells to resist cytotoxic drugs byactively transporting toxic compounds out of the cell. When cells arestained with the Hoechst 33342 fluorescent dye, ABC transporters in thestem cells actively pump the dye out of the cell. Stem cells thus appearas a “Hoechst-low” population when analyzed by FACS; whereas non-stemcells are more highly fluorescent. Since the “Hoechst-low” fraction lieson the side of the FACS profile, it is termed the ‘Side Population’(SP). The SP selection technique has been successfully applied toidentify and isolate stem cells and CSCs from a variety of tissues,including the blood, brain, and breast (Zhou et al., 2001; Goodell etal., 1996; Hirschmann-Jax et al., 2004; Patrawala et al., 2005;Engelmann et al., 2008).

Using well-established xenograft models, Patrawala et al. (2007)determined that prostate cancer cells are organized as a hierarchyencompassing a spectrum of cells at different stages of differentiation(Patrawala et al., 2007). In LAPC-9, a prostate xenograft isolated froma bone metastasis (Reiters and Sawyers, 2001), the SP cells comprise0.1% of the total population and are 1000-fold more tumorigenic than thecorresponding non-SP cells (Patrawala et al., 2005). CD44, a marker fornormal prostate stem cells, identifies CSCs in LAPC-9, LAPC-4 (lymphnode metastasis; Reiters and Sawyers, 2001) and Du145 (brain metastasis;Stone et al., 1978) tumors. CD44⁺ cells are more tumorigenic, invasive,and metastatic, as compared with their more differentiated counterparts,and display asymmetric cell-division, a hall-mark of self-renewal(Patrawala et al., 2006).

Both, the SP and CD44-expressing cells preferentially express genes thatare associated with stem cell capacity, such as genes in the Notch, Wnt,and Hedgehog (Hh) signaling pathways. These three pathways arefrequently implicated in self-renewal and maintenance of anundifferentiated state in stem cells and CSCs. For example, Hh signalingis required for prostate epithelium generation, and constitutive Hhsignaling in undifferentiated stem/progenitor cells leads to oncogenictransformation (Karhadkar et al., 2004). Knockdown of Gli2, thetranscription factor that primarily mediates Hh signaling, results ininhibition of colony-formation and tumor growth of prostate cancer cells(Thiyagarajan et al., 2007). Hh pathway components PTCH, Gli1, and Gli2also regulate self-renewal of CD44⁺CD24⁻ breast CSCs (Liu et al., 2006).Treatment of medulloblastoma cells with cyclopamine, a Hh pathwayantagonist, results in induction of genes related to neuronaldifferentiation (Berman et al., 2002). Notch and Wnt/β-catenin signalingare also required for maintenance of CSCs in a number of tumors(Malanchi et al., 2008; Li et al., 2003). Other stem cell capacity genesmisregulated in CSCs include ALDH (Ginestier et al., 2007; Dylla et al.,2008), embryonic stem cell transcription factors such as Nanog, Oct-4,Sox-2, and Sox-4 (Zhang et al., 2008; Gu et al., 2007), PTEN(Hambardzumyan et al., 2008; Wang et al., 2006), and Bmi (Li et al.,2003; Hurt et al., 2008). These observations highlight the value of thisstem cell-related pathway for treating cancers.

Several groups have also published large-scale gene-expression analysescomparing CSCs to their non-CSC counterparts (Hurt et al., 2008; Birnieet al., 2008; Liu et al., 2007). Liu et al. (2007) showed that the‘invasive gene signature’ (IGS) derived from CD44⁺CD24⁻ breast CSCscould predict overall survival of patients with breast cancer,medulloblastoma, lung cancer, and prostate cancer. An independent studyinvestigating gene expression in prostate CSCs found that 118 of 187 IGSgenes were also represented in their arrays (Hurt et al., 2008). Thesedata reiterate the notion that common pathways govern CSC propertiesacross a variety of cancers.

Common genetic regulatory mechanisms govern the unique properties ofCSCs from different tumor types. For instance, cross-talk betweenhedgehog signaling components PTCH and Gli1, and the Polycomb proteinBmi-1 regulates self-renewal in CD44⁺CD24⁻ breast CSCs (Bao et al.,2006). Hedgehog signaling maintains self-renewal in normal prostate stemcells, and aberrant activation of this pathway (mediated through Bmi-1and SMO) leads to neoplastic transformation of the cells (Karhadkar etal., 2004; Fan et al., 2004). Other CSCs requiring Sonic Hedgehogactivation for survival include those from multiple myeloma (Peacock etal., 2007), leukemia (Lessard and Sauvageau, 2003), and pancreaticcancer (Li et al., 2007). In short, CSCs derived from various cancersappear to have shared characteristics that are driven by the samemechanistic forces.

Other genes frequently implicated in CSC maintenance include PTEN (Wanget al., 2006; Hambardzumyan et al., 2008), Stat3 (Zhou et al., 2007),Bcl-2 (Konopleva et al., 2006), Ras (Yu et al., 2007), TGF-β (Shipitsinet al., 2007; Tang et al., 2007), and genes in the Notch (Fan et al.,2006; Shipitsin et al., 2007) and Wnt (Li et al., 2003; Jamieson et al.,2004) pathways. Furthermore, embryonic stem cell genes such as Nanog,Oct-4, Sox-2, and Sox-4 are increasingly reported to be associated withCSC self-renewal (Zhang et al., 2008; Gu et al., 2007; Zhang et al.,2006; Hurt et al., 2008). Several investigators have compared geneexpression in CSCs with gene expression in their non-CSC counterparts orin normal stem cells from the matched tissue to generate CSC geneexpression signatures for individual tumor types (Shepherd et al., 2008;Birnie et al., 2008; Liu et al., 2007; Shipitsin et al., 2007; Liu etal., 2006; Beier et al., 2007). In addition, expression patterns ofgenes in breast CSCs, also known as the ‘Invasive Gene Signature’ (IGS),were successfully used to predict the clinical outcome of patients thatdeveloped not only metastatic breast cancer, but also prostate cancer,lung cancer, and medulloblastoma (Liu et al., 2007), highlighting theprognostic value of this information.

II. Therapeutic Methods

Certain embodiments of the invention concern nucleic acids that performthe activities of or inhibit endogenous miRNAs, mRNA, or other cellularcomponents when introduced into cells. In certain aspects, therapeuticnucleic acids (also referred to as nucleic acids) can be synthetic,non-synthetic, or a combination of synthetic and non-synthetic miRNAsequences. Sequence-specific miRNA inhibitors can be used to inhibitsequentially or in combination the activities of one or more miRNAs incells, as well those genes and associated pathways (including thosepathways indicative of CSCs) modulated by an miRNA.

The present invention concerns, in certain aspects, short nucleic acidmolecules (therapeutic nucleic acids) that function as miRNAs or asinhibitors of miRNA in a cell. The term “short” refers to a length of asingle polynucleotide that is 10, 15, 16, 17, 18, 19, 20, 21, 22, 23,24, 25, 50, 100, or 150 nucleotides or fewer, including all integers orranges derivable there between. The nucleic acid molecules are typicallysynthetic. The term “synthetic” refers to nucleic acid molecule that isisolated and not produced naturally in a cell. In certain aspects all orpart of the sequence and/or chemical structure deviates from anaturally-occurring nucleic acid molecule (e.g., an endogenous precursormiRNA or miRNA molecule).

In certain aspects, nucleic acids of the invention do not have an entiresequence that is identical or complementary to a sequence of anaturally-occurring nucleic acids (e.g., miRNA), such molecules mayencompass all or part of a naturally-occurring sequence or a complementthereof. It is contemplated, however, that a synthetic nucleic acidadministered to a cell may subsequently be modified or altered in thecell such that its structure or sequence is the same or substantiallythe same as all or part of a non-synthetic or naturally occurring miRNA,such as a mature miRNA sequence. For example, a synthetic nucleic acidmay have a sequence that differs from the sequence of a precursor miRNA,but that sequence may be altered once in a cell to be the same as anendogenous, processed miRNA or an inhibitor thereof.

The term “isolated” means that the nucleic acid molecules of theinvention are initially separated from different (in terms of sequenceor structure) and unwanted nucleic acid molecules such that a populationof isolated nucleic acids is at least about 90% homogenous, and may beat least about 95, 96, 97, 98, 99, or 100% homogenous with respect toother polynucleotide molecules. In many aspects of the invention, anucleic acid is isolated by virtue of it having been synthesized invitro separate from endogenous nucleic acids in a cell. It will beunderstood, however, that isolated nucleic acids may be subsequentlymixed or pooled together.

In certain aspects, synthetic miRNA of the invention are RNA or RNAanalogs. miRNA inhibitors may be DNA and/or RNA, or analogs thereof.miRNA and miRNA inhibitors of the invention are collectively referred toas “synthetic nucleic acids.”

In some embodiments, a therapeutic nucleic acid can have a miRNA or asynthetic miRNA sequence of between 10-200 to between 17-130 residues,including all values and ranges there between. The present inventionconcerns miRNA or synthetic miRNA molecules that are, are at least, orare at most 10, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28,29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46,47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64,65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82,83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100,101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114,115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128,129, 130, 140, 145, 150, 160, 170, 180, 190, 200 or more residues inlength, including any integer or any range there between.

In certain aspects, synthetic nucleic acids have (a) a “miRNA region”whose sequence or binding region from 5′ to 3′ is identical orcomplementary to all or a segment of a mature miRNA sequence, and (b) a“complementary region” whose sequence from 5′ to 3′ is between 60% and100% complementary to the miRNA sequence in (a). In certain embodiments,these synthetic nucleic acids are also isolated, as defined above. Theterm “miRNA region” refers to a region on the synthetic nucleic acidthat is at least 75, 80, 85, 90, 95, or 100% identical, including allintegers there between, to the entire sequence of a mature, naturallyoccurring miRNA sequence or a complement thereof In certain embodiments,the miRNA region is or is at least 90, 91, 92, 93, 94, 95, 96, 97, 98,99, 99.1, 99.2, 99.3, 99.4, 99.5, 99.6, 99.7, 99.8, 99.9 or 100%identical to the sequence of a naturally-occurring miRNA, or segmentthereof, or complement thereof.

The term “complementary region” or “complement” refers to a region of anucleic acid or mimetic that is or is at least 60% complementary to themature, naturally occurring miRNA sequence. The complementary region isor is at least 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73,74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91,92, 93, 94, 95, 96, 97, 98, 99, 99.1, 99.2, 99.3, 99.4, 99.5, 99.6,99.7, 99.8, 99.9 or 100% complementary, or any range derivable therein.With single polynucleotide sequences, there may be a hairpin loopstructure as a result of chemical bonding between the miRNA region andthe complementary region. In other embodiments, the complementary regionis on a different nucleic acid molecule than the miRNA region, in whichcase the complementary region is on the complementary strand and themiRNA region is on the active strand.

In other embodiments of the invention, there are synthetic nucleic acidsthat are miRNA inhibitors. A miRNA inhibitor is between about 10 to 30or 17 to 25 nucleotides in length and comprises a 5′ to 3′ sequence thatis at least 90% complementary to the 5′ to 3′ sequence of a maturemiRNA. In certain embodiments, a miRNA inhibitor molecule is 10, 15, 16,17, 18, 19, 20, 21, 22, 23, 24, or 25 nucleotides in length, or anyrange or value there between. Moreover, an miRNA inhibitor may have asequence (from 5′ to 3′) that is or is at least 70, 75, 80, 85, 90, 91,92, 93, 94, 95, 96, 97, 98, 99, 99.1, 99.2, 99.3, 99.4, 99.5, 99.6,99.7, 99.8, 99.9 or 100% complementary, or any range derivable therein,to the 5′ to 3′ sequence of a mature miRNA, particularly a mature,naturally occurring miRNA. A portion of a nucleic acid sequence can bealtered so that it comprises an appropriate percentage ofcomplementarity to the sequence of a mature miRNA or mRNA.

In some embodiments, of the invention, a therapeutic nucleic acidcontains one or more design element(s). These design elements include,but are not limited to: (i) a replacement group for the phosphate orhydroxyl of the nucleotide at the 5′ terminus of the complementaryregion; (ii) one or more sugar modifications in the first or last 1 to 6residues of the complementary region; or (iii) noncomplementaritybetween one or more nucleotides in the last 1 to 5 residues at the 3′end of the complementary region and the corresponding nucleotides of themiRNA region. A variety of design modifications are known in the art,see below.

In certain embodiments, a synthetic miRNA has a nucleotide at its 5′ endof the complementary region in which the phosphate and/or hydroxyl grouphas been replaced with another chemical group (referred to as the“replacement design”). In some cases, the phosphate group is replaced,while in others, the hydroxyl group has been replaced. In particularembodiments, the replacement group is biotin, an amine group, a loweralkylamine group, an aminohexyl phosphate group, an acetyl group, 2′O-Me(2′oxygen-methyl), DMTO (4,4′-dimethoxytrityl with oxygen), fluorescein,a thiol, or acridine, though other replacement groups are well known tothose of skill in the art and can be used as well. This design elementcan also be used with a miRNA inhibitor.

In certain aspects, a synthetic miRNA can have one or more sugarmodifications in the first or last 1 to 6 residues of the complementaryregion (referred to as the “sugar replacement design”). In certaincases, there is one or more sugar modifications in the first 1, 2, 3, 4,5, 6 or more residues of the complementary region, or any rangederivable therein. In additional cases, there is one or more sugarmodifications in the last 1, 2, 3, 4, 5, 6 or more residues of thecomplementary region, or any range derivable there between. It will beunderstood that the terms “first” and “last” are with respect to theorder of residues from the 5′ end to the 3′ end of the region. Inparticular embodiments, the sugar modification is a 2′O-Me modification,a 2′F modification, a 2′H modification, a 2′amino modification, a4′thioribose modification or a phosphorothioate modification on thecarboxy group linked to the carbon at position 6′. In furtherembodiments, there is one or more sugar modifications in the first orlast 2 to 4 residues of the complementary region or the first or last 4to 6 residues of the complementary region. This design element can alsobe used with an miRNA inhibitor. Thus, an miRNA inhibitor can have thisdesign element and/or a replacement group on the nucleotide at the 5′terminus, as discussed above.

In other embodiments of the invention, the therapeutic nucleic acid canhave one or more nucleotides in the last 1 to 5 residues at the 3′ endof the complementary region that are not complementary to thecorresponding nucleotides of the miRNA region (“noncomplementarity”)(referred to as the “noncomplementarity design”). The noncomplementaritymay be in the last 1, 2, 3, 4, and/or 5 residues of the complementarymiRNA. In certain embodiments, there is noncomplementarity with at least2 nucleotides in the complementary region.

It is contemplated that therapeutic nucleic acids of the invention haveone or more of the replacement, sugar modification, ornoncomplementarity designs. In certain cases, synthetic nucleic acidmolecules have two of them, while in others these molecules have allthree designs in place.

The miRNA region and the complementary region may be on the same orseparate polynucleotides. In cases in which they are contained on or inthe same polynucleotide, the miRNA molecule will be considered a singlepolynucleotide. In embodiments in which the different regions are onseparate polynucleotides, the synthetic miRNA will be considered to becomprised of two polynucleotides.

When the RNA molecule is a single polynucleotide, there can be a linkerregion between the miRNA region and the complementary region. In someembodiments, the single polynucleotide is capable of forming a hairpinloop structure as a result of bonding between the miRNA region and thecomplementary region. The linker constitutes the hairpin loop. It iscontemplated that in some embodiments, the linker region is, is atleast, or is at most 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,35, 36, 37, 38, 39, or 40 residues in length, or any range derivabletherein. In certain embodiments, the linker is between 3 and 30 residues(inclusive) in length.

In addition to having a miRNA or inhibitor region and a complementaryregion, there may be flanking sequences as well at either the 5′ or 3′end of the region. In some embodiments, there is or is at least 1, 2, 3,4, 5, 6, 7, 8, 9, 10 nucleotides or more, or any range derivabletherein, flanking one or both sides of these regions.

Methods of the invention include reducing or eliminating activity of oneor more miRNAs in a cell comprising introducing into a cell atherapeutic nucleic acid, such as a miRNA inhibitor, (the description ofmiRNA, where appropriate, also will refer to a miRNA inhibitor); orsupplying or enhancing the activity of one or more miRNAs in a cell. Thepresent invention also concerns inducing certain cellularcharacteristics by providing to a cell a particular nucleic acid, suchas a specific therapeutic nucleic acid molecule or a miRNA inhibitormolecule. The therapeutic nucleic acid or miRNA inhibitor need not besynthetic. They may have a sequence that is identical to a naturallyoccurring miRNA or they may not have any design modifications. Incertain embodiments, the therapeutic nucleic acid and/or the miRNAinhibitor are synthetic, as discussed above.

In certain aspects, a particular nucleic acid molecule provided to thecell is understood to correspond to a particular miRNA in the cell, andthus, the miRNA in the cell is referred to as the “corresponding miRNA.”In situations in which a named miRNA molecule is introduced into a cell,the corresponding miRNA will be understood to be the induced orinhibited miRNA function. It is contemplated, however, that thetherapeutic nucleic acid introduced into a cell is not a mature miRNAbut is capable of becoming or functioning as a mature miRNA under theappropriate physiological conditions. In cases in which a particularcorresponding miRNA is being inhibited by a miRNA inhibitor, theparticular miRNA will be referred to as the “targeted miRNA.” It iscontemplated that multiple corresponding or targeted or combinations ofmiRNAs may be involved. In particular embodiments, more than onetherapeutic nucleic acid is introduced into a cell. Moreover, in otherembodiments, more than one miRNA inhibitor is introduced into a cell.Furthermore, a combination of therapeutic nucleic acid(s) and miRNAinhibitor(s) may be introduced into a cell. The inventors contemplatethat a combination of therapeutic nucleic acids may act at one or morepoints in cellular pathways of cells and that such combination may haveincreased efficacy on the target cell while not adversely effectingnormal or non-targeted cells. Thus, a combination of therapeutic nucleicacids may have a minimal adverse effect on a subject or patient whilesupplying a sufficient therapeutic effect, such as amelioration of acondition, growth inhibition of a cell, death of a targeted cell,alteration of cell phenotype or physiology, slowing of cellular growth,sensitization to a second therapy, sensitization to a particulartherapy, and the like.

Methods include identifying a cell or patient in need of inducing thosecellular characteristics. Also, it will be understood that an amount ofa therapeutic nucleic acid that is provided to a cell or organism is an“effective amount,” which refers to an amount needed (or a sufficientamount) to achieve a desired goal, such as inducing a particularcellular characteristic(s) or reducing cancer growth or killing cancercells or alleviating symptoms associated with a cancer.

In certain aspects methods can include providing or introducing to acell a nucleic acid molecule corresponding to a mature miRNA in the cellin an amount effective to achieve a desired physiological result.Moreover, methods can involve providing synthetic or nonsynthetictherapeutic nucleic acids. It is contemplated that in these embodiments,that methods may or may not be limited to providing only one or moresynthetic molecules or only one or more nonsynthetic molecules. Thus, incertain embodiments, methods may involve providing both synthetic andnonsynthetic therapeutic nucleic acids. In this situation, a cell orcells are most likely provided a synthetic molecule corresponding to aparticular miRNA and a nonsynthetic molecule corresponding to adifferent miRNA or an inhibitor thereof. Furthermore, any methodarticulated using a list of miRNA targets using Markush group languagemay be articulated without the Markush group language and a disjunctivearticle (i.e., or) instead, and vice versa.

In some embodiments, there is a method for reducing or inhibiting cellproliferation, propagation, or renewal in a cell comprising introducinginto or providing to the cell an effective amount of (i) a therapeuticnucleic acid or (ii) a synthetic or nonsynthetic molecule thatcorresponds to a miRNA sequence. In certain embodiments the methodsinvolve introducing into the cell an effective amount of (i) a miRNAinhibitor molecule having a 5′ to 3′ sequence that is at least 90%complementary to the 5′ to 3′ sequence of one or more miRNA.

Certain aspects of the invention include methods of treating apathologic condition, such as cancer or precancerous conditions. In oneaspect, the method comprises contacting a target cell with one or morenucleic acids comprising at least one nucleic acid segment having all ora portion of a miRNA sequence or a complement thereof. The segment maybe 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,23, 24, 25, 30 or more nucleotides or nucleotide analog, including allintegers there between. An aspect of the invention includes themodulation of gene expression, miRNA expression or function or mRNAexpression or function within a target cell, such as a prostate cancercell or CSC.

Typically, an endogenous gene, miRNA or mRNA is modulated in the cell.In certain aspects, a therapeutic nucleic acid sequence comprises atleast one segment that is at least 70, 75, 80, 85, 90, 95, or 100%identical in nucleic acid sequence to one or more miRNA or gene sequenceor complement thereof Modulation of the expression or processing of agene, miRNA, or mRNA of the cell or a virus can be through modulation ofthe processing of a nucleic acid, such processing includingtranscription, transportation and/or translation with in a cell.Modulation may also be effected by the inhibition or enhancement ofmiRNA activity with a cell, tissue, or organ. Such processing may affectthe expression of an encoded product or the stability of the mRNA.

It will be understood in methods of the invention that a cell or otherbiological matter such as an organism (including patients) can beprovided a therapeutic nucleic acid corresponding to or targeting aparticular miRNA by administering to the cell or organism a nucleic acidmolecule that functions as the corresponding miRNA once inside the cell.Thus, it is contemplated that a nucleic acid is provided such that itbecomes processed into a mature and active miRNA once it has access tothe cell's processing machinery. In certain aspects, it is specificallycontemplated that the miRNA molecule provided is not a mature moleculebut a nucleic acid molecule that can be processed into the mature miRNAor its functional equivalent once it is accessible to processingmachinery.

The term “nonsynthetic” in the context of miRNA means that the miRNA isnot “synthetic,” as defined herein. Furthermore, it is contemplated thatin embodiments of the invention that concern the use of syntheticmiRNAs, the use of corresponding nonsynthetic miRNAs is also consideredan aspect of the invention, and vice versa. It will be understood thatthe term “providing” an agent is used to include “administering” theagent to a patient.

In certain embodiments, methods also include targeting an miRNA in acell or organism. The term “targeting a miRNA” means a nucleic acid ofthe invention will be employed so as to regulate a selected miRNA. Insome embodiments the regulation is achieved with a synthetic ornon-synthetic nucleic acid that corresponds to the targeted miRNA, whicheffectively provides the function of the targeted miRNA to the cell ororganism (positive regulation). In other embodiments, the modulation isachieved with a miRNA inhibitor, which effectively inhibits the targetedmiRNA in the cell or organism (negative regulation).

In certain methods of the invention, there is a further step ofadministering a therapeutic nucleic acid to a cell, tissue, organ, ororganism (collectively “biological matter”) in need of treatment relatedto modulation of the targeted miRNA or in need of the physiological orbiological results discussed herein (such as with respect to aparticular cellular pathway involved in cancer or CSC cycle).Consequently, in some methods of the invention there is a step ofidentifying a patient in need of treatment that can be provided by thetherapeutic nucleic acids of the invention. It is contemplated that aneffective amount of a therapeutic nucleic acid can be administered, insome embodiments. In certain aspects, there is a therapeutic benefitconferred on the biological matter, where a “therapeutic benefit” refersto an improvement in the one or more conditions or symptoms associatedwith a disease or condition or an improvement in the prognosis,duration, or status with respect to the disease. It is contemplated thata therapeutic benefit includes, but is not limited to, a decrease inpain, a decrease in morbidity, a decrease in a symptom. For example,with respect to cancer, it is contemplated that a therapeutic benefitcan be inhibition of tumor growth, prevention of metastasis, reductionin number of metastases, inhibition of cancer cell proliferation,induction of cell death in cancer cells, inhibition of angiogenesis nearcancer cells, induction of apoptosis of cancer cells, reduction in pain,reduction in risk of recurrence, induction of chemo- or radiosensitivityin cancer cells, prolongation of life, and/or delay of death directly orindirectly related to cancer.

Furthermore, it is contemplated that the nucleic acid compositions maybe provided as part of a therapy to a patient, in conjunction withtraditional therapies or preventative agents. Moreover, it iscontemplated that any method discussed in the context of therapy may beapplied as preventatively, particularly in a patient identified to bepotentially in need of the therapy or at risk of the condition ordisease for which a therapy is needed.

In addition, methods of the invention concern employing one or morenucleic acid corresponding to a miRNA and a therapeutic drug. Thenucleic acid can enhance the effect or efficacy of the drug, reduce anyside effects or toxicity, modify its bioavailability, and/or decreasethe dosage or frequency needed. In certain embodiments, the therapeuticdrug is a cancer therapeutic. Consequently, in some embodiments, thereis a method of treating a HPV related precancer or cancer in a patientcomprising administering to the patient a cancer therapeutic (i.e., asecond therapeutic) and an effective amount of at least one nucleic acidmolecule that improves the efficacy of the cancer therapeutic orprotects non-cancer cells. Cancer therapies also include a variety ofcombination therapies with both chemical and radiation based treatments.

Generally, inhibitors of miRNAs can be given to decrease the activity ofa miRNA and further regulate a nucleic acid targeted by the miRNA.Similarly, nucleic acid molecules corresponding to the mature miRNA canbe given to achieve the opposite effect as compared to when inhibitorsof the miRNA are given. Methods of the invention are generallycontemplated to include providing or introducing one or more differentnucleic acid molecules corresponding to one or more different miRNAmolecules. It is contemplated that the following, at least thefollowing, or at most the following number of different nucleic acid ormiRNA molecules may be detected, assessed, provided or introduced: 1, 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40,41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58,59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76,77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,95, 96, 97, 98, 99, 100, or more, including any value or range derivablethere between.

III. Pharmaceutical Formulations and Delivery

Methods of the present invention include the delivery of an effectiveamount of a therapeutic nucleic acid or an expression constructcomprising or encoding the same. An “effective amount” of thepharmaceutical composition, generally, is defined as that amountsufficient to detectably and repeatedly to achieve the stated desiredresult, for example, to ameliorate, reduce, minimize or limit the extentof the disease or its symptoms. Other more rigorous definitions mayapply, including elimination, eradication or cure of disease.

A. Administration

In certain embodiments, it is desired to kill cells, inhibit cellgrowth, inhibit metastasis, decrease tumor or tissue size, and/orreverse or reduce the malignant or disease phenotype of cells. Theroutes of administration will vary, naturally, with the location andnature of the lesion or site to be targeted, and include, e.g.,intradermal, subcutaneous, regional, parenteral, intravenous,intramuscular, intranasal, systemic, and oral administration andformulation. Injection or perfusion of a therapeutic nucleic acid isspecifically contemplated for discrete, solid, accessible precancers orcancers, or other accessible target areas. Local, regional, or systemicadministration also may be appropriate.

In the case of surgical intervention, the present invention may be usedpreoperatively, to render an inoperable lesion subject to resection.Alternatively, the present invention may be used at the time of surgery,and/or thereafter, to treat residual or metastatic disease. For example,a resected tumor bed may be injected or perfused with a formulationcomprising a therapeutic nucleic acid or combinations thereof.Administration may be continued post-resection, for example, by leavinga catheter implanted at the site of the surgery. Periodic post-surgicaltreatment also is envisioned. Continuous perfusion of an expressionconstruct or a viral construct also is contemplated.

Continuous administration also may be applied where appropriate, forexample, where a tumor or other undesired affected area is excised andthe tumor bed or targeted site is treated to eliminate residual,microscopic disease. Delivery via syringe or catherization iscontemplated. Such continuous perfusion may take place for a period fromabout 1-2 hours, to about 2-6 hours, to about 6-12 hours, to about 12-24hours, to about 1-2 days, to about 1-2 wk or longer following theinitiation of treatment. Generally, the dose of the therapeuticcomposition via continuous perfusion will be equivalent to that given bya single or multiple injections, adjusted over a period of time duringwhich the perfusion occurs.

Treatment regimens may vary as well and often depend on the type oflesion, location, immune condition, target site, disease progression,and health and age of the patient. Certain tumor types will require moreaggressive treatment. The clinician will be best suited to make suchdecisions based on the known efficacy and toxicity (if any) of thetherapeutic formulations.

In certain embodiments, the lesion or affected area being treated maynot, at least initially, be resectable. Treatments with compositions ofthe invention may increase the resectability of the lesion due toshrinkage at the margins or by elimination of certain particularlyinvasive portions. Following treatments, resection may be possible.Additional treatments subsequent to resection may serve to eliminatemicroscopic residual disease at the tumor or targeted site.

Treatments may include various “unit doses.” A unit dose is defined ascontaining a predetermined quantity of a therapeutic composition(s). Thequantity to be administered, and the particular route and formulation,are within the skill of those in the clinical arts. A unit dose need notbe administered as a single injection but may comprise continuousinfusion over a set period of time. With respect to a viral component ofthe present invention, a unit dose may conveniently be described interms of ng, μg, or mg of miRNA or miRNA mimetic. Alternatively, theamount specified may be the amount administered as the average daily,average weekly, or average monthly dose.

A therapeutic nucleic acid can be administered to the patient in a doseor doses of about or of at least about 0.5, 1, 5, 10, 15, 20, 25, 30,35, 40, 45, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170,180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310,320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450,460, 470, 480, 490, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590,600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730,740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870,880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, 1000 ng, μgor mg, or more, or any range derivable therein. Alternatively, theamount specified may be the amount administered as the average daily,average weekly, or average monthly dose, or it may be expressed in termsof mg/kg, where kg refers to the weight of the patient and the mg isspecified above. In other embodiments, the amount specified is anynumber discussed above but expressed as mg/m² (with respect to tumorsize or patient surface area).

B. Injectable Compositions and Formulations

In some embodiments, the method for the delivery of a therapeuticnucleic acid or an expression construct encoding such or combinationsthereof is via local or systemic administration. However, thepharmaceutical compositions disclosed herein may also be administeredparenterally, subcutaneously, intratracheally, intravenously,intradermally, intramuscularly, or even intraperitoneally as describedin U.S. Pat. Nos. 5,543,158; 5,641,515 and 5,399,363 (each specificallyincorporated herein by reference in its entirety).

Injection of nucleic acids may be delivered by syringe or any othermethod used for injection of a solution, as long as the nucleic acid andany associated components can pass through the particular gauge ofneedle required for injection. A syringe system has also been describedfor use in gene therapy that permits multiple injections ofpredetermined quantities of a solution precisely at any depth (U.S. Pat.No. 5,846,225).

Solutions of the active compounds as free base or pharmacologicallyacceptable salts may be prepared in water suitably mixed with asurfactant, such as hydroxypropylcellulose. Dispersions may also beprepared in glycerol, liquid polyethylene glycols, mixtures thereof, andin oils. Under ordinary conditions of storage and use, thesepreparations contain a preservative to prevent the growth ofmicroorganisms. The pharmaceutical forms suitable for injectable useinclude sterile aqueous solutions or dispersions and sterile powders forthe extemporaneous preparation of sterile injectable solutions ordispersions (U.S. Pat. No. 5,466,468, specifically incorporated hereinby reference in its entirety). Typically, the form must be sterile andmust be fluid to the extent that easy syringability exists. It must bestable under the conditions of manufacture and storage and preservedagainst the contaminating action of microorganisms, such as bacteria andfungi. The carrier can be a solvent or dispersion medium containing, forexample, water, ethanol, polyol (e.g., glycerol, propylene glycol, andliquid polyethylene glycol, and the like), suitable mixtures thereof,and/or vegetable oils. Proper fluidity may be maintained, for example,by the use of a coating, such as lecithin, by the maintenance of therequired particle size in the case of dispersion and by the use ofsurfactants. The prevention of the action of microorganisms can bebrought about by various antibacterial and antifungal agents, forexample, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, andthe like. In many cases, it will be preferable to include isotonicagents, for example, sugars or sodium chloride. Prolonged absorption ofthe injectable compositions can be brought about by the use in thecompositions of agents delaying absorption, for example, aluminummonostearate and gelatin.

In certain formulations, a water-based formulation is employed while inothers, it may be lipid-based. In particular embodiments of theinvention, a composition comprising a nucleic acid of the invention isin a water-based formulation. In other embodiments, the formulation islipid based.

For parenteral administration in an aqueous solution, for example, thesolution should be suitably buffered if necessary and the liquid diluentfirst rendered isotonic with sufficient saline or glucose. Theseparticular aqueous solutions are especially suitable for intravenous,intramuscular, subcutaneous, intratumoral, intralesional, andintraperitoneal administration. In this connection, sterile aqueousmedia which can be employed will be known to those of skill in the artin light of the present disclosure. For example, one dosage may bedissolved in 1 ml of isotonic NaCl solution and either added to 1000 mlof hypodermoclysis fluid or injected at the proposed site of infusion,(see for example, “Remington's Pharmaceutical Sciences” 15th Edition,pages 1035-1038 and 1570-1580). Some variation in dosage willnecessarily occur depending on the condition of the subject beingtreated. The person responsible for administration will, in any event,determine the appropriate dose for the individual subject. Moreover, forhuman administration, preparations should meet sterility, pyrogenicity,general safety and purity standards as required by FDA Office ofBiologics standards.

As used herein, a “carrier” includes any and all solvents, dispersionmedia, vehicles, coatings, diluents, antibacterial and antifungalagents, isotonic and absorption delaying agents, buffers, carriersolutions, suspensions, colloids, and the like. The use of such mediaand agents for pharmaceutical active substances is well known in theart. Except insofar as any conventional media or agent is incompatiblewith the active ingredient, its use in the therapeutic compositions iscontemplated. Supplementary active ingredients can also be incorporatedinto the compositions.

The phrase “pharmaceutically acceptable” refers to molecular entitiesand compositions that do not produce an allergic or similar untowardreaction when administered to a human.

The nucleic acid(s) are administered in a manner compatible with thedosage formulation, and in such amount as will be therapeuticallyeffective. The quantity to be administered depends on the subject to betreated, including, e.g., the aggressiveness of the disease or cancer,the size of any tumor(s) or lesions, the previous or other courses oftreatment. Precise amounts of active ingredient required to beadministered depend on the judgment of the practitioner. Suitableregimes for initial administration and subsequent administration arealso variable, but are typified by an initial administration followed byother administrations. Such administration may be systemic, as a singledose, continuous over a period of time spanning 10, 20, 30, 40, 50, 60minutes, and/or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, 23, 24 or more hours, and/or 1, 2, 3, 4, 5, 6,7, days or more. Moreover, administration may be through a time releaseor sustained release mechanism, implemented by formulation and/or modeof administration.

C. Combination Treatments

In certain embodiments, the compositions and methods of the presentinvention involve a therapeutic nucleic acid, or expression constructencoding such. These compositions can be used in combination with asecond therapy to enhance the effect of the miRNA therapy, or increasethe therapeutic effect of another therapy being employed. Thesecompositions would be provided in a combined amount effective to achievethe desired effect, such as the killing of a cancer cell and/or theinhibition of cellular hyperproliferation. This process may involvecontacting the cells with the therapeutic nucleic acid or second therapyat the same or different time. This may be achieved by contacting thecell with one or more compositions or pharmacological formulation thatincludes or more of the agents, or by contacting the cell with two ormore distinct compositions or formulations, wherein one compositionprovides (1) therapeutic nucleic acid; and/or (2) a second therapy. Asecond composition or method may be administered that includes achemotherapy, radiotherapy, surgical therapy, immunotherapy or genetherapy.

It is contemplated that one may provide a patient with the miRNA therapyand the second therapy within about 12-24 h of each other and, morepreferably, within about 6-12 h of each other. In some situations, itmay be desirable to extend the time period for treatment significantly,however, where several days (2, 3, 4, 5, 6 or 7) to several weeks (1, 2,3, 4, 5, 6, 7 or 8) lapse between the respective administrations.

In certain embodiments, a course of treatment will last 1, 2, 3, 4, 5,6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24,25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42,43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60,61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78,79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90 days or more. It iscontemplated that one agent may be given on day 1, 2, 3, 4, 5, 6, 7, 8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44,45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62,63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,81, 82, 83, 84, 85, 86, 87, 88, 89, and/or 90, any combination thereof,and another agent is given on day 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66,67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84,85, 86, 87, 88, 89, and/or 90, or any combination thereof. Within asingle day (24-hour period), the patient may be given one or multipleadministrations of the agent(s). Moreover, after a course of treatment,it is contemplated that there is a period of time at which no treatmentis administered. This time period may last 1, 2, 3, 4, 5, 6, 7 days,and/or 1, 2, 3, 4, 5 weeks, and/or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12months or more, depending on the condition of the patient, such as theirprognosis, strength, health, etc.

Various combinations may be employed, for example miRNA therapy is “A”and a second therapy is “B”:

A/B/A B/A/B B/B/A A/A/B A/B/B B/A/A A/B/B/B B/A/B/B

B/B/B/A B/B/A/B A/A/B/B A/B/A/B A/B/B/A B/B/A/A

B/A/B/A B/A/A/B A/A/A/B B/A/A/A A/B/A/A A/A/B/A

Administration of any compound or therapy of the present invention to apatient will follow general protocols for the administration of suchcompounds, taking into account the toxicity, if any, of the vector orany protein or other agent. Therefore, in some embodiments there is astep of monitoring toxicity that is attributable to combination therapy.It is expected that the treatment cycles would be repeated as necessary.It also is contemplated that various standard therapies, as well assurgical intervention, may be applied in combination with the describedtherapy.

In specific aspects, it is contemplated that a second therapy, such aschemotherapy, radiotherapy, immunotherapy, surgical therapy or othergene therapy, is employed in combination with the miRNA therapy, asdescribed herein.

1. Chemotherapy

A wide variety of chemotherapeutic agents may be used in accordance withthe present invention. The term “chemotherapy” refers to the use ofdrugs to treat cancer. A “chemotherapeutic agent” is used to connote acompound or composition that is administered in the treatment of cancer.These agents or drugs are categorized by their mode of activity within acell, for example, whether and at what stage they affect the cell cycle.Alternatively, an agent may be characterized based on its ability todirectly cross-link DNA, to intercalate into DNA, or to inducechromosomal and mitotic aberrations by affecting nucleic acid synthesis.Most chemotherapeutic agents fall into the following categories:alkylating agents, antimetabolites, antitumor antibiotics, mitoticinhibitors, and nitrosoureas.

a. Alkylating Agents

Alkylating agents are drugs that directly interact with genomic DNA toprevent the cancer cell from proliferating. This category ofchemotherapeutic drugs represents agents that affect all phases of thecell cycle, that is, they are not phase-specific. Alkylating agents canbe implemented to treat chronic leukemia, non-Hodgkin's lymphoma,Hodgkin's disease, multiple myeloma, and particular cancers of thebreast, lung, and ovary. They include: busulfan, chlorambucil,cisplatin, cyclophosphamide (cytoxan), dacarbazine, ifosfamide,mechlorethamine (mustargen), and melphalan. Troglitazaone can be used totreat cancer in combination with any one or more of these alkylatingagents.

b. Antimetabolites

Antimetabolites disrupt DNA and RNA synthesis. Unlike alkylating agents,they specifically influence the cell cycle during S phase. They havebeen used to combat chronic leukemias in addition to tumors of breast,ovary and the gastrointestinal tract. Antimetabolites include5-fluorouracil (5-FU), cytarabine (Ara-C), fludarabine, gemcitabine, andmethotrexate.

5-Fluorouracil (5-FU) has the chemical name of5-fluoro-2,4(1H,3H)-pyrimidinedione. Its mechanism of action is thoughtto be by blocking the methylation reaction of deoxyuridylic acid tothymidylic acid. Thus, 5-FU interferes with the synthesis ofdeoxyribonucleic acid (DNA) and to a lesser extent inhibits theformation of ribonucleic acid (RNA). Since DNA and RNA are essential forcell division and proliferation, it is thought that the effect of 5-FUis to create a thymidine deficiency leading to cell death. Thus, theeffect of 5-FU is found in cells that rapidly divide, a characteristicof metastatic cancers.

c. Antitumor Antibiotics

Antitumor antibiotics have both antimicrobial and cytotoxic activity.These drugs also interfere with DNA by chemically inhibiting enzymes andmitosis or altering cellular membranes. These agents are not phasespecific so they work in all phases of the cell cycle. Thus, they arewidely used for a variety of cancers. Examples of antitumor antibioticsinclude bleomycin, dactinomycin, daunorubicin, doxorubicin (Adriamycin),and idarubicin, some of which are discussed in more detail below. Widelyused in clinical setting for the treatment of neoplasms, these compoundsare administered through bolus injections intravenously at doses rangingfrom 25-75 mg/m² at 21 day intervals for adriamycin, to 35-100 mg/m² foretoposide intravenously or orally.

d. Mitotic Inhibitors

Mitotic inhibitors include plant alkaloids and other natural agents thatcan inhibit either protein synthesis required for cell division ormitosis. They operate during a specific phase during the cell cycle.Mitotic inhibitors comprise docetaxel, etoposide (VP16), paclitaxel,taxol, taxotere, vinblastine, vincristine, and vinorelbine.

e. Nitrosureas

Nitrosureas, like alkylating agents, inhibit DNA repair proteins. Theyare used to treat non-Hodgkin's lymphomas, multiple myeloma, malignantmelanoma, in addition to brain tumors. Examples include carmustine andlomustine.

2. Radiotherapy

Radiotherapy, also called radiation therapy, is the treatment of cancerand other diseases with ionizing radiation. Ionizing radiation depositsenergy that injures or destroys cells in the area being treated bydamaging their genetic material, making it impossible for these cells tocontinue to grow. Although radiation damages both cancer cells andnormal cells, the latter are able to repair themselves and functionproperly. Radiotherapy may be used to treat localized solid tumors, suchas cancers of the skin, tongue, larynx, brain, breast, or cervix. It canalso be used to treat leukemia and lymphoma (cancers of theblood-forming cells and lymphatic system, respectively).

Radiation therapy used according to the present invention may include,but is not limited to, the use of γ-rays, X-rays, and/or the directeddelivery of radioisotopes to tumor cells. Other forms of DNA damagingfactors are also contemplated such as microwaves, proton beamirradiation (U.S. Pat. Nos. 5,760,395 and 4,870,287) and UV-irradiation.It is most likely that all of these factors effect a broad range ofdamage on DNA, on the precursors of DNA, on the replication and repairof DNA, and on the assembly and maintenance of chromosomes. Dosageranges for X-rays range from daily doses of 50 to 200 roentgens forprolonged periods of time (3 to 4 wk), to single doses of 2000 to 6000roentgens. Dosage ranges for radioisotopes vary widely, and depend onthe half-life of the isotope, the strength and type of radiationemitted, and the uptake by the neoplastic cells. Radiotherapy maycomprise the use of radiolabeled antibodies to deliver doses ofradiation directly to the cancer site (radioimmunotherapy). Onceinjected into the body, the antibodies actively seek out the cancercells, which are destroyed by the cell-killing (cytotoxic) action of theradiation. This approach can minimize the risk of radiation damage tohealthy cells.

Stereotactic radio-surgery (gamma knife) for brain and other tumors doesnot use a knife, but very precisely targeted beams of gamma radiotherapyfrom hundreds of different angles. Only one session of radiotherapy,taking about four to five hours, is needed. For this treatment aspecially made metal frame is attached to the head. Then, several scansand x-rays are carried out to find the precise area where the treatmentis needed. During the radiotherapy for brain tumors, the patient lieswith their head in a large helmet, which has hundreds of holes in it toallow the radiotherapy beams through. Related approaches permitpositioning for the treatment of tumors in other areas of the body.

3. Immunotherapy

In the context of cancer treatment, immunotherapeutics, generally, relyon the use of immune effector cells and molecules to target and destroycancer cells. Trastuzumab (Herceptin™) is such an example. The immuneeffector may be, for example, an antibody specific for some marker onthe surface of a tumor cell. The antibody alone may serve as an effectorof therapy or it may recruit other cells to actually affect cellkilling. The antibody also may be conjugated to a drug or toxin(chemotherapeutic, radionuclide, ricin A chain, cholera toxin, pertussistoxin, etc.) and serve merely as a targeting agent. Alternatively, theeffector may be a lymphocyte carrying a surface molecule that interacts,either directly or indirectly, with a tumor cell target. Variouseffector cells include cytotoxic T cells and NK cells. The combinationof therapeutic modalities, i.e., direct cytotoxic activity andinhibition or reduction of ErbB2 would provide therapeutic benefit inthe treatment of ErbB2 overexpressing cancers.

In one aspect of immunotherapy, the tumor or disease cell must bear somemarker that is amenable to targeting, i.e., is not present on themajority of other cells. Many tumor markers exist and any of these maybe suitable for targeting in the context of the present invention.Common tumor markers include carcinoembryonic antigen, prostate specificantigen, urinary tumor associated antigen, fetal antigen, tyrosinase(p97), gp68, TAG-72, HMFG, Sialyl Lewis Antigen, MucA, MucB, PLAP,estrogen receptor, laminin receptor, erb B and p155. An alternativeaspect of immunotherapy is to combine anticancer effects with immunestimulatory effects. Immune stimulating molecules also exist including:cytokines such as IL-2, IL-4, IL-12, GM-CSF, gamma-IFN, chemokines suchas MIP-1, MCP-1, IL-8 and growth factors such as FLT3 ligand. Combiningimmune stimulating molecules, either as proteins or using gene deliveryin combination with a tumor suppressor such as MDA-7 has been shown toenhance anti-tumor effects (Ju et al., 2000). Moreover, antibodiesagainst any of these compounds can be used to target the anti-canceragents discussed herein.

Examples of immunotherapies currently under investigation or in use areimmune adjuvants e.g., Mycobacterium bovis, Plasmodium falciparum,dinitrochlorobenzene and aromatic compounds (U.S. Pat. Nos. 5,801,005and 5,739,169; Hui and Hashimoto, 1998; Christodoulides et al., 1998),cytokine therapy e.g., interferons α, β and γ; IL-1, GM-CSF and TNF(Bukowski et al., 1998; Davidson et al., 1998; Hellstrand et al., 1998)gene therapy e.g., TNF, IL-1, IL-2, p53 (Qin et al., 1998; Austin-Wardand Villaseca, 1998; U.S. Pat. Nos. 5,830,880 and 5,846,945) andmonoclonal antibodies e.g., anti-ganglioside GM2, anti-HER-2, anti-p185;Pietras et al., 1998; Hanibuchi et al., 1998; U.S. Pat. No. 5,824,311).Herceptin (trastuzumab) is a chimeric (mouse-human) monoclonal antibodythat blocks the HER2-neu receptor. It possesses anti-tumor activity andhas been approved for use in the treatment of malignant tumors (Dillman,1999). A non-limiting list of several known anti-cancerimmunotherapeutic agents and their targets includes (GenericName/Target) Cetuximab/EGFR, Panitumuma/EGFR, Trastuzumab/erbB2receptor, Bevacizumab/VEGF, Alemtuzumab/CD52, Gemtuzumabozogamicin/CD33, Rituximab/CD20, Tositumomab/CD20, Matuzumab/EGFR,Ibritumomab tiuxetan/CD20, Tositumomab/CD20, HuPAM4/MUC1,MORAb-009/Mesothelin, G250/carbonic anhydrase IX, mAb 8H9/8H9 antigen,M195/CD33, Ipilimumab/CTLA4, HuLuc63/CS1, Alemtuzumab/CD53,Epratuzumab/CD22, BC8/CD45, HuJ591/Prostate specific membrane antigen,hA20/CD20, Lexatumumab/TRAIL receptor-2, Pertuzumab/HER-2 receptor,Mik-beta-1/IL-2R, RAV12/RAAG12, SGN-30/CD30, AME-133v/CD20, HeFi-1/CD30,BMS-663513/CD137, Volociximab/anti-α5β1 integrin, GC1008/TGFβ,HCD122/CD40, Siplizumab/CD2, MORAb-003/Folate receptor alpha, CNTO328/IL-6, MDX-060/CD30, Ofatumumab/CD20, and SGN-33/CD33. It iscontemplated that one or more of these therapies may be employed withthe miRNA therapies described herein.

A number of different approaches for passive immunotherapy of cancerexist. They may be broadly categorized into the following: injection ofantibodies alone; injection of antibodies coupled to toxins orchemotherapeutic agents; injection of antibodies coupled to radioactiveisotopes; injection of anti-idiotype antibodies; and finally, purging oftumor cells in bone marrow.

4. Gene Therapy

In yet another embodiment, a combination treatment involves gene therapyin which a therapeutic polynucleotide is administered before, after, orat the same time as one or more therapeutic miRNA. Delivery of atherapeutic polypeptide or encoding nucleic acid in conjunction with amiRNA may have a combined therapeutic effect on target tissues. Avariety of proteins are encompassed within the invention, some of whichare described below. Various genes that may be targeted for gene therapyof some form in combination with the present invention include, but arenot limited to inducers of cellular proliferation, inhibitors ofcellular proliferation, regulators of programmed cell death, cytokinesand other therapeutic nucleic acids or nucleic acid that encodetherapeutic proteins.

The tumor suppressor oncogenes function to inhibit excessive cellularproliferation. The inactivation of these genes destroys their inhibitoryactivity, resulting in unregulated proliferation. The tumor suppressors(e.g., therapeutic polypeptides) p53, FHIT, p16 and C-CAM can beemployed.

In addition to p53, another inhibitor of cellular proliferation is p16.The major transitions of the eukaryotic cell cycle are triggered bycyclin-dependent kinases, or CDK's. One CDK, cyclin-dependent kinase 4(CDK4), regulates progression through the G1. The activity of thisenzyme may be to phosphorylate Rb at late G1. The activity of CDK4 iscontrolled by an activating subunit, D-type cyclin, and by an inhibitorysubunit, the p16INK4 has been biochemically characterized as a proteinthat specifically binds to and inhibits CDK4, and thus may regulate Rbphosphorylation (Serrano et al., 1993; Serrano et al., 1995). Since thep16INK4 protein is a CDK4 inhibitor (Serrano, 1993), deletion of thisgene may increase the activity of CDK4, resulting inhyperphosphorylation of the Rb protein. p16 also is known to regulatethe function of CDK6.

p16INK4 belongs to a newly described class of CDK-inhibitory proteinsthat also includes p16B, p19, p21WAF1, and p27KIP1. The p16INK4 genemaps to 9p21, a chromosome region frequently deleted in many tumortypes. Homozygous deletions and mutations of the p16INK4 gene arefrequent in human tumor cell lines. This evidence suggests that thep16INK4 gene is a tumor suppressor gene. This interpretation has beenchallenged, however, by the observation that the frequency of thep16INK4 gene alterations is much lower in primary uncultured tumors thanin cultured cell lines (Caldas et al., 1994; Cheng et al., 1994;Hussussian et al., 1994; Kamb et al., 1994; Mori et al., 1994; Okamotoet al., 1994; Nobori et al., 1995; Orlow et al., 1994; Arap et al.,1995). Restoration of wild-type p16INK4 function by transfection with aplasmid expression vector reduced colony formation by some human cancercell lines (Okamoto, 1994; Arap, 1995).

Other genes that may be employed according to the present inventioninclude Rb, APC, DCC, NF-1, NF-2, WT-1, MEN-I, MEN-II, zac1, p73, VHL,MMAC1/PTEN, DBCCR-1, FCC, rsk-3, p27, p27/p16 fusions, p21/p27 fusions,anti-thrombotic genes (e.g., COX-1, TFPI), PGS, Dp, E2F, ras, myc, neu,raf, erb, fms, trk, ret, gsp, hst, abl, E1A, p300, genes involved inangiogenesis (e.g., VEGF, FGF, thrombospondin, BAI-1, GDAIF, or theirreceptors) and MCC.

5. Surgery

Approximately 60% of persons with cancer will undergo surgery of sometype, which includes preventative, diagnostic or staging, curative andpalliative surgery. Curative surgery is a cancer treatment that may beused in conjunction with other therapies, such as the treatment of thepresent invention, chemotherapy, radiotherapy, hormonal therapy, genetherapy, immunotherapy and/or alternative therapies.

Curative surgery includes resection in which all or part of canceroustissue is physically removed, excised, and/or destroyed. Tumor resectionrefers to physical removal of at least part of a tumor. In addition totumor resection, treatment by surgery includes laser surgery,cryosurgery, electrosurgery, and microscopically controlled surgery(Mohs' surgery). It is further contemplated that the present inventionmay be used in conjunction with removal of superficial cancers,precancers, or incidental amounts of normal tissue.

Upon excision of part of all of cancerous cells, tissue, or tumor, acavity may be formed in the body. Treatment may be accomplished byperfusion, direct injection or local application of the area with anadditional anti-cancer therapy. Such treatment may be repeated, forexample, every 1, 2, 3, 4, 5, 6, or 7 days, or every 1, 2, 3, 4, and 5weeks or every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 months. Thesetreatments may be of varying dosages as well.

6. Other Agents

It is contemplated that other agents may be used in combination with thepresent invention to improve the therapeutic efficacy of treatment.These additional agents include immunomodulatory agents, agents thataffect the upregulation of cell surface receptors and GAP junctions,cytostatic and differentiation agents, inhibitors of cell adhesion,agents that increase the sensitivity of the hyperproliferative cells toapoptotic inducers, or other biological agents. Immunomodulatory agentsinclude tumor necrosis factor; interferon alpha, beta, and gamma; IL-2and other cytokines; F42K and other cytokine analogs; or MIP-1,MIP-1beta, MCP-1, RANTES, and other chemokines. It is furthercontemplated that the upregulation of cell surface receptors or theirligands such as Fas/Fas ligand, DR4 or DR5/TRAIL (Apo-2 ligand) wouldpotentiate the apoptotic inducing abilities of the present invention byestablishment of an autocrine or paracrine effect on hyperproliferativecells. Increases intercellular signaling by elevating the number of GAPjunctions would increase the anti-hyperproliferative effects on theneighboring hyperproliferative cell population. In other embodiments,cytostatic or differentiation agents can be used in combination with thepresent invention to improve the anti-hyperproliferative efficacy of thetreatments. Inhibitors of cell adhesion are contemplated to improve theefficacy of the present invention. Examples of cell adhesion inhibitorsare focal adhesion kinase (FAKs) inhibitors and Lovastatin. It isfurther contemplated that other agents that increase the sensitivity ofa hyperproliferative cell to apoptosis, such as the antibody c225, couldbe used in combination with the present invention to improve thetreatment efficacy.

Apo2 ligand (Apo2L, also called TRAIL) is a member of the tumor necrosisfactor (TNF) cytokine family. TRAIL activates rapid apoptosis in manytypes of cancer cells, yet is not toxic to normal cells. TRAIL mRNAoccurs in a wide variety of tissues. Most normal cells appear to beresistant to TRAIL's cytotoxic action, suggesting the existence ofmechanisms that can protect against apoptosis induction by TRAIL. Thefirst receptor described for TRAIL, called death receptor 4 (DR4),contains a cytoplasmic “death domain”; DR4 transmits the apoptosissignal carried by TRAIL. Additional receptors have been identified thatbind to TRAIL. One receptor, called DR5, contains a cytoplasmic deathdomain and signals apoptosis much like DR4. The DR4 and DR5 mRNAs areexpressed in many normal tissues and tumor cell lines. Recently, decoyreceptors such as DcR1 and DcR2 have been identified that prevent TRAILfrom inducing apoptosis through DR4 and DR5. These decoy receptors thusrepresent a novel mechanism for regulating sensitivity to apro-apoptotic cytokine directly at the cell's surface. The preferentialexpression of these inhibitory receptors in normal tissues suggests thatTRAIL may be useful as an anticancer agent that induces apoptosis incancer cells while sparing normal cells. (Marsters et al., 1999).

There have been many advances in the therapy of cancer following theintroduction of cytotoxic chemotherapeutic drugs. However, one of theconsequences of chemotherapy is the development/acquisition ofdrug-resistant phenotypes and the development of multiple drugresistance. The development of drug resistance remains a major obstaclein the treatment of such tumors and therefore, there is an obvious needfor alternative approaches such as gene therapy.

Another form of therapy for use in conjunction with chemotherapy,radiation therapy or biological therapy includes hyperthermia, which isa procedure in which a patient's tissue is exposed to high temperatures(up to 106° F.). External or internal heating devices may be involved inthe application of local, regional, or whole-body hyperthermia. Localhyperthermia involves the application of heat to a small area, such as atumor. Heat may be generated externally with high-frequency wavestargeting a tumor from a device outside the body. Internal heat mayinvolve a sterile probe, including thin, heated wires or hollow tubesfilled with warm water, implanted microwave antennae, or radiofrequencyelectrodes.

A patient's organ or a limb is heated for regional therapy, which isaccomplished using devices that produce high energy, such as magnets.Alternatively, some of the patient's blood may be removed and heatedbefore being perfused into an area that will be internally heated.Whole-body heating may also be implemented in cases where cancer hasspread throughout the body. Warm-water blankets, hot wax, inductivecoils, and thermal chambers may be used for this purpose.

Hormonal therapy may also be used in conjunction with the presentinvention or in combination with any other cancer therapy previouslydescribed. The use of hormones may be employed in the treatment ofcertain cancers such as breast, prostate, ovarian, or cervical cancer tolower the level or block the effects of certain hormones such astestosterone or estrogen. This treatment is often used in combinationwith at least one other cancer therapy as a treatment option or toreduce the risk of metastases.

This application incorporates U.S. application Ser. No. 11/349,727 filedon Feb. 8, 2006 claiming priority to U.S. Provisional Application Ser.No. 60/650,807 filed Feb. 8, 2005 herein by references in its entirety.

IV. Therapeutic Nucleic Acids

Therapeutic nucleic acids typically include segments of sequence orcomplementary sequences to microRNA (“miRNA” or “miR”) molecules, whichare generally 21 to 22 nucleotides in length, though lengths of 17 andup to 24 nucleotides have been reported. The miRNAs are each processedfrom a longer precursor RNA molecule (“precursor miRNA”). PrecursormiRNAs are transcribed from non-protein-encoding genes. The precursormiRNAs have two regions of complementarity that enables them to form astem-loop- or fold-back-like structure, which is cleaved in animals by aribonuclease III-like nuclease enzyme called Dicer. The processed miRNAis typically a portion of the stem.

The processed miRNA (also referred to as “mature miRNA”) become part ofa large complex to down-regulate a particular target gene. Examples ofanimal miRNAs include those that imperfectly basepair with the target,which halts translation (Olsen et al., 1999; Seggerson et al., 2002).siRNA molecules also are processed by Dicer, but from a long,double-stranded RNA molecule. siRNAs are not naturally found in animalcells, but they can direct the sequence-specific cleavage of an mRNAtarget through a RNA-induced silencing complex (RISC) (Denli et al.,2003).

In certain aspects, therapeutic nucleic acids of the invention are RNAor RNA analogs. miRNA inhibitors may be DNA or RNA, or analogs thereof.In other aspects, an miRNA inhibitor can be a protein or a polypeptidethat interacts with an endogenous miRNA or processing.

In some embodiments, there is a synthetic or isolated miRNA having alength of between 17 and 130 residues. The present invention concernssynthetic miRNA molecules that are, are at least, or are at most 15, 16,17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52,53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88,89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104,105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118,119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 140, 145,150, 160, 170, 180, 190, 200 or more residues in length, including anyinteger or any range derivable therein.

In certain embodiments, therapeutic nucleic acids have (a) a “miRNAregion” whose sequence from 5′ to 3′ is identical to all or a segment ofa mature miRNA sequence, and (b) a “complementary region” whose sequencefrom 5′ to 3′ is between 60% and 100% complementary to the miRNAsequence. In certain embodiments, these synthetic miRNA are alsoisolated, as defined above. The term “miRNA region” refers to a regionon the synthetic miRNA that is at least 75, 80, 85, 90, 95, or 100%identical, including all integers there between, to the entire sequenceof a mature, naturally occurring miRNA sequence. In certain embodiments,the miRNA region is or is at least 90, 91, 92, 93, 94, 95, 96, 97, 98,99, 99.1, 99.2, 99.3, 99.4, 99.5, 99.6, 99.7, 99.8, 99.9 or 100%identical to the sequence of a naturally-occurring miRNA. Alternatively,the miRNA region can comprise 18, 19, 20, 21, 22, 23, 24 or morenucleotide positions in common with a naturally-occurring miRNA ascompared by sequence alignment algorithms and methods well known in theart.

The term “complementary region” refers to a region of a synthetic miRNAthat is or is at least 60% complementary to the mature, naturallyoccurring miRNA sequence that the miRNA region is identical to. Thecomplementary region is or is at least 60, 61, 62, 63, 64, 65, 66, 67,68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85,86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 99.1, 99.2,99.3, 99.4, 99.5, 99.6, 99.7, 99.8, 99.9 or 100% complementary, or anyrange derivable therein. With single polynucleotide sequences, there maybe a hairpin loop structure as a result of chemical bonding between themiRNA region and the complementary region. In other embodiments, thecomplementary region is on a different nucleic acid molecule than themiRNA region, in which case the complementary region is on thecomplementary strand and the miRNA region is on the active strand.

In other embodiments of the invention, there are therapeutic nucleicacids that are miRNA inhibitors. A miRNA inhibitor is between about 17to 25 nucleotides in length and comprises a 5′ to 3′ sequence that is atleast 90% complementary to the 5′ to 3′ sequence of a mature miRNA. Incertain embodiments, a miRNA inhibitor molecule is 17, 18, 19, 20, 21,22, 23, 24, or 25 nucleotides in length, or any range derivable therein.Moreover, a miRNA inhibitor has a sequence (from 5′ to 3′) that is or isat least 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 99.1, 99.2, 99.3, 99.4,99.5, 99.6, 99.7, 99.8, 99.9 or 100% complementary, or any rangederivable therein, to the 5′ to 3′ sequence of a mature miRNA,particularly a mature, naturally occurring miRNA. One of skill in theart could use a portion of the probe sequence that is complementary tothe sequence of a mature miRNA as the sequence for a miRNA inhibitor.Moreover, that portion of the probe sequence can be altered so that itis still 90% complementary to the sequence of a mature miRNA.

In some embodiments, of the invention, a therapeutic nucleic acidcontains one or more design elements. These design elements include, butare not limited to: (i) a replacement group for the phosphate orhydroxyl of the nucleotide at the 5′ terminus of the complementaryregion; (ii) one or more sugar modifications in the first or last 1 to 6residues of the complementary region; or, (iii) noncomplementaritybetween one or more nucleotides in the last 1 to 5 residues at the 3′end of the complementary region and the corresponding nucleotides of themiRNA region.

In certain embodiments, a synthetic miRNA has a nucleotide at its 5′ endof the complementary region in which the phosphate and/or hydroxyl grouphas been replaced with another chemical group (referred to as the“replacement design”). In some cases, the phosphate group is replaced,while in others, the hydroxyl group has been replaced. In particularembodiments, the replacement group is biotin, an amine group, a loweralkylamine group, an acetyl group, 2′O-Me (2′oxygen-methyl), DMTO(4,4′-dimethoxytrityl with oxygen), fluorescein, a thiol, or acridine,though other replacement groups are well known to those of skill in theart and can be used as well. This design element can also be used with amiRNA inhibitor.

Additional embodiments concern a synthetic miRNA having one or moresugar modifications in the first or last 1 to 6 residues of thecomplementary region (referred to as the “sugar replacement design”). Incertain cases, there is one or more sugar modifications in the first 1,2, 3, 4, 5, 6 or more residues of the complementary region, or any rangederivable therein. In additional cases, there is one or more sugarmodifications in the last 1, 2, 3, 4, 5, 6 or more residues of thecomplementary region, or any range derivable therein, have a sugarmodification. It will be understood that the terms “first” and “last”are with respect to the order of residues from the 5′ end to the 3′ endof the region. In particular embodiments, the sugar modification is a2′O-Me modification, a 2′F modification, a 2′H modification, a 2′aminomodification, a 4′thioribose modification or a phosphorothioatemodification on the carboxy group linked to the carbon at position 6′,or combinations thereof. In further embodiments, there is one or moresugar modifications in the first or last 2 to 4 residues of thecomplementary region or the first or last 4 to 6 residues of thecomplementary region. This design element can also be used with a miRNAinhibitor. Thus, a miRNA inhibitor can have this design element and/or areplacement group on the nucleotide at the 5′ terminus, as discussedabove.

In other embodiments of the invention, there is a synthetic miRNA inwhich one or more nucleotides in the last 1 to 5 residues at the 3′ endof the complementary region are not complementary to the correspondingnucleotides of the miRNA region (“noncomplementarity”) (referred to asthe “noncomplementarity design”). The noncomplementarity may be in thelast 1, 2, 3, 4, and/or 5 residues of the complementary miRNA. Incertain embodiments, there is noncomplementarity with at least 2nucleotides in the complementary region.

It is contemplated that synthetic miRNA of the invention have one ormore of the replacement, sugar modification, or noncomplementaritydesigns. In certain cases, synthetic RNA molecules have two of them,while in others these molecules have all three designs in place.

The miRNA region and the complementary region may be on the same orseparate polynucleotides. In cases in which they are contained on or inthe same polynucleotide, the miRNA molecule will be considered a singlepolynucleotide. In embodiments in which the different regions are onseparate polynucleotides, the synthetic miRNA will be considered to becomprised of two polynucleotides.

When the RNA molecule is a single polynucleotide, there is a linkerregion between the miRNA region and the complementary region. In someembodiments, the single polynucleotide is capable of forming a hairpinloop structure as a result of bonding between the miRNA region and thecomplementary region. The linker constitutes the hairpin loop. It iscontemplated that in some embodiments, the linker region is, is atleast, or is at most 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,35, 36, 37, 38, 39, or 40 residues in length, or any range derivabletherein. In certain embodiments, the linker is between 3 and 30 residues(inclusive) in length.

In addition to having a miRNA region and a complementary region, theremay be flanking sequences as well at either the 5′ or 3′ end of theregion. In some embodiments, there is or is at least 1, 2, 3, 4, 5, 6,7, 8, 9, 10 nucleotides or more, or any range derivable therein,flanking one or both sides of these regions.

In some embodiments of the invention, methods and compositions involvingmiRNA may concern miRNA and/or other nucleic acids. Nucleic acids maybe, be at least, or be at most 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14,15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32,33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50,51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68,69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86,87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103,104, 105, 106, 107, 108, 109, 110, 120, 130, 140, 150, 160, 170, 180,190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320,330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 441, 450,460, 470, 480, 490, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590,600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730,740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870,880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, or 1000nucleotides, or any range derivable therein, in length. Such lengthscover the lengths of processed miRNA, miRNA probes, precursor miRNA,miRNA containing vectors, control nucleic acids, and other probes andprimers. In many embodiments, miRNA are 19-24 nucleotides in length,while miRNA probes are 5, 10, 15, 19, 20, 25, 30, to 35 nucleotides inlength, including all values and ranges there between, depending on thelength of the processed miRNA and any flanking regions added. miRNAprecursors are generally between 62 and 110 nucleotides in humans.

Nucleic acids of the invention may have regions of identity orcomplementarity to another nucleic acid. It is contemplated that theregion of complementarity or identity can be at least 5 contiguousresidues, though it is specifically contemplated that the region is, isat least, or is at most 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36,37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54,55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90,91, 92, 93, 94, 95, 96, 97, 98, 99, 100, or 110 contiguous nucleotides.It is further understood that the length of complementarity within aprecursor miRNA or between a miRNA probe and a miRNA or a miRNA gene aresuch lengths. Moreover, the complementarity may be expressed as apercentage, meaning that the complementarity between a probe and itstarget is 90% identical or greater over the length of the probe. In someembodiments, complementarity is or is at least 90%, 95% or 100%identical. In particular, such lengths may be applied to any nucleicacid comprising a nucleic acid sequence identified in any of SEQ ID NOsdisclosed herein.

The term “recombinant” may be used and this generally refers to amolecule that has been manipulated in vitro or that is a replicated orexpressed product of such a molecule.

The term “miRNA” generally refers to a single-stranded molecule, but inspecific embodiments, molecules implemented in the invention will alsoencompass a region or an additional strand that is partially (between 10and 50% complementary across length of strand), substantially (greaterthan 50% but less than 100% complementary across length of strand) orfully complementary to another region of the same single-strandedmolecule or to another nucleic acid. Thus, nucleic acids may encompass amolecule that comprises one or more complementary or self-complementarystrand(s) or “complement(s)” of a particular sequence comprising amolecule. For example, precursor miRNA may have a self-complementaryregion, which is up to 100% complementary miRNA probes or nucleic acidsof the invention can include, can be or can be at least 60, 65, 70, 75,80, 85, 90, 95, 96, 97, 98, 99 or 100% complementary to their target.

Nucleic acids of the invention may be made by any technique known to oneof ordinary skill in the art, such as for example, chemical synthesis,enzymatic production or biological production. It is specificallycontemplated that miRNA probes of the invention are chemicallysynthesized.

In some embodiments of the invention, miRNAs are recovered or isolatedfrom a biological sample. The miRNA may be recombinant or it may benatural or endogenous to the cell (produced from the cell's genome). Itis contemplated that a biological sample may be treated in a way so asto enhance the recovery of small RNA molecules such as miRNA. U.S.patent application Ser. No. 10/667,126 describes such methods and it isspecifically incorporated by reference herein. Generally, methodsinvolve lysing cells with a solution having guanidinium and a detergent.

A. Isolation of Nucleic Acids

Nucleic acids may be isolated using techniques well known to those ofskill in the art, though in particular embodiments, methods forisolating small nucleic acid molecules, and/or isolating RNA moleculescan be employed. Chromatography is a process often used to separate orisolate nucleic acids from protein or from other nucleic acids. Suchmethods can involve electrophoresis with a gel matrix, filter columns,alcohol precipitation, and/or other chromatography.

If miRNA from cells is to be used or evaluated, methods generallyinvolve lysing the cells with a chaotropic (e.g., guanidiniumisothiocyanate) and/or detergent (e.g., N-lauroyl sarcosine) prior toimplementing processes for isolating particular populations of RNA.

In particular methods for separating miRNA from other nucleic acids, agel matrix is prepared using polyacrylamide, though agarose can also beused. The gels may be graded by concentration or they may be uniform.Plates or tubing can be used to hold the gel matrix for electrophoresis.Usually one-dimensional electrophoresis is employed for the separationof nucleic acids. Plates are used to prepare a slab gel, while thetubing (glass or rubber, typically) can be used to prepare a tube gel.The phrase “tube electrophoresis” refers to the use of a tube or tubing,instead of plates, to form the gel. Materials for implementing tubeelectrophoresis can be readily prepared by a person of skill in the artor purchased, such as from C.B.S. Scientific Co., Inc. or Scie-Plas.

Methods may involve the use of organic solvents and/or alcohol toisolate nucleic acids, particularly miRNA used in methods andcompositions of the invention. Some embodiments are described in U.S.patent application Ser. No. 10/667,126, which is hereby incorporated byreference. Generally, this disclosure provides methods for efficientlyisolating small RNA molecules from cells comprising: adding an alcoholsolution to a cell lysate and applying the alcohol/lysate mixture to asolid support before eluting the RNA molecules from the solid support.In some embodiments, the amount of alcohol added to a cell lysateachieves an alcohol concentration of about 55% to 60%. While differentalcohols can be employed, ethanol works well. A solid support may be anystructure, and it includes beads, filters, and columns, which mayinclude a mineral or polymer support with electronegative groups. Aglass fiber filter or column has worked particularly well for suchisolation procedures.

In specific embodiments, miRNA isolation processes include: a) lysingcells in the sample with a lysing solution comprising guanidinium,wherein a lysate with a concentration of at least about 1 M guanidiniumis produced; b) extracting miRNA molecules from the lysate with anextraction solution comprising phenol; c) adding to the lysate analcohol solution for form a lysate/alcohol mixture, wherein theconcentration of alcohol in the mixture is between about 35% to about70%; d) applying the lysate/alcohol mixture to a solid support; e)eluting the miRNA molecules from the solid support with an ionicsolution; and, f) capturing the miRNA molecules. Typically the sample isdried down and resuspended in a liquid and volume appropriate forsubsequent manipulation.

B. Preparation of Nucleic Acids

Alternatively, nucleic acid synthesis is performed according to standardmethods. See, for example, Itakura and Riggs (1980). Additionally, U.S.Pat. Nos. 4,704,362, 5,221,619, and 5,583,013 each describe variousmethods of preparing synthetic nucleic acids. Non-limiting examples of asynthetic nucleic acid (e.g., a synthetic oligonucleotide), include anucleic acid made by in vitro chemically synthesis usingphosphotriester, phosphite, or phosphoramidite chemistry and solid phasetechniques such as described in EP 266,032, incorporated herein byreference, or via deoxynucleoside H-phosphonate intermediates asdescribed by Froehler et al., 1986 and U.S. Pat. No. 5,705,629, eachincorporated herein by reference. In the methods of the presentinvention, one or more oligonucleotide may be used. Various differentmechanisms of oligonucleotide synthesis have been disclosed in forexample, U.S. Pat. Nos. 4,659,774, 4,816,571, 5,141,813, 5,264,566,4,959,463, 5,428,148, 5,554,744, 5,574,146, 5,602,244, each of which isincorporated herein by reference.

A non-limiting example of an enzymatically produced nucleic acid includeone produced by enzymes in amplification reactions such as PCR™ (see forexample, U.S. Pat. Nos. 4,683,202 and 4,682,195, each incorporatedherein by reference), or the synthesis of an oligonucleotide describedin U.S. Pat. No. 5,645,897, incorporated herein by reference. Anon-limiting example of a biologically produced nucleic acid includes arecombinant nucleic acid produced (i.e., replicated) in a living cell,such as a recombinant DNA vector replicated in bacteria (see forexample, Sambrook et al., 2001, incorporated herein by reference).

Oligonucleotide synthesis is well known to those of skill in the art.Various different mechanisms of oligonucleotide synthesis have beendisclosed in for example, U.S. Pat. Nos. 4,659,774, 4,816,571,5,141,813, 5,264,566, 4,959,463, 5,428,148, 5,554,744, 5,574,146,5,602,244, each of which is incorporated herein by reference.

Recombinant methods for producing nucleic acids in a cell are well knownto those of skill in the art. These include the use of vectors (viraland non-viral), plasmids, cosmids, and other vehicles for delivering anucleic acid to a cell, which may be the target cell (e.g., a cancercell) or simply a host cell (to produce large quantities of the desiredRNA molecule). Alternatively, such vehicles can be used in the contextof a cell free system so long as the reagents for generating the RNAmolecule are present. Such methods include those described in Sambrook,2003, Sambrook, 2001 and Sambrook, 1989, which are hereby incorporatedby reference.

In certain embodiments, the present invention concerns nucleic acidmolecules that are not synthetic. In some embodiments, the nucleic acidmolecule has a chemical structure of a naturally occurring nucleic acidand a sequence of a naturally occurring nucleic acid, such as the exactand entire sequence of a single stranded primary miRNA (see Lee, 2002),a single-stranded precursor miRNA, or a single-stranded mature miRNA. Inaddition to the use of recombinant technology, such non-syntheticnucleic acids may be generated chemically, such as by employingtechnology used for creating oligonucleotides.

C. Labels and Labeling Techniques

In some embodiments, the present invention concerns miRNA that aredirectly or indirectly labeled. It is contemplated that miRNA may firstbe isolated and/or purified prior to labeling. This may achieve areaction that more efficiently labels the miRNA, as opposed to other RNAin a sample in which the miRNA is not isolated or purified prior tolabeling. In many embodiments of the invention, the label isnon-radioactive. Generally, nucleic acids may be labeled by addinglabeled nucleotides (one-step process) or adding nucleotides andlabeling the added nucleotides (two-step process).

In some embodiments, nucleic acids are labeled by catalytically addingto the nucleic acid an already labeled nucleotide or nucleotides. One ormore labeled nucleotides can be added to miRNA molecules. See U.S. Pat.No. 6,723,509, which is hereby incorporated by reference.

In other embodiments, an unlabeled nucleotide or nucleotides iscatalytically added to a miRNA, and the unlabeled nucleotide is modifiedwith a chemical moiety that enables it to be subsequently labeled. Inembodiments of the invention, the chemical moiety is a reactive aminesuch that the nucleotide is an amine-modified nucleotide. Examples ofamine-modified nucleotides are well known to those of skill in the art,many being commercially available such as from Ambion, Sigma, JenaBioscience, and TriLink.

In contrast to labeling of cDNA during its synthesis, the issue forlabeling miRNA is how to label the already existing molecule. Thepresent invention concerns the use of an enzyme capable of using a di-or tri-phosphate ribonucleotide or deoxyribonucleotide as a substratefor its addition to a miRNA. Moreover, in specific embodiments, itinvolves using a modified di- or tri-phosphate ribonucleotide, which isadded to the 3′ end of a miRNA. The source of the enzyme is notlimiting. Examples of sources for the enzymes include yeast,gram-negative bacteria such as E. coli, Lactococcus lactis, and sheeppox virus.

Enzymes capable of adding such nucleotides include, but are not limitedto, poly(A) polymerase, terminal transferase, and polynucleotidephosphorylase. In specific embodiments of the invention, a ligase iscontemplated as not being the enzyme used to add the label, and instead,a non-ligase enzyme is employed.

Terminal transferase catalyzes the addition of nucleotides to the 3′terminus of a nucleic acid.

Polynucleotide phosphorylase can polymerize nucleotide diphosphateswithout the need for a primer.

Labels on miRNA or miRNA probes may be colorimetric (includes visibleand UV spectrum, including fluorescent), luminescent, enzymatic, orpositron emitting (including radioactive). The label may be detecteddirectly or indirectly. Radioactive labels include ¹²⁵I, ³²P, ³³P, and³⁵S. Examples of enzymatic labels include alkaline phosphatase,luciferase, horseradish peroxidase, and β-galactosidase. Labels can alsobe proteins with luminescent properties, e.g., green fluorescent proteinand phycoerythrin.

The colorimetric and fluorescent labels contemplated for use asconjugates include, but are not limited to, Alexa Fluor dyes, BODIPYdyes, such as BODIPY FL; Cascade Blue; Cascade Yellow; coumarin and itsderivatives, such as 7-amino-4-methylcoumarin, aminocoumarin andhydroxycoumarin; cyanine dyes, such as Cy3 and Cy5; eosins anderythrosins; fluorescein and its derivatives, such as fluoresceinisothiocyanate; macrocyclic chelates of lanthanide ions, such as QuantumDye™; Marina Blue; Oregon Green; rhodamine dyes, such as rhodamine red,tetramethylrhodamine and rhodamine 6G; Texas Red; fluorescent energytransfer dyes, such as thiazole orange-ethidium heterodimer; and, TOTAB.

Specific examples of dyes include, but are not limited to, thoseidentified above and the following: Alexa Fluor 350, Alexa Fluor 405,Alexa Fluor 430, Alexa Fluor 488, Alexa Fluor 500. Alexa Fluor 514,Alexa Fluor 532, Alexa Fluor 546, Alexa Fluor 555, Alexa Fluor 568,Alexa Fluor 594, Alexa Fluor 610, Alexa Fluor 633, Alexa Fluor 647,Alexa Fluor 660, Alexa Fluor 680, Alexa Fluor 700, and, Alexa Fluor 750;amine-reactive BODIPY dyes, such as BODIPY 493/503, BODIPY 530/550,BODIPY 558/568, BODIPY 564/570, BODIPY 576/589, BODIPY 581/591, BODIPY630/650, BODIPY 650/655, BODIPY FL, BODIPY R6G, BODIPY TMR, and,BODIPY-TR; Cy3, Cy5, 6-FAM, Fluorescein Isothiocyanate, HEX, 6-JOE,Oregon Green 488, Oregon Green 500, Oregon Green 514, Pacific Blue, REG,Rhodamine Green, Rhodamine Red, Renographin, ROX, SYPRO, TAMRA,2′,4′,5′,7′-Tetrabromosulfonefluorescein, and TET.

Specific examples of fluorescently labeled ribonucleotides are availablefrom Molecular Probes, and these include, Alexa Fluor 488-5-UTP,Fluorescein-12-UTP, BODIPY FL-14-UTP, BODIPY TMR-14-UTP,Tetramethylrhodamine-6-UTP, Alexa Fluor 546-14-UTP, Texas Red-5-UTP, andBODIPY TR-14-UTP. Other fluorescent ribonucleotides are available fromAmersham Biosciences, such as Cy3-UTP and Cy5-UTP.

Examples of fluorescently labeled deoxyribonucleotides includeDinitrophenyl (DNP)-11-dUTP, Cascade Blue-7-dUTP, Alexa Fluor488-5-dUTP, Fluorescein-12-dUTP, Oregon Green 488-5-dUTP, BODIPYFL-14-dUTP, Rhodamine Green-5-dUTP, Alexa Fluor 532-5-dUTP, BODIPYTMR-14-dUTP, Tetramethylrhodamine-6-dUTP, Alexa Fluor 546-14-dUTP, AlexaFluor 568-5-dUTP, Texas Red-12-dUTP, Texas Red-5-dUTP, BODIPYTR-14-dUTP, Alexa Fluor 594-5-dUTP, BODIPY 630/650-14-dUTP, BODIPY650/665-14-dUTP; Alexa Fluor 488-7-OBEA-dCTP, Alexa Fluor546-16-OBEA-dCTP, Alexa Fluor 594-7-OBEA-dCTP, Alexa Fluor647-12-OBEA-dCTP.

It is contemplated that nucleic acids may be labeled with two differentlabels. Furthermore, fluorescence resonance energy transfer (FRET) maybe employed in methods of the invention (e.g., Klostermeier et al.,2002; Emptage, 2001; Didenko, 2001, each incorporated by reference).

Alternatively, the label may not be detectable per se, but indirectlydetectable or allowing for the isolation or separation of the targetednucleic acid. For example, the label could be biotin, digoxigenin,polyvalent cations, chelator groups and the other ligands, includeligands for an antibody.

A number of techniques for visualizing or detecting labeled nucleicacids are readily available. Such techniques include, microscopy,arrays, Fluorometry, Light cyclers or other real time PCR machines, FACSanalysis, scintillation counters, Phosphoimagers, Geiger counters, MRI,CAT, antibody-based detection methods (Westerns, immunofluorescence,immunohistochemistry), histochemical techniques, HPLC (Griffey et al.,1997), spectroscopy, capillary gel electrophoresis (Cummins et al.,1996), spectroscopy; mass spectroscopy; radiological techniques; andmass balance techniques.

When two or more differentially colored labels are employed, fluorescentresonance energy transfer (FRET) techniques may be employed tocharacterize association of one or more nucleic acid. Furthermore, aperson of ordinary skill in the art is well aware of ways ofvisualizing, identifying, and characterizing labeled nucleic acids, andaccordingly, such protocols may be used as part of the invention.Examples of tools that may be used also include fluorescent microscopy,a BioAnalyzer, a plate reader, Storm (Molecular Dynamics), ArrayScanner, FACS (fluorescent activated cell sorter), or any instrumentthat has the ability to excite and detect a fluorescent molecule.

V. Evaluation of miRNA Levels

It is contemplated that a number of assays could be employed to analyzemiRNAs, their activities, and their effects. Such assays include, butare not limited to, array hybridization, solution hybridization, nucleicamplification, polymerase chain reaction, quantitative PCR, RT-PCR, insitu hybridization, Northern hybridization, hybridization protectionassay (HPA) (GenProbe), branched DNA (bDNA) assay (Chiron), rollingcircle amplification (RCA), single molecule hybridization detection (USGenomics), Invader assay (ThirdWave Technologies), and/or Oligo LigationAssay (OLA), hybridization, and array analysis.

U.S. patent application Ser. No. 11/141,707, filed May 31, 2005; Ser.No. 11/857,948, filed Sep. 19, 2007; Ser. No. 11/273,640, filed Nov. 14,2005 and provisional patent application 60/869,295, filed Dec. 8, 2006are incorporated by reference in their entirety.

A. Sample Preparation

While endogenous miRNA is contemplated for use with compositions andmethods of the invention, recombinant miRNA—including nucleic acids thatare complementary or identical to endogenous miRNA or precursormiRNA—can also be handled and analyzed as described herein. Samples maybe biological samples, in which case, they can be from lavage, biopsy,fine needle aspirates, exfoliates, blood, sputum, tissue, organs, semen,saliva, tears, urine, cerebrospinal fluid, body fluids, hair follicles,skin, or any sample containing or constituting biological cells. Incertain embodiments, samples may be, but are not limited to, fresh,frozen, fixed, formalin fixed, preserved, RNAlater preserved, paraffinembedded, or formalin fixed and paraffin embedded. Alternatively, thesample may not be a biological sample, but be a chemical mixture, suchas a cell-free reaction mixture (which may contain one or morebiological enzymes).

B. Differential Expression Analyses

Methods of the invention can be used to detect differences in miRNAexpression or levels between two samples, or a sample and a reference(e.g., a tissue reference or a digital reference representative of anon-cancerous state). Specifically contemplated applications includeidentifying and/or quantifying differences between miRNA from a samplethat is normal and from a sample that is not normal, between a cancerouscondition and a non-cancerous condition, or between two differentlytreated samples (e.g., a pretreatment versus a posttreatment sample).Also, miRNA may be compared between a sample believed to be susceptibleto a particular therapy, disease, or condition and one believed to benot susceptible or resistant to that therapy, disease, or condition. Asample that is not normal is one exhibiting phenotypic trait(s) of adisease or condition or one believed to be not normal with respect tothat disease or condition. It may be compared to a cell that is normalwith respect to that disease or condition. Phenotypic traits includesymptoms of a disease or condition of which a component is or may or maynot be genetic or caused by a hyperproliferative or neoplastic cell orcells.

It is specifically contemplated that the invention can be used toevaluate differences between cell types (normal cells from stem cells);stages of disease, such as between hyperplasia, neoplasia, pre-cancerand cancer, or between a primary tumor and a metastasized tumor.

Phenotypic traits also include characteristics such as longevity,morbidity, susceptibility or receptivity to particular drugs ortherapeutic treatments (drug efficacy), and risk of drug toxicity.

In certain embodiments, miRNA profiles may be generated to evaluate andcorrelate those profiles with pharmacokinetics. For example, miRNAprofiles may be created and evaluated for patient tumor and bloodsamples prior to the patient's being treated or during treatment todetermine if there are miRNAs whose expression correlates with theoutcome of treatment. Identification of differential miRNAs can lead toa diagnostic assay involving them that can be used to evaluate tumorand/or blood samples to determine what drug regimen the patient shouldbe provided. In addition, it can be used to identify or select patientssuitable for a particular clinical trial. If a miRNA profile isdetermined to be correlated with drug efficacy or drug toxicity that maybe relevant to whether that patient is an appropriate patient forreceiving the drug or for a particular dosage of the drug.

In addition to the above assay, blood samples from patients can beevaluated to identify a disease or a condition based on miRNA levels,such as metastatic disease. A diagnostic assay can be created based onthe profiles that doctors can use to identify individuals with a diseaseor who are at risk to develop a disease. Alternatively, treatments canbe designed based on miRNA profiling. Examples of such methods andcompositions are described in the U.S. Provisional Patent Applicationentitled “Methods and Compositions Involving miRNA and miRNA InhibitorMolecules” filed on May 23, 2005, which is hereby incorporated byreference in its entirety.

C. Amplification

Many methods exist for evaluating miRNA levels by amplifying all or partof miRNA nucleic acid sequences such as mature miRNAs, precursor miRNAs,and primary miRNAs. Suitable nucleic acid polymerization andamplification techniques include reverse transcription (RT), polymerasechain reaction (PCR), real-time PCR (quantitative PCR (q-PCR)), nucleicacid sequence-base amplification (NASBA), ligase chain reaction,multiplex ligatable probe amplification, invader technology (ThirdWave), rolling circle amplification, in vitro transcription (IVT),strand displacement amplification, transcription-mediated amplification(TMA), RNA (Eberwine) amplification, and other methods that are known topersons skilled in the art. In certain embodiments, more than oneamplification method may be used, such as reverse transcription followedby real time PCR (Chen et al., 2005 and/or U.S. patent application Ser.No. 11/567,082, filed Dec. 5, 2006, which are incorporated herein byreference in its entirety).

A typical PCR reaction includes multiple amplification steps, or cyclesthat selectively amplify target nucleic acid species. Typical PCRreactions include 20 or more cycles of denaturation, annealing, andelongation. In many cases, the annealing and elongation steps can beperformed concurrently, in which case the cycle contains only two steps.Since mature miRNAs are single stranded, a reverse transcriptionreaction (which produces a complementary cDNA sequence) is typicallyperformed prior to PCR reactions. Reverse transcription reactionsinclude the use of, e.g., a RNA-based DNA polymerase (reversetranscriptase) and a primer.

In PCR and q-PCR methods, for example, a set of primers is used for eachtarget sequence. In certain embodiments, the lengths of the primersdepends on many factors, including, but not limited to, the desiredhybridization temperature between the primers, the target nucleic acidsequence, and the complexity of the different target nucleic acidsequences to be amplified. In certain embodiments, a primer is about 15to about 35 nucleotides in length. In other embodiments, a primer isequal to or fewer than 15, 20, 25, 30, or 35 nucleotides in length. Inadditional embodiments, a primer is at least 35 nucleotides in length.

In a further aspect, a forward primer can comprise at least one sequencethat anneals to a target miRNA and alternatively can comprise anadditional 5′ noncomplementary region. In another aspect, a reverseprimer can be designed to anneal to the complement of a reversetranscribed miRNA. The reverse primer may be independent of the miRNAsequence, and multiple miRNAs may be amplified using the same reverseprimer. Alternatively, a reverse primer may be specific for a miRNA.

In some embodiments, two or more miRNAs or nucleic acids are amplifiedin a single reaction volume or multiple reaction volumes. In certainaspects, one or more miRNA or nucleic may be used as a normalizationcontrol or a reference nucleic acid for normalization. Normalization maybe performed in separate or the same reaction volumes as otheramplification reactions. One aspect includes multiplex q-PCR, such asqRT-PCR, which enables simultaneous amplification and quantification ofat least one miRNA of interest and at least one reference nucleic acidin one reaction volume by using more than one pair of primers and/ormore than one probe. The primer pairs comprise at least oneamplification primer that uniquely binds each nucleic acid, and theprobes are labeled such that they are distinguishable from one another,thus allowing simultaneous quantification of multiple miRNAs. MultiplexqRT-PCR has research and diagnostic uses, including but not limited todetection of miRNAs for diagnostic, prognostic, and therapeuticapplications.

A single combined reaction for q-PCR, may be used to: (1) decreased riskof experimenter error, (2) reduction in assay-to-assay variability, (3)decreased risk of target or product contamination, and (4) increasedassay speed. The qRT-PCR reaction may further be combined with thereverse transcription reaction by including both a reverse transcriptaseand a DNA-based thermostable DNA polymerase. When two polymerases areused, a “hot start” approach may be used to maximize assay performance(U.S. Pat. Nos. 5,411,876 and 5,985,619). For example, the componentsfor a reverse transcriptase reaction and a PCR reaction may besequestered using one or more thermoactivation methods or chemicalalteration to improve polymerization efficiency (U.S. Pat. Nos.5,550,044, 5,413,924, and 6,403,341).

To assess the expression of microRNAs, real-time RT-PCR detection can beused to screen nucleic acids or RNA isolated from samples of interestand a related reference such as normal adjacent tissue (NAT) samples.

A panel of amplification targets is chosen for real-time RT-PCRquantification. The selection of the panel or targets can be based onthe results of microarray expression analyses, such as mirVana™ miRNABioarray V1, Ambion. In one aspect, the panel of targets includes one ormore miRNA described herein. One example of a normalization target is 5SrRNA and other can be included. Reverse transcription (RT) reactioncomponents are typically assembled on ice prior to the addition of RNAtemplate. Total RNA template is added and mixed. RT reactions areincubated in an appropriate PCR System at an appropriate temperature(15-30° C., including all values and ranges there between) for anappropriate time, 15 to 30 minutes or longer, then at a temperature of35 to 42 to 50° C. for 10 to 30 to 60 minutes, and then at 80 to 85 to95° C. for 5 minutes, then placed on wet ice. Reverse Transcriptionreaction components typically include nuclease-free water, reversetranscription buffer, dNTP mix, RT Primer, RNase Inhibitor, ReverseTranscriptase, and RNA.

PCR reaction components are typically assembled on ice prior to theaddition of the cDNA from the RT reactions. Following assembly of thePCR reaction components a portion of the RT reaction is transferred tothe PCR mix. PCR reaction are then typically incubated in an PCR systemat an elevated temperature (e.g., 95° C.) for 1 minute or so, then for anumber of cycles of denaturing, annealing, and extension (e.g., 40cycles of 95° C. for 5 seconds and 60° C. for 30 seconds). Results canbe analyzed, for example, with SDS V2.3 (Applied Biosystems). Real-timePCR components typically include Nuclease-free water, MgCl₂, PCR Buffer,dNTP mix, one or more primers, DNA Polymerase, cDNA from RT reaction andone or more detectable label.

Software tools such as NormFinder (Andersen et al., 2004) are used todetermine targets for normalization with the targets of interest andtissue sample set. For normalization of the real-time RT-PCR results,the cycle threshold (C_(t)) value (a log value) for the microRNA ofinterest is subtracted from the geometric mean C_(t) value ofnormalization targets. Fold change can be determined by subtracting thedC_(t) normal reference (N) from the corresponding dC_(t) sample beingevaluated (T), producing a ddC_(t)(T-N) value for each sample. Theaverage ddC_(t)(T-N) value across all samples is converted to foldchange by 2^(ddCt). The representative p-values are determined by atwo-tailed paired Student's t-test from the dC_(t) values of sample andnormal reference.

D. Nucleic Acid Arrays

Certain aspects of the present invention concerns the preparation anduse of miRNA arrays or miRNA probe arrays, which are ordered macroarraysor microarrays of nucleic acid molecules (probes) that are fully ornearly complementary or identical to a plurality of miRNA molecules orprecursor miRNA molecules and are positioned on a support or supportmaterial in a spatially separated organization. Macroarrays aretypically sheets of nitrocellulose or nylon upon which probes have beenspotted. Microarrays position the nucleic acid probes more densely suchthat up to 10,000 nucleic acid molecules can be fit into a regiontypically 1 to 4 square centimeters.

Representative methods and apparatus for preparing a microarray havebeen described, for example, in U.S. Pat. Nos. 5,143,854; 5,202,231;5,242,974; 5,288,644; 5,324,633; 5,384,261; 5,405,783; 5,412,087;5,424,186; 5,429,807; 5,432,049; 5,436,327; 5,445,934; 5,468,613;5,470,710; 5,472,672; 5,492,806; 5,525,464; 5,503,980; 5,510,270;5,525,464; 5,527,681; 5,529,756; 5,532,128; 5,545,531; 5,547,839;5,554,501; 5,556,752; 5,561,071; 5,571,639; 5,580,726; 5,580,732;5,593,839; 5,599,695; 5,599,672; 5,610;287; 5,624,711; 5,631,134;5,639,603; 5,654,413; 5,658,734; 5,661,028; 5,665,547; 5,667,972;5,695,940; 5,700,637; 5,744,305; 5,800,992; 5,807,522; 5,830,645;5,837,196; 5,871,928; 5,847,219; 5,876,932; 5,919,626; 6,004,755;6,087,102; 6,368,799; 6,383,749; 6,617,112; 6,638,717; 6,720,138, aswell as WO 93/17126; WO 95/11995; WO 95/21265; WO 95/21944; WO 95/35505;WO 96/31622; WO 97/10365; WO 97/27317; WO 99/35505; WO 09923256; WO09936760; WO 0138580; WO 0168255; WO 03020898; WO 03040410; WO 03053586;WO 03087297; WO 03091426; WO 03100012; WO 04020085; WO 04027093; EP 373203; EP 785 280; EP 799 897 and UK 8 803 000; the disclosures of whichare all herein incorporated by reference. Moreover, a person of ordinaryskill in the art could readily analyze data generated using an array.Such protocols are disclosed above, and include information found in WO9743450; WO 03023058; WO 03022421; WO 03029485; WO 03067217; WO03066906; WO 03076928; WO 03093810; WO 03100448A1, all of which arespecifically incorporated by reference.

E. Hybridization

After an array or a set of miRNA probes is prepared and the miRNA in thesample is labeled, the population of target nucleic acids is contactedwith the array or probes under hybridization conditions, where suchconditions can be adjusted, as desired, to provide for an optimum levelof specificity in view of the particular assay being performed. Suitablehybridization conditions are well known to those of skill in the art andreviewed in Sambrook et al. (2001) and WO 95/21944. Of particularinterest in many embodiments is the use of stringent conditions duringhybridization. Stringent conditions are known to those of skill in theart.

VI. Kits

Any of the compositions or components described herein may be comprisedin a kit. In a non-limiting example, reagents for isolating miRNA,labeling miRNA, and/or evaluating a miRNA population using an array,nucleic acid amplification, and/or hybridization can be included in akit, as well reagents for preparation of samples from colon samples. Thekit may further include reagents for creating or synthesizing miRNAprobes. The kits will thus comprise, in suitable container means, anenzyme for labeling the miRNA by incorporating labeled nucleotide orunlabeled nucleotides that are subsequently labeled. In certain aspects,the kit can include amplification reagents. In other aspects, the kitmay include various supports, such as glass, nylon, polymeric beads,magnetic beads, and the like, and/or reagents for coupling any probesand/or target nucleic acids. It may also include one or more buffers,such as reaction buffer, labeling buffer, washing buffer, or ahybridization buffer, compounds for preparing the miRNA probes, andcomponents for isolating miRNA. Other kits of the invention may includecomponents for making a nucleic acid array comprising miRNA, and thus,may include, for example, a solid support.

Kits for implementing methods of the invention described herein arespecifically contemplated. In some embodiments, there are kits forpreparing miRNA for multi-labeling and kits for preparing miRNA probesand/or miRNA arrays. In these embodiments, kit comprise, in suitablecontainer means, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more of thefollowing: 1) poly(A) polymerase; 2) unmodified nucleotides (G, A, T, C,and/or U); 3) a modified nucleotide (labeled or unlabeled); 4) poly(A)polymerase buffer; and, 5) at least one microfilter; 6) label that canbe attached to a nucleotide; 7) at least one miRNA probe; 8) reactionbuffer; 9) a miRNA array or components for making such an array; 10)acetic acid; 11) alcohol; 12) solutions for preparing, isolating,enriching, and purifying miRNAs or miRNA probes or arrays. Otherreagents include those generally used for manipulating RNA, such asformamide, loading dye, ribonuclease inhibitors, and DNase.

In specific embodiments, kits of the invention include an arraycontaining miRNA probes, as described in the application. An array mayhave probes corresponding to all known miRNAs of an organism or aparticular tissue or organ in particular conditions, or to a subset ofsuch probes. The subset of probes on arrays of the invention may be orinclude those identified as relevant to a particular diagnostic,therapeutic, or prognostic application. For example, the array maycontain one or more probes that is indicative or suggestive of (1) adisease or condition (colon cancer), (2) susceptibility or resistance toa particular drug or treatment; (3) susceptibility to toxicity from adrug or substance; (4) the stage of development or severity of a diseaseor condition (prognosis); and (5) genetic predisposition to a disease orcondition.

For any kit embodiment, including an array, there can be nucleic acidmolecules that contain or can be used to amplify a sequence that is avariant of, identical to or complementary to all or part of any of SEQID NOs described herein. Any nucleic acid discussed above may beimplemented as part of a kit.

The components of the kits may be packaged either in aqueous media or inlyophilized form. The container means of the kits will generally includeat least one vial, test tube, flask, bottle, syringe or other containermeans, into which a component may be placed, and preferably, suitablyaliquotted. Where there is more than one component in the kit (labelingreagent and label may be packaged together), the kit also will generallycontain a second, third or other additional container into which theadditional components may be separately placed. However, variouscombinations of components may be comprised in a vial. The kits of thepresent invention also will typically include a means for containing thenucleic acids, and any other reagent containers in close confinement forcommercial sale. Such containers may include injection or blow moldedplastic containers into which the desired vials are retained.

When the components of the kit are provided in one and/or more liquidsolutions, the liquid solution is an aqueous solution, with a sterileaqueous solution being particularly preferred.

However, the components of the kit may be provided as dried powder(s).When reagents and/or components are provided as a dry powder, the powdercan be reconstituted by the addition of a suitable solvent. It isenvisioned that the solvent may also be provided in another containermeans. In some embodiments, labeling dyes are provided as a dried power.It is contemplated that 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120,120, 130, 140, 150, 160, 170, 180, 190, 200, 300, 400, 500, 600, 700,800, 900, 1000 μg or at least or at most those amounts of dried dye areprovided in kits of the invention. The dye may then be resuspended inany suitable solvent, such as DMSO.

The container means will generally include at least one vial, test tube,flask, bottle, syringe and/or other container means, into which thenucleic acid formulations are placed, preferably, suitably allocated.The kits may also comprise a second container means for containing asterile, pharmaceutically acceptable buffer and/or other diluent.

The kits of the present invention will also typically include a meansfor containing the vials in close confinement for commercial sale, suchas, e.g., injection and/or blow-molded plastic containers into which thedesired vials are retained.

Such kits may also include components that facilitate isolation of thelabeled miRNA. It may also include components that preserve or maintainthe miRNA or that protect against its degradation. Such components maybe RNase-free or protect against RNases. Such kits generally willcomprise, in suitable means, distinct containers for each individualreagent or solution.

A kit will also include instructions for employing the kit components aswell the use of any other reagent not included in the kit. Instructionsmay include variations that can be implemented.

Kits of the invention may also include one or more of the following:Control RNA; nuclease-free water; RNase-free containers, such as 1.5 mltubes; RNase-free elution tubes; PEG or dextran; ethanol; acetic acid;sodium acetate; ammonium acetate; guanidinium; detergent; nucleic acidsize marker; RNase-free tube tips; and RNase or DNase inhibitors.

It is contemplated that such reagents are embodiments of kits of theinvention. Such kits, however, are not limited to the particular itemsidentified above and may include any reagent used for the manipulationor characterization of miRNA.

VII. Examples

The following examples are included to demonstrate preferred embodimentsof the invention. It should be appreciated by those of skill in the artthat the techniques disclosed in the examples which follow representtechniques discovered by the inventor to function well in the practiceof the invention, and thus can be considered to constitute preferredmodes for its practice. However, those of skill in the art should, inlight of the present disclosure, appreciate that many changes can bemade in the specific embodiments which are disclosed and still obtain alike or similar result without departing from the spirit and scope ofthe invention.

Example 1 miRNAs Differentially Expressed in Prostate Cancer Stem Cells

The inventors identified miRNAs that are differentially regulated inprostate CSCs. CSCs were isolated from three, well-characterized humanprostate cancer xenograft tumors (LAPC4, LAPC9, and Du145), followingtumor growth in mice. LAPC4 and LAPC9 prostate xenograft cells werekindly provided by C. Sawyers (Reiters and Sawyers, 1999). Du145 cellswere obtained from ATCC (Manassas, Va., USA) and maintained in cultureusing RPMI (Invitrogen Corp., Carlsbad, Calif., USA) supplemented with10% fetal bovine serum (FBS) as recommended by the company. Cells (3×10⁶per cell type) were injected subcutaneously into the flanks of NOD/SCIDmice (non-obese diabetic/severe combined immunodeficiency) (JAX® Miceand Services, Bar Harbor, Me., USA), and tumor growth was measuredbiweekly with calipers. Tumors were harvested when they reached ˜400 mm³in size and dissociated into single cells by methods previouslydescribed (Patrawala et al., 2006). Briefly, the tumors were minced into1 mm³ pieces in RPMI+10% FBS, washed with phosphate buffered saline(PBS), and incubated with 1× Accumax (1,200-2,000 U/ml proteolyticactivity containing collagenase and DNase; Innovative Cell TechnologiesInc., San Diego, Calif., USA) at 10 ml/g tissue. A single cellsuspension was obtained by filtering the supernatant through a 40-μMcell strainer (BD Falcon, Bedford, Mass., USA), and viable cells werecounted using the erythrosine B dye (ATCC). The cell suspension wasgently loaded onto a layer of Histopaque-1077 gradient (Sigma-Aldrich,St. Louis, Mo., USA) and centrifuged at 400 g for 30 minutes at roomtemperature. Contaminating mouse cells were removed using the MACSLineage Cell Depletion kit (Cat. No. 130-090-858; Miltenyi Biotec, Inc.;Auburn, Calif., USA).

The most common method for identifying CSCs in a tumor is by thepresence of specific cell surface markers that tag normal stem cells inthe tissue of origin. Prostate cancer stem cells are CD133+CD44+, thesame phenotype as normal prostate stem cells (Collins et al., 2005;Richardson et al., 2004). CD44 identifies CSCs in LAPC9, LAPC4 (lymphnode metastasis, Reiters and Sawyers, 2001) and Du145 (brain metastasis,Stone et al., 1978) tumors. CD44 and ITGA2 were shown to identify asubset of highly tumorigenic metastatic cells in prostate cancerxenografts (Patrawala et al., 2006, 2007). Single cell suspensions werestained with fluorescein isothiocyanate- or phycoerythrin-conjugatedantibodies against CD44 (LAPC4, LAPC9, Du145) or CD133 (LAPC4) for 15minutes at 4° C. All antibodies were purchased from BD Biosciences (SanJose, Calif., USA) or Chemicon (Temecula, Calif., USA). CD133⁺ and CD44⁺cells were sorted using a Beckman-Coulter EPICS Elite fluorescenceactivated cell-sorter (FACS). The purity of the sorted cell populationswas ˜99% as determined by visual examination under a fluorescencemicroscope and by FACS analysis of the sorted fraction. Cells wereharvested by centrifugation and immediately frozen for RNA isolation.

Total RNA was extracted using the mirVana™ miRNA Isolation kit (cat. no.AM1561; Ambion, Inc.; Austin, Tex., USA) according to the manufacturer'srecommended protocol. Expression of 137 miRNAs was determined induplicate by quantitative real-time PCR using (1) RNA from cells derivedfrom LAPC4, LAPC9, and Du145 xenografts and carrying the CD44 or CD133epitopes and (2) RNA from the population of tumor cells recovered afterCSC removal from the respective tumors. Quantitative real-time PCRassays employed TaqMan® MicroRNA Assay reagents (Applied Biosystems,Foster City, Calif., USA). Raw Ct values from CSCs were normalized tothose of miR-103, a housekeeping miRNA (Peltier & Latham, 2008), andexpressed relative to the normalized values generated in theCSC-depleted prostate tumor cell population (Table 1 and Table 2).

TABLE 1 miRNAs differentially expressed in prostate cancer stem cells(CSCs) purified from human prostate xenograft tumors of LAPC4, LAPC9, orDU145 cells, using antibodies against the CD44 surface antigen,representing prostate cancer stem cells. Relative Expression (log₂)miRNA LAPC4 LAPC9 Du145 miRNAs downregulated in CD44(+) cells hsa-let-7a0.76 1.15 1.79 hsa-let-7b 1.75 1.4 1.46 hsa-let-7c 1.05 NS NS hsa-let-7e0.54 0.83 0.7 hsa-let-7f 0.66 0.75 1.41 hsa-miR-101 NS NS 0.75hsa-miR-106a NS NS 0.57 hsa-miR-10a 16.9 0.96 1.12 hsa-miR-125a NS 1.04NS hsa-miR-126 NS 2.29 1.62 hsa-miR-132 0.72 0.92 0.61 hsa-miR-141 NS1.03 2.8 hsa-miR-148a NS 1.69 NS hsa-miR-148b 1.45 1.62 0.9 hsa-miR-1490.96 0.76 NS hsa-miR-151 0.67 0.73 1.03 hsa-miR-15b NS NS 2.03hsa-miR-181b 1.37 1.19 1.07 hsa-miR-182 NS NS 0.64 hsa-miR-183 0.54 1.080.73 hsa-miR-18a 12.55 NS NS hsa-miR-191 NS 1.12 NS hsa-miR-193b 1.5 NSNS hsa-miR-196a 2.69 0.99 2.57 hsa-miR-199a 12.39 4.25 3.67 hsa-miR-200c1.05 1.02 NS hsa-miR-203 0.56 0.74 7.27 hsa-miR-214 1.97 3.25 NShsa-miR-218 3.6 3.49 6.94 hsa-miR-222 2.19 0.98 NS hsa-miR-24 0.73 0.71NS hsa-miR-25 1.85 NS 1.05 hsa-miR-26a NS 0.52 NS hsa-miR-27a 0.68 NS NShsa-miR-29b 1.33 1.07 NS hsa-miR-30a-3p NS 0.54 1.18 hsa-miR-30a-5p 0.98NS 0.74 hsa-miR-30d 0.7 NS NS hsa-miR-324-5p 3.45 NS NS hsa-miR-331 NSNS 1.35 hsa-miR-335 0.77 0.52 NS hsa-miR-340 NS 0.51 1.41 hsa-miR-3422.81 1.17 NS hsa-miR-345 NS 0.75 1.69 hsa-miR-34a 4.88 11.76 6.37hsa-miR-365 0.51 NS 0.87 hsa-miR-375 19.18 NS NS hsa-miR-378 NS 5.7710.22 hsa-miR-422a 11.67 7.66 NS hsa-miR-422b 1.88 4.9 1.29 hsa-miR-425NS NS 4.28 hsa-miR-7 NS NS 1.9 hsa-miR-92 0.72 NS 0.79 hsa-miR-93 1.57NS NS hsa-miR-99b NS 0.7 NS miRNAs upregulated in CD44+ cellshsa-miR-100 NS NS −6.37 hsa-miR-124a NS −0.61 −1.27 hsa-miR-125b NS−0.61 −1.27 hsa-miR-133a NS −9.49 −1.27 hsa-miR-142-3p NS NS −3.9hsa-miR-181a NS −0.61 −1.27 hsa-miR-181d NS −0.61 −1.27 hsa-miR-19a NS−2.63 −0.71 hsa-miR-205 NS −0.61 −11.42 hsa-miR-22 −1.85 NS NShsa-miR-29a NS NS −0.92 hsa-miR-29c NS NS −0.79 hsa-miR-301 −1.09 −0.76−0.76 hsa-miR-328 −1.76 NS NS hsa-miR-33 NS −7.61 −1.27 hsa-miR-338 NS−0.61 −1.27 hsa-miR-374 NS NS −2.99 hsa-miR-451 NS −0.61 −14 hsa-miR-452NS −2.9 −11.28 hsa-miR-501 NS NS −0.84 Positive values indicate thatmiRNAs are expressed at reduced levels in CD44(+) cells compared toexpression in the CD44(−) prostate tumor cell population. Negativevalues indicate that miRNAs are expressed at increased levels in CSCs.Expression changes <0.5 were deemed non-significant (NS).

TABLE 2 miRNAs differentially expressed in prostate cancer stem cells(CSCs) purified from human prostate xenograft tumor of LAPC4 usingantibodies against the CD133 surface antigen, representing prostatecancer stem cells. miRs downregulated in CD133(+) cells RelativeExpression (log2) miRNA LAPC4 hsa-let-7i 0.5564 hsa-miR-124a 1.3196hsa-miR-126 2.2628 hsa-miR-133a 5.45 hsa-miR-152 0.6367 hsa-miR-15a1.333 hsa-miR-196b 0.5323 hsa-miR-200a 0.8372 hsa-miR-22 0.7699hsa-miR-320 0.8032 hsa-miR-335 13.6781 hsa-miR-340 0.7567 hsa-miR-34a6.1466 hsa-miR-362 0.7987 hsa-miR-365 18.7994 hsa-miR-375 0.6335hsa-miR-425 0.8198 hsa-miR-500 12.5725 hsa-miR-92 0.5556 hsa-miR-930.6517 hsa-miR-98 0.5612 miRs upregulated in CD133(+) cells RelativeExpression (log2) LAPC4 hsa-let-7c −0.5581 hsa-let-7e −0.5223hsa-miR-101 −0.7509 hsa-miR-105 −1.7903 hsa-miR-10a −0.5333 hsa-miR-10b−0.5592 hsa-miR-125a −0.7016 hsa-miR-125b −6.945 hsa-miR-127 −1.0802hsa-miR-133b −1.848 hsa-miR-140 −1.2409 hsa-miR-142-3p −6.4863hsa-miR-142-5p −8.6407 hsa-miR-145 −2.5335 hsa-miR-146a −6.3199hsa-miR-146b −3.069 hsa-miR-147 −6.945 hsa-miR-148a −0.9964 hsa-miR-148b−0.5955 hsa-miR-15b −0.5743 hsa-miR-16 −0.6147 hsa-miR-181a −6.945hsa-miR-181d −6.945 hsa-miR-183 −0.5309 hsa-miR-18a −1.8224 hsa-miR-190−2.0407 hsa-miR-192 −0.8115 hsa-miR-193b −0.6514 hsa-miR-195 −0.5163hsa-miR-19a −0.6698 hsa-miR-19b −0.7572 hsa-miR-203 −0.6154 hsa-miR-205−0.5496 hsa-miR-21 −26.4581 hsa-miR-214 −0.9359 hsa-miR-218 −2.3908hsa-miR-221 −1.4197 hsa-miR-222 −1.8574 hsa-miR-223 −6.9422 hsa-miR-24−0.7757 hsa-miR-25 −0.6531 hsa-miR-26b −0.5395 hsa-miR-27a −1.9827hsa-miR-27b −0.6736 hsa-miR-28 −0.9031 hsa-miR-29a −2.8784 hsa-miR-29b−2.0327 hsa-miR-29c −1.2433 Has-miR-30a-3p −1.1645 Has-miR-30a-5p−0.9717 hsa-miR-30b −0.5051 hsa-miR-30c −1 hsa-miR-30d −0.8061Has-miR-30e-5p −1.455 hsa-miR-32 −0.7289 Has-miR-324-3p −0.638Has-miR-324-5p −1.2068 hsa-miR-328 −3.0956 hsa-miR-33 −2.1178hsa-miR-331 −0.7065 hsa-miR-338 −6.945 hsa-miR-339 −2.0332 hsa-miR-345−0.7191 hsa-miR-361 −1.1723 hsa-miR-374 −1.108 hsa-miR-378 −1.2293hsa-miR-422a −0.904 hsa-miR-422b −0.5609 hsa-miR-423 −2.138 hsa-miR-433−2.2554 hsa-miR-451 −6.4959 hsa-miR-452 −6.945 hsa-miR-501 −0.5931hsa-miR-9 −1.9282 hsa-miR-96 −1.7889 Positive values indicate thatmiRNAs are expressed at reduced levels in CD133(+) cells compared toexpression in the CD133(−) prostate tumor cell population. Negativevalues indicate that miRNAs are expressed at increased levels in CSCs.Expression changes <0.5 were deemed non-significant and were notincluded in the table.

The differentially expressed miRNAs in Tables 1 and 2 represent targetsfor therapeutic intervention in prostate cancer. In particular, miRNAswith reduced expression in CSCs may be playing a tumor-suppressive roleand can be used in ‘replacement therapy’ to retard tumor growth. miRNAsthat are upregulated could be playing an oncogenic role and thereforecan be silenced to eliminate cancer stem cells and the disease.

Example 2 miRNAs Differentially Expressed in Cancer Stem Cells Isolatedfrom Side Population-Enriched Prostate Cancer Cells

The inventors also identified miRNAs that are differentially regulatedin prostate CSCs, purified as a side population (SP) by flow cytometry.CSCs preferentially express high levels of a family of multi-drugresistance (MDR) proteins known as ABC transporters (Zhou et al., 2001;Lechner et al., 2002). High expression of ABC transporters enablesefficient efflux of cytotoxic agents from the cell, thereby conferringchemoresistance to CSCs (Doyle and Ross, 2003). The Hoechst 33342fluorescent dye is efficiently exported from CSCs by the ABC transportercomplex, enabling identification and separation of CSCs. SP prostatecancer cells are a fraction of prostate cancer cells, highly enrichedfor CSCs, that are detected by dual-wavelength flow cytometry based ontheir ability to efflux fluorescent Hoechst 33342 dye (Patrawala et al.,2005; Hirschmann-Jax et al., 2004).

LAPC9 tumor xenografts were established in mice, and tumors weredissociated as described above in Example 1. Dissociated LAPC9 tumorcells were incubated for 2 hr at 37° C. in culture medium containing 5μg/ml of Hoechst 33342 dye (cat. no. B2261; Sigma-Aldrich Co.; St.Louis, Mo., USA). Cells were analyzed for fluorescence using aBeckman-Coulter EPICS Elite fluorescence activated cell-sorter. Hoechst33342 was excited with a UV laser at 351 to 364 nm, and its fluorescencewas measured with a 515 nm SP filter (Hoechst blue) and a 608 nm EFLPoptical filter (Hoechst red). CSCs expressing high levels of the ABCtransporter proteins exported fluorescent dye and appeared on the ‘side’of the FACS profile as a distinct Hoechst-low fraction. This sidepopulation was purified and was previously shown to be highly enrichedfor CSCs in LAPC9 tumors (Patrawala et al., 2005). The SP and the non-SPcell fractions were harvested and frozen immediately upon sorting. RNAwas isolated as described above in Example 1.

Expression levels of 137 miRNAs were determined in duplicate byquantitative real-time PCR (as described above in Example 1) in CSCsenriched in the LAPC9 SP. Raw Ct values from CSCs were normalized tomiR-24, a house-keeping miRNA, and expressed relative to the onesgenerated in the non-SP LAPC9 prostate cancer cells. miRNAsdifferentially expressed between the two populations are shown in Table3.

TABLE 3 miRNAs differentially expressed in prostate cancer stem cellsenriched as a side population (SP) of LAPC9 tumor cells. Relativeexpression (log₂) miRNA LAPC9 miRNAs downregulated in SP cellsHas-let-7c 1.91743 hsa-miR-103 10.258164 hsa-miR-10b 8.1560155hsa-miR-126 3.0722085 Has-miR-146a 6.823249 Has-miR-146b 6.153386hsa-miR-15a 10.643113 hsa-miR-15b 12.1120955 hsa-miR-182 2.563866hsa-miR-183 5.2617965 hsa-miR-191 1.1364705 hsa-miR-195 2.9771485hsa-miR-200a 1.5385825 hsa-miR-200c 0.939588 hsa-miR-203 0.87379hsa-miR-205 9.0347945 hsa-miR-21 0.5807815 hsa-miR-218 1.0871205hsa-miR-27a 1.095363 hsa-miR-29b 2.434234 hsa-miR-29c 0.7804065hsa-miR-30a-3p 1.0177615 hsa-miR-30a-5p 2.217874 hsa-miR-328 9.5805905hsa-miR-335 10.700541 hsa-miR-365 0.9593445 hsa-miR-375 1.3379015hsa-miR-422a 3.120847 hsa-miR-429 0.608145 hsa-miR-9* 1.2157095 miRNAsupregulated in SP cells Has-let-7b −1.0670255 hsa-miR-133b −1.379272hsa-miR-142-3p −0.510159 hsa-miR-196a −1.835175 hsa-miR-196b −1.514786hsa-miR-221 −0.7282025 hsa-miR-222 −1.017886 hsa-miR-223 −1.3750955hsa-miR-320 −1.8956015 hsa-miR-33 −0.752666 hsa-miR-378 −1.941396hsa-miR-425 −1.4846465 hsa-miR-451 −7.5747555 hsa-miR-452 −3.483306hsa-miR-500 −5.137463 Positive values indicate that miRNAs are expressedat reduced levels in the SP CSCs compared to expression in non-SP LAPC9cells. Negative values indicate that miRNAs are expressed at increasedlevels in SP CSCs.

TABLE 4 miRNAs commonly deregulated in at least two fractions ofprostate cancer stem cells marked by either the CD44+ epitope, theCD133+ epitope, or enriched in the side population (SP). miRNA miRNAsdownregulated in CD44+ and CD133+ cells hsa-miR-126 hsa-miR-335hsa-miR-340 hsa-miR-34a hsa-miR-365 hsa-miR-375 hsa-miR-425 hsa-miR-92hsa-miR-93 miRNAs upregulated in CD44+ and CD133+ cells hsa-miR-125bhsa-miR-142-3p hsa-miR-181a hsa-miR-181d hsa-miR-205 hsa-miR-29ahsa-miR-29c hsa-miR-328 hsa-miR-33 hsa-miR-338 hsa-miR-374 hsa-miR-451hsa-miR-452 hsa-miR-501 miRNAs downregulated in CD44+ and SP cellshsa-let-7c hsa-miR-126 hsa-miR-15b hsa-miR-182 hsa-miR-183 hsa-miR-191hsa-miR-200c hsa-miR-203 hsa-miR-218 hsa-miR-27a hsa-miR-29bhsa-miR-30a-3p hsa-miR-30a-5p hsa-miR-335 hsa-miR-365 hsa-miR-375hsa-miR-422a miRNAs upregulated in CD44+ and SP cells hsa-miR-142-3phsa-miR-33 hsa-miR-451 hsa-miR-452 miRs downregulated in CD133+ and SPcells hsa-miR-126 hsa-miR-15a hsa-miR-200a hsa-miR-335 hsa-miR-365hsa-miR-375 miRs upregulated in CD133+ and SP cells hsa-miR-133bhsa-miR-142-3p hsa-miR-221 hsa-miR-222 hsa-miR-223 hsa-miR-33hsa-miR-378 hsa-miR-451 hsa-miR-452

TABLE 5 miRNAs commonly deregulated in prostate cancer stem cells markedby the CD44+ and CD133+ epitopes, and enriched in the side population(SP). miRNA miRNAs downregulated CD44+/CD133+/SP cells hsa-miR-126hsa-miR-335 hsa-miR-365 hsa-miR-375 miRNAs upregulated CD44+/CD133+/SPcells hsa-miR-142-3p hsa-miR-33 hsa-miR-451 hsa-miR-452

The miRNAs in Table 3 represent targets for therapeutic intervention inprostate cancer. Importantly, functional manipulation of these miRNAsmay sensitize the CSCs to chemotherapeutic agents effectively preventingrecurrence.

Cells selected by the CD44 and CD133 epitopes, or enriched in the sidepopulation represent cancer stem cells (Tables 1, 2 and 3). Therefore,miRNAs differentially expressed in each of these cell populations arelikely to indicate and/or contribute to the properties of cancer stemcells. miRNAs listed in Tables 1, 2 and 3 represent useful candidatesfor therapeutic intervention in the treatment of prostate cancer orcancer stem cells in general.

Table 4 shows miRNAs that are commonly deregulated in eitherCD44+/CD133+, CD44+/SP, or CD133+/SP cells. Table 5 shows miRNAs thatare commonly deregulated in CD44+/CD133+/SP cells. Since these miRNAsrepresent a unique signature among various cancer stem cell populations,the miRNAs listed in Tables 4 and 5 represent preferred therapeutictargets or agents. miRNAs upregulated are ideal candidates to developmiRNA inhibitors in an effort to treat prostate cancer or cancer stemcells in general; miRNAs downregulated are ideal candidates for “miRNAreplacement therapy” to treat prostate cancer or cancer stem cells ingeneral.

Example 3 miRNAs Predicted to Regulate Cancer Stem Cell Genes

Common genetic regulatory mechanisms govern the unique properties ofCSCs from different tumor types. For example, several types of CSCs,including multiple myeloma CSCs (Peacock et al., 2007), leukemia CSCs(Lessard and Sauvageau, 2003), and pancreatic CSCs (Li et al., 2007),are known to require activation of Sonic Hedgehog for survival. Tofurther elucidate the elements regulating CSCs, the inventors compiled alist of CSC-related genes reported in the literature, and predictedwhether transcripts of these genes were targeted by miRNAs. For thispurpose, the 3′UTRs of the CSC-related genes were analyzed for regionsof perfect complementarity with the seed sequences (nt 2-8 at the 5′end) of over 800 miRNAs listed in mirBase (Release 12.0, September 2008)(Griffiths-Jones et al., 2008). Gene targets for the 800 miRNAs werealso predicted from the list of CSC-related genes using the proprietaryalgorithm miRNATarget (Asuragen Inc. Austin, Tex., USA), and thecombined results are displayed in Table 5. CSC genes included in thisanalysis are NANOG (Ben-Porath et al., 2008; Gu et al., 2007), POUF51(also known as Oct-3/4) (Ben Porath et al., 2008; Gu et al., 2007), GLI1(Liu et al., 2006; Clement et al., 2007), SMO (smoothened) (Karhadkar etal., 2004), PTCH-1/PTCH (patched) (Liu et al., 2006; Yang et al., 2008),WNT3A (Willert et al., 2003; Lu et al., 2006; Li et al., 2008; Dai etal., 2008), CTNNB1 (beta-catenin) (Jamieson et al., 2004; Malanchi etal., 2008), NOTCH1 (Fan et al., 2006), JAG1 (jagged) (Leong & Gao,2008), SOX2 (Ben Porath et al., 2008; Gu et al., 2007), PROM1 (CD133)(Shepherd et al., 2008; Miki et al., 2007; Liu et al., 2006; Collins etal., 2005; Singh et al., 2003; Hermann et al., 2007), CD44 (Patrawala etal., 2006; Patrawala et al., 2007; Hurt et al., 2008; Al-Haji et al.,2003; Collins et al., 2005; Zhang et al., 2008; Gu et al., 2007),BMI1/PCFG4 (Liu et al., 2006; Lessard et al., 2003; Hurt et al., 2008),ABCG2/BCRP (Zhou et al., 2001; Lechner et al., 2002; Patrawala et al.,2005; Hirschmann-Jax et al., 2004; Dontu et al., 2003), ABCB1(Bourguignon et al., 2008; Ho et al., 2008; Keshet et al., 2008; Lechneret al., 2002), ITGA2 (Collins et al., 2005; Patrawala et al., 2007),ITGB1 (Collins et al., 2005; Patrawala et al., 2007), PTEN(Hambardzumuyan et al., 2008; Wang et al., 2006; Zhou et al., 2007),STAT3 (Zhou et al., 2007), SOX4 (Sinner et al., 2007; Vermeulen et al.,2008), ALDH1A (Ginestier et al., 2007; Dylla et al., 2008), PSCA(prostate stem cell antigen) (Watabe et al., 2002; Birnie et al., 2008),ITGAV (integrin alpha V) (Birnie et al., 2008), NFKB1 (Birnie et al.,2008), BCL2 (Liu et al., 2006; Wang et al., 2006), CXCR4 (Miki et al.,2007; Liu et al., 2006; Hermann et al., 2007), PAPPA (Birnie et al.,2008), TJP2 (tight junction protein 2) (Birnie et al., 2008), ABI1(Abl-interactor 1) (Birnie et al., 2008), BTG1 (Birnie et al., 2008),IL6 (Birnie et al., 2008), CFLAR (Birnie et al., 2008), SMU1 (Birnie etal., 2008), S100A3 (S 100 calcium binding protein A3) (Birnie et al.,2008), RASEF (Ras and EF-hand domain containing) (Birnie et al., 2008),IFNGR1 (interferon gamma receptor 1) (Birnie et al., 2008), IGFL1(Birnie et al., 2008), MSMB (Birnie et al., 2008), CEACAM5 (Birnie etal., 2008), S100A7 (S100 calcium binding protein A7) (Birnie et al.,2008), HPGD (Birnie et al., 2008), CEACAM7 (Birnie et al., 2008), TFF1(trefoil factor 1) (Birnie et al., 2008), PIP (prolactin-inducedprotein) (Birnie et al., 2008), Secretagogin (SCGN) (Liu et al., 2007),SWAP70 (Liu et al., 2007), Cyclin Y (CCYN) (Liu et al., 2007), C10orf9(Liu et al., 2007), cell division cycle 123 homolog (CDC123, C10orf7)(Liu et al., 2007), alkylation repair homolog 1 (ALKBH1) (Liu et al.,2007), transducer of ERBB2 (TOB2) (Liu et al., 2007), xenotropic andpolytropic retrovirus receptor (XPR1) (Liu et al., 2007), CD59 molecule(CD59) (Liu et al., 2007), low density lipoprotein-related protein 2(LRP2) (Liu et al., 2007), proteolipid protein 2 (PLP2) (Liu et al.,2007), mitogen-activated protein kinase 14 (MAPK14) (Liu et al., 2007),matrix metallopeptidase 7 (MMPI) (Liu et al., 2007), matrix Gla protein(MGP) (Liu et al., 2007), myeloid leukemia factor 1 (MLF1) (Liu et al.,2007), filaminB beta (actin binding protein 278) (FLNB) (Liu et al.,2007), sodium channel modifier 1 (SCNM1) (Liu et al., 2007), cornichonhomolog 4 (CNIH4 also known as HSPC163) (Liu et al., 2007), receptoraccessory protein 5 (REEP5) (Liu et al., 2007), solute carrier family25, member 33 (SLC25A33) (Liu et al., 2007), solute carrier family 44,member 1 (SLC44A1) (Liu et al., 2007), transmembrane channel-like 4(TMC4) (Liu et al., 2007), zinc finger DHHC-type containing 2 (ZDHHC2)(Liu et al., 2007), toll-like receptor adaptor molecule 2 (TICAM2) (Liuet al., 2007), KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum proteinretention receptor 3 (KDELR3) (Liu et al., 2007),glucosamine-6-phosphate deaminase 1 (GNPDA1) (Liu et al., 2007),thioesterase superfamily member 2 (THEM2) (Liu et al., 2007),debranching enzyme homolog 1 (DBR1) (Liu et al., 2007), solute carrierfamily 38, member 9 (SLC38A9) (Liu et al., 2007), N-acetyltrans-ferase10 (GCN5-related) (NAT10) (Liu et al., 2007), chromosome 16 open readingframe 33 (C16orf33) (Liu et al., 2007), lactate dehydrogenase A (LDHA)(Liu et al., 2007), major histocompatibility complex, class I-related(MR1) (Liu et al., 2007), leucyl-tRNA synthetase (LARS) (Liu et al.,2007), GTP binding protein 1 (GTPBP1) (Liu et al., 2007), proteaseserine 16 (PRSS16) (Liu et al., 2007), WAP four-disulfide core domain 2(WFDC2) (Liu et al., 2007), aurora kinase B (AURKB) (Liu et al., 2007),3-hydroxybutyrate dehydrogenase, type 2 (BDH2) (Liu et al., 2007),dehydrogenase/reductase (SDR family) member 4 (DHRS4) (Liu et al.,2007), abhydrolase domain containing 14B (ABHD14B) (Liu et al., 2007),EF-hand calcium binding domain 4A (EFCAB4A) (Liu et al., 2007), enoylcoenzyme A hydratase domain containing 2 (ECHDC2) (Liu et al., 2007),golgi autoantigen, golgin subfamily a,*B (GOLGA8B) (Liu et al., 2007),ATPase type 13A3 (ATP13A3) (Liu et al., 2007), prolyl endopeptidase-like(PREPL) (Liu et al., 2007), cytochrome P450, family 4, subfamily V,polypeptide 2 (CYP4V2) (Liu et al., 2007), JTV1 (Liu et al., 2007),isoprenyl-cysteine carboxyl methyltransferase (ICMT) (Liu et al., 2007),DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) (Liu et al., 2007),histamine N-methyltransferase (HNMT) (Liu et al., 2007),methyltransferase like 7A (METTL7A) (Liu et al., 2007),methyltransferase like 2A (METTL2A) (Liu et al., 2007),methyltransferase like 2B (METTL2B) (Liu et al., 2007), ezrin (EZR) (Liuet al., 2007), tumor protein D52 (TPD52) (Liu et al., 2007), actinrelated protein 2/3 complex, subunit 5 16 kDa (ARPC5) (Liu et al.,2007), nucleolar protein 8 (NOL8) (Liu et al., 2007),N-ehylmaleimide-sensitive factor (NSF) (Liu et al., 2007), RAD23 homologB (RAD23B) (Liu et al., 2007), signal recognition particle 54 kDa(SRP54) (Liu et al., 2007), heat shock 70kDa protein 2 (HSPA2) (Liu etal., 2007), mediator complex subunit 1 (MED 1) (Liu et al., 2007), THAPdomain containing, apoptosis associated protein 2 (THAP2) (Liu et al.,2007), cold inducible RNA binding protein (CIRBP) (Liu et al., 2007),small nuclear ribonucleoprotein polypeptide N (SNRPN) (Liu et al.,2007), superkiller viralicidic activity 2-like 2 (SKIV2L2) (Liu et al.,2007), dual specificity phosphatase 10 (DUSP10) (Liu et al., 2007),signal sequence receptor, alpha (SSR1) (Liu et al., 2007), v-erb-aerythroblastic leukemia viral oncogene homolog 4 (ERBB4) (Liu et al.,2007), epithelial membrane protein 1 (EMP1) (Liu et al., 2007), lowdensity lipoprotein receptor-related protein associated protein 1(LRPAP1) (Liu et al., 2007), SCY1-like binding protein 1 (SCYL1BP1) (Liuet al., 2007), cleavage stimulation factor, 3′ pre-RNA, subunit 1, 50kDa (CSTF1) (Liu et al., 2007), Kelch-like 20 (KLHL20) (Liu et al.,2007), DnaJ (Hsp40) homolog, subfamily C, member 13 (DNAJC13) (Liu etal., 2007), amyloid beta (A4) precursor-like protein 2 (APLP2) (Liu etal., 2007), sorbin and SH3 domain containing 2 (SORBS2) (Liu et al.,2007), DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1) (Liu et al.,2007), nebulette (NEBL) (Liu et al., 2007), SH3 domain binding glutamicacid-rich protein like (SH3BGRL) (Liu et al., 2007), nudix (nucleosidediphosphate linked moiety X)-type motif 5 (NUDT5) (Liu et al., 2007),GABA(A) receptor-associated protein like 1 (GABARAPL1) (Liu et al.,2007), microtubule-associated protein tau (MAPT) (Liu et al., 2007),discoidin, CUB and LCCL domain containing 1 (DCBLD1) (Liu et al., 2007),serine threonine kinase 39 (STK39) (Liu et al., 2007), protein kinase N2(PKN2) (Liu et al., 2007), casein kinase 2, alpha 1 polypeptide(CSNK2A1) (Liu et al., 2007), paired immunoglobin-like type 2 receptorbeta (PILRB) (Liu et al., 2007), endoplasmic reticulum to nucleussignaling 1 (ERN1) (Liu et al., 2007), serum/gluco-corticoid regulatedkinase family, member 3 (SGK3) (Liu et al., 2007), WEE1 homolog (WEE1)(Liu et al., 2007), microtubule associated serine/threonine kinasefamily member 4 (MAST4) (Liu et al., 2007), chromosome 11 open readingframe 17 (C11orf17) (Liu et al., 2007), nucleoproin 37 kDa (NUP37) (Liuet al., 2007), clathrin, heavy chain (Hc) (CLTC) (Liu et al., 2007),coatomer protein complex, subunit beta 2 (beta prime) (COPB2) (Liu etal., 2007), solute carrier family 25 (mitochondrial carrier; phosphatecarrier) member 25 (SLC25A25) (Liu et al., 2007), EGFR-coamplified andoverexpressed protein (ECOP) (Liu et al., 2007), phosphodi-esterase 8A(PDE8A) (Liu et al., 2007), signal tranducing adaptor molecule (SH3domain and ITAM motif) 1 (STAM) (Liu et al., 2007), tubulin, beta (TUBB)(Liu et al., 2007), sorting nexin 6 (SNX6) (Liu et al., 2007), RAB23,member RAS oncogene family (RAB23) (Liu et al., 2007), phospholipaseA2-activating protein (PLAA) (Liu et al., 2007), stanniocalcin 2 (STC2)(Liu et al., 2007), lactotransferrin (LTF) (Liu et al., 2007),interferon regulator factor 9 (IRF9) (Liu et al., 2007), ataxin 3(ATXN3) (Liu et al., 2007), general transcription factor IIIC,polypeptide 3, 102 kDa (GTF3C3) (Liu et al., 2007), glycogen synthasekinase 3 beta (GSK3B) (Liu et al., 2007), kruppel-like factor 10 (KLF10)(Liu et al., 2007), elongation factor, RNA polymerase II,2 (ELL2) (Liuet al., 2007), zinc finger and BTB domain containing 20 (ZBTB20) (Liu etal., 2007), iroquois homeobox 3 (IRX3) (Liu et al., 2007), v-etserythroblastosis virus E26 oncogene homolog 1 (ETS1) (Liu et al., 2007),SERTA domain containing 1 (SERTAD1) (Liu et al., 2007), transmembraneprotein 101 (TMEM101) (Liu et al., 2007), v-maf musculo-aponeuroticfibrosarcoma oncogene homolog F (MAFF) (Liu et al., 2007), splicingfactor proline/glutamine-rich (polypyrimidine tract binding proteinassociated) (SFPQ) (Liu et al., 2007), Cbp/p300-interactingtransactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (CITED4)(Liu et al., 2007), CCAAT/enhancer binding protein (C/EBP), delta(CEBPD) (Liu et al., 2007), eukaryotic translation initiation factor 4Efamily member 2 (EIF4E2) (Liu et al., 2007), heparan sulfate2-O-sulfotransferase 1 (HS2ST1) (Liu et al., 2007), alkylglyceronephosphate synthase (AGPS) (Liu et al., 2007), phospho-glycerate kinase 1(PGK1) (Liu et al., 2007), 5-aminoimidazole-4-carboxamide ribonucleotideformyltrans-ferase/IMP cyclohydrolase (ATIC) (Liu et al., 2007),ethanolamine kinase 1 (ETNK1) (Liu et al., 2007), asparagine-linkedglycosylation 2 homolog (ALG2) (Liu et al., 2007), ubiquitin-conjugatingenzyme E2F (UBE2F) (Liu et al., 2007), membrane-associated ring finger(C3HC4) 8 (MARCH8) (Liu et al., 2007), CCR4-NOT transcription complex,subunit 4 (CNOT4) (Liu et al., 2007), ring finger protein 8 (RNF8) (Liuet al., 2007), proteasome (prosome, macropain) subunit, alpha type, 5(PSMA5) (Liu et al., 2007), alport syndrome, mental retardation, midfacehypoplasia and elliptocytosis chromosomal region gene 1 (AMMERCR1) (Liuet al., 2007), integrator complex subunit 2 (1NTS2) (Liu et al., 2007),family with sequence similarity 152, member A (FAM152A) (Liu et al.,2007), integrator complex subunit 8 (INTS8) (Liu et al., 2007), THUMPdomain containing 3 (THUMPD3) (Liu et al., 2007), centrosomal protein350 kDa (CEP350) (Liu et al., 2007), Ewing tumor-associated antigen 1(ETAA1) (Liu et al., 2007), WD repeat domain 68 (WDR68) (Liu et al.,2007), viral DNA polymerase-transactivated protein 6 (DNAPTP6) (Liu etal., 2007), chromosome 7 open reading frame 25 (C7orf25) (Liu et al.,2007), chromosome 2 open reading frame 60 (C2orf60) (Liu et al., 2007),chromosome 17 open reading frame 71 (C17orf71) (Liu et al., 2007),chromosome 7 open reading frame 36 (C7orf36) (Liu et al., 2007),elongation protein 4 homolog (ELP4) (Liu et al., 2007), nudE nucleardistribution gene E homolog (A. nidulans)-like 1 (NDEL1) (Liu et al.,2007), chromosome 1 open reading frame 63 (C1orf63) (Liu et al., 2007),family with sequence similarity 172, member A (FAM172A) (Liu et al.,2007), family with sequence similarity 53, member C (FAM53C) (Liu etal., 2007), immediate early response 5 (IER5) (Liu et al., 2007),KIAA0146 (Liu et al., 2007), transmembrane protein 63A (TMEM63A) (Liu etal., 2007), NEDD4 binding protein 2-like 1 (N4BP2L1) (Liu et al., 2007),LY6/PLAUR domain containing 6B (LYPD6B) (Liu et al., 2007), BEX familymember 5 (BEX5) (Liu et al., 2007), KIAAl217 (Liu et al., 2007),chromosome 4 open reading frame 7 (C4orf7) (Liu et al., 2007),chromosome 9 open reading frame 64 (C9orf64) (Liu et al., 2007), Zyg-11homolog B (ZYG11B) (Liu et al., 2007), family with sequence similarity160, member B1 (FAM160B1) (Liu et al., 2007), limb region 1 homolog(LMBR1) (Liu et al., 2007), nuclear casein kinase and cyclin-dependentkinase substrate 1 (NUCKS1) (Liu et al., 2007), ankyrin repeat domain13C (ANKRD13C) (Liu et al., 2007), coiled-coil domain containing 43(CCDC43) (Liu et al., 2007), UHRF1 binding protein 1 (UHRF1BP1) (Liu etal., 2007), chromosome 1 open reading frame 163 (C1orf163) (Liu et al.,2007), axin interactor, dorsalization associated (AIDA) (Liu et al.,2007), chromosome 4 open reading frame 32 (C4orf32) (Liu et al., 2007),NES (nestin) (Zhang et al., 2008; Gu et al., 2007; Lechner et al.,2002), c-kit (KIT, CD 117) (Zhang et al., 2008), GLI2 (Liu et al., 2006;Thiyagarajan et al., 2007), MCL1 (Konopleva et al., 2006), IL4(Francipane et al., 2008), MUC1 (Engelmann et al., 2008), ABCA3(Hirschmann-Jax et al., 2004), SHH (sonic hedgehog) (Peacock et al.,2007; Karhadkar et al., 2004; Vezina & Bushman 2007), IHH (Indianhedgehog) (Peacock et al., 2007; Karhadkar et al., 2004; Vezina &Bushman 2007).

CSC-related genes that contain predicted target sites for human miRNAsinclude, but are not limited to (listed as—Gene title, Gene symbol,Accession no., miRNA):

Nanog—NANOG—NM_(—)024865—hsa-miR-1207-5p, hsa-miR-1243, hsa-miR-1273,hsa-miR-128, hsa-miR-1283, hsa-miR-130b*, hsa-miR-1321, hsa-miR-150,hsa-miR-154, hsa-miR-1827, hsa-miR-198, hsa-miR-199a-5p,hsa-miR-199b-5p, hsa-miR-202*, hsa-miR-20b*, hsa-miR-29b-2*,hsa-miR-302a*, hsa-miR-30b*, hsa-miR-340*, hsa-miR-34a, hsa-miR-34c,hsa-miR-363*, hsa-miR-376a*, hsa-miR-432*, hsa-miR-485-5p,hsa-miR-508-5p, hsa-miR-511, hsa-miR-513b, hsa-miR-520d-5p,hsa-miR-524-5p, hsa-miR-526b, hsa-miR-541*, hsa-miR-545,hsa-miR-548c-3p, hsa-miR-548l, hsa-miR-548n, hsa-miR-548p,hsa-miR-551b*, hsa-miR-553, hsa-miR-566, hsa-miR-567, hsa-miR-575,hsa-miR-579, hsa-miR-589*, hsa-miR-605, hsa-miR-624, hsa-miR-643,hsa-miR-661, hsa-miR-664, hsa-miR-664*, hsa-miR-7-1*, hsa-miR-7-2*,hsa-miR-720, hsa-miR-765, hsa-miR-766, hsa-miR-769-5p, hsa-miR-886-3p,hsa-miR-889, and hsa-miR-940.

Oct-3/4—POUF51 variant 1/PouF51 variant2—NM_(—)002701/NM_(—)203289—hsa-miR-1257, hsa-miR-221*, hsa-miR-299-3p,hsa-miR-324-3p, hsa-miR-335, hsa-miR-339-5p, hsa-miR-384, hsa-miR-412,hsa-miR-508-5p, hsa-miR-548d-3p, hsa-miR-551b*, hsa-miR-595, andhsa-miR-892a.

Gli1—GUI—NM_(—)005269—hsa-let-7f-2*, hsa-miR-1184, hsa-miR-1255a,hsa-miR-1255b, hsa-miR-1284, hsa-miR-1288, hsa-miR-1299, hsa-miR-1301,hsa-miR-34a, hsa-miR-34b, hsa-miR-34c, hsa-miR-361-3p, hsa-miR-373*,hsa-miR-374a*, hsa-miR-424*, hsa-miR-509-3-5p, hsa-miR-509-5p,hsa-miR-513a-3p, hsa-miR-616*, and hsa-miR-875-5p.

Smoothened—SMO—NM_(—)005631—hsa-let-7a*, hsa-let-7b*, hsa-let-7f-1*,hsa-miR-1184, hsa-miR-1185, hsa-miR-1205, hsa-miR-1207-3p,hsa-miR-1207-5p, hsa-miR-1227, hsa-miR-1252, hsa-miR-125a-5p,hsa-miR-125b, hsa-miR-1269, hsa-miR-1270, hsa-miR-1271, hsa-miR-127-5p,hsa-miR-1280, hsa-miR-1291, hsa-miR-1299, hsa-miR-1301, hsa-miR-130b*,hsa-miR-1322, hsa-miR-135a, hsa-miR-135b, hsa-miR-143, hsa-miR-146b-3p,hsa-miR-149*, hsa-miR-188-3p, hsa-miR-203, hsa-miR-218-1*,hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-31*, hsa-miR-324-3p,hsa-miR-326, hsa-miR-328, hsa-miR-330-5p, hsa-miR-338-3p,hsa-miR-339-5p, hsa-miR-370, hsa-miR-377*, hsa-miR-381, hsa-miR-423-3p,hsa-miR-425, hsa-miR-452*, hsa-miR-483-5p, hsa-miR-490-3p, hsa-miR-503,hsa-miR-504, hsa-miR-505, hsa-miR-508-5p, hsa-miR-516a-3p,hsa-miR-516b*, hsa-miR-518c*, hsa-miR-518d-5p, hsa-miR-518e*,hsa-miR-518f*, hsa-miR-519a*, hsa-miR-519b-5p, hsa-miR-519c-5p,hsa-miR-520c-5p, hsa-miR-522*, hsa-miR-523*, hsa-miR-526a,hsa-miR-548d-3p, hsa-miR-574-5p, hsa-miR-583, hsa-miR-588, hsa-miR-619,hsa-miR-620, hsa-miR-626, hsa-miR-629*, hsa-miR-645, hsa-miR-646,hsa-miR-657, hsa-miR-659, hsa-miR-661, hsa-miR-668, hsa-miR-7,hsa-miR-768-5p, hsa-miR-874, hsa-miR-877, hsa-miR-943, and hsa-miR-96.

Patched-1—PTCH-1/PTCH—NM_(—)000264—hsa-abi-13135, hsa-abi-13142,hsa-abi-13268, hsa-let-7a*, hsa-let-7b*, hsa-let-7f-1*, hsa-let-7f-2*,hsa-miR-100*, hsa-miR-101, hsa-miR-103, hsa-miR-107, hsa-miR-1178,hsa-miR-1179, hsa-miR-1182, hsa-miR-1183, hsa-miR-1202, hsa-miR-1203,hsa-miR-1205, hsa-miR-1208, hsa-miR-1225-5p, hsa-miR-1226, hsa-miR-1228,hsa-miR-124*, hsa-miR-1246, hsa-miR-1249, hsa-miR-1258, hsa-miR-125a-3p,hsa-miR-125a-5p, hsa-miR-125b, hsa-miR-126*, hsa-miR-1262, hsa-miR-1272,hsa-miR-1275, hsa-miR-127-5p, hsa-miR-1276, hsa-miR-1283, hsa-miR-1284,hsa-miR-1286, hsa-miR-1296, hsa-miR-1299, hsa-miR-1300, hsa-miR-1303,hsa-miR-130a*, hsa-miR-132, hsa-miR-1324, hsa-miR-135a*, hsa-miR-136,hsa-miR-138, hsa-miR-140-3p, hsa-miR-141, hsa-miR-143, hsa-miR-144,hsa-miR-146a*, hsa-miR-148a*, hsa-miR-148b*, hsa-miR-149*, hsa-miR-150,hsa-miR-151-5p, hsa-miR-153, hsa-miR-154*, hsa-miR-155*, hsa-miR-15a,hsa-miR-15b, hsa-miR-16, hsa-miR-16-2*, hsa-miR-182, hsa-miR-186,hsa-miR-188-3p, hsa-miR-18a, hsa-miR-18b, hsa-miR-192*, hsa-miR-193b*,hsa-miR-194, hsa-miR-194*, hsa-miR-195, hsa-miR-195*, hsa-miR-197,hsa-miR-199a*, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, hsa-miR-203,hsa-miR-204, hsa-miR-20a*, hsa-miR-211, hsa-miR-212, hsa-miR-214,hsa-miR-22, hsa-miR-220c, hsa-miR-221*, hsa-miR-23a, hsa-miR-23b,hsa-miR-24, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-27a, hsa-miR-27b,hsa-miR-28-5p, hsa-miR-296-3p, hsa-miR-299-3p, hsa-miR-29a*,hsa-miR-300, hsa-miR-302c*, hsa-miR-30a*, hsa-miR-30c-1*,hsa-miR-30c-2*, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-31*, hsa-miR-324-3p,hsa-miR-326, hsa-miR-329, hsa-miR-330-5p, hsa-miR-337-3p,hsa-miR-338-3p, hsa-miR-338-5p, hsa-miR-339-3p, hsa-miR-33a*,hsa-miR-342-3p, hsa-miR-345, hsa-miR-34a*, hsa-miR-362-3p,hsa-miR-369-3p, hsa-miR-373*, hsa-miR-377, hsa-miR-378*, hsa-miR-379*,hsa-miR-381, hsa-miR-410, hsa-miR-411*, hsa-miR-421, hsa-miR-423-5p,hsa-miR-424, hsa-miR-425, hsa-miR-429, hsa-miR-432*, hsa-miR-486-3p,hsa-miR-487a, hsa-miR-488, hsa-miR-493*, hsa-miR-495, hsa-miR-497,hsa-miR-498, hsa-miR-499-3p, hsa-miR-499-5p, hsa-miR-502-5p,hsa-miR-505*, hsa-miR-513b, hsa-miR-539, hsa-miR-541*, hsa-miR-542-3p,hsa-miR-543, hsa-miR-544, hsa-miR-545, hsa-miR-548a-3p, hsa-miR-548a-5p,hsa-miR-548b-5p, hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-5p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548h, hsa-miR-548i,hsa-miR-548j, hsa-miR-548n, hsa-miR-548p, hsa-miR-558, hsa-miR-559,hsa-miR-561, hsa-miR-564, hsa-miR-570, hsa-miR-576-5p, hsa-miR-578,hsa-miR-583, hsa-miR-587, hsa-miR-589, hsa-miR-591, hsa-miR-593,hsa-miR-593*, hsa-miR-597, hsa-miR-605, hsa-miR-608, hsa-miR-609,hsa-miR-615-5p, hsa-miR-616*, hsa-miR-624, hsa-miR-625*, hsa-miR-629*,hsa-miR-634, hsa-miR-637, hsa-miR-646, hsa-miR-651, hsa-miR-655,hsa-miR-656, hsa-miR-659, hsa-miR-665, hsa-miR-708, hsa-miR-767-3p,hsa-miR-767-5p, hsa-miR-768-3p, hsa-miR-769-5p, hsa-miR-770-5p,hsa-miR-802, hsa-miR-875-3p, hsa-miR-877, hsa-miR-885-5p, hsa-miR-888,hsa-miR-891b, hsa-miR-9, hsa-miR-922, hsa-miR-92a-2*, hsa-miR-939, andhsa-miR-944.

Wnt3A—WNT3A—NM_(—)033131—hsa-abi-4629, hsa-miR-100*, hsa-miR-103,hsa-miR-107, hsa-miR-1179, hsa-miR-1205, hsa-miR-1207-5p,hsa-miR-1225-3p, hsa-miR-1233, hsa-miR-1236, hsa-miR-1247, hsa-miR-1249,hsa-miR-1254, hsa-miR-1255a, hsa-miR-1255b, hsa-miR-1260, hsa-miR-1266,hsa-miR-127-3p, hsa-miR-1274a, hsa-miR-1278, hsa-miR-128, hsa-miR-1281,hsa-miR-1285, hsa-miR-1287, hsa-miR-1289, hsa-miR-1293, hsa-miR-1296,hsa-miR-1304, hsa-miR-1321, hsa-miR-138, hsa-miR-145*, hsa-miR-146b-3p,hsa-miR-148b*, hsa-miR-149*, hsa-miR-15a, hsa-miR-15b, hsa-miR-16,hsa-miR-1827, hsa-miR-185, hsa-miR-185*, hsa-miR-195, hsa-miR-214,hsa-miR-221*, hsa-miR-25*, hsa-miR-27a, hsa-miR-27b, hsa-miR-296-5p,hsa-miR-298, hsa-miR-30b*, hsa-miR-323-5p, hsa-miR-324-3p, hsa-miR-326,hsa-miR-330-5p, hsa-miR-331-3p, hsa-miR-339-5p, hsa-miR-361-3p,hsa-miR-363*, hsa-miR-410, hsa-miR-421, hsa-miR-423-5p, hsa-miR-424,hsa-miR-432, hsa-miR-432*, hsa-miR-483-3p, hsa-miR-483-5p,hsa-miR-485-5p, hsa-miR-491-5p, hsa-miR-497, hsa-miR-503, hsa-miR-513,hsa-miR-516b, hsa-miR-518a-5p, hsa-miR-518c*, hsa-miR-527, hsa-miR-541,hsa-miR-564, hsa-miR-600, hsa-miR-608, hsa-miR-612, hsa-miR-629*,hsa-miR-634, hsa-miR-637, hsa-miR-646, hsa-miR-654-5p, hsa-miR-658,hsa-miR-661, hsa-miR-663, hsa-miR-664, hsa-miR-671-3p, hsa-miR-744,hsa-miR-765, hsa-miR-874, hsa-miR-923, hsa-miR-92a-1*, hsa-miR-92a-2*,hsa-miR-92b*, hsa-miR-938, hsa-miR-939, and hsa-miR-940.

β-catenin—CTNNB1—NM_(—)001904—hsa-abi-11143, hsa-abi-371, hsa-abi-408,hsa-abi-4400, hsa-abi-693, hsa-abi-8027, hsa-let-7a*, hsa-let-7b*,hsa-let-7f-1*, hsa-miR-, 483, hsa-miR-, 589, hsa-miR-, 659,hsa-miR-1233, hsa-miR-1260, hsa-miR-1264, hsa-miR-1276, hsa-miR-138-1*,hsa-miR-139, hsa-miR-148a*, hsa-miR-148b*, hsa-miR-150, hsa-miR-16-1*,hsa-miR-1826, hsa-miR-183*, hsa-miR-200a, hsa-miR-214, hsa-miR-29a*,hsa-miR-302f, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d,hsa-miR-330-3p, hsa-miR-33a*, hsa-miR-33b, hsa-miR-340, hsa-miR-381,hsa-miR-496, hsa-miR-497*, hsa-miR-512-5p, hsa-miR-526b, hsa-miR-532-3p,hsa-miR-543, hsa-miR-545, hsa-miR-548g, hsa-miR-548l, hsa-miR-548n,hsa-miR-561, hsa-miR-568, hsa-miR-578, hsa-miR-579, hsa-miR-581,hsa-miR-582-3p, hsa-miR-589*, hsa-miR-592, hsa-miR-618, hsa-miR-624,hsa-miR-624*, hsa-miR-640, hsa-miR-641, hsa-miR-657, hsa-miR-668,hsa-miR-768-3p, hsa-miR-885-5p, hsa-miR-892b, and hsa-miR-935.

Notch-1—NOTCH1—NM_(—)017617—hsa-miR-101, hsa-miR-1207-5p, hsa-miR-1227,hsa-miR-1228*, hsa-miR-1234, hsa-miR-1254, hsa-miR-125a-3p,hsa-miR-125a-5p, hsa-miR-125b, hsa-miR-1263, hsa-miR-1264, hsa-miR-1275,hsa-miR-1281, hsa-miR-1282, hsa-miR-1283, hsa-miR-1290, hsa-miR-1291,hsa-miR-1293, hsa-miR-1301, hsa-miR-1308, hsa-miR-1322, hsa-miR-138,hsa-miR-138-2*, hsa-miR-139, hsa-miR-139-5p, hsa-miR-148a, hsa-miR-148b,hsa-miR-149, hsa-miR-150, hsa-miR-152, hsa-miR-155*, hsa-miR-1825,hsa-miR-183, hsa-miR-18a*, hsa-miR-196a*, hsa-miR-200b, hsa-miR-200c,hsa-miR-221*, hsa-miR-28-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-331-3p,hsa-miR-335*, hsa-miR-34a, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p,hsa-miR-369-3p, hsa-miR-421, hsa-miR-425, hsa-miR-429, hsa-miR-433,hsa-miR-449a, hsa-miR-449b, hsa-miR-455-3p, hsa-miR-455-5p,hsa-miR-485-5p, hsa-miR-488*, hsa-miR-490-3p, hsa-miR-509-3p,hsa-miR-511, hsa-miR-513b, hsa-miR-515-5p, hsa-miR-516b, hsa-miR-518c*,hsa-miR-519e*, hsa-miR-541, hsa-miR-545*, hsa-miR-548c-3p, hsa-miR-548k,hsa-miR-548n, hsa-miR-551b*, hsa-miR-561, hsa-miR-564, hsa-miR-568,hsa-miR-577, hsa-miR-582, hsa-miR-582-5p, hsa-miR-593*, hsa-miR-602,hsa-miR-603, hsa-miR-604, hsa-miR-608, hsa-miR-637, hsa-miR-643,hsa-miR-654-5p, hsa-miR-663b, hsa-miR-664, hsa-miR-665, hsa-miR-671-5p,hsa-miR-708, hsa-miR-760, hsa-miR-766, hsa-miR-874, hsa-miR-876-3p,hsa-miR-885-3p, hsa-miR-886-5p, hsa-miR-92, hsa-miR-92a-1*, hsa-miR-92b,and hsa-miR-940.

Jagged 1—JAG1—NM_(—)000214—hsa-abi-13097, hsa-abi-13196, hsa-abi-13248,hsa-abi-13259, hsa-abi-13261, hsa-abi-13268, hsa-abi-371, hsa-abi-4629,hsa-abi-6374, hsa-abi-6775, hsa-abi-9630, hsa-let-7a*, hsa-let-7a*,hsa-let-7b*, hsa-let-7b*, hsa-let-7f-1*, hsa-let-7f-1*, hsa-miR-1184,hsa-miR-1201, hsa-miR-1208, hsa-miR-124, hsa-miR-1245, hsa-miR-1246,hsa-miR-1253, hsa-miR-126, hsa-miR-126*, hsa-miR-1262, hsa-miR-1267,hsa-miR-128, hsa-miR-1282, hsa-miR-1284, hsa-miR-1284, hsa-miR-1285,hsa-miR-129, hsa-miR-1290, hsa-miR-129-5p, hsa-miR-129-5p, hsa-miR-1297,hsa-miR-1300, hsa-miR-1301, hsa-miR-130a*, hsa-miR-1323, hsa-miR-140-3p,hsa-miR-140-3p, hsa-miR-140-5p, hsa-miR-141, hsa-miR-142-5p,hsa-miR-145, hsa-miR-146a, hsa-miR-146b-5p, hsa-miR-148a*, hsa-miR-153,hsa-miR-16-1*hsa-abi-13242, hsa-miR-182, hsa-miR-185*, hsa-miR-186,hsa-miR-196a*, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-200a,hsa-miR-200a*, hsa-miR-200b, hsa-miR-200b*, hsa-miR-200c, hsa-miR-21,hsa-miR-21, hsa-miR-214, hsa-miR-214*, hsa-miR-217, hsa-miR-218,hsa-miR-218-2*, hsa-miR-218-2*, hsa-miR-22*, hsa-miR-220c, hsa-miR-23a,hsa-miR-23b, hsa-miR-26a, hsa-miR-26b, hsa-miR-26b*, hsa-miR-297,hsa-miR-298, hsa-miR-300, hsa-miR-30a*, hsa-miR-30a*, hsa-miR-30d*,hsa-miR-30d*, hsa-miR-30e*, hsa-miR-30e*, hsa-miR-32*, hsa-miR-320,hsa-miR-335*, hsa-miR-345, hsa-miR-34a, hsa-miR-34b*, hsa-miR-34c-5p,hsa-miR-369-3p, hsa-miR-371-5p, hsa-miR-371-5p, hsa-miR-377,hsa-miR-381, hsa-miR-381, hsa-miR-410, hsa-miR-421, hsa-miR-424*,hsa-miR-425, hsa-miR-429, hsa-miR-432, hsa-miR-432*, hsa-miR-448,hsa-miR-449a, hsa-miR-449b, hsa-miR-450b-3p, hsa-miR-450b-5p,hsa-miR-484, hsa-miR-485-3p, hsa-miR-489, hsa-miR-490-5p, hsa-miR-495,hsa-miR-497, hsa-miR-498, hsa-miR-499-5p, hsa-miR-506, hsa-miR-507,hsa-miR-507, hsa-miR-508-5p, hsa-miR-509-3p, hsa-miR-509-3p,hsa-miR-512-5p, hsa-miR-513a-3p, hsa-miR-518a-5p, hsa-miR-518a-5p,hsa-miR-520a*, hsa-miR-520d-5p, hsa-miR-524-5p, hsa-miR-525,hsa-miR-527, hsa-miR-527, hsa-miR-548a-5p, hsa-miR-548b-5p,hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-3p, hsa-miR-548d-5p,hsa-miR-548g, hsa-miR-548h, hsa-miR-548i, hsa-miR-548j, hsa-miR-548l,hsa-miR-548o, hsa-miR-551b*, hsa-miR-557, hsa-miR-558, hsa-miR-559,hsa-miR-561, hsa-miR-567, hsa-miR-569, hsa-miR-574-5p, hsa-miR-576,hsa-miR-576-5p, hsa-miR-578, hsa-miR-579, hsa-miR-579, hsa-miR-584,hsa-miR-586, hsa-miR-589*, hsa-miR-590-5p, hsa-miR-590-5p, hsa-miR-598,hsa-miR-606, hsa-miR-607, hsa-miR-607, hsa-miR-612, hsa-miR-624,hsa-miR-625, hsa-miR-626, hsa-miR-628-5p, hsa-miR-629*, hsa-miR-630,hsa-miR-634, hsa-miR-638, hsa-miR-642, hsa-miR-649, hsa-miR-653,hsa-miR-655, hsa-miR-656, hsa-miR-769-3p, hsa-miR-770-5p, hsa-miR-9*,hsa-miR-920, hsa-miR-922, hsa-miR-93*, hsa-miR-936, hsa-miR-940, andhsa-miR-944.

Sox2—SOX2—NM_(—)003106—hsa-abi-13242, hsa-abi-13248, hsa-abi-13259,hsa-abi-6775, hsa-let-7a*, hsa-let-7b*, hsa-let-7f-1*, hsa-miR-1246,hsa-miR-126, hsa-miR-1262, hsa-miR-1282, hsa-miR-1284, hsa-miR-1290,hsa-miR-129-5p, hsa-miR-1301, hsa-miR-140-3p, hsa-miR-145, hsa-miR-182,hsa-miR-200b, hsa-miR-200c, hsa-miR-21, hsa-miR-218-2*, hsa-miR-300,hsa-miR-30a*, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-32*, hsa-miR-320,hsa-miR-369-3p, hsa-miR-371-5p, hsa-miR-381, hsa-miR-429, hsa-miR-432,hsa-miR-432*, hsa-miR-450b-3p, hsa-miR-450b-5p, hsa-miR-490-5p,hsa-miR-507, hsa-miR-509-3p, hsa-miR-513a-3p, hsa-miR-518a-5p,hsa-miR-520a*, hsa-miR-525, hsa-miR-527, hsa-miR-548g, hsa-miR-557,hsa-miR-561, hsa-miR-574-5p, hsa-miR-576-5p, hsa-miR-578, hsa-miR-579,hsa-miR-590-5p, hsa-miR-607, hsa-miR-624, hsa-miR-625, hsa-miR-626,hsa-miR-629*, hsa-miR-638, hsa-miR-655, hsa-miR-656, hsa-miR-769-3p,hsa-miR-770-5p, and hsa-miR-9*.

CD133—PROM1—NM_(—)006017—hsa-miR-124*, hsa-miR-1246, hsa-miR-1299,hsa-miR-1305, hsa-miR-130a*, hsa-miR-1321, hsa-miR-135a, hsa-miR-135b,hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-149*, hsa-miR-216b, hsa-miR-218,hsa-miR-219-2-3p, hsa-miR-22*, hsa-miR-23a, hsa-miR-23b, hsa-miR-29a,hsa-miR-29b, hsa-miR-29c, hsa-miR-32*, hsa-miR-337-3p, hsa-miR-33a*,hsa-miR-362-5p, hsa-miR-369-3p, hsa-miR-374a, hsa-miR-374b, hsa-miR-375,hsa-miR-377, hsa-miR-495, hsa-miR-501-5p, hsa-miR-513c, hsa-miR-542-3p,hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-3p, hsa-miR-548c-5p,hsa-miR-548d-5p, hsa-miR-548g, hsa-miR-548h, hsa-miR-548i, hsa-miR-548j,hsa-miR-548l, hsa-miR-548m, hsa-miR-548n, hsa-miR-559, hsa-miR-579,hsa-miR-582-3p, hsa-miR-591, hsa-miR-603, hsa-miR-607, hsa-miR-625,hsa-miR-631, hsa-miR-637, hsa-miR-657, hsa-miR-758, hsa-miR-885-5p, andhsa-miR-888.

CD44—CD44—NM_(—)000610—hsa-miR-124*, hsa-miR-1246, hsa-miR-1299,hsa-miR-1305, hsa-miR-130a*, hsa-miR-1321, hsa-miR-135a, hsa-miR-135b,hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-149*, hsa-miR-216b, hsa-miR-218,hsa-miR-219-2-3p, hsa-miR-22*, hsa-miR-23a, hsa-miR-23b, hsa-miR-29a,hsa-miR-29b, hsa-miR-29c, hsa-miR-32*, hsa-miR-337-3p, hsa-miR-33a*,has-miR-34a, has-miR-34b, has-miR-34c, hsa-miR-362-5p, hsa-miR-369-3p,hsa-miR-374a, hsa-miR-374b, hsa-miR-377, hsa-miR-495, hsa-miR-501-5p,hsa-miR-513c, hsa-miR-542-3p, hsa-miR-548a-5p, hsa-miR-548b-5p,hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-548g,hsa-miR-548h, hsa-miR-548i, hsa-miR-548j, hsa-miR-548l, hsa-miR-548m,hsa-miR-548n, hsa-miR-559, hsa-miR-579, hsa-miR-582-3p, hsa-miR-591,hsa-miR-603, hsa-miR-607, hsa-miR-625, hsa-miR-631, hsa-miR-637,hsa-miR-657, hsa-miR-758, hsa-miR-885-5p, and hsa-miR-888.

Bmi-1—BMI1/PCFG4—NM_(—)005180—hsa-abi-13272, hsa-abi-408, hsa-miR-1245,hsa-miR-1248, hsa-miR-1256, hsa-miR-1262, hsa-miR-1264, hsa-miR-128,hsa-miR-1283, hsa-miR-1290, hsa-miR-132, hsa-miR-142-5p, hsa-miR-154,hsa-miR-154*, hsa-miR-15b*, hsa-miR-16-2*, hsa-miR-183, hsa-miR-187*,hsa-miR-192*, hsa-miR-193b*, hsa-miR-194, hsa-miR-195*, hsa-miR-19a*,hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-200b, hsa-miR-200c, hsa-miR-203,hsa-miR-208a, hsa-miR-208b, hsa-miR-212, hsa-miR-218, hsa-miR-219-2-3p,hsa-miR-221, hsa-miR-222, hsa-miR-224, hsa-miR-27a, hsa-miR-27b,hsa-miR-298, hsa-miR-29b-1*, hsa-miR-302f, hsa-miR-30a, hsa-miR-30b,hsa-miR-30c, hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-30d, hsa-miR-30e,hsa-miR-32*, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d,hsa-miR-329, hsa-miR-330-3p, hsa-miR-338-5p, hsa-miR-33a*, hsa-miR-340,hsa-miR-362-3p, hsa-miR-370, hsa-miR-376c, hsa-miR-380, hsa-miR-429,hsa-miR-431, hsa-miR-448, hsa-miR-452, hsa-miR-455-5p, hsa-miR-485-3p,hsa-miR-487a, hsa-miR-493-5p, hsa-miR-495, hsa-miR-501-5p,hsa-miR-508-3p, hsa-miR-509-3-5p, hsa-miR-509-5p, hsa-miR-513a-3p,hsa-miR-518a-5p, hsa-miR-520d, hsa-miR-524, hsa-miR-527, hsa-miR-532-5p,hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-548a-5p, hsa-miR-548b-5p,hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-548e, hsa-miR-548f,hsa-miR-548h, hsa-miR-548i, hsa-miR-548j, hsa-miR-548l, hsa-miR-548n,hsa-miR-548p, hsa-miR-551b*, hsa-miR-553, hsa-miR-559, hsa-miR-576-3p,hsa-miR-576-5p, hsa-miR-577, hsa-miR-586, hsa-miR-587, hsa-miR-590-3p,hsa-miR-624, hsa-miR-629, hsa-miR-636, hsa-miR-758, hsa-miR-802, andhsa-miR-92a-2*.

ABCG2—ABCG2/BCRP—NM_(—)004827—hsa-miR-105, hsa-miR-106a, hsa-miR-106b,hsa-miR-10b*, hsa-miR-1185, hsa-miR-1200, hsa-miR-1228, hsa-miR-124*,hsa-miR-1252, hsa-miR-1284, hsa-miR-1322, hsa-miR-134, hsa-miR-135b*,hsa-miR-138-2*, hsa-miR-141*, hsa-miR-142-5p, hsa-miR-143*,hsa-miR-145*, hsa-miR-146a, hsa-miR-146b-5p, hsa-miR-148a*,hsa-miR-150*, hsa-miR-154*, hsa-miR-17, hsa-miR-181a-2*, hsa-miR-183*,hsa-miR-186, hsa-miR-187*, hsa-miR-199a-5p, hsa-miR-199b-5p,hsa-miR-203, hsa-miR-20a, hsa-miR-20b, hsa-miR-218, hsa-miR-302a,hsa-miR-302b, hsa-miR-302c, hsa-miR-302c*, hsa-miR-302d, hsa-miR-302e,hsa-miR-302f, hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-323-3p,hsa-miR-328, hsa-miR-372, hsa-miR-373, hsa-miR-378, hsa-miR-411,hsa-miR-422a, hsa-miR-450b-5p, hsa-miR-487a, hsa-miR-491-5p,hsa-miR-497*, hsa-miR-499-5p, hsa-miR-508-3p, hsa-miR-512-3p,hsa-miR-516b, hsa-miR-519d, hsa-miR-520a-3p, hsa-miR-520b,hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520e, hsa-miR-520f,hsa-miR-520g, hsa-miR-520h, hsa-miR-522, hsa-miR-526b*, hsa-miR-542-3p,hsa-miR-548a-3p, hsa-miR-548e, hsa-miR-548f, hsa-miR-548l, hsa-miR-548n,hsa-miR-555, hsa-miR-561, hsa-miR-570, hsa-miR-577, hsa-miR-583,hsa-miR-590-3p, hsa-miR-619, hsa-miR-633, hsa-miR-651, hsa-miR-655,hsa-miR-656, hsa-miR-664, hsa-miR-665, hsa-miR-7-1*, hsa-miR-7-2*,hsa-miR-758, hsa-miR-873, hsa-miR-888*, hsa-miR-890, hsa-miR-891b,hsa-miR-93, and hsa-miR-944.

ABCB1—ABCB1—NM_(—)000927—hsa-let-7a*, hsa-let-7b*, hsa-let-7f-1*,hsa-miR-101*, hsa-miR-1253, hsa-miR-129-5p, hsa-miR-138-1*,hsa-miR-146a*, hsa-miR-16-2*, hsa-miR-188-3p, hsa-miR-195*, hsa-miR-214,hsa-miR-218-2*, hsa-miR-223, hsa-miR-298, hsa-miR-302c*, hsa-miR-331-5p,hsa-miR-338-5p, hsa-miR-34a*, hsa-miR-34b*, hsa-miR-455-3p,hsa-miR-485-3p, hsa-miR-491-3p, hsa-miR-508-5p, hsa-miR-513a-5p,hsa-miR-548l, hsa-miR-548n, hsa-miR-561, hsa-miR-593, hsa-miR-7-1*,hsa-miR-7-2*, hsa-miR-875-5p, hsa-miR-877*, hsa-miR-935, andhsa-miR-944.

ITGA2—ITGA2—NM_(—)002203—hsa-let-7a*, hsa-let-7b*, hsa-let-7f-1*,hsa-let-7f-2*, hsa-miR-101, hsa-miR-103, hsa-miR-106a, hsa-miR-106b,hsa-miR-107, hsa-miR-10a, hsa-miR-10b, hsa-miR-1182, hsa-miR-1200,hsa-miR-1224-5p, hsa-miR-1226, hsa-miR-1231, hsa-miR-1237,hsa-miR-1255a, hsa-miR-1255b, hsa-miR-1256, hsa-miR-1258,hsa-miR-125b-2*, hsa-miR-126*, hsa-miR-1263, hsa-miR-1265, hsa-miR-1267,hsa-miR-1269, hsa-miR-1272, hsa-miR-1283, hsa-miR-1288, hsa-miR-1290,hsa-miR-1293, hsa-miR-1297, hsa-miR-1303, hsa-miR-1321, hsa-miR-134,hsa-miR-135a, hsa-miR-135b, hsa-miR-138-2*, hsa-miR-139-5p,hsa-miR-140-5p, hsa-miR-141*, hsa-miR-142-3p, hsa-miR-143*,hsa-miR-146a, hsa-miR-146a*, hsa-miR-146b-3p, hsa-miR-146b-5p,hsa-miR-150, hsa-miR-155*, hsa-miR-15a, hsa-miR-15b, hsa-miR-16,hsa-miR-16-2*, hsa-miR-17, hsa-miR-17*, hsa-miR-181a, hsa-miR-181b,hsa-miR-181c, hsa-miR-181d, hsa-miR-1825, hsa-miR-1826, hsa-miR-185,hsa-miR-186, hsa-miR-186*, hsa-miR-18a, hsa-miR-18b, hsa-miR-190,hsa-miR-190b, hsa-miR-193a-5p, hsa-miR-193b*, hsa-miR-195, hsa-miR-195*,hsa-miR-198, hsa-miR-19a, hsa-miR-19b, hsa-miR-200a*, hsa-miR-200b,hsa-miR-200b*, hsa-miR-200c, hsa-miR-200c*, hsa-miR-202, hsa-miR-203,hsa-miR-20a, hsa-miR-20b, hsa-miR-20b*, hsa-miR-21, hsa-miR-21*,hsa-miR-216b, hsa-miR-219-5p, hsa-miR-223*, hsa-miR-24, hsa-miR-26a,hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-27b*, hsa-miR-297,hsa-miR-299-3p, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-302a,hsa-miR-302b, hsa-miR-302c, hsa-miR-302c*, hsa-miR-302d, hsa-miR-302e,hsa-miR-30a, hsa-miR-30a*, hsa-miR-30b, hsa-miR-30c, hsa-miR-30c-1*,hsa-miR-30c-2*, hsa-miR-30d, hsa-miR-30d*, hsa-miR-30e, hsa-miR-30e*,hsa-miR-324-3p, hsa-miR-326, hsa-miR-329, hsa-miR-330-5p,hsa-miR-331-5p, hsa-miR-335*, hsa-miR-338-5p, hsa-miR-339-5p,hsa-miR-33a*, hsa-miR-33b*, hsa-miR-340, hsa-miR-342-5p, hsa-miR-34b,hsa-miR-361-3p, hsa-miR-362-3p, hsa-miR-371-5p, hsa-miR-372,hsa-miR-373, hsa-miR-374a, hsa-miR-374b, hsa-miR-376a, hsa-miR-376b,hsa-miR-378, hsa-miR-378*, hsa-miR-382, hsa-miR-422a, hsa-miR-424,hsa-miR-429, hsa-miR-431, hsa-miR-432, hsa-miR-452*, hsa-miR-486-3p,hsa-miR-489, hsa-miR-491-3p, hsa-miR-495, hsa-miR-497, hsa-miR-498,hsa-miR-500*, hsa-miR-504, hsa-miR-508-5p, hsa-miR-509-3-5p,hsa-miR-509-5p, hsa-miR-511, hsa-miR-513a-3p, hsa-miR-513c,hsa-miR-515-3p, hsa-miR-516b, hsa-miR-517*, hsa-miR-518d-5p,hsa-miR-518e*, hsa-miR-518f*, hsa-miR-519a*, hsa-miR-519b-5p,hsa-miR-519c-5p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520a-3p,hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520c-5p, hsa-miR-520d-3p,hsa-miR-520d-5p, hsa-miR-520e, hsa-miR-520f, hsa-miR-520g, hsa-miR-520h,hsa-miR-522, hsa-miR-522*, hsa-miR-523*, hsa-miR-524-5p, hsa-miR-526a,hsa-miR-526b*, hsa-miR-532-5p, hsa-miR-539, hsa-miR-543, hsa-miR-544,hsa-miR-545, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-5p,hsa-miR-548d-3p, hsa-miR-548d-5p, hsa-miR-548h, hsa-miR-548i,hsa-miR-548j, hsa-miR-548n, hsa-miR-548p, hsa-miR-550, hsa-miR-550*,hsa-miR-551b*, hsa-miR-552, hsa-miR-559, hsa-miR-562, hsa-miR-567,hsa-miR-568, hsa-miR-575, hsa-miR-578, hsa-miR-581, hsa-miR-582-5p,hsa-miR-583, hsa-miR-586, hsa-miR-588, hsa-miR-590-3p, hsa-miR-590-5p,hsa-miR-595, hsa-miR-606, hsa-miR-607, hsa-miR-624, hsa-miR-634,hsa-miR-636, hsa-miR-640, hsa-miR-643, hsa-miR-645, hsa-miR-646,hsa-miR-649, hsa-miR-650, hsa-miR-653, hsa-miR-654-3p, hsa-miR-656,hsa-miR-664, hsa-miR-665, hsa-miR-671-3p, hsa-miR-7-1*, hsa-miR-7-2*,hsa-miR-765, hsa-miR-766, hsa-miR-768-3p, hsa-miR-768-5p, hsa-miR-873,hsa-miR-874, hsa-miR-875-3p, hsa-miR-889, hsa-miR-890, hsa-miR-891b,hsa-miR-924, hsa-miR-93, hsa-miR-93*, and hsa-miR-939.

ITGB1—TGB1—NM_(—)002211—hsa-miR-100*, hsa-miR-1226, hsa-miR-124,hsa-miR-1264, hsa-miR-1279, hsa-miR-1286, hsa-miR-129-5p, hsa-miR-1300,hsa-miR-134, hsa-miR-138-2*, hsa-miR-144, hsa-miR-146a*, hsa-miR-153,hsa-miR-16-2*, hsa-miR-183, hsa-miR-183*, hsa-miR-18b*, hsa-miR-190,hsa-miR-190b, hsa-miR-195*, hsa-miR-200c*, hsa-miR-221*, hsa-miR-223,hsa-miR-297, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-302b*,hsa-miR-302d*, hsa-miR-302f, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c,hsa-miR-30d, hsa-miR-30e, hsa-miR-367*, hsa-miR-373*, hsa-miR-374b*,hsa-miR-423-3p, hsa-miR-493*, hsa-miR-493-5p, hsa-miR-499-5p,hsa-miR-500, hsa-miR-506, hsa-miR-507, hsa-miR-511, hsa-miR-513a-3p,hsa-miR-513c, hsa-miR-522, hsa-miR-542-3p, hsa-miR-544, hsa-miR-545,hsa-miR-545*, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-3p,hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-548h, hsa-miR-548i,hsa-miR-548j, hsa-miR-548k, hsa-miR-548l, hsa-miR-548n, hsa-miR-548p,hsa-miR-550*, hsa-miR-551b*, hsa-miR-557, hsa-miR-559, hsa-miR-616*,hsa-miR-621, hsa-miR-634, hsa-miR-641, hsa-miR-655, hsa-miR-7-1*,hsa-miR-7-2*, hsa-miR-768-3p, hsa-miR-888, hsa-miR-888*, and hsa-miR-9*.

PTEN—PTEN—NM_(—)000314—hsa-abi-10411, hsa-abi-13106, hsa-abi-13159,hsa-abi-13252, hsa-abi-13253, hsa-abi-4400, hsa-abi-801, hsa-let-7i*,hsa-miR-100*, hsa-miR-103, hsa-miR-106a, hsa-miR-106b, hsa-miR-107,hsa-miR-10a, hsa-miR-10b, hsa-miR-10b*, hsa-miR-1179, hsa-miR-1183,hsa-miR-1227, hsa-miR-1238, hsa-miR-1244, hsa-miR-1255a, hsa-miR-1255b,hsa-miR-1259, hsa-miR-125b-2*, hsa-miR-1265, hsa-miR-1270, hsa-miR-1272,hsa-miR-1279, hsa-miR-1283, hsa-miR-1285, hsa-miR-1287, hsa-miR-1294,hsa-miR-1297, hsa-miR-1299, hsa-miR-1305, hsa-miR-130a, hsa-miR-130a*,hsa-miR-130b, hsa-miR-1323, hsa-miR-136, hsa-miR-139-5p, hsa-miR-140-3p,hsa-miR-141, hsa-miR-142-5p, hsa-miR-144, hsa-miR-148a, hsa-miR-148a*,hsa-miR-148b, hsa-miR-148b*, hsa-miR-150*, hsa-miR-152, hsa-miR-153,hsa-miR-16-1*, hsa-miR-16-2*, hsa-miR-17, hsa-miR-181a, hsa-miR-181b,hsa-miR-181c, hsa-miR-181d, hsa-miR-186, hsa-miR-187*, hsa-miR-188-5p,hsa-miR-193a-3p, hsa-miR-193b, hsa-miR-195*, hsa-miR-198, hsa-miR-19a,hsa-miR-19b, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, hsa-miR-205,hsa-miR-20a, hsa-miR-20b, hsa-miR-214, hsa-miR-216a, hsa-miR-219-2-3p,hsa-miR-22, hsa-miR-221, hsa-miR-23a, hsa-miR-23b, hsa-miR-25,hsa-miR-26a, hsa-miR-26a-1*, hsa-miR-26a-2*, hsa-miR-26b, hsa-miR-28-5p,hsa-miR-296-3p, hsa-miR-298, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c,hsa-miR-301a, hsa-miR-301b, hsa-miR-30a*, hsa-miR-30d*, hsa-miR-30e*,hsa-miR-32, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d,hsa-miR-325, hsa-miR-328, hsa-miR-335*, hsa-miR-337-3p, hsa-miR-337-5p,hsa-miR-338-3p, hsa-miR-338-5p, hsa-miR-33a*, hsa-miR-363, hsa-miR-363*,hsa-miR-367, hsa-miR-367*, hsa-miR-373*, hsa-miR-374a, hsa-miR-374b,hsa-miR-382, hsa-miR-424*, hsa-miR-425, hsa-miR-425-5p, hsa-miR-429,hsa-miR-454, hsa-miR-485-5p, hsa-miR-486-5p, hsa-miR-494, hsa-miR-495,hsa-miR-498, hsa-miR-505, hsa-miR-509-3p, hsa-miR-511, hsa-miR-513a-3p,hsa-miR-514, hsa-miR-518a-5p, hsa-miR-519a, hsa-miR-519b-3p,hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520a*,hsa-miR-520a-5p, hsa-miR-520b, hsa-miR-520c, hsa-miR-520d,hsa-miR-520d-5p, hsa-miR-520e, hsa-miR-524-5p, hsa-miR-525-5p,hsa-miR-526b*, hsa-miR-527, hsa-miR-532-5p, hsa-miR-542-3p, hsa-miR-543,hsa-miR-545, hsa-miR-548a-3p, hsa-miR-548a-5p, hsa-miR-548b-5p,hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-3p, hsa-miR-548d-5p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548h, hsa-miR-548i, hsa-miR-548j,hsa-miR-548l, hsa-miR-548m, hsa-miR-548n, hsa-miR-548o, hsa-miR-548p,hsa-miR-551b*, hsa-miR-554, hsa-miR-559, hsa-miR-561, hsa-miR-568,hsa-miR-569, hsa-miR-570, hsa-miR-577, hsa-miR-578, hsa-miR-579,hsa-miR-582-3p, hsa-miR-582-5p, hsa-miR-584, hsa-miR-586, hsa-miR-589*,hsa-miR-590-3p, hsa-miR-607, hsa-miR-612, hsa-miR-616, hsa-miR-616*,hsa-miR-618, hsa-miR-620, hsa-miR-622, hsa-miR-624, hsa-miR-628-3p,hsa-miR-631, hsa-miR-642, hsa-miR-649, hsa-miR-653, hsa-miR-664,hsa-miR-708, hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-744*, hsa-miR-768-3p,hsa-miR-875-3p, hsa-miR-888*, hsa-miR-889, hsa-miR-9*, hsa-miR-92a,hsa-miR-92b, hsa-miR-93, hsa-miR-939, and hsa-miR-944.

Stat3—STAT3—NM_(—)139276—hsa-abi-13160, hsa-abi-13252, hsa-abi-9134,hsa-let-7c*, hsa-miR-106a, hsa-miR-106a*, hsa-miR-106b, hsa-miR-10a,hsa-miR-10b, hsa-miR-1184, hsa-miR-1200, hsa-miR-1207-5p, hsa-miR-122*,hsa-miR-1224-5p, hsa-miR-1226, hsa-miR-1227, hsa-miR-1229, hsa-miR-124,hsa-miR-1243, hsa-miR-1244, hsa-miR-1251, hsa-miR-1252, hsa-miR-1255a,hsa-miR-1255b, hsa-miR-125a-5p, hsa-miR-125b, hsa-miR-1274b,hsa-miR-129-5p, hsa-miR-1299, hsa-miR-1301, hsa-miR-1303, hsa-miR-1305,hsa-miR-1308, hsa-miR-130a, hsa-miR-130b, hsa-miR-1321, hsa-miR-138-2*,hsa-miR-143*, hsa-miR-144*, hsa-miR-145*, hsa-miR-146a*, hsa-miR-149*,hsa-miR-150, hsa-miR-15a*, hsa-miR-17, hsa-miR-17-5p, hsa-miR-181a,hsa-miR-181b, hsa-miR-181c, hsa-miR-181d, hsa-miR-1827, hsa-miR-186*,hsa-miR-187*, hsa-miR-193b*, hsa-miR-202, hsa-miR-20a, hsa-miR-20b,hsa-miR-21, hsa-miR-21*, hsa-miR-214, hsa-miR-220b, hsa-miR-24,hsa-miR-26b*, hsa-miR-27a*, hsa-miR-296-5p, hsa-miR-298, hsa-miR-29a,hsa-miR-29b, hsa-miR-29c, hsa-miR-301a, hsa-miR-301b, hsa-miR-302a,hsa-miR-302a*, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-302e,hsa-miR-31*, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d,hsa-miR-323-3p, hsa-miR-337-3p, hsa-miR-338-5p, hsa-miR-34a,hsa-miR-34c-5p, hsa-miR-372, hsa-miR-373, hsa-miR-374a*, hsa-miR-376a*,hsa-miR-378*, hsa-miR-410, hsa-miR-421, hsa-miR-425, hsa-miR-431*,hsa-miR-449a, hsa-miR-449b, hsa-miR-454, hsa-miR-483-5p, hsa-miR-485-5p,hsa-miR-486-3p, hsa-miR-488, hsa-miR-488*, hsa-miR-493, hsa-miR-495,hsa-miR-497*, hsa-miR-498, hsa-miR-504, hsa-miR-506, hsa-miR-512-3p,hsa-miR-516-5p, hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p,hsa-miR-519d, hsa-miR-519e, hsa-miR-520a-3p, hsa-miR-520a-5p,hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520d-5p,hsa-miR-520e, hsa-miR-520g, hsa-miR-520h, hsa-miR-524-5p,hsa-miR-525-5p, hsa-miR-526b*, hsa-miR-544, hsa-miR-548b-3p,hsa-miR-548c-3p, hsa-miR-548d-3p, hsa-miR-566, hsa-miR-577,hsa-miR-590-5p, hsa-miR-593*, hsa-miR-600, hsa-miR-608, hsa-miR-629*,hsa-miR-641, hsa-miR-642, hsa-miR-646, hsa-miR-648, hsa-miR-649,hsa-miR-650, hsa-miR-663, hsa-miR-664*, hsa-miR-665, hsa-miR-671-5p,hsa-miR-765, hsa-miR-874, hsa-miR-876-3p, hsa-miR-877*, hsa-miR-885-5p,hsa-miR-886-5p, hsa-miR-892b, hsa-miR-922, hsa-miR-92a-2*, hsa-miR-93,hsa-miR-93*, hsa-miR-940, and hsa-miR-96*.

Sox4—SOX4—NM_(—)003107—hsa-abi-12897, hsa-abi-13252, hsa-abi-3135,hsa-abi-685, hsa-abi-7510, hsa-abi-9651, hsa-let-7c*, hsa-let-7f-2*,hsa-miR-106a, hsa-miR-106b, hsa-miR-10a*, hsa-miR-1203, hsa-miR-1229,hsa-miR-1236, hsa-miR-1237, hsa-miR-1248, hsa-miR-1251, hsa-miR-1252,hsa-miR-1253, hsa-miR-1274b, hsa-miR-1275, hsa-miR-1277, hsa-miR-1279,hsa-miR-1281, hsa-miR-1285, hsa-miR-129*, hsa-miR-129-3p,hsa-miR-129-5p, hsa-miR-130a, hsa-miR-130b, hsa-miR-132, hsa-miR-1321,hsa-miR-133a, hsa-miR-133b, hsa-miR-138, hsa-miR-140-5p, hsa-miR-145,hsa-miR-146b-3p, hsa-miR-149*, hsa-miR-155*, hsa-miR-16-1*, hsa-miR-17,hsa-miR-181a-2*, hsa-miR-185*, hsa-miR-188-5p, hsa-miR-191,hsa-miR-191*, hsa-miR-19a, hsa-miR-19b, hsa-miR-204, hsa-miR-20a,hsa-miR-20b, hsa-miR-21*, hsa-miR-211, hsa-miR-212, hsa-miR-214*,hsa-miR-219-2-3p, hsa-miR-221, hsa-miR-222, hsa-miR-25, hsa-miR-25*,hsa-miR-299-5p, hsa-miR-29a*, hsa-miR-300, hsa-miR-301a, hsa-miR-301b,hsa-miR-30a, hsa-miR-30a*, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d,hsa-miR-30d*, hsa-miR-30e, hsa-miR-30e*, hsa-miR-32, hsa-miR-320a,hsa-miR-320b, hsa-miR-320c, hsa-miR-320d, hsa-miR-324-3p, hsa-miR-335*,hsa-miR-337, hsa-miR-338, hsa-miR-339-5p, hsa-miR-33b*, hsa-miR-342-5p,hsa-miR-34a, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-363,hsa-miR-363*, hsa-miR-367, hsa-miR-369-3p, hsa-miR-373*, hsa-miR-374a,hsa-miR-374b, hsa-miR-381, hsa-miR-384, hsa-miR-421, hsa-miR-432*,hsa-miR-449a, hsa-miR-449b, hsa-miR-450, hsa-miR-454, hsa-miR-483-5p,hsa-miR-486-5p, hsa-miR-497*, hsa-miR-498, hsa-miR-499-5p, hsa-miR-500,hsa-miR-501-5p, hsa-miR-511, hsa-miR-513a-5p, hsa-miR-515-3p,hsa-miR-517*, hsa-miR-518c*, hsa-miR-519a, hsa-miR-519b-3p,hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520b, hsa-miR-520c,hsa-miR-520d-5p, hsa-miR-524*, hsa-miR-524-5p, hsa-miR-526b*,hsa-miR-539, hsa-miR-541*, hsa-miR-548a-3p, hsa-miR-548c-3p,hsa-miR-548d-3p, hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548p,hsa-miR-550, hsa-miR-561, hsa-miR-571, hsa-miR-573, hsa-miR-576-3p,hsa-miR-583, hsa-miR-590-3p, hsa-miR-595, hsa-miR-596, hsa-miR-600,hsa-miR-603, hsa-miR-612, hsa-miR-616*, hsa-miR-618, hsa-miR-622,hsa-miR-623, hsa-miR-629*, hsa-miR-637, hsa-miR-649, hsa-miR-655,hsa-miR-656, hsa-miR-657, hsa-miR-658, hsa-miR-767-3p, hsa-miR-877*,hsa-miR-888, hsa-miR-892a, hsa-miR-892b, hsa-miR-9*, hsa-miR-92a,hsa-miR-92a-2*, hsa-miR-92b, hsa-miR-93, hsa-miR-939, hsa-miR-99a*, andhsa-miR-99b*.

ALDH1—ALDH1A1—NM_(—)000689—hsa-miR-126*, hsa-miR-1283, hsa-miR-130a*,hsa-miR-132, hsa-miR-134, hsa-miR-154*, hsa-miR-17*, hsa-miR-187*,hsa-miR-21, hsa-miR-212, hsa-miR-221, hsa-miR-222, hsa-miR-23a,hsa-miR-23b, hsa-miR-297, hsa-miR-335*, hsa-miR-455-3p, hsa-miR-485-3p,hsa-miR-487a, hsa-miR-489, hsa-miR-511, hsa-miR-520d-5p, hsa-miR-524-5p,hsa-miR-548c-3p, hsa-miR-548n, hsa-miR-551b*, hsa-miR-562, hsa-miR-567,hsa-miR-590-5p, hsa-miR-606, hsa-miR-643, hsa-miR-651, hsa-miR-942,hsa-miR-943, and hsa-miR-944.

ALDH1A2—Isoform 1—NM_(—)003888—hsa-abi-13135, hsa-abi-9651, hsa-let-7c*,hsa-let-7g*, hsa-miR-103, hsa-miR-107, hsa-miR-10b*, hsa-miR-1179,hsa-miR-1184, hsa-miR-1200, hsa-miR-1207-3p, hsa-miR-1228, hsa-miR-1243,hsa-miR-1248, hsa-miR-1251, hsa-miR-1252, hsa-miR-1254, hsa-miR-1261,hsa-miR-1262, hsa-miR-1272, hsa-miR-1300, hsa-miR-1303, hsa-miR-130a*,hsa-miR-132*, hsa-miR-1321, hsa-miR-1323, hsa-miR-137, hsa-miR-142-3p,hsa-miR-143*, hsa-miR-148a*, hsa-miR-149*, hsa-miR-151-5p, hsa-miR-15a*,hsa-miR-16-2*, hsa-miR-182, hsa-miR-182*, hsa-miR-188-3p, hsa-miR-192*,hsa-miR-195*, hsa-miR-19a*, hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-203,hsa-miR-204, hsa-miR-20a*, hsa-miR-20b*, hsa-miR-211, hsa-miR-221*,hsa-miR-23a, hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-28-5p,hsa-miR-298, hsa-miR-29b-1*, hsa-miR-31, hsa-miR-324-3p, hsa-miR-326,hsa-miR-329, hsa-miR-330-5p, hsa-miR-335*, hsa-miR-337, hsa-miR-338-3p,hsa-miR-338-5p, hsa-miR-345, hsa-miR-362-3p, hsa-miR-369-3p,hsa-miR-423-5p, hsa-miR-432*, hsa-miR-453, hsa-miR-455-3p,hsa-miR-483-3p, hsa-miR-489, hsa-miR-490-5p, hsa-miR-502-5p,hsa-miR-509-3-5p, hsa-miR-509-5p, hsa-miR-542-3p, hsa-miR-548a-3p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548m, hsa-miR-548o,hsa-miR-556-5p, hsa-miR-582-3p, hsa-miR-600, hsa-miR-608, hsa-miR-617,hsa-miR-621, hsa-miR-632, hsa-miR-635, hsa-miR-641, hsa-miR-645,hsa-miR-654-3p, hsa-miR-655, hsa-miR-659, hsa-miR-663b, hsa-miR-664,hsa-miR-708, hsa-miR-744*, hsa-miR-758, hsa-miR-768-3p, hsa-miR-875-3p,hsa-miR-890, and hsa-miR-93*.

ALDH1A2 isoform 2—NM_(—)170696—hsa-abi-13135, hsa-abi-9651, hsa-let-7c*,hsa-let-7g*, hsa-miR-103, hsa-miR-107, hsa-miR-10b*, hsa-miR-1179,hsa-miR-1184, hsa-miR-1200, hsa-miR-1207-3p, hsa-miR-1228, hsa-miR-1243,hsa-miR-1248, hsa-miR-1251, hsa-miR-1252, hsa-miR-1254, hsa-miR-1261,hsa-miR-1262, hsa-miR-1272, hsa-miR-1300, hsa-miR-1303, hsa-miR-130a*,hsa-miR-132*, hsa-miR-1321, hsa-miR-1323, hsa-miR-137, hsa-miR-142-3p,hsa-miR-143*, hsa-miR-148a*, hsa-miR-149*, hsa-miR-151-5p, hsa-miR-15a*,hsa-miR-16-2*, hsa-miR-182, hsa-miR-182*, hsa-miR-188-3p, hsa-miR-192*,hsa-miR-195*, hsa-miR-19a*, hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-203,hsa-miR-204, hsa-miR-20a*, hsa-miR-20b*, hsa-miR-211, hsa-miR-221*,hsa-miR-23a, hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-28-5p,hsa-miR-298, hsa-miR-29b-1*, hsa-miR-31, hsa-miR-324-3p, hsa-miR-326,hsa-miR-329, hsa-miR-330-5p, hsa-miR-335*, hsa-miR-337, hsa-miR-338-3p,hsa-miR-338-5p, hsa-miR-345, hsa-miR-362-3p, hsa-miR-369-3p,hsa-miR-423-5p, hsa-miR-432*, hsa-miR-453, hsa-miR-455-3p,hsa-miR-483-3p, hsa-miR-489, hsa-miR-490-5p, hsa-miR-502-5p,hsa-miR-509-3-5p, hsa-miR-509-5p, hsa-miR-542-3p, hsa-miR-548a-3p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548m, hsa-miR-548o,hsa-miR-556-5p, hsa-miR-582-3p, hsa-miR-600, hsa-miR-608, hsa-miR-617,hsa-miR-621, hsa-miR-632, hsa-miR-635, hsa-miR-641, hsa-miR-645,hsa-miR-654-3p, hsa-miR-655, hsa-miR-659, hsa-miR-663b, hsa-miR-664,hsa-miR-708, hsa-miR-744*, hsa-miR-758, hsa-miR-768-3p, hsa-miR-875-3p,hsa-miR-890, and hsa-miR-93*.

ALDH1A2 isoform 3—NM_(—)170697—hsa-abi-13135, hsa-abi-9651, hsa-let-7c*,hsa-let-7g*, hsa-miR-103, hsa-miR-107, hsa-miR-10b*, hsa-miR-1179,hsa-miR-1184, hsa-miR-1200, hsa-miR-1207-3p, hsa-miR-1228, hsa-miR-1243,hsa-miR-1248, hsa-miR-1251, hsa-miR-1252, hsa-miR-1254, hsa-miR-1261,hsa-miR-1262, hsa-miR-1272, hsa-miR-1300, hsa-miR-1303, hsa-miR-130a*,hsa-miR-132*, hsa-miR-1321, hsa-miR-1323, hsa-miR-137, hsa-miR-142-3p,hsa-miR-143*, hsa-miR-148a*, hsa-miR-149*, hsa-miR-151-5p, hsa-miR-15a*,hsa-miR-16-2*, hsa-miR-182, hsa-miR-182*, hsa-miR-188-3p, hsa-miR-192*,hsa-miR-195*, hsa-miR-19a*, hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-203,hsa-miR-204, hsa-miR-20a*, hsa-miR-20b*, hsa-miR-211, hsa-miR-221*,hsa-miR-23a, hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-28-5p,hsa-miR-298, hsa-miR-29b-1*, hsa-miR-31, hsa-miR-324-3p, hsa-miR-326,hsa-miR-329, hsa-miR-330-5p, hsa-miR-335*, hsa-miR-337, hsa-miR-338-3p,hsa-miR-338-5p, hsa-miR-345, hsa-miR-362-3p, hsa-miR-369-3p,hsa-miR-423-5p, hsa-miR-432*, hsa-miR-453, hsa-miR-455-3p,hsa-miR-483-3p, hsa-miR-489, hsa-miR-490-5p, hsa-miR-502-5p,hsa-miR-509-3-5p, hsa-miR-509-5p, hsa-miR-542-3p, hsa-miR-548a-3p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548m, hsa-miR-548o,hsa-miR-556-5p, hsa-miR-582-3p, hsa-miR-600, hsa-miR-608, hsa-miR-617,hsa-miR-621, hsa-miR-632, hsa-miR-635, hsa-miR-641, hsa-miR-645,hsa-miR-654-3p, hsa-miR-655, hsa-miR-659, hsa-miR-663b, hsa-miR-664,hsa-miR-708, hsa-miR-744*, hsa-miR-758, hsa-miR-768-3p, hsa-miR-875-3p,hsa-miR-890, and hsa-miR-93*.

ALDHIA3—NM_(—)000693—hsa-abi-13268, hsa-miR-101, hsa-miR-106a,hsa-miR-106b, hsa-miR-10b*, hsa-miR-1184, hsa-miR-1224-3p,hsa-miR-1225-3p, hsa-miR-1233, hsa-miR-1249, hsa-miR-125a-5p,hsa-miR-125b, hsa-miR-1260, hsa-miR-1274a, hsa-miR-1274b,hsa-miR-127-5p, hsa-miR-1286, hsa-miR-1288, hsa-miR-1301, hsa-miR-1323,hsa-miR-138, hsa-miR-140-3p, hsa-miR-144, hsa-miR-145, hsa-miR-15a,hsa-miR-15b, hsa-miR-16, hsa-miR-16-1*, hsa-miR-16-2*, hsa-miR-17,hsa-miR-183*, hsa-miR-186*, hsa-miR-188-3p, hsa-miR-193b*, hsa-miR-194,hsa-miR-195, hsa-miR-195*, hsa-miR-199a, hsa-miR-200b, hsa-miR-200c,hsa-miR-20a, hsa-miR-20b, hsa-miR-216a, hsa-miR-220c, hsa-miR-25,hsa-miR-29a*, hsa-miR-29b-1*, hsa-miR-30a*, hsa-miR-30d*, hsa-miR-30e*,hsa-miR-31*, hsa-miR-32, hsa-miR-324-5p, hsa-miR-326, hsa-miR-330-3p,hsa-miR-330-5p, hsa-miR-335, hsa-miR-338-5p, hsa-miR-33b*, hsa-miR-34b*,hsa-miR-34c-3p, hsa-miR-363, hsa-miR-367, hsa-miR-374b*, hsa-miR-379,hsa-miR-412, hsa-miR-424, hsa-miR-429, hsa-miR-450b-5p, hsa-miR-452*,hsa-miR-487b, hsa-miR-493, hsa-miR-497, hsa-miR-497*, hsa-miR-498,hsa-miR-500, hsa-miR-501-5p, hsa-miR-504, hsa-miR-505, hsa-miR-508-5p,hsa-miR-510, hsa-miR-515-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-526b*,hsa-miR-545, hsa-miR-548d-3p, hsa-miR-548k, hsa-miR-548l, hsa-miR-548m,hsa-miR-548n, hsa-miR-548o, hsa-miR-570, hsa-miR-577, hsa-miR-579,hsa-miR-583, hsa-miR-589, hsa-miR-589*, hsa-miR-590-3p, hsa-miR-603,hsa-miR-607, hsa-miR-618, hsa-miR-622, hsa-miR-641, hsa-miR-7,hsa-miR-766, hsa-miR-889, hsa-miR-890, hsa-miR-92a, hsa-miR-92b,hsa-miR-93, hsa-miR-936, and hsa-miR-940.

ALDH1B1—NM_(—)000692—hsa-let-7c*, hsa-miR-100*, hsa-miR-1178,hsa-miR-1179, hsa-miR-1224-3p, hsa-miR-1246, hsa-miR-1260, hsa-miR-1265,hsa-miR-1269, hsa-miR-1273, hsa-miR-1283, hsa-miR-129-5p, hsa-miR-1300,hsa-miR-134, hsa-miR-150, hsa-miR-154*, hsa-miR-15b*, hsa-miR-182,hsa-miR-185*, hsa-miR-187*, hsa-miR-188-3p, hsa-miR-193b*, hsa-miR-214,hsa-miR-219-1-3p, hsa-miR-221*, hsa-miR-222*, hsa-miR-24-1*,hsa-miR-24-2*, hsa-miR-25*, hsa-miR-27a*, hsa-miR-29a*, hsa-miR-29b-1*,hsa-miR-302f, hsa-miR-30b*, hsa-miR-331-3p, hsa-miR-363*, hsa-miR-377*,hsa-miR-378, hsa-miR-422a, hsa-miR-485-3p, hsa-miR-485-5p, hsa-miR-487a,hsa-miR-490-5p, hsa-miR-493*, hsa-miR-494, hsa-miR-508-5p, hsa-miR-510,hsa-miR-520a-5p, hsa-miR-522, hsa-miR-525-5p, hsa-miR-532-3p,hsa-miR-548p, hsa-miR-552, hsa-miR-581, hsa-miR-587, hsa-miR-589*,hsa-miR-592, hsa-miR-605, hsa-miR-609, hsa-miR-622, hsa-miR-658,hsa-miR-661, hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-766, hsa-miR-876-3p,hsa-miR-885-5p, hsa-miR-886-3p, hsa-miR-92a-1*, and hsa-miR-96*.

ALDH1L1—NM_(—)012190—hsa-miR-1207-5p, hsa-miR-1228, hsa-miR-1321,hsa-miR-149*, hsa-miR-296-5p, hsa-miR-30b*, hsa-miR-361-3p,hsa-miR-423-5p, hsa-miR-484, hsa-miR-486-3p, hsa-miR-629*, andhsa-miR-940.

Prostate stem cell antigen—PSCA—NM_(—)005672—hsa-abi-13100, hsa-miR-103,hsa-miR-107, hsa-miR-1184, hsa-miR-1200, hsa-miR-1205, hsa-miR-1207-5p,hsa-miR-1225-3p, hsa-miR-1258, hsa-miR-1265, hsa-miR-1275, hsa-miR-1289,hsa-miR-145, hsa-miR-149, hsa-miR-149*, hsa-miR-15a, hsa-miR-15b,hsa-miR-16, hsa-miR-195, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-214*,hsa-miR-220c, hsa-miR-296-3p, hsa-miR-296-5p, hsa-miR-30b*,hsa-miR-33b*, hsa-miR-361-3p, hsa-miR-363*, hsa-miR-370, hsa-miR-376a,hsa-miR-376b, hsa-miR-423-5p, hsa-miR-424, hsa-miR-455-3p,hsa-miR-455-5p, hsa-miR-484, hsa-miR-485-5p, hsa-miR-497,hsa-miR-515-3p, hsa-miR-516a-3p, hsa-miR-516b, hsa-miR-516b*,hsa-miR-518c*, hsa-miR-519e, hsa-miR-532-3p, hsa-miR-541, hsa-miR-550,hsa-miR-552, hsa-miR-592, hsa-miR-593*, hsa-miR-608, hsa-miR-625,hsa-miR-631, hsa-miR-637, hsa-miR-651, hsa-miR-654-5p, hsa-miR-661,hsa-miR-675, hsa-miR-744, hsa-miR-768-5p, hsa-miR-873, hsa-miR-922, andhsa-miR-92a-2*.

Integrin, alpha V—ITGAV—NM_(—)002210—ambi_miR_(—)7079, hsa-let-7a*,hsa-let-7b*, hsa-let-7f-1*, hsa-let-7g*, hsa-miR-10b*, hsa-miR-1183,hsa-miR-1206, hsa-miR-1224-5p, hsa-miR-1229, hsa-miR-1244, hsa-miR-1246,hsa-miR-1252, hsa-miR-125a-3p, hsa-miR-125b-2*, hsa-miR-1260,hsa-miR-1262, hsa-miR-1263, hsa-miR-1264, hsa-miR-1269, hsa-miR-1276,hsa-miR-1284, hsa-miR-1288, hsa-miR-1290, hsa-miR-1303, hsa-miR-130b*,hsa-miR-1323, hsa-miR-135a, hsa-miR-135b, hsa-miR-136, hsa-miR-137,hsa-miR-141, hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-144, hsa-miR-144*,hsa-miR-150, hsa-miR-155*, hsa-miR-16-1*, hsa-miR-16-2*, hsa-miR-183,hsa-miR-186, hsa-miR-188-5p, hsa-miR-192, hsa-miR-192*, hsa-miR-194,hsa-miR-195*, hsa-miR-196a*, hsa-miR-197, hsa-miR-200a, hsa-miR-20b*,hsa-miR-215, hsa-miR-216b, hsa-miR-217, hsa-miR-224, hsa-miR-25,hsa-miR-297, hsa-miR-299-3p, hsa-miR-29a*, hsa-miR-300, hsa-miR-302a*,hsa-miR-302c*, hsa-miR-30a*, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-31,hsa-miR-32, hsa-miR-323-3p, hsa-miR-328, hsa-miR-331-5p, hsa-miR-335*,hsa-miR-33a*, hsa-miR-340, hsa-miR-34b, hsa-miR-361-5p, hsa-miR-363,hsa-miR-367, hsa-miR-369-3p, hsa-miR-373*, hsa-miR-374a, hsa-miR-374b,hsa-miR-377, hsa-miR-380, hsa-miR-380*, hsa-miR-381, hsa-miR-432*,hsa-miR-433, hsa-miR-448, hsa-miR-450b-5p, hsa-miR-452*, hsa-miR-495,hsa-miR-496, hsa-miR-498, hsa-miR-509-3-5p, hsa-miR-509-3p,hsa-miR-509-5p, hsa-miR-513a-3p, hsa-miR-513b, hsa-miR-513c,hsa-miR-515-5p, hsa-miR-517*, hsa-miR-518d-5p, hsa-miR-518e*,hsa-miR-518f*, hsa-miR-519a*, hsa-miR-519b-5p, hsa-miR-519c-5p,hsa-miR-519e*, hsa-miR-520c-5p, hsa-miR-520g, hsa-miR-520h,hsa-miR-522*, hsa-miR-523*, hsa-miR-526a, hsa-miR-541*, hsa-miR-545,hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-548a-5p, hsa-miR-548b-5p,hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-548e,hsa-miR-548f, hsa-miR-548g, hsa-miR-548h, hsa-miR-548i, hsa-miR-548j,hsa-miR-548k, hsa-miR-548m, hsa-miR-548n, hsa-miR-548o, hsa-miR-548p,hsa-miR-549, hsa-miR-551b*, hsa-miR-555, hsa-miR-559, hsa-miR-561,hsa-miR-563, hsa-miR-569, hsa-miR-575, hsa-miR-576-5p, hsa-miR-577,hsa-miR-580, hsa-miR-582-3p, hsa-miR-589*, hsa-miR-590-3p, hsa-miR-605,hsa-miR-606, hsa-miR-607, hsa-miR-615-5p, hsa-miR-616*, hsa-miR-623,hsa-miR-624, hsa-miR-630, hsa-miR-641, hsa-miR-643, hsa-miR-647,hsa-miR-651, hsa-miR-654-3p, hsa-miR-655, hsa-miR-660, hsa-miR-664,hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-802, hsa-miR-875-5p, hsa-miR-885-5p,hsa-miR-888, hsa-miR-889, hsa-miR-891b, hsa-miR-9*, hsa-miR-92a,hsa-miR-92b, hsa-miR-943, hsa-miR-944, and hsa-miR-96*.

Nuclear factor kappa B1—NFKB1—NM_(—)003998—hsa-abi-9451,hsa-miR-1207-3p, hsa-miR-1252, hsa-miR-129-5p, hsa-miR-1322,hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-183, hsa-miR-195,hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-214, hsa-miR-299-5p,hsa-miR-424, hsa-miR-450b-5p, hsa-miR-497, hsa-miR-508-3p,hsa-miR-516a-5p, hsa-miR-532-5p, hsa-miR-539, hsa-miR-548a-5p,hsa-miR-548b-5p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-548h,hsa-miR-548i, hsa-miR-548j, hsa-miR-548l, hsa-miR-548n, hsa-miR-548p,hsa-miR-559, hsa-miR-572, hsa-miR-575, R-579, hsa-miR-590-3p,hsa-miR-625, hsa-miR-640, hsa-miR-646, hsa-miR-664, hsa-miR-671-5p, andhsa-miR-9.

Bcl-2—BCL2 variant alpha—NM_(—)000633—hsa-abi-13135, hsa-abi-13156,hsa-abi-13159, hsa-abi-13248, hsa-abi-13268, hsa-let-7c*, hsa-let-7g*,hsa-miR-1, hsa-miR-100*, hsa-miR-101, hsa-miR-103, hsa-miR-106a,hsa-miR-106b, hsa-miR-107, hsa-miR-10a, hsa-miR-10b, hsa-miR-1178,hsa-miR-1184, hsa-miR-1201, hsa-miR-1204, hsa-miR-1225-5p,hsa-miR-1226*, hsa-miR-1228, hsa-miR-1229, hsa-miR-1231, hsa-miR-1233,hsa-miR-1234, hsa-miR-1237, hsa-miR-1243, hsa-miR-1246, hsa-miR-1250,hsa-miR-1251, hsa-miR-1257, hsa-miR-1259, hsa-miR-125a-5p, hsa-miR-125b,hsa-miR-126*, hsa-miR-1260, hsa-miR-1265, hsa-miR-1266, hsa-miR-1267,hsa-miR-1274b, hsa-miR-1276, hsa-miR-1285, hsa-miR-129*, hsa-miR-1290,hsa-miR-129-3p, hsa-miR-1299, hsa-miR-1301, hsa-miR-1302, hsa-miR-1304,hsa-miR-1305, hsa-miR-1308, hsa-miR-130a*, hsa-miR-130b*, hsa-miR-132*,hsa-miR-1321, hsa-miR-1324, hsa-miR-135a, hsa-miR-135a*, hsa-miR-135b,hsa-miR-136, hsa-miR-139-5p, hsa-miR-140-3p, hsa-miR-146b-3p,hsa-miR-148b*, hsa-miR-149*, hsa-miR-150*, hsa-miR-151-5p, hsa-miR-15a,hsa-miR-15a*, hsa-miR-15b, hsa-miR-15b*, hsa-miR-16, hsa-miR-16-1*,hsa-miR-16-2*, hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c,hsa-miR-181d, hsa-miR-182, hsa-miR-1826, hsa-miR-183*, hsa-miR-185,hsa-miR-18a*, hsa-miR-194*, hsa-miR-195, hsa-miR-195*, hsa-miR-198,hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-19a*, hsa-miR-19b-1*,hsa-miR-19b-2*, hsa-miR-200a*, hsa-miR-200b, hsa-miR-200b*,hsa-miR-200c, hsa-miR-202*, hsa-miR-203, hsa-miR-204, hsa-miR-205,hsa-miR-206, hsa-miR-20a, hsa-miR-20a*, hsa-miR-20b, hsa-miR-211,hsa-miR-216a, hsa-miR-217, hsa-miR-218-2*, hsa-miR-219-2-3p,hsa-miR-219-5p, hsa-miR-22*, hsa-miR-221, hsa-miR-222, hsa-miR-224,hsa-miR-23 a, hsa-miR-23b, hsa-miR-24, hsa-miR-25, hsa-miR-27a*,hsa-miR-296-5p, hsa-miR-29a, hsa-miR-29a*, hsa-miR-29b, hsa-miR-29c,hsa-miR-302a*, hsa-miR-302f, hsa-miR-30b*, hsa-miR-32, hsa-miR-323-3p,hsa-miR-324-3p, hsa-miR-326, hsa-miR-330-5p, hsa-miR-335*,hsa-miR-338-5p, hsa-miR-339-5p, hsa-miR-33a*, hsa-miR-34a,hsa-miR-342-3p, hsa-miR-342-5p, hsa-miR-345, hsa-miR-34b,hsa-miR-361-3p, hsa-miR-363, hsa-miR-365, hsa-miR-367, hsa-miR-367*,hsa-miR-371-5p, hsa-miR-373*, hsa-miR-374a, hsa-miR-374b, hsa-miR-377,hsa-miR-380, hsa-miR-383, hsa-miR-384, hsa-miR-409-3p, hsa-miR-410,hsa-miR-412, hsa-miR-421, hsa-miR-424, hsa-miR-424*, hsa-miR-425,hsa-miR-429, hsa-miR-431*, hsa-miR-432, hsa-miR-432*, hsa-miR-433,hsa-miR-448, hsa-miR-449, hsa-miR-450b-5p, hsa-miR-452, hsa-miR-453,hsa-miR-455-3p, hsa-miR-485-5p, hsa-miR-486-3p, hsa-miR-489,hsa-miR-490-5p, hsa-miR-493*, hsa-miR-493-5p, hsa-miR-496, hsa-miR-497,hsa-miR-497*, hsa-miR-499-3p, hsa-miR-499-5p, hsa-miR-503, hsa-miR-504,hsa-miR-505*, hsa-miR-510, hsa-miR-513a-3p, hsa-miR-513a-5p,hsa-miR-515-5p, hsa-miR-516a-3p, hsa-miR-516b, hsa-miR-516b*,hsa-miR-518a-5p, hsa-miR-518a-2*, hsa-miR-518c* hsa-miR-519a,hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e*,hsa-miR-520a-5p, hsa-miR-520g, hsa-miR-520h, hsa-miR-522,hsa-miR-525-5p, hsa-miR-526b*, hsa-miR-527, hsa-miR-532-3p, hsa-miR-541,hsa-miR-542-3p, hsa-miR-545, hsa-miR-545*, hsa-miR-548a-3p,hsa-miR-548c-3p, hsa-miR-548e, hsa-miR-548f, hsa-miR-548k, hsa-miR-548l,hsa-miR-548n, hsa-miR-548p, hsa-miR-552, hsa-miR-555, hsa-miR-556-5p,hsa-miR-558, hsa-miR-561, hsa-miR-568, hsa-miR-571, hsa-miR-575,hsa-miR-577, hsa-miR-579, hsa-miR-582-5p, hsa-miR-583, hsa-miR-587,hsa-miR-589*, hsa-miR-590-3p, hsa-miR-593, hsa-miR-595, hsa-miR-596,hsa-miR-605, hsa-miR-606, hsa-miR-607, hsa-miR-612, hsa-miR-613,hsa-miR-616*, hsa-miR-617, hsa-miR-618, hsa-miR-619, hsa-miR-624,hsa-miR-624*, hsa-miR-629, hsa-miR-629*, hsa-miR-633, hsa-miR-636,hsa-miR-640, hsa-miR-641, hsa-miR-642, hsa-miR-643, hsa-miR-646,hsa-miR-648, hsa-miR-650, hsa-miR-651, hsa-miR-653, hsa-miR-654-5p,hsa-miR-655, hsa-miR-656, hsa-miR-657, hsa-miR-660, hsa-miR-664,hsa-miR-668, hsa-miR-7, hsa-miR-708*, hsa-miR-7-1*, hsa-miR-7-2*,hsa-miR-744*, hsa-miR-758, hsa-miR-760, hsa-miR-765, hsa-miR-766,hsa-miR-768-5p, hsa-miR-873, hsa-miR-874, hsa-miR-876-5p, hsa-miR-877*,hsa-miR-888, hsa-miR-888*, hsa-miR-889, hsa-miR-92a, hsa-miR-92b,hsa-miR-93, hsa-miR-940, hsa-miR-96*, and hsa-miR-576-3p.

Bcl-2—BCL2 variant beta—NM_(—)000657—hsa-miR-29a*, hsa-miR-492, andhsa-miR-665.

CXCR4—CXCR4—NM_(—)003467—hsa-miR-1, hsa-miR-1183, hsa-miR-1207-3p,hsa-miR-1264, hsa-miR-1299, hsa-miR-139-5p, hsa-miR-16-2*, hsa-miR-185,hsa-miR-195*, hsa-miR-204, hsa-miR-206, hsa-miR-211, hsa-miR-300,hsa-miR-302c*, has-miR-335, hsa-miR-338-3p, hsa-miR-338-5p, hsa-miR-381,hsa-miR-424*, hsa-miR-452*, hsa-miR-483-3p, hsa-miR-518c*, hsa-miR-545,hsa-miR-548a-3p, hsa-miR-548c-3p, hsa-miR-548d-3p, hsa-miR-548e,hsa-miR-548f, hsa-miR-548g, hsa-miR-548p, hsa-miR-551b*, hsa-miR-588,hsa-miR-613, hsa-miR-634, hsa-miR-655, and hsa-miR-9.

PAPPA—PAPPA—NM_(—)002581—hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7d,hsa-let-7e, hsa-let-7f, hsa-let-7g, hsa-let-7g*, hsa-let-7i,hsa-miR-103, hsa-miR-105, hsa-miR-107, hsa-miR-1185, hsa-miR-1208,hsa-miR-122, hsa-miR-1224-3p, hsa-miR-1229, hsa-miR-1236, hsa-miR-1237,hsa-miR-1244, hsa-miR-1251, hsa-miR-1252, hsa-miR-1254, hsa-miR-126*,hsa-miR-1261, hsa-miR-1264, hsa-miR-1266, hsa-miR-1269, hsa-miR-1271,hsa-miR-1272, hsa-miR-1274a, hsa-miR-1275, hsa-miR-1278, hsa-miR-1287,hsa-miR-1288, hsa-miR-1294, hsa-miR-1296, hsa-miR-1297, hsa-miR-1298,hsa-miR-1300, hsa-miR-1301, hsa-miR-1303, hsa-miR-1305, hsa-miR-1306,hsa-miR-130b*, hsa-miR-1321, hsa-miR-1323, hsa-miR-1324, hsa-miR-133a,hsa-miR-133b, hsa-miR-138, hsa-miR-141, hsa-miR-142-5p, hsa-miR-143,hsa-miR-143*, hsa-miR-144, hsa-miR-145, -146a, hsa-miR-146b,hsa-miR-147, hsa-miR-149*, hsa-miR-150, hsa-miR-150*, hsa-miR-154,hsa-miR-155*, hsa-miR-15a, hsa-miR-15a*, hsa-miR-15b, hsa-miR-16,hsa-miR-181a-2*, hsa-miR-182, hsa-miR-1825, hsa-miR-1826, hsa-miR-185,hsa-miR-185*, hsa-miR-186, hsa-miR-186*, hsa-miR-18a, hsa-miR-18a*,hsa-miR-18b, hsa-miR-190, hsa-miR-190b, hsa-miR-192*, hsa-miR-193a-5p,hsa-miR-194*, hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-199a-3p,hsa-miR-199b-3p, hsa-miR-200a, hsa-miR-203, hsa-miR-20a*, hsa-miR-21*,hsa-miR-214, hsa-miR-216b, hsa-miR-217, hsa-miR-218-1*,hsa-miR-219-1-3p, hsa-miR-219-2-3p, hsa-miR-22, hsa-miR-22*,hsa-miR-23a*, hsa-miR-23b*, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-26a,hsa-miR-26a-1*, hsa-miR-26a-2*, hsa-miR-26b, hsa-miR-26b*, hsa-miR-27a,hsa-miR-27a*, hsa-miR-27b, hsa-miR-28-5p, hsa-miR-296-3p, hsa-miR-298,hsa-miR-299-3p, hsa-miR-29a*, hsa-miR-300, hsa-miR-302a, hsa-miR-302b,hsa-miR-302c, hsa-miR-302d, hsa-miR-302e, hsa-miR-30a*, hsa-miR-30b*,hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-31,hsa-miR-326, hsa-miR-328, hsa-miR-330-5p, hsa-miR-331-5p, hsa-miR-335*,hsa-miR-338-3p, hsa-miR-338-5p, hsa-miR-339-5p, hsa-miR-33a,hsa-miR-33b, hsa-miR-340, hsa-miR-342-3p, hsa-miR-34a, hsa-miR-34a*,hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-362-5p, hsa-miR-365,hsa-miR-369-3p, hsa-miR-372, hsa-miR-373, hsa-miR-373*, hsa-miR-374a,hsa-miR-374b, hsa-miR-374b*, hsa-miR-376a, hsa-miR-376b, hsa-miR-376c,hsa-miR-377, hsa-miR-377*, hsa-miR-378, hsa-miR-379*, hsa-miR-381,hsa-miR-383, hsa-miR-384, hsa-miR-411, hsa-miR-411*, hsa-miR-421,hsa-miR-422a, hsa-miR-424, hsa-miR-432*, hsa-miR-448, hsa-miR-449a,hsa-miR-449b, hsa-miR-452, hsa-miR-485-5p, hsa-miR-489, hsa-miR-490-3p,hsa-miR-494, hsa-miR-496, hsa-miR-497, hsa-miR-500, hsa-miR-501-5p,hsa-miR-503, hsa-miR-507, hsa-miR-509-3p, hsa-miR-510, hsa-miR-511,hsa-miR-512-3p, hsa-miR-513a-3p, hsa-miR-513a-5p, hsa-miR-513c,hsa-miR-515-5p, hsa-miR-516a-3p, hsa-miR-516b*, hsa-miR-517*,hsa-miR-517b, hsa-miR-518c*, hsa-miR-519e*, hsa-miR-519f*,hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p,hsa-miR-520e, hsa-miR-520g, hsa-miR-520h, hsa-miR-522, hsa-miR-526a,hsa-miR-526b, hsa-miR-526c, hsa-miR-532-3p, hsa-miR-532-5p,hsa-miR-541*, hsa-miR-544, hsa-miR-545, hsa-miR-548a-3p,hsa-miR-548d-3p, hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548l,hsa-miR-548m, hsa-miR-548n, hsa-miR-548o, hsa-miR-548p, hsa-miR-549,hsa-miR-551b*, hsa-miR-555, hsa-miR-556-3p, hsa-miR-557, hsa-miR-558,hsa-miR-561, hsa-miR-562, hsa-miR-570, hsa-miR-571, hsa-miR-574-5p,hsa-miR-576-5p, hsa-miR-578, hsa-miR-579, hsa-miR-582-3p, hsa-miR-583,hsa-miR-584, hsa-miR-586, hsa-miR-588, hsa-miR-589, hsa-miR-590-3p,hsa-miR-591, hsa-miR-592, hsa-miR-593, hsa-miR-599, hsa-miR-600,hsa-miR-605, hsa-miR-616*, hsa-miR-619, hsa-miR-625, hsa-miR-626,hsa-miR-627, hsa-miR-628-5p, hsa-miR-629, hsa-miR-629*, hsa-miR-637,hsa-miR-646, hsa-miR-649, hsa-miR-651, hsa-miR-653, hsa-miR-654-3p,hsa-miR-656, hsa-miR-659, hsa-miR-664, hsa-miR-665, hsa-miR-708,hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-760, hsa-miR-767-3p, hsa-miR-768-3p,hsa-miR-768-5p, hsa-miR-875-3p, hsa-miR-876-3p, hsa-miR-877,hsa-miR-877*, hsa-miR-889, hsa-miR-892b, hsa-miR-922, hsa-miR-92a-1*,hsa-miR-92a-2*, hsa-miR-93*, hsa-miR-936, hsa-miR-942, hsa-miR-943,hsa-miR-944, hsa-miR-96, and hsa-miR-98.

Tight Junction Protein 2—TJP2 variant 1—NM_(—)004817—hsa-miR-105,hsa-miR-106a*, hsa-miR-1197, hsa-miR-1224-5p, hsa-miR-1226,hsa-miR-1233, hsa-miR-1234, hsa-miR-124, hsa-miR-1253, hsa-miR-1260,hsa-miR-128, hsa-miR-1289, hsa-miR-1297, hsa-miR-130a*, hsa-miR-132,hsa-miR-137, hsa-miR-142-5p, hsa-miR-144, hsa-miR-148a, hsa-miR-148b,hsa-miR-148b*, hsa-miR-152, hsa-miR-16-1*, hsa-miR-17*, hsa-miR-181a-2*,hsa-miR-188-3p, hsa-miR-194, hsa-miR-212, hsa-miR-218, hsa-miR-221*,hsa-miR-23a, hsa-miR-23b, hsa-miR-26a, hsa-miR-26b, hsa-miR-30c-1*,hsa-miR-30c-2*, hsa-miR-32*, hsa-miR-331-3p, hsa-miR-33a*,hsa-miR-342-3p, hsa-miR-345, hsa-miR-425, hsa-miR-455-3p, hsa-miR-495,hsa-miR-498, hsa-miR-506, hsa-miR-507, hsa-miR-509-3-5p, hsa-miR-509-5p,hsa-miR-513a-3p, hsa-miR-520d-5p, hsa-miR-524-5p, hsa-miR-532-5p,hsa-miR-548a-3p, hsa-miR-548b-3p, hsa-miR-548e, hsa-miR-548f,hsa-miR-548g, hsa-miR-548k, hsa-miR-557, hsa-miR-629, hsa-miR-635,hsa-miR-661, hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-760, hsa-miR-802,hsa-miR-9*, and hsa-miR-940.

TJP2 variant 2—NM_(—)201629—hsa-miR-105, hsa-miR-106a*, hsa-miR-1197,hsa-miR-1224-5p, hsa-miR-1226, hsa-miR-1233, hsa-miR-1234, hsa-miR-124,hsa-miR-1253, hsa-miR-1260, hsa-miR-128, hsa-miR-1289, hsa-miR-1297,hsa-miR-130a*, hsa-miR-132, hsa-miR-137, hsa-miR-142-5p, hsa-miR-144,hsa-miR-148a, hsa-miR-148b, hsa-miR-148b*, hsa-miR-152, hsa-miR-16-1*,hsa-miR-17*, hsa-miR-181a-2*, hsa-miR-188-3p, hsa-miR-194, hsa-miR-212,hsa-miR-218, hsa-miR-221*, hsa-miR-23a, hsa-miR-23b, hsa-miR-26a,hsa-miR-26b, hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-32*,hsa-miR-331-3p, hsa-miR-33a*, hsa-miR-342-3p, hsa-miR-345, hsa-miR-425,hsa-miR-455-3p, hsa-miR-495, hsa-miR-498, hsa-miR-506, hsa-miR-507,hsa-miR-509-3-5p, hsa-miR-509-5p, hsa-miR-513a-3p, hsa-miR-520d-5p,hsa-miR-524-5p, hsa-miR-532-5p, hsa-miR-548a-3p, hsa-miR-548b-3p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-548k, hsa-miR-557,hsa-miR-629, hsa-miR-635, hsa-miR-661, hsa-miR-7-1*, hsa-miR-7-2*,hsa-miR-760, hsa-miR-802, hsa-miR-9*, and hsa-miR-940.

Abl-interactor 1—ABI1 variant 1—NM_(—)005470—hsa-abi-13197, hsa-let-7a*,hsa-let-7b*, hsa-let-7f-1*, hsa-miR-106a, hsa-miR-106b, hsa-miR-1208,hsa-miR-1224-3p, hsa-miR-1226, hsa-miR-1246, hsa-miR-1248, hsa-miR-1252,hsa-miR-1279, hsa-miR-129-5p, hsa-miR-1302, hsa-miR-130a*,hsa-miR-138-1*, hsa-miR-142-5p, hsa-miR-144, hsa-miR-148b*,hsa-miR-150*, hsa-miR-154, hsa-miR-15a*, hsa-miR-15b*, hsa-miR-16-1*,hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d,hsa-miR-188-3p, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-19a*,hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-200c*, hsa-miR-20a,hsa-miR-20a*, hsa-miR-20b, hsa-miR-216b, hsa-miR-222*, hsa-miR-23a,hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-29a, hsa-miR-29a*,hsa-miR-29b, hsa-miR-29c, hsa-miR-302c*, hsa-miR-302f, hsa-miR-32*,hsa-miR-323-3p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-338-5p,hsa-miR-33a, hsa-miR-33b, hsa-miR-33b*, hsa-miR-34c-3p, hsa-miR-361-3p,hsa-miR-379, hsa-miR-380, hsa-miR-409-3p, hsa-miR-432, hsa-miR-433,hsa-miR-448, hsa-miR-452, hsa-miR-491-3p, hsa-miR-493*, hsa-miR-494,hsa-miR-495, hsa-miR-497*, hsa-miR-500, hsa-miR-507, hsa-miR-513a-3p,hsa-miR-514, hsa-miR-515-3p, hsa-miR-519a, hsa-miR-519b-3p,hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520g, hsa-miR-520h,hsa-miR-522, hsa-miR-526b*, hsa-miR-544, hsa-miR-548c-3p,hsa-miR-548d-3p, hsa-miR-548m, hsa-miR-550*, hsa-miR-55 1 b*,hsa-miR-554, hsa-miR-557, hsa-miR-561, hsa-miR-568, hsa-miR-570,hsa-miR-576-5p, hsa-miR-578, hsa-miR-590-3p, hsa-miR-600, hsa-miR-607,hsa-miR-633, hsa-miR-634, hsa-miR-643, hsa-miR-655, hsa-miR-656,hsa-miR-659, hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-769-5p, hsa-miR-770-5p,hsa-miR-885-5p, hsa-miR-888*, hsa-miR-889, hsa-miR-9, hsa-miR-93,hsa-miR-936, and hsa-miR-944.

ABI1 variant 2—NM_(—)001012750—hsa-abi-13197, hsa-let-7a*, hsa-let-7b*,hsa-let-7f-1*, hsa-miR-106a, hsa-miR-106b, hsa-miR-1208,hsa-miR-1224-3p, hsa-miR-1226, hsa-miR-1246, hsa-miR-1248, hsa-miR-1252,hsa-miR-1279, hsa-miR-129-5p, hsa-miR-1302, hsa-miR-130a*,hsa-miR-138-1*, hsa-miR-142-5p, hsa-miR-144, hsa-miR-148b*,hsa-miR-150*, hsa-miR-154, hsa-miR-15a*, hsa-miR-15b*, hsa-miR-16-1*,hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d,hsa-miR-188-3p, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-19a*,hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-200c*, hsa-miR-20a,hsa-miR-20a*, hsa-miR-20b, hsa-miR-216b, hsa-miR-222*, hsa-miR-23a,hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-29a, hsa-miR-29a*,hsa-miR-29b, hsa-miR-29c, hsa-miR-302c*, hsa-miR-302f, hsa-miR-32*,hsa-miR-323-3p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-338-5p,hsa-miR-33a, hsa-miR-33b, hsa-miR-33b*, hsa-miR-34c-3p, hsa-miR-361-3p,hsa-miR-379, hsa-miR-380, hsa-miR-409-3p, hsa-miR-432, hsa-miR-433,hsa-miR-448, hsa-miR-452, hsa-miR-491-3p, hsa-miR-493*, hsa-miR-494,hsa-miR-495, hsa-miR-497*, hsa-miR-500, hsa-miR-507, hsa-miR-513a-3p,hsa-miR-514, hsa-miR-515-3p, hsa-miR-519a, hsa-miR-519b-3p,hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520g, hsa-miR-520h,hsa-miR-522, hsa-miR-526b*, hsa-miR-544, hsa-miR-548c-3p,hsa-miR-548d-3p, hsa-miR-548m, hsa-miR-550*, hsa-miR-551b*, hsa-miR-554,hsa-miR-557, hsa-miR-561, hsa-miR-568, hsa-miR-570, hsa-miR-576-5p,hsa-miR-578, hsa-miR-590-3p, hsa-miR-600, hsa-miR-607, hsa-miR-633,hsa-miR-634, hsa-miR-643, hsa-miR-655, hsa-miR-656, hsa-miR-659,hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-769-5p, hsa-miR-770-5p,hsa-miR-885-5p, hsa-miR-888*, hsa-miR-889, hsa-miR-9, hsa-miR-93,hsa-miR-936, and hsa-miR-944.

ABI1 variant 3—NM_(—)001012751—hsa-abi-13197, hsa-let-7a*, hsa-let-7b*,hsa-let-7f-1*, hsa-miR-106a, hsa-miR-106b, hsa-miR-1208,hsa-miR-1224-3p, hsa-miR-1226, hsa-miR-1246, hsa-miR-1248, hsa-miR-1252,hsa-miR-1279, hsa-miR-129-5p, hsa-miR-1302, hsa-miR-130a*,hsa-miR-138-1*, hsa-miR-142-5p, hsa-miR-144, hsa-miR-148b*,hsa-miR-150*, hsa-miR-154, hsa-miR-15a*, hsa-miR-15b*, hsa-miR-16-1*,hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d,hsa-miR-188-3p, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-19a*,hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-200c*, hsa-miR-20a,hsa-miR-20a*, hsa-miR-20b, hsa-miR-216b, hsa-miR-222*, hsa-miR-23 a,hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-29a, hsa-miR-29a*,hsa-miR-29b, hsa-miR-29c, hsa-miR-302c*, hsa-miR-302f, hsa-miR-32*,hsa-miR-323-3p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-338-5p,hsa-miR-33a, hsa-miR-33b, hsa-miR-33b*, hsa-miR-34c-3p, hsa-miR-361-3p,hsa-miR-379, hsa-miR-380, hsa-miR-409-3p, hsa-miR-432, hsa-miR-433,hsa-miR-448, hsa-miR-452, hsa-miR-491-3p, hsa-miR-493*, hsa-miR-494,hsa-miR-495, hsa-miR-497*, hsa-miR-500, hsa-miR-507, hsa-miR-513a-3p,hsa-miR-514, hsa-miR-515-3p, hsa-miR-519a, hsa-miR-519b-3p,hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520g, hsa-miR-520h,hsa-miR-522, hsa-miR-526b*, hsa-miR-544, hsa-miR-548c-3p,hsa-miR-548d-3p, hsa-miR-548m, hsa-miR-550*, hsa-miR-551b*, hsa-miR-554,hsa-miR-557, hsa-miR-561, hsa-miR-568, hsa-miR-570, hsa-miR-576-5p,hsa-miR-578, hsa-miR-590-3p, hsa-miR-600, hsa-miR-607, hsa-miR-633,hsa-miR-634, hsa-miR-643, hsa-miR-655, hsa-miR-656, hsa-miR-659,hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-769-5p, hsa-miR-770-5p,hsa-miR-885-5p, hsa-miR-888*, hsa-miR-889, hsa-miR-9, hsa-miR-93,hsa-miR-936, and hsa-miR-944.

ABI1 variant 4—NM_(—)001012752—hsa-abi-13197, hsa-let-7a*, hsa-let-7b*,hsa-let-7f-1*, hsa-miR-106a, hsa-miR-106b, hsa-miR-1208,hsa-miR-1224-3p, hsa-miR-1226, hsa-miR-1246, hsa-miR-1248, hsa-miR-1252,hsa-miR-1279, hsa-miR-129-5p, hsa-miR-1302, hsa-miR-130a*,hsa-miR-138-1*, hsa-miR-142-5p, hsa-miR-144, hsa-miR-148b*,hsa-miR-150*, hsa-miR-154, hsa-miR-15a*, hsa-miR-15b*, hsa-miR-16-1*,hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d,hsa-miR-188-3p, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-19a*,hsa-miR-19b-1*, hsa-miR-19b-2*, hsa-miR-200c*, hsa-miR-20a,hsa-miR-20a*, hsa-miR-20b, hsa-miR-216b, hsa-miR-222*, hsa-miR-23a,hsa-miR-23b, hsa-miR-24-1*, hsa-miR-24-2*, hsa-miR-29a, hsa-miR-29a*,hsa-miR-29b, hsa-miR-29c, hsa-miR-302c*, hsa-miR-302f, hsa-miR-32*,hsa-miR-323-3p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-338-5p,hsa-miR-33a, hsa-miR-33b, hsa-miR-33b*, hsa-miR-34c-3p, hsa-miR-361-3p,hsa-miR-379, hsa-miR-380, hsa-miR-409-3p, hsa-miR-432, hsa-miR-433,hsa-miR-448, hsa-miR-452, hsa-miR-491-3p, hsa-miR-493*, hsa-miR-494,hsa-miR-495, hsa-miR-497*, hsa-miR-500, hsa-miR-507, hsa-miR-513a-3p,hsa-miR-514, hsa-miR-515-3p, hsa-miR-519a, hsa-miR-519b-3p,hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520g, hsa-miR-520h,hsa-miR-522, hsa-miR-526b*, hsa-miR-544, hsa-miR-548c-3p,hsa-miR-548d-3p, hsa-miR-548m, hsa-miR-550*, hsa-miR-551b*, hsa-miR-554,hsa-miR-557, hsa-miR-561, hsa-miR-568, hsa-miR-570, hsa-miR-576-5p,hsa-miR-578, hsa-miR-590-3p, hsa-miR-600, hsa-miR-607, hsa-miR-633,hsa-miR-634, hsa-miR-643, hsa-miR-655, hsa-miR-656, hsa-miR-659,hsa-miR-7-1*, hsa-miR-7-2*, hsa-miR-769-5p, hsa-miR-770-5p,hsa-miR-885-5p, hsa-miR-888*, hsa-miR-889, hsa-miR-9, hsa-miR-93,hsa-miR-936, and hsa-miR-944.

B-cell translocation gene 1—BTG1—NM_(—)001731—hsa-abi-10411,hsa-abi-10617, hsa-abi-13182, hsa-abi-13209, hsa-abi-13242,hsa-abi-13255, hsa-abi-13268, hsa-abi-3046, hsa-abi-9508, hsa-let-7g*,hsa-miR-10b*, hsa-miR-1182, hsa-miR-1231, hsa-miR-1245, hsa-miR-1253,hsa-miR-1264, hsa-miR-130a, hsa-miR-130b, hsa-miR-138, hsa-miR-140-3p,hsa-miR-142-5p, hsa-miR-183, hsa-miR-186*, hsa-miR-193a-5p, hsa-miR-19a,hsa-miR-19b, hsa-miR-21*, hsa-miR-22, hsa-miR-27a, hsa-miR-27b,hsa-miR-300, hsa-miR-301a, hsa-miR-301b, hsa-miR-302a, hsa-miR-302b,hsa-miR-302c, hsa-miR-302d, hsa-miR-302e, hsa-miR-30c-1*,hsa-miR-30c-2*, hsa-miR-32*, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c,hsa-miR-320d, hsa-miR-330-3p, hsa-miR-331-5p, hsa-miR-367*, hsa-miR-372,hsa-miR-373, hsa-miR-381, hsa-miR-424*, hsa-miR-454, hsa-miR-488,hsa-miR-493*, hsa-miR-497*, hsa-miR-498, hsa-miR-509-3-5p,hsa-miR-509-5p, hsa-miR-511, hsa-miR-512-3p, hsa-miR-513a-3p,hsa-miR-513a-5p, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520c-3p,hsa-miR-520d-3p, hsa-miR-520e, hsa-miR-520f, hsa-miR-539, hsa-miR-541*,hsa-miR-548c-3p, hsa-miR-548m, hsa-miR-548p, hsa-miR-551b*, hsa-miR-565,hsa-miR-581, hsa-miR-587, hsa-miR-617, hsa-miR-621, hsa-miR-624,hsa-miR-633, hsa-miR-640, hsa-miR-654-3p, hsa-miR-744*, hsa-miR-770-5p,hsa-miR-876-3p, hsa-miR-890, and hsa-miR-93.

Interleukin 6—IL6—NM_(—)000600—hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7e, hsa-let-7g, hsa-let-7i, hsa-miR-1252, hsa-miR-126*,hsa-miR-1323, hsa-miR-146a*, hsa-miR-148a*, hsa-miR-148b*, hsa-miR-149,hsa-miR-153, hsa-miR-217, hsa-miR-338-5p, hsa-miR-33a*, hsa-miR-365,hsa-miR-512-5p, hsa-miR-548d-3p, hsa-miR-548o, hsa-miR-568,hsa-miR-574-3p, hsa-miR-613, hsa-miR-655, hsa-miR-760, and hsa-miR-98.

CASP8 and FADD-like apoptosis regulator—CFLAR variant1—NM_(—)003879—hsa-miR-106a, hsa-miR-106b, hsa-miR-1224-3p,hsa-miR-1245, hsa-miR-1260, hsa-miR-150, hsa-miR-17, hsa-miR-186*,hsa-miR-18a*, hsa-miR-20a, hsa-miR-20b, hsa-miR-29b-2*, hsa-miR-302a,hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-302e, hsa-miR-372,hsa-miR-373, hsa-miR-378*, hsa-miR-450b-3p, hsa-miR-504, hsa-miR-512-3p,hsa-miR-519d, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520c-3p,hsa-miR-520d-3p, hsa-miR-520e, hsa-miR-520g, hsa-miR-520h,hsa-miR-526b*, hsa-miR-532-3p, hsa-miR-552, hsa-miR-573, hsa-miR-769-3p,and hsa-miR-93.

CFLAR variant 2—NM_(—)001127183—hsa-miR-106a, hsa-miR-106b,hsa-miR-1245, hsa-miR-150, hsa-miR-17, hsa-miR-186*, hsa-miR-18a*,hsa-miR-20a, hsa-miR-20b, hsa-miR-29b-2*, hsa-miR-302a, hsa-miR-302b,hsa-miR-302c, hsa-miR-302d, hsa-miR-302e, hsa-miR-372, hsa-miR-373,hsa-miR-378*, hsa-miR-512-3p, hsa-miR-519d, hsa-miR-520a-3p,hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520e,hsa-miR-520g, hsa-miR-520h, hsa-miR-526b*, hsa-miR-552, hsa-miR-573, andhsa-miR-93.

CFLAR variant 3—NM_(—)001127184—hsa-miR-126*, hsa-miR-1827,hsa-miR-34b*, and hsa-miR-802.

Smu-1 suppressor of mec-8 and unc-52homolog—SMU1—NM_(—)018225—hsa-miR-101, hsa-miR-103, hsa-miR-105,hsa-miR-106a, hsa-miR-106b, hsa-miR-107, hsa-miR-10a, hsa-miR-10b,hsa-miR-1184, hsa-miR-1202, hsa-miR-1203, hsa-miR-1205, hsa-miR-1208,hsa-miR-122, hsa-miR-1224-3p, hsa-miR-1226*, hsa-miR-1227, hsa-miR-1228,hsa-miR-124, hsa-miR-1246, hsa-miR-1251, hsa-miR-1252, hsa-miR-1257,hsa-miR-1259, hsa-miR-126*, hsa-miR-1260, hsa-miR-1264, hsa-miR-1267,hsa-miR-1269, hsa-miR-127-3p, hsa-miR-1274a, hsa-miR-127-5p,hsa-miR-1278, hsa-miR-128, hsa-miR-1284, hsa-miR-1285, hsa-miR-1289,hsa-miR-129*, hsa-miR-1291, hsa-miR-1293, hsa-miR-129-3p, hsa-miR-1299,hsa-miR-1300, hsa-miR-1304, hsa-miR-1305, hsa-miR-1322, hsa-miR-1323,hsa-miR-134, hsa-miR-135b*, hsa-miR-140-5p, hsa-miR-141, hsa-miR-141*,hsa-miR-142-5p, hsa-miR-143*, hsa-miR-146a*, hsa-miR-148a, hsa-miR-148b,hsa-miR-149*, hsa-miR-150, hsa-miR-151-5p, hsa-miR-152, hsa-miR-154*,hsa-miR-155*, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-16-1*,hsa-miR-16-2*, hsa-miR-17, hsa-miR-181a-2*, hsa-miR-1825, hsa-miR-1827,hsa-miR-183, hsa-miR-186*, hsa-miR-187, hsa-miR-188-3p, hsa-miR-194,hsa-miR-195, hsa-miR-195*, hsa-miR-196a, hsa-miR-196a*, hsa-miR-196b,hsa-miR-19a, hsa-miR-19b, hsa-miR-200a, hsa-miR-203, hsa-miR-205,hsa-miR-208a, hsa-miR-208b, hsa-miR-20a, hsa-miR-20a*, hsa-miR-20b,hsa-miR-20b*, hsa-miR-216a, hsa-miR-217, hsa-miR-218, hsa-miR-219-1-3p,hsa-miR-219-2-3p, hsa-miR-220b, hsa-miR-23a*, hsa-miR-23b*, hsa-miR-25,hsa-miR-25*, hsa-miR-26a-1*, hsa-miR-26a-2*, hsa-miR-26b*,hsa-miR-28-3p, hsa-miR-296-5p, hsa-miR-29a*, hsa-miR-29b-1*,hsa-miR-300, hsa-miR-302a, hsa-miR-302a*, hsa-miR-302b, hsa-miR-302c,hsa-miR-302c*, hsa-miR-302d, hsa-miR-302e, hsa-miR-30b*, hsa-miR-31,hsa-miR-32, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d,hsa-miR-323-3p, hsa-miR-323-5p, hsa-miR-324-3p, hsa-miR-337-5p,hsa-miR-338-5p, hsa-miR-33a, hsa-miR-33a*, hsa-miR-33b, hsa-miR-340,hsa-miR-34a, hsa-miR-34c-5p, hsa-miR-363, hsa-miR-363*, hsa-miR-367,hsa-miR-369-3p, hsa-miR-372, hsa-miR-373, hsa-miR-373*, hsa-miR-374a*,hsa-miR-376a*, hsa-miR-377*, hsa-miR-378*, hsa-miR-380, hsa-miR-381,hsa-miR-382, hsa-miR-384, hsa-miR-409-5p, hsa-miR-424, hsa-miR-431,hsa-miR-449a, hsa-miR-449b, hsa-miR-452, hsa-miR-455-5p, hsa-miR-485-5p,hsa-miR-487a, hsa-miR-489, hsa-miR-490-3p, hsa-miR-490-5p, hsa-miR-493*,hsa-miR-494, hsa-miR-497, hsa-miR-500*, hsa-miR-501-5p, hsa-miR-503,hsa-miR-506, hsa-miR-507, hsa-miR-508-5p, hsa-miR-511, hsa-miR-512-3p,hsa-miR-513c, hsa-miR-517a, hsa-miR-517c, hsa-miR-519d, hsa-miR-520a-3p,hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520d-5p,hsa-miR-520e, hsa-miR-520g, hsa-miR-520h, hsa-miR-524-5p, hsa-miR-526b*,hsa-miR-532-3p, hsa-miR-542-3p, hsa-miR-545, hsa-miR-548a-5p,hsa-miR-548b-3p, hsa-miR-548b-5p, hsa-miR-548c-3p, hsa-miR-548c-5p,hsa-miR-548d-3p, hsa-miR-548d-5p, hsa-miR-548g, hsa-miR-548h,hsa-miR-548i, hsa-miR-548j, hsa-miR-548k, hsa-miR-548m, hsa-miR-548n,hsa-miR-548o, hsa-miR-548p, hsa-miR-551b*, hsa-miR-553, hsa-miR-554,hsa-miR-557, hsa-miR-559, hsa-miR-561, hsa-miR-568, hsa-miR-570,hsa-miR-577, hsa-miR-578, hsa-miR-580, hsa-miR-582-3p, hsa-miR-583,hsa-miR-586, hsa-miR-589, hsa-miR-589*, hsa-miR-590-3p, hsa-miR-593*,hsa-miR-597, hsa-miR-607, hsa-miR-612, hsa-miR-616*, hsa-miR-619,hsa-miR-624*, hsa-miR-628-5p, hsa-miR-630, hsa-miR-633, hsa-miR-640,hsa-miR-643, hsa-miR-647, hsa-miR-649, hsa-miR-653, hsa-miR-655,hsa-miR-657, hsa-miR-658, hsa-miR-661, hsa-miR-671-5p, hsa-miR-708*,hsa-miR-766, hsa-miR-875-3p, hsa-miR-875-5p, hsa-miR-876-5p,hsa-miR-885-5p, hsa-miR-886-3p, hsa-miR-888*, hsa-miR-890, hsa-miR-920,hsa-miR-922, hsa-miR-924, hsa-miR-92a, hsa-miR-92b, hsa-miR-92b*,hsa-miR-93, hsa-miR-933, hsa-miR-937, hsa-miR-938, hsa-miR-939,hsa-miR-940, hsa-miR-942, hsa-miR-943, and hsa-miR-944.

S100 calcium binding protein A3—S100A3—NM_(—)002960—hsa-miR-1200,hsa-miR-1233, hsa-miR-1281, hsa-miR-1285, hsa-miR-1298, hsa-miR-1321,hsa-miR-185, hsa-miR-198, hsa-miR-220c, hsa-miR-296-5p, hsa-miR-298,hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-326, hsa-miR-330-5p,hsa-miR-331-3p, hsa-miR-342-5p, hsa-miR-488, hsa-miR-612, hsa-miR-631,hsa-miR-675, hsa-miR-93*, and hsa-miR-940.

Ras and EF-hand domain containing—RASEF—NM_(—)152573—hsa-miR-1227,hsa-miR-1265, hsa-miR-1299, hsa-miR-16-1*, hsa-miR-222*, hsa-miR-224,hsa-miR-34b, hsa-miR-377, hsa-miR-455-5p, hsa-miR-492, hsa-miR-513a-5p,hsa-miR-520a-5p, hsa-miR-525-5p, hsa-miR-630, and hsa-miR-875-3p.

Interferon gamma receptor 1—IFNGR1—NM_(—)000416—hsa-miR-100*,hsa-miR-1178, hsa-miR-1243, hsa-miR-1278, hsa-miR-1283, hsa-miR-136,hsa-miR-183*, hsa-miR-187*, hsa-miR-216b, hsa-miR-224, hsa-miR-335*,hsa-miR-33a*, hsa-miR-520d-5p, hsa-miR-524-5p, hsa-miR-548a-3p,hsa-miR-548c-3p, hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-573,hsa-miR-665, hsa-miR-668, hsa-miR-767-3p, and hsa-miR-891b.

Insulin growth factor-like family member1—IGFL1—NM_(—)198541—hsa-miR-1205, hsa-miR-1226, hsa-miR-1266,hsa-miR-1293, hsa-miR-130b*, hsa-miR-1324, hsa-miR-142-5p, hsa-miR-143,hsa-miR-146a, hsa-miR-146b-5p, hsa-miR-198, hsa-miR-21*, hsa-miR-216a,hsa-miR-218, hsa-miR-23a*, hsa-miR-23b*, hsa-miR-296-5p, hsa-miR-324-5p,hsa-miR-335*, hsa-miR-340, hsa-miR-492, hsa-miR-512-5p, hsa-miR-541,hsa-miR-548k, hsa-miR-573, hsa-miR-574-5p, hsa-miR-608, hsa-miR-654-5p,and hsa-miR-665.

Microseminoprotein, beta-(PSP94)—MSMB—NM_(—)002443—hsa-miR-1197,hsa-miR-1233, hsa-miR-146b-3p, hsa-miR-223*, hsa-miR-24-1*,hsa-miR-24-2*, hsa-miR-33a*, hsa-miR-373*, hsa-miR-548c-3p,hsa-miR-551b*, hsa-miR-616*, hsa-miR-630, and hsa-miR-661.

CEACAM5—CEACAM5—NM_(—)004363—hsa-miR-105, hsa-miR-106a, hsa-miR-106b,hsa-miR-1183, hsa-miR-1184, hsa-miR-1200, hsa-miR-1206, hsa-miR-1264,hsa-miR-127-5p, hsa-miR-1276, hsa-miR-1307, hsa-miR-1324, hsa-miR-134,hsa-miR-135a*, hsa-miR-143*, hsa-miR-148a, hsa-miR-148b, hsa-miR-151-3p,hsa-miR-152, hsa-miR-17, hsa-miR-186, hsa-miR-193b*, hsa-miR-203,hsa-miR-20a, hsa-miR-20b, hsa-miR-216a, hsa-miR-220b, hsa-miR-223,hsa-miR-302a, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-302e,hsa-miR-302f, hsa-miR-335*, hsa-miR-338-5p, hsa-miR-33a*, hsa-miR-34a*,hsa-miR-361-5p, hsa-miR-362-5p, hsa-miR-367*, hsa-miR-372, hsa-miR-373,hsa-miR-376c, hsa-miR-378*, hsa-miR-410, hsa-miR-421, hsa-miR-431,hsa-miR-483-5p, hsa-miR-485-3p, hsa-miR-498, hsa-miR-509-3-5p,hsa-miR-509-5p, hsa-miR-512-3p, hsa-miR-513a-3p, hsa-miR-514,hsa-miR-516b, hsa-miR-519d, hsa-miR-520a-3p, hsa-miR-520b,hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520d-5p, hsa-miR-520e,hsa-miR-520g, hsa-miR-520h, hsa-miR-524-5p, hsa-miR-526b*, hsa-miR-545,hsa-miR-548l, hsa-miR-548n, hsa-miR-548p, hsa-miR-552, hsa-miR-556-3p,hsa-miR-561, hsa-miR-590-3p, hsa-miR-607, hsa-miR-629, hsa-miR-630,hsa-miR-641, hsa-miR-643, hsa-miR-656, hsa-miR-671-5p, hsa-miR-744*,hsa-miR-892a, hsa-miR-924, hsa-miR-93, and hsa-miR-944.

S100 calcium binding protein A7—S100A7—NM_(—)002963—hsa-miR-1253,hsa-miR-185*, hsa-miR-30c-1*, hsa-miR-30c-2*, hsa-miR-516b,hsa-miR-518c*, hsa-miR-593, hsa-miR-641, and hsa-miR-92a-2*.

Hydroxyprostaglandin dehydrogenase15—(NAD)—HPGD—NM_(—)000860—hsa-abi-13106, hsa-let-7c*, hsa-let-7d*,hsa-miR-1183, hsa-miR-1200, hsa-miR-1201, hsa-miR-1208, hsa-miR-1225-5p,hsa-miR-1252, hsa-miR-1255a, hsa-miR-1255b, hsa-miR-1259, hsa-miR-126*,hsa-miR-1270, hsa-miR-1284, hsa-miR-1285, hsa-miR-129-5p, hsa-miR-1297,hsa-miR-1308, hsa-miR-130a*, hsa-miR-1324, hsa-miR-133a, hsa-miR-133b,hsa-miR-137, hsa-miR-148a*, hsa-miR-154, hsa-miR-1826, hsa-miR-186*,hsa-miR-190, hsa-miR-190b, hsa-miR-203, hsa-miR-20b*, hsa-miR-21,hsa-miR-216a, hsa-miR-218, hsa-miR-223*, hsa-miR-23a, hsa-miR-23b,hsa-miR-26a, hsa-miR-26a-1*, hsa-miR-26a-2*, hsa-miR-26b, hsa-miR-297,hsa-miR-29a*, hsa-miR-29b-1*, hsa-miR-30b*, hsa-miR-31, hsa-miR-32*,hsa-miR-324-3p, hsa-miR-330-3p, hsa-miR-335*, hsa-miR-361-5p,hsa-miR-374a, hsa-miR-374b, hsa-miR-374b*, hsa-miR-376c, hsa-miR-379*,hsa-miR-383, hsa-miR-410, hsa-miR-411*, hsa-miR-421, hsa-miR-424*,hsa-miR-452*, hsa-miR-485-5p, hsa-miR-488, hsa-miR-488*, hsa-miR-498,hsa-miR-499-3p, hsa-miR-511, hsa-miR-516b, hsa-miR-518a-5p,hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-527,hsa-miR-543, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-5p,hsa-miR-548d-5p, hsa-miR-548g, hsa-miR-548h, hsa-miR-548i, hsa-miR-548j,hsa-miR-548l, hsa-miR-548p, hsa-miR-554, hsa-miR-559, hsa-miR-561,hsa-miR-562, hsa-miR-578, hsa-miR-579, hsa-miR-582-5p, hsa-miR-587,hsa-miR-589*, hsa-miR-590-5p, hsa-miR-607, hsa-miR-612, hsa-miR-616,hsa-miR-620, hsa-miR-633, hsa-miR-643, hsa-miR-654-3p, hsa-miR-655,hsa-miR-770-5p, hsa-miR-9, hsa-miR-935, and hsa-miR-944.

CEACAM7—CEACAM7—NM_(—)006890—hsa-let-7c*, hsa-miR-103, hsa-miR-107,hsa-miR-1205, hsa-miR-1236, hsa-miR-1254, hsa-miR-125a-3p, hsa-miR-1261,hsa-miR-1268, hsa-miR-1272, hsa-miR-1274a, hsa-miR-1274b, hsa-miR-1285,hsa-miR-129-5p, hsa-miR-1300, hsa-miR-1302, hsa-miR-1303, hsa-miR-1324,hsa-miR-136, hsa-miR-149, hsa-miR-154, hsa-miR-154*, hsa-miR-15a,hsa-miR-15b, hsa-miR-16, hsa-miR-182, hsa-miR-1827, hsa-miR-186,hsa-miR-188-5p, hsa-miR-194*, hsa-miR-195, hsa-miR-200a*, hsa-miR-200b*,hsa-miR-21, hsa-miR-223, hsa-miR-26b*, hsa-miR-28-5p, hsa-miR-30a*,hsa-miR-30d*, hsa-miR-30e*, hsa-miR-324-5p, hsa-miR-345, hsa-miR-378,hsa-miR-422a, hsa-miR-424, hsa-miR-425, hsa-miR-450b-3p,hsa-miR-450b-5p, hsa-miR-455-3p, hsa-miR-485-3p, hsa-miR-487a,hsa-miR-497, hsa-miR-509-3p, hsa-miR-516a-3p, hsa-miR-516b,hsa-miR-516b*, hsa-miR-517b, hsa-miR-518d-5p, hsa-miR-518e*,hsa-miR-518f*, hsa-miR-519a*, hsa-miR-519b-5p, hsa-miR-519c-5p,hsa-miR-520c-5p, hsa-miR-522*, hsa-miR-523*, hsa-miR-524-3p,hsa-miR-525-3p, hsa-miR-526a, hsa-miR-544, hsa-miR-548a-3p,hsa-miR-548e, hsa-miR-548f, hsa-miR-548g, hsa-miR-552, hsa-miR-561,hsa-miR-578, hsa-miR-583, hsa-miR-590-5p, hsa-miR-612, hsa-miR-617,hsa-miR-618, hsa-miR-622, hsa-miR-627, hsa-miR-628-5p, hsa-miR-640,hsa-miR-647, hsa-miR-653, hsa-miR-660, hsa-miR-663b, hsa-miR-708,hsa-miR-758, hsa-miR-766, hsa-miR-769-3p, hsa-miR-873, hsa-miR-892b,hsa-miR-935, hsa-miR-936, and hsa-miR-940.

Trefoil factor 1—TFF1—NM_(—)003225—hsa-miR-187, hsa-miR-298,hsa-miR-326, hsa-miR-330-5p, hsa-miR-889, and hsa-miR-92b*.

Prolactin-induced protein—PIP—NM_(—)002652—hsa-miR-1324, hsa-miR-140-3p,hsa-miR-644, hsa-miR-877, and hsa-miR-922.

Secretagogin—SCGN—NM_(—)006998—hsa-miR-22 hsa-miR-920, hsa-miR-330-3p,hsa-miR-134, hsa-miR-1252, hsa-miR-548p, hsa-miR-329, hsa-miR-494,hsa-miR-30a*, hsa-miR-622, hsa-miR-324-3p, hsa-miR-220c, hsa-miR-939,hsa-miR-26b*, hsa-miR-653, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-570,hsa-miR-1274a, hsa-miR-362-3p, hsa-miR-634, hsa-miR-1185, hsa-miR-30b*,hsa-miR-339-5p, hsa-miR-1228, hsa-miR-548c-3p, hsa-miR-1274b,hsa-miR-924, hsa-miR-892a, hsa-miR-627, hsa-miR-512-5p.

SWAP70—SWAP70—NM_(—)015055—hsa-miR-557, hsa-miR-200b, hsa-miR-520b,hsa-miR-34c-5p, hsa-miR-645, hsa-miR-16, hsa-miR-448, hsa-miR-515-5p,hsa-miR-380*, hsa-miR-22, hsa-miR-562, hsa-miR-1276, hsa-miR-125b-2*,hsa-miR-520g, hsa-miR-519b-3p, hsa-miR-513b, hsa-let-7g*, hsa-miR-5637,hsa-miR-532-3p, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-1267,hsa-miR-548b-5p, hsa-miR-516a-3p, hsa-miR-452, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-511, hsa-miR-513a-3p, hsa-miR-544,hsa-miR-379*, hsa-miR-335*, hsa-miR-507, hsa-miR-449a, hsa-miR-183*,hsa-miR-330-3p, hsa-miR-519c-3p, hsa-miR-129-5p, hsa-miR-943,hsa-miR-548n, hsa-miR-302e, hsa-let-7c*, hsa-miR-548c-5p,hsa-miR-574-3p, hsa-miR-134, hsa-miR-519a, hsa-miR-1303, hsa-miR-216b,hsa-miR-1252, hsa-miR-651, hsa-miR-548p, hsa-miR-586, hsa-miR-338-5p,hsa-miR-30b, hsa-miR-143*, hsa-miR-34a*, hsa-miR-374a*, hsa-miR-23a,hsa-miR-449b, hsa-miR-33a*, hsa-miR-302c, hsa-miR-302f, hsa-miR-548i,hsa-miR-516b*, hsa-miR-646, hsa-let-7b*, hsa-miR-1281, hsa-miR-494,hsa-miR-371-5p, hsa-miR-30a, hsa-miR-489, hsa-miR-1227, hsa-miR-373,hsa-miR-200c, hsa-miR-145, hsa-miR-552, hsa-miR-1286, hsa-miR-720,hsa-miR-302d, hsa-miR-1202, hsa-miR-15b, hsa-miR-320d, hsa-miR-590-3p,hsa-miR-495, hsa-miR-29c, hsa-miR-591, hsa-miR-1208, hsa-miR-34a,hsa-miR-29b, hsa-miR-579, hsa-miR-411*, hsa-miR-1259, hsa-miR-186*,hsa-miR-520c-3p, hsa-miR-302a, hsa-miR-888, hsa-miR-429, hsa-miR-29a,hsa-miR-570, hsa-miR-124, hsa-miR-517*, hsa-miR-548d-5p, hsa-miR-1294,hsa-miR-34b*, hsa-miR-148b*, hsa-miR-125a-3p, hsa-miR-1285,hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-195, hsa-miR-450b-5p,hsa-miR-610, hsa-miR-519d, hsa-miR-545, hsa-miR-612, hsa-miR-9*,hsa-miR-548j, hsa-miR-607, hsa-miR-520e, hsa-miR-30d, hsa-miR-93,hsa-miR-29b-2*, hsa-miR-548b-3p, hsa-miR-942, hsa-miR-23b,hsa-miR-1274a, hsa-miR-567, hsa-miR-302d*, hsa-miR-328, hsa-miR-526b*,hsa-miR-548h, hsa-miR-744*, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-432*,hsa-miR-150, hsa-miR-30c, hsa-miR-181a-2*, hsa-miR-451, hsa-miR-221*,hsa-miR-20b, hsa-miR-378*, hsa-miR-640, hsa-miR-100*, hsa-miR-1224-3p,hsa-miR-106a, hsa-miR-138-2*, hsa-miR-18a*, hsa-miR-130a*, hsa-miR-520h,hsa-miR-320a, hsa-miR-197, hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-17,hsa-miR-182, hsa-miR-320b, hsa-miR-297, hsa-miR-1274b, hsa-miR-424,hsa-miR-506, hsa-miR-302b, hsa-miR-626, hsa-miR-655, hsa-miR-924,hsa-miR-577, hsa-miR-15a, hsa-miR-632, hsa-miR-20a, hsa-miR-409-3p,hsa-miR-455-3p, hsa-let-7a*, hsa-miR-340, hsa-miR-140-3p, hsa-miR-106b,hsa-miR-497, hsa-miR-369-3p, hsa-miR-639, hsa-miR-302b*, hsa-miR-372,hsa-miR-367*, hsa-miR-497*, hsa-miR-433, hsa-miR-499-3p, hsa-miR-662,hsa-miR-1225-3p, hsa-miR-512-5p, hsa-miR-30e.

Cyclin Y—CCYN (C10orf9)—Variant 1 and Variant 2—NM_(—)145012 andNM_(—)181698—hsa-miR-194*, hsa-miR-520b, hsa-miR-16, hsa-miR-141, *hsa-miR-922, hsa-miR-493*, hsa-miR-130b*, hsa-let-7d, hsa-miR-875-5p,hsa-miR-513a-5p, hsa-miR-192, hsa-miR-550*, hsa-miR-222*, hsa-miR-551b*,hsa-miR-644, hsa-miR-204, hsa-let-7g*, hsa-miR-638, hsa-miR-890,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-27a, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-520a-3p, hsa-miR-511, hsa-miR-31*,hsa-miR-513a-3p, hsa-miR-148a*, hsa-miR-29b-1*, hsa-miR-330-3p,hsa-miR-561, hsa-miR-548n, hsa-miR-302e, hsa-miR-548c-5p, hsa-miR-603,hsa-miR-342-3p, hsa-miR-298, hsa-miR-508-5p, hsa-miR-130b, hsa-let-7e,hsa-miR-370, hsa-miR-1207-5p, hsa-miR-216b, hsa-miR-1252, hsa-miR-1246,hsa-miR-600, hsa-miR-586, hsa-miR-876-5p, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-374a*, hsa-miR-301b, hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-302c,hsa-miR-491-5p, hsa-miR-548i, hsa-miR-202, hsa-miR-520a-5p,hsa-miR-548d-3p, hsa-miR-516b*, hsa-let-7b*, hsa-miR-525-5p,hsa-miR-494, hsa-miR-371-5p, hsa-miR-30a, hsa-miR-29a*, hsa-miR-373,hsa-miR-130a, hsa-miR-220c, hsa-miR-26b, hsa-let-7f, hsa-miR-302d,hsa-miR-15b, hsa-miR-96*, hsa-miR-617, hsa-miR-599, hsa-miR-590-3p,hsa-miR-495, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-215, hsa-miR-1253,hsa-miR-193a-3p, hsa-miR-361-5p, hsa-miR-186*, hsa-miR-200c*,hsa-miR-520c-3p, hsa-miR-770-5p, hsa-miR-509-3p, hsa-miR-144,hsa-miR-653, hsa-miR-302a, hsa-miR-553, hsa-miR-802, hsa-miR-592,hsa-miR-570, hsa-miR-105, hsa-let-7g, hsa-miR-124, hsa-miR-940,hsa-miR-548d-5p, hsa-miR-432, hsa-miR-769-3p, hsa-miR-768-3p,hsa-miR-450b-3p, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-195,hsa-miR-331-5p, hsa-miR-27b, hsa-miR-548j, hsa-miR-607, hsa-miR-520e,hsa-miR-30d, hsa-miR-193b, hsa-let-7i, hsa-miR-942, hsa-miR-1263,hsa-miR-545*, hsa-miR-539, hsa-miR-33b, hsa-let-7b, hsa-miR-139-5p,hsa-miR-301a, hsa-let-7a, hsa-miR-98, hsa-miR-203, hsa-miR-548h,hsa-miR-211, hsa-let-7f-1*, hsa-miR-1300, hsa-miR-628-5p, hsa-miR-30c,hsa-miR-205, hsa-miR-1284, hsa-miR-659, hsa-miR-199a-3p, hsa-miR-191*,hsa-miR-1225-5p, hsa-let-7c, hsa-miR-182, hsa-miR-454, hsa-miR-1264,hsa-miR-297, hsa-miR-548l, hsa-miR-424, hsa-miR-506, hsa-miR-302b,hsa-miR-655, hsa-miR-199b-3p, hsa-miR-137, hsa-miR-1278, hsa-miR-7-2*,hsa-miR-33a, hsa-miR-15a, hsa-miR-1244, hsa-miR-627, hsa-let-7a*,hsa-miR-497, hsa-let-7f-2*, hsa-miR-1197, hsa-miR-16-1*, hsa-miR-649,hsa-miR-372, hsa-miR-367*, hsa-miR-26a, hsa-miR-520d-5p, hsa-miR-30e.

Cell division cycle 123 homolog—CDC123(C10orf7)—NM_(—)006023—hsa-miR-376b, hsa-miR-493*, hsa-miR-562,hsa-miR-92a-2*, hsa-miR-574-3p, hsa-miR-663, hsa-miR-1203,hsa-miR-374a*, hsa-miR-646, hsa-miR-376a, hsa-miR-145, hsa-miR-589*,hsa-miR-361-5p, hsa-miR-144, hsa-miR-886-5p, hsa-miR-125a-3p,hsa-miR-935, hsa-miR-101, hsa-miR-1257, hsa-miR-877*, hsa-miR-202*,hsa-miR-744, hsa-miR-584.

Alkb, alkylation repair homolog 1—ALKBH1—NM_(—)006020—hsa-miR-515-5p,hsa-miR-22, hsa-miR-922, hsa-miR-130b*, hsa-miR-875-5p, hsa-miR-1276,hsa-miR-520g, hsa-miR-374b, hsa-miR-551b*, hsa-miR-195*, hsa-miR-204,hsa-miR-96, hsa-miR-548a-5p, hsa-miR-490-3p, hsa-miR-559,hsa-miR-548b-5p, hsa-miR-16-2*, hsa-miR-575, hsa-miR-31, hsa-miR-379*,hsa-miR-486-3p, hsa-miR-335*, hsa-miR-541*, hsa-miR-548c-5p,hsa-miR-938, hsa-miR-134, hsa-miR-1231, hsa-miR-619, hsa-miR-651,hsa-miR-129*, hsa-miR-299-5p, hsa-miR-586, hsa-miR-186, hsa-miR-548i,hsa-miR-202, hsa-miR-520a-5p, hsa-miR-548d-3p, hsa-miR-525-5p,hsa-miR-145, hsa-miR-1286, hsa-miR-664, hsa-miR-1269, hsa-miR-96*,hsa-miR-590-3p, hsa-miR-1271, hsa-miR-591, hsa-miR-1253, hsa-miR-411*,hsa-miR-186*, hsa-miR-1233, hsa-miR-144, hsa-miR-802, hsa-miR-570,hsa-miR-548d-5p, hsa-miR-769-3p, hsa-miR-593, hsa-miR-450b-3p,hsa-miR-198, hsa-miR-545, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607,hsa-miR-1258, hsa-miR-629, hsa-miR-942, hsa-miR-1322, hsa-miR-23a*,hsa-miR-1274a, hsa-miR-539, hsa-miR-23b*, hsa-miR-33b, hsa-miR-149*,hsa-miR-139-5p, hsa-miR-22*, hsa-miR-548h, hsa-miR-744*, hsa-miR-211,hsa-miR-519e*, hsa-miR-1300, hsa-miR-1321, hsa-miR-550, hsa-miR-520h,hsa-miR-339-5p, hsa-miR-129-3p, hsa-miR-196a*, hsa-miR-485-5p,hsa-miR-488*, hsa-miR-577, hsa-miR-33a, hsa-miR-188-5p, hsa-miR-374a,hsa-miR-556-3p, hsa-miR-1272, hsa-miR-340, hsa-miR-1265, hsa-miR-135b*.

Transducer of ERBB2—TOB2—NM_(—)016272—hsa-miR-194*, hsa-miR-509-3-5p,hsa-miR-877, hsa-miR-520b, hsa-miR-1266, hsa-miR-34c-5p, hsa-miR-32,hsa-miR-642, hsa-miR-16, hsa-miR-500, hsa-miR-20b*, hsa-miR-542-3p,hsa-miR-493*, hsa-miR-138, hsa-miR-130b*, hsa-let-7d, hsa-miR-875-5p,hsa-miR-513a-5p, hsa-miR-766, hsa-miR-1184, hsa-miR-9, hsa-miR-615-5p,hsa-miR-1301, hsa-miR-125a-5p, hsa-miR-483-3p, hsa-miR-548g,hsa-let-7g*, hsa-miR-1826, hsa-miR-335, hsa-miR-92a-2*, hsa-miR-520a-3p,hsa-miR-661, hsa-miR-31, hsa-miR-544, hsa-miR-143, hsa-miR-24-1*,hsa-miR-449a, hsa-miR-378, hsa-miR-1237, hsa-miR-561, hsa-miR-217,hsa-miR-1288, hsa-miR-302e, hsa-miR-93*, hsa-miR-603, hsa-miR-508-5p,hsa-miR-92b, hsa-let-7e, hsa-miR-370, hsa-miR-1207-5p, hsa-miR-1287,hsa-miR-623, hsa-miR-216b, hsa-miR-103, hsa-miR-630, hsa-miR-548p,hsa-miR-367, hsa-miR-543, hsa-miR-25, hsa-miR-365, hsa-miR-449b,hsa-miR-618, hsa-miR-302c, hsa-miR-491-5p, hsa-miR-24-2*, hsa-miR-646,hsa-miR-329, hsa-miR-622, hsa-miR-324-3p, hsa-miR-548o, hsa-miR-373,hsa-miR-874, hsa-miR-548f, hsa-miR-569, hsa-miR-484, hsa-let-7f,hsa-miR-302d, hsa-miR-765, hsa-miR-15b, hsa-miR-635, hsa-miR-1253,hsa-miR-34a, hsa-miR-135a, hsa-miR-605, hsa-miR-768-5p, hsa-miR-186*,hsa-miR-147, hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-608,hsa-miR-185*, hsa-miR-1262, hsa-miR-1323, hsa-miR-125b, hsa-miR-302a,hsa-miR-488, hsa-miR-105, hsa-miR-508-3p, hsa-let-7g, hsa-miR-940,hsa-miR-34b*, hsa-miR-125a-3p, hsa-miR-512-3p, hsa-miR-520d-3p,hsa-miR-195, hsa-miR-450b-5p, hsa-miR-610, hsa-miR-92a-1*, hsa-miR-20a*,hsa-miR-545, hsa-miR-504, hsa-miR-135b, hsa-miR-520e, hsa-miR-192*,hsa-miR-1206, hsa-miR-1260, hsa-let-7i, hsa-miR-422a, hsa-miR-1274a,hsa-miR-362-3p, hsa-miR-548a-3p, hsa-miR-1255a, hsa-miR-33b, hsa-let-7b,hsa-miR-149*, hsa-miR-330-5p, hsa-miR-551a, hsa-let-7a, hsa-miR-98,hsa-miR-571, hsa-miR-92a, hsa-miR-708*, hsa-miR-597, hsa-miR-1185,hsa-miR-361-3p, hsa-miR-432*, hsa-miR-1300, hsa-miR-583, hsa-miR-501-5p,hsa-miR-342-5p, hsa-miR-221*, hsa-miR-527, hsa-miR-17*, hsa-miR-556-5p,hsa-miR-1321, hsa-miR-640, hsa-miR-631, hsa-miR-18a*, hsa-miR-30b*,hsa-miR-550, hsa-let-7c, hsa-miR-202*, hsa-miR-1827, hsa-miR-24,hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-663b, hsa-miR-656, hsa-miR-1274b,hsa-miR-424, hsa-miR-654-5p, hsa-miR-302b, hsa-miR-548e, hsa-miR-655,hsa-miR-485-5p, hsa-miR-122, hsa-miR-33a, hsa-miR-377*, hsa-miR-107,hsa-miR-15a, hsa-miR-126*, hsa-miR-363, hsa-miR-1272, hsa-miR-509-5p,hsa-miR-944, hsa-miR-574-5p, hsa-miR-497, hsa-miR-296-3p, hsa-miR-1197,hsa-miR-551b, hsa-miR-372, hsa-miR-326, hsa-miR-602, hsa-miR-1255b,hsa-miR-541, hsa-miR-1205, hsa-miR-671-5p.

Xenotropic and polytropic retrovirusreceptor—XPR1—NM_(—)004736—hsa-miR-140-5p, hsa-miR-637, hsa-miR-520b,hsa-miR-32, hsa-miR-16, hsa-miR-22, hsa-miR-216a, hsa-miR-562,hsa-miR-548g, hsa-miR-1289, hsa-miR-30c-1*, hsa-miR-548a-5p,hsa-miR-1826, hsa-miR-647, hsa-miR-559, hsa-miR-1248, hsa-miR-548b-5p,hsa-miR-520a-3p, hsa-miR-142-5p, hsa-miR-335*, hsa-miR-548m,hsa-miR-378, hsa-miR-1226*, hsa-miR-194, hsa-miR-541*, hsa-miR-548n,hsa-miR-302e, hsa-miR-548c-5p, hsa-miR-1825, hsa-miR-128, hsa-miR-92b,hsa-miR-199a-5p, hsa-miR-875-3p, hsa-miR-1252, hsa-miR-367, hsa-miR-30b,hsa-miR-25, hsa-miR-374a*, hsa-miR-30c-2*, hsa-miR-1236, hsa-miR-1305,hsa-miR-33a*, hsa-miR-302c, hsa-miR-548i, hsa-miR-202, hsa-miR-606,hsa-miR-548d-3p, hsa-miR-146a*, hsa-miR-145*, hsa-miR-582-3p,hsa-miR-30a, hsa-miR-373, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f,hsa-miR-26b, hsa-miR-573, hsa-miR-302d, hsa-miR-628-3p, hsa-miR-15b,hsa-miR-590-3p, hsa-miR-502-5p, hsa-miR-513c, hsa-miR-1297,hsa-miR-7-1*, hsa-miR-26b*, hsa-miR-921, hsa-miR-579, hsa-miR-361-5p,hsa-miR-520c-3p, hsa-miR-633, hsa-miR-302a, hsa-miR-802, hsa-miR-624*,hsa-miR-570, hsa-miR-508-3p, hsa-miR-548d-5p, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-195, hsa-miR-331-5p, hsa-miR-299-3p,hsa-miR-664*, hsa-miR-548j, hsa-miR-520e, hsa-miR-200a, hsa-miR-30d,hsa-miR-1260, hsa-miR-422a, hsa-miR-539, hsa-miR-548a-3p, hsa-miR-33b*,hsa-miR-302d*, hsa-miR-141, hsa-miR-223, hsa-miR-889, hsa-miR-22*,hsa-miR-203, hsa-miR-548h, hsa-miR-92a, hsa-miR-30c, hsa-miR-583,hsa-miR-501-5p, hsa-miR-199b-5p, hsa-miR-205, hsa-miR-877*,hsa-miR-18a*, hsa-miR-519e, hsa-miR-548c-3p, hsa-miR-106a*, hsa-miR-382,hsa-miR-182, hsa-miR-424, hsa-miR-302b, hsa-miR-548e, hsa-miR-655,hsa-miR-888*, hsa-miR-892a, hsa-miR-122, hsa-miR-7-2*, hsa-miR-377*,hsa-miR-15a, hsa-miR-126*, hsa-miR-363, hsa-miR-515-3p, hsa-miR-497,hsa-miR-302b*, hsa-miR-372, hsa-miR-223*, hsa-miR-595, hsa-miR-26a,hsa-miR-891b, hsa-miR-671-5p, hsa-miR-584, hsa-miR-30e.

CD59 molecule—CD59—Variant 1, Variant 2, Variant 3, Variant 4, Variant5, Variant 6, Variant 7 and Variant 8—NM_(—)203330, NM_(—)000602,NM_(—)203329, NM_(—)203331, NM_(—)001127223, NM_(—)001127225,NM_(—)001127226 and NM_(—)001127227—hsa-miR-194*, hsa-miR-140-5p,hsa-miR-124*, hsa-miR-665, hsa-miR-518d-5p, hsa-miR-510, hsa-miR-200b,hsa-miR-509-3-5p, hsa-miR-877, hsa-miR-490-5p, hsa-miR-1266, hsa-miR-32,hsa-miR-1254, hsa-miR-642, hsa-miR-645, hsa-miR-380, hsa-miR-448,hsa-miR-519a*, hsa-miR-27b*, hsa-miR-141*, hsa-miR-522*, hsa-miR-22,hsa-miR-922, hsa-miR-648, hsa-miR-216a, hsa-miR-562, hsa-let-7d,hsa-miR-513a-5p, hsa-miR-766, hsa-miR-650, hsa-miR-9, hsa-miR-133a,hsa-miR-125b-2*, hsa-miR-616, hsa-miR-615-5p, hsa-miR-181a,hsa-miR-195*, hsa-miR-644, hsa-miR-548g, hsa-miR-204, hsa-miR-96,hsa-miR-1179, hsa-miR-214, hsa-miR-30c-1*, hsa-miR-549, hsa-miR-548a-5p,hsa-miR-376c, hsa-miR-1826, hsa-miR-647, hsa-miR-559, hsa-miR-1248,hsa-miR-335, hsa-miR-920, hsa-miR-138-1*, hsa-miR-92a-2*, hsa-miR-363*,hsa-miR-548b-5p, hsa-miR-516a-3p, hsa-miR-16-2*, hsa-miR-575,hsa-miR-320c, hsa-miR-511, hsa-miR-544, hsa-miR-26a-1*, hsa-miR-24-1*,hsa-miR-486-3p, hsa-miR-335*, hsa-miR-29b-1*, hsa-miR-548m,hsa-miR-183*, hsa-miR-378, hsa-miR-330-3p, hsa-miR-28-5p, hsa-miR-1226*,hsa-miR-190, hsa-miR-561, hsa-miR-129-5p, hsa-miR-217, hsa-miR-892b,hsa-miR-885-5p, hsa-miR-93*, hsa-miR-548c-5p, hsa-miR-603,hsa-miR-342-3p, hsa-miR-508-5p, hsa-miR-92b, hsa-let-7e, hsa-miR-370,hsa-miR-199a-5p, hsa-miR-1287, hsa-miR-623, hsa-miR-1252, hsa-miR-580,hsa-miR-660, hsa-miR-1246, hsa-miR-379, hsa-miR-600, hsa-miR-586,hsa-miR-367, hsa-miR-582-5p, hsa-miR-524-5p, hsa-miR-25,hsa-miR-516a-5p, hsa-miR-23a, hsa-miR-365, hsa-miR-30c-2*, hsa-miR-1236,hsa-miR-618, hsa-miR-1305, hsa-miR-548i, hsa-miR-520a-5p, hsa-miR-24-2*,hsa-miR-641, hsa-miR-212, hsa-miR-548d-3p, hsa-miR-516b*, hsa-miR-329,hsa-let-7b*, hsa-miR-708, hsa-miR-146a*, hsa-miR-153, hsa-miR-145*,hsa-miR-525-5p, hsa-miR-411, hsa-miR-30a*, hsa-miR-371-5p, hsa-miR-29a*,hsa-miR-324-3p, hsa-miR-548o, hsa-miR-1227, hsa-miR-200c, hsa-miR-581,hsa-miR-874, hsa-miR-548f, hsa-miR-220c, hsa-miR-664, hsa-miR-484,hsa-let-7f, hsa-miR-765, hsa-miR-320d, hsa-miR-599, hsa-miR-590-3p,hsa-miR-502-5p, hsa-miR-1271, hsa-miR-29c, hsa-miR-513c, hsa-miR-132,hsa-miR-7-1*, hsa-miR-589, hsa-miR-635, hsa-miR-767-3p, hsa-miR-589*,hsa-miR-190b, hsa-miR-1200, hsa-miR-29b, hsa-miR-135a, hsa-miR-579,hsa-miR-26a-2*, hsa-miR-146a, hsa-miR-768-5p, hsa-miR-1259,hsa-miR-374b*, hsa-miR-186*, hsa-miR-147, hsa-miR-873, hsa-miR-518a-5p,hsa-miR-27a*, hsa-miR-770-5p, hsa-miR-18b, hsa-miR-1226, hsa-miR-144,hsa-miR-1323, hsa-miR-323-5p, hsa-miR-220b, hsa-miR-505*,hsa-miR-1224-5p, hsa-miR-888, hsa-miR-30d*, hsa-miR-802, hsa-miR-568,hsa-miR-30e*, hsa-miR-21*, hsa-miR-429, hsa-miR-29a, hsa-miR-624*,hsa-miR-488, hsa-miR-105, hsa-let-7g, hsa-miR-124, hsa-miR-517*,hsa-miR-155, hsa-miR-548d-5p, hsa-miR-325, hsa-miR-1294, hsa-miR-588,hsa-miR-210, hsa-miR-593, hsa-miR-518f*, hsa-miR-768-3p, hsa-miR-148b*,hsa-miR-1285, hsa-miR-15a*, hsa-miR-610, hsa-miR-198, hsa-miR-20a*,hsa-miR-181d, hsa-miR-504, hsa-miR-935, hsa-miR-612, hsa-miR-135b,hsa-miR-664*, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607,hsa-miR-520c-5p, hsa-miR-200a, hsa-miR-578, hsa-miR-629*, hsa-miR-629,hsa-miR-29b-2*, hsa-miR-934, hsa-miR-518c*, hsa-miR-548b-3p, hsa-let-7i,hsa-miR-942, hsa-miR-422a, hsa-miR-1292, hsa-miR-23b, hsa-miR-1322,hsa-miR-23a*, hsa-miR-362-3p, hsa-miR-545*, hsa-miR-609,hsa-miR-548a-3p, hsa-miR-23b*, hsa-miR-33b, hsa-miR-146b-5p,hsa-miR-634, hsa-miR-516b, hsa-miR-526b, hsa-miR-133b, hsa-let-7b,hsa-miR-302d*, hsa-miR-330-5p, hsa-miR-139-5p, hsa-miR-141, hsa-miR-223,hsa-let-7a, hsa-miR-22*, hsa-miR-98, hsa-miR-203, hsa-miR-548h,hsa-miR-92a, hsa-miR-381, hsa-miR-211, hsa-miR-361-3p, hsa-miR-518e*,hsa-miR-593*, hsa-let-7f-1*, hsa-miR-432*, hsa-miR-1300, hsa-miR-628-5p,hsa-miR-181c, hsa-miR-526a, hsa-miR-760, hsa-miR-583, hsa-miR-501-5p,hsa-miR-199b-5p, hsa-miR-342-5p, hsa-miR-18a, hsa-miR-224, hsa-miR-221*,hsa-miR-527, hsa-miR-17*, hsa-miR-378*, hsa-miR-1256, hsa-miR-556-5p,hsa-miR-523*, hsa-miR-1224-3p, hsa-miR-877*, hsa-miR-149, hsa-miR-18a*,hsa-miR-130a*, hsa-miR-550, hsa-miR-320a, hsa-miR-1225-5p, hsa-let-7c,hsa-miR-197, hsa-miR-486-5p, hsa-miR-202*, hsa-miR-1228, hsa-miR-1827,hsa-miR-1299, hsa-miR-135a*, hsa-miR-196a*, hsa-miR-500*, hsa-miR-182,hsa-miR-320b, hsa-miR-1264, hsa-miR-297, hsa-miR-345, hsa-miR-654-5p,hsa-miR-506, hsa-miR-181b, hsa-miR-1283, hsa-miR-548e, hsa-miR-1251,hsa-miR-655, hsa-miR-485-5p, hsa-miR-888*, hsa-miR-924, hsa-miR-892a,hsa-miR-488*, hsa-miR-577, hsa-miR-122, hsa-miR-7-2*, hsa-miR-33a,hsa-miR-196a, hsa-miR-377*, hsa-miR-300, hsa-miR-425, hsa-miR-627,hsa-miR-423-5p, hsa-miR-196b, hsa-miR-363, hsa-miR-519b-5p, hsa-let-7a*,hsa-miR-338-3p, hsa-miR-509-5p, hsa-miR-574-5p, hsa-miR-1265,hsa-let-7f-2*, hsa-miR-1197, hsa-miR-519c-5p, hsa-miR-16-1*,hsa-miR-302b*, hsa-miR-649, hsa-miR-326, hsa-miR-1183, hsa-miR-602,hsa-miR-1234, hsa-miR-541, hsa-miR-520d-5p, hsa-miR-891b,hsa-miR-1225-3p, hsa-miR-671-5p.

Low density lipoprotein-related protein2—LRP2—NM_(—)004525—hsa-miR-376b, hsa-miR-557, hsa-miR-510,hsa-miR-520b, hsa-miR-1254, hsa-miR-380, hsa-miR-16, hsa-miR-922,hsa-miR-875-5p, hsa-miR-222*, hsa-miR-454*, hsa-miR-195*, hsa-miR-204,hsa-let-7g*, hsa-miR-549, hsa-miR-218-1*, hsa-miR-1304, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-335, hsa-miR-548b-5p, hsa-miR-16-2*,hsa-miR-520a-3p, hsa-miR-142-5p, hsa-miR-335*, hsa-miR-507, hsa-miR-378,hsa-miR-1237, hsa-miR-19b, hsa-miR-129-5p, hsa-miR-194, hsa-miR-302e,hsa-miR-548c-5p, hsa-miR-128, hsa-miR-298, hsa-miR-130b, hsa-miR-103,hsa-miR-148a, hsa-miR-576-5p, hsa-miR-876-5p, hsa-miR-338-5p,hsa-miR-34a*, hsa-miR-301b, hsa-miR-302c, hsa-miR-302f, hsa-miR-548i,hsa-miR-218-2*, hsa-miR-606, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-145*,hsa-miR-582-3p, hsa-miR-376a, hsa-miR-373, hsa-miR-130a, hsa-miR-145,hsa-miR-616*, hsa-miR-148b, hsa-miR-373*, hsa-miR-220c, hsa-miR-1286,hsa-miR-664, hsa-miR-1269, hsa-miR-302d, hsa-miR-15b, hsa-miR-590-3p,hsa-miR-7-1*, hsa-miR-921, hsa-miR-146a, hsa-miR-520c-3p,hsa-miR-518a-5p, hsa-miR-384, hsa-miR-302a, hsa-miR-888, hsa-miR-802,hsa-miR-548d-5p, hsa-miR-148b*, hsa-miR-125a-3p, hsa-miR-520d-3p,hsa-miR-195, hsa-miR-198, hsa-miR-452*, hsa-miR-548j, hsa-miR-520e,hsa-miR-578, hsa-miR-29b-2*, hsa-miR-518c*, hsa-miR-152, hsa-miR-422a,hsa-miR-101, hsa-miR-539, hsa-miR-146b-5p, hsa-miR-139-5p, hsa-miR-301a,hsa-miR-548h, hsa-miR-625*, hsa-miR-211, hsa-let-7f-1*, hsa-miR-1284,hsa-miR-527, hsa-miR-199a-3p, hsa-miR-877*, hsa-miR-30b*, hsa-miR-1299,hsa-miR-663b, hsa-miR-500*, hsa-miR-182, hsa-miR-454, hsa-miR-548k,hsa-miR-424, hsa-miR-302b, hsa-miR-485-5p, hsa-miR-199b-3p,hsa-miR-1278, hsa-miR-7-2*, hsa-miR-107, hsa-miR-19a, hsa-miR-15a,hsa-miR-556-3p, hsa-miR-409-3p, hsa-let-7a*, hsa-miR-944, hsa-miR-497,hsa-miR-1197, hsa-miR-372, hsa-miR-595, hsa-miR-499-3p, hsa-miR-744,hsa-miR-671-5p.

Proteolipid protein 2—PLP2—NM_(—)002668—hsa-miR-517a, hsa-miR-665,hsa-miR-1254, hsa-miR-642, hsa-miR-92a-2*, hsa-miR-220a, hsa-miR-378,hsa-miR-298, hsa-miR-1296, hsa-miR-33a*, hsa-miR-491-5p, hsa-miR-218-2*,hsa-miR-146a*, hsa-miR-582-3p, hsa-miR-1, hsa-miR-664, hsa-miR-765,hsa-miR-608, hsa-miR-220b, hsa-miR-124, hsa-miR-588, hsa-miR-422a,hsa-miR-539, hsa-miR-571, hsa-miR-150, hsa-miR-583, hsa-miR-151-5p,hsa-miR-758, hsa-miR-7, hsa-miR-506, hsa-miR-206, hsa-miR-409-3p,hsa-miR-296-3p, hsa-miR-517c, hsa-miR-613.

Mitogen-activated protein kinase 14—MAPK14—Variant 1 and Variant2—NM_(—)001315 and NM_(—)139012—hsa-miR-124*, hsa-miR-637, hsa-miR-510,hsa-miR-1266, hsa-miR-642, hsa-miR-22, hsa-miR-513a-5p, hsa-miR-766,hsa-miR-133a, hsa-miR-520g, hsa-miR-615-5p, hsa-miR-550*,hsa-miR-125a-5p, hsa-miR-532-3p, hsa-miR-377, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-1248, hsa-miR-335, hsa-miR-92a-2*,hsa-miR-548b-5p, hsa-miR-575, hsa-miR-143, hsa-miR-142-5p,hsa-miR-486-3p, hsa-miR-335*, hsa-miR-19b, hsa-miR-1178,hsa-miR-548c-5p, hsa-miR-603, hsa-miR-128, hsa-miR-587, hsa-miR-1303,hsa-miR-1280, hsa-miR-216b, hsa-miR-548p, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-23a, hsa-miR-1236, hsa-miR-337-3p, hsa-miR-10a,hsa-miR-1201, hsa-miR-548i, hsa-miR-520a-5p, hsa-miR-92b*, hsa-miR-646,hsa-let-7b*, hsa-miR-145*, hsa-miR-525-5p, hsa-miR-489, hsa-miR-622,hsa-miR-1227, hsa-miR-145, hsa-miR-616*, hsa-miR-874, hsa-miR-373*,hsa-miR-1286, hsa-miR-573, hsa-miR-188-3p, hsa-miR-589, hsa-miR-589*,hsa-miR-1259, hsa-miR-200c*, hsa-miR-518a-5p, hsa-miR-185*,hsa-miR-125b, hsa-miR-488, hsa-miR-570, hsa-miR-124, hsa-miR-548d-5p,hsa-miR-769-3p, hsa-miR-450b-3p, hsa-miR-144*, hsa-miR-545, hsa-miR-27b,hsa-miR-548j, hsa-miR-607, hsa-miR-200a, hsa-miR-629*, hsa-miR-155*,hsa-miR-1206, hsa-miR-139-3p, hsa-miR-518c*, hsa-miR-548b-3p,hsa-miR-942, hsa-miR-23b, hsa-miR-539, hsa-miR-33b, hsa-miR-516b,hsa-miR-133b, hsa-miR-141, hsa-miR-889, hsa-miR-548h, hsa-miR-381,hsa-miR-1185, hsa-let-7f-1*, hsa-miR-432*, hsa-let-7e*, hsa-miR-224,hsa-miR-1284, hsa-miR-527, hsa-miR-17*, hsa-miR-18a*, hsa-miR-130a*,hsa-miR-520h, hsa-miR-10b, hsa-miR-555, hsa-miR-339-5p, hsa-miR-24,hsa-miR-196a*, hsa-miR-1279, hsa-miR-1264, hsa-miR-506, hsa-miR-485-5p,hsa-miR-33a, hsa-miR-19a, hsa-miR-300, hsa-miR-632, hsa-let-7a*,hsa-miR-340, hsa-miR-16-1*, hsa-miR-346, hsa-miR-433.

MAPK14—Variant 3—NM_(—)139013—hsa-miR-605, hsa-miR-607.

MAPK14—Variant 4—NM_(—)139014—hsa-miR-124*, hsa-miR-637, hsa-miR-510,hsa-miR-1266, hsa-miR-642, hsa-miR-22, hsa-miR-513 a-5p, hsa-miR-766,hsa-miR-133 a, hsa-miR-520g, hsa-miR-615-5p, hsa-miR-550*,hsa-miR-125a-5p, hsa-miR-532-3p, hsa-miR-377, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-1248, hsa-miR-335, hsa-miR-92a-2*,hsa-miR-548b-5p, hsa-miR-575, hsa-miR-320c, hsa-miR-143, hsa-miR-142-5p,hsa-miR-486-3p, hsa-miR-335*, hsa-miR-19b, hsa-miR-1178,hsa-miR-548c-5p, hsa-miR-603, hsa-miR-128, hsa-miR-587, hsa-miR-1303,hsa-miR-1280, hsa-miR-216b, hsa-miR-548p, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-23a, hsa-miR-1236, hsa-miR-337-3p, hsa-miR-10a,hsa-miR-1201, hsa-miR-548i, hsa-miR-520a-5p, hsa-miR-92b*, hsa-miR-646,hsa-let-7b*, hsa-miR-145*, hsa-miR-525-5p, hsa-miR-489, hsa-miR-622,hsa-miR-1227, hsa-miR-145, hsa-miR-616*, hsa-miR-874, hsa-miR-373*,hsa-miR-1286, hsa-miR-573, hsa-miR-320d, hsa-miR-188-3p, hsa-miR-589,hsa-miR-589*, hsa-miR-1259, hsa-miR-200c*, hsa-miR-518a-5p, hsa-miR-608,hsa-miR-185*, hsa-miR-125b, hsa-miR-488, hsa-miR-570, hsa-miR-124,hsa-miR-548d-5p, hsa-miR-769-3p, hsa-miR-450b-3p, hsa-miR-144*,hsa-miR-545, hsa-miR-27b, hsa-miR-548j, hsa-miR-607, hsa-miR-200a,hsa-miR-629*, hsa-miR-155*, hsa-miR-1206, hsa-miR-139-3p, hsa-miR-518c*,hsa-miR-548b-3p, hsa-miR-942, hsa-miR-23b, hsa-miR-539, hsa-miR-33b,hsa-miR-516b, hsa-miR-133b, hsa-miR-141, hsa-miR-889, hsa-miR-548h,hsa-miR-381, hsa-miR-1185, hsa-let-7f-1*, hsa-miR-432*, hsa-let-7e*,hsa-miR-224, hsa-miR-1284, hsa-miR-527, hsa-miR-17*, hsa-miR-18a*,hsa-miR-130a*, hsa-miR-520h, hsa-miR-320a, hsa-miR-10b, hsa-miR-555,hsa-miR-339-5p, hsa-miR-24, hsa-miR-196a*, hsa-miR-1279, hsa-miR-320b,hsa-miR-1264, hsa-miR-506, hsa-miR-485-5p, hsa-miR-33 a, hsa-miR-19a,hsa-miR-300, hsa-miR-632, hsa-let-7a*, hsa-miR-340, hsa-miR-16-1*,hsa-miR-346, hsa-miR-433, hsa-miR-1293.

Matrix metallopeptidase 7—MMP7—NM_(—)002423—hsa-miR-181a, hsa-miR-379*,hsa-miR-302f, hsa-miR-641, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-489,hsa-miR-411*, hsa-miR-520f, hsa-miR-181d, hsa-let-7f-1*, hsa-miR-181c,hsa-miR-297, hsa-miR-181b, hsa-let-7a*.

Matrix Gla protein—MGP—NM000900—hsa-miR-637, hsa-miR-509-3-5p,hsa-miR-148a, hsa-miR-30a*, hsa-miR-148b, hsa-miR-1202, hsa-miR-30d*,hsa-miR-30e*, hsa-miR-155, hsa-miR-152, hsa-miR-342-5p, hsa-miR-17*,hsa-miR-548l, hsa-miR-509-5p, hsa-let-7f-2*.

Myeloid leukemia factor 1—MLF1—NM_(—)022443—hsa-miR-181a, hsa-miR-551b*,hsa-miR-885-5p, hsa-miR-338-5p, hsa-miR-543, hsa-miR-29a*, hsa-miR-548o,hsa-miR-590-3p, hsa-miR-29c, hsa-miR-7-1*, hsa-miR-29b, hsa-miR-361-5p,hsa-miR-509-3p, hsa-miR-1323, hsa-miR-29a, hsa-miR-105, hsa-miR-144*,hsa-miR-181d, hsa-miR-9*, hsa-miR-181c, hsa-miR-583, hsa-miR-205,hsa-miR-181b, hsa-miR-7-2*, hsa-miR-556-3p, hsa-miR-767-5p, hsa-miR-340.

FilaminB, beta (actin binding protein278)—FLNB—NM_(—)001457—hsa-miR-557, hsa-miR-510, hsa-miR-509-3-5p,hsa-miR-16, hsa-miR-515-5p, hsa-miR-141*, hsa-miR-1290, hsa-miR-195*,hsa-miR-548g, hsa-let-7g*, hsa-miR-890, hsa-miR-647, hsa-miR-452,hsa-miR-16-2*, hsa-miR-575, hsa-miR-544, hsa-miR-507, hsa-miR-29b-1*,hsa-miR-183*, hsa-miR-1226*, hsa-miR-886-3p, hsa-miR-548p,hsa-miR-876-5p, hsa-miR-33a*, hsa-miR-92b*, hsa-miR-646, hsa-miR-145,hsa-miR-548f, hsa-miR-484, hsa-miR-296-5p, hsa-miR-15b, hsa-miR-1208,hsa-miR-568, hsa-miR-940, hsa-miR-588, hsa-miR-184, hsa-miR-148b*,hsa-miR-195, hsa-miR-545, hsa-miR-299-3p, hsa-miR-192*, hsa-miR-942,hsa-miR-609, hsa-miR-548a-3p, hsa-miR-1255a, hsa-miR-634, hsa-miR-302d*,hsa-miR-203, hsa-miR-519e*, hsa-miR-1300, hsa-miR-17*, hsa-miR-100*,hsa-miR-1245, hsa-miR-18a*, hsa-miR-24, hsa-miR-500*, hsa-miR-182,hsa-miR-424, hsa-miR-654-5p, hsa-miR-548e, hsa-miR-488*, hsa-miR-122,hsa-miR-15a, hsa-miR-632, hsa-miR-509-5p, hsa-miR-499-5p, hsa-miR-193b*,hsa-miR-497, hsa-miR-346, hsa-miR-302b*, hsa-miR-1255b, hsa-miR-541,hsa-miR-1205, hsa-miR-135b*.

Sodium channel modifier 1—SCNM1—NM_(—)024041—hsa-miR-148a*, hsa-miR-660,hsa-miR-1257.

Cornichon homolog 4—CNIH4 also known asHSPC163—NM_(—)014184—hsa-miR-20b*, hsa-miR-766, hsa-miR-182*,hsa-miR-548p, hsa-miR-593, hsa-miR-545, hsa-miR-149, hsa-miR-1183,hsa-miR-142-3p.

Receptor accessory protein 5—REEP5—NM_(—)005669—hsa-miR-200b,hsa-miR-877, hsa-miR-520b, hsa-miR-380, hsa-miR-448, hsa-miR-493*,hsa-miR-766, hsa-miR-550*, hsa-miR-1301, hsa-miR-181a, hsa-miR-551b*,hsa-miR-302c*, hsa-miR-548g, hsa-let-7g*, hsa-miR-218-1*,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-548b-5p, hsa-miR-452,hsa-miR-520a-3p, hsa-miR-513a-3p, hsa-miR-379*, hsa-miR-335*,hsa-miR-29b-1*, hsa-miR-1226*, hsa-miR-302a*, hsa-miR-561, hsa-miR-541*,hsa-miR-548n, hsa-miR-217, hsa-miR-892b, hsa-miR-302e, hsa-let-7c*,hsa-miR-548c-5p, hsa-miR-587, hsa-miR-370, hsa-miR-1287, hsa-miR-424*,hsa-miR-524-5p, hsa-miR-186, hsa-miR-23a, hsa-miR-618, hsa-miR-33a*,hsa-miR-302c, hsa-miR-302f, hsa-miR-548i, hsa-miR-218-2*, hsa-miR-410,hsa-miR-421, hsa-miR-151-3p, hsa-miR-590-5p, hsa-miR-582-3p,hsa-miR-411, hsa-miR-29a*, hsa-miR-622, hsa-miR-373, hsa-miR-200c,hsa-miR-581, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f, hsa-miR-484,hsa-miR-302d, hsa-miR-1202, hsa-miR-1324, hsa-miR-590-3p, hsa-miR-513c,hsa-miR-1208, hsa-miR-34c-3p, hsa-miR-767-3p, hsa-miR-26b*, hsa-miR-579,hsa-miR-411*, hsa-miR-146a, hsa-miR-200c*, hsa-miR-520c-3p,hsa-miR-1226, hsa-miR-144, hsa-miR-323-5p, hsa-miR-302a, hsa-miR-802,hsa-miR-429, hsa-miR-548d-5p, hsa-miR-768-3p, hsa-miR-34b*,hsa-miR-520d-3p, hsa-miR-610, hsa-miR-519d, hsa-miR-198, hsa-miR-20a*,hsa-miR-181d, hsa-miR-9*, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607,hsa-miR-520e, hsa-miR-629*, hsa-miR-93, hsa-miR-29b-2*, hsa-miR-554,hsa-miR-200b*, hsa-miR-23b, hsa-miR-1322, hsa-miR-545*, hsa-miR-548a-3p,hsa-miR-1255a, hsa-miR-146b-5p, hsa-miR-634, hsa-miR-136, hsa-miR-889,hsa-miR-526b*, hsa-miR-548h, hsa-miR-150, hsa-miR-181c, hsa-miR-20b,hsa-miR-640, hsa-miR-106a, hsa-miR-130a*, hsa-miR-522, hsa-miR-197,hsa-miR-17, hsa-miR-196a*, hsa-miR-656, hsa-miR-548k, hsa-miR-548l,hsa-miR-302b, hsa-miR-181b, hsa-miR-1283, hsa-miR-548e, hsa-miR-1251,hsa-miR-21, hsa-miR-924, hsa-miR-577, hsa-miR-20a, hsa-miR-425,hsa-miR-126*, hsa-miR-340, hsa-miR-140-3p, hsa-miR-106b, hsa-miR-16-1*,hsa-miR-372, hsa-miR-1255b, hsa-miR-520d-5p, hsa-miR-200a*,hsa-miR-1205, hsa-miR-671-5p.

Solute carrier family 25, member 33(MGC4399)—SLC25A33—NM_(—)032315—hsa-miR-518d-5p, hsa-miR-519a*,hsa-miR-1180, hsa-miR-522*, hsa-miR-30a*, hsa-miR-371-5p, hsa-miR-552,hsa-miR-569, hsa-miR-32*, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-517*,hsa-miR-518P, hsa-miR-125a-3p, hsa-miR-520c-5p, hsa-miR-518e*,hsa-miR-526a, hsa-miR-523*, hsa-miR-488*, hsa-miR-519b-5p,hsa-miR-519c-5p, hsa-miR-1234.

Solute carrier family 44, member 1—SLC44A1—NM_(—)080546—hsa-miR-16,hsa-miR-650, hsa-miR-101*, hsa-miR-551b*, hsa-miR-302c*, hsa-miR-337-5p,hsa-let-7g*, hsa-miR-28-3p, hsa-miR-1179, hsa-miR-548a-5p, hsa-miR-559,hsa-miR-1248, hsa-miR-548b-5p, hsa-miR-516a-3p, hsa-miR-452,hsa-miR-496, hsa-miR-513a-3p, hsa-miR-99a, hsa-miR-142-5p, hsa-miR-548m,hsa-miR-183*, hsa-miR-561, hsa-miR-548n, hsa-miR-885-5p,hsa-miR-548c-5p, hsa-miR-409-5p, hsa-miR-130b, hsa-miR-587,hsa-miR-199a-5p, hsa-miR-630, hsa-miR-548p, hsa-miR-586, hsa-miR-582-5p,hsa-miR-301b, hsa-miR-33a*, hsa-miR-302f, hsa-miR-548i, hsa-miR-641,hsa-miR-212, hsa-miR-548d-3p, hsa-miR-516b*, hsa-miR-329, hsa-let-7b*,hsa-miR-146a*, hsa-miR-29a*, hsa-miR-1, hsa-miR-130a, hsa-miR-548f,hsa-miR-147b, hsa-miR-720, hsa-miR-664, hsa-miR-32*, hsa-miR-15b,hsa-miR-617, hsa-miR-590-3p, hsa-miR-132, hsa-miR-589*, hsa-miR-643,hsa-miR-135a, hsa-miR-605, hsa-miR-768-5p, hsa-miR-147, hsa-miR-21*,hsa-miR-488, hsa-miR-570, hsa-miR-508-3p, hsa-miR-548d-5p,hsa-miR-148b*, hsa-miR-195, hsa-miR-135b, hsa-miR-548j, hsa-miR-323-3p,hsa-miR-607, hsa-miR-29b-2*, hsa-miR-192*, hsa-miR-518c*,hsa-miR-491-3p, hsa-miR-1322, hsa-miR-1274a, hsa-miR-362-3p,hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-516b, hsa-miR-567, hsa-miR-301a,hsa-miR-571, hsa-miR-548h, hsa-miR-492, hsa-let-7f-1*, hsa-miR-181a-2*,hsa-miR-199b-5p, hsa-miR-556-5p, hsa-miR-99b, hsa-miR-548c-3p,hsa-miR-100, hsa-miR-1279, hsa-miR-454, hsa-miR-297, hsa-miR-1274b,hsa-miR-424, hsa-miR-1283, hsa-miR-548e, hsa-miR-206, hsa-miR-15a,hsa-miR-409-3p, hsa-miR-183, hsa-miR-455-3p, hsa-let-7a*,hsa-miR-338-3p, hsa-miR-944, hsa-miR-497, hsa-miR-369-3p, hsa-let-7f-2*,hsa-miR-613.

Transmembrane channel-like 4—TMC4—NM_(—)144686—hsa-miR-645, hsa-miR-192,hsa-miR-604, hsa-miR-320c, hsa-miR-661, hsa-miR-1268, hsa-miR-875-3p,hsa-miR-145, hsa-miR-320d, hsa-miR-215, hsa-miR-1291, hsa-miR-381,hsa-miR-758, hsa-miR-320a, hsa-miR-320b, hsa-miR-924, hsa-miR-488*,hsa-miR-300, hsa-miR-423-5p.

Zinc finger DHHC-type containing 2—ZDHHC2—NM_(—)016353—hsa-miR-509-3-5p,hsa-miR-490-5p, hsa-miR-32, hsa-miR-642, hsa-miR-380, hsa-miR-448,hsa-miR-515-5p, hsa-miR-27b*, hsa-miR-922, hsa-miR-192, hsa-miR-133a,hsa-miR-150*, hsa-miR-551b*, hsa-miR-302c*, hsa-miR-548g,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-1248, hsa-miR-335, hsa-miR-127-5p,hsa-miR-548b-5p, hsa-miR-496, hsa-miR-513a-3p, hsa-miR-544, hsa-miR-143,hsa-miR-142-5p, hsa-miR-548m, hsa-miR-183*, hsa-miR-378, hsa-miR-561,hsa-miR-548n, hsa-miR-548c-5p, hsa-miR-603, hsa-miR-92b, hsa-miR-619,hsa-miR-587, hsa-miR-1287, hsa-miR-424*, hsa-miR-216b, hsa-miR-630,hsa-miR-576-5p, hsa-miR-367, hsa-miR-582-5p, hsa-miR-543, hsa-miR-25,hsa-miR-374a*, hsa-miR-186, hsa-miR-1236, hsa-miR-1305, hsa-miR-337-3p,hsa-miR-33a*, hsa-miR-302f, hsa-miR-548i, hsa-miR-606, hsa-miR-146a*,hsa-miR-590-5p, hsa-miR-145*, hsa-miR-582-3p, hsa-miR-371-5p,hsa-miR-622, hsa-miR-145, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f,hsa-miR-590-3p, hsa-miR-495, hsa-miR-215, hsa-miR-26b*, hsa-miR-1253,hsa-miR-135a, hsa-miR-146a, hsa-miR-605, hsa-miR-1259, hsa-miR-633,hsa-miR-653, hsa-miR-888, hsa-miR-570, hsa-miR-124, hsa-miR-517*,hsa-miR-155, hsa-miR-548d-5p, hsa-miR-432, hsa-miR-331-5p, hsa-miR-144*,hsa-miR-20a*, hsa-miR-135b, hsa-miR-548j, hsa-miR-607, hsa-miR-10b*,hsa-miR-1206, hsa-miR-422a, hsa-miR-101, hsa-miR-539, hsa-miR-548a-3p,hsa-miR-146b-5p, hsa-miR-133b, hsa-miR-889, hsa-miR-548h, hsa-miR-92a,hsa-miR-381, hsa-miR-519e*, hsa-miR-150, hsa-miR-185, hsa-miR-877*,hsa-miR-522, hsa-miR-548c-3p, hsa-miR-106a*, hsa-miR-382, hsa-miR-548l,hsa-miR-506, hsa-miR-548e, hsa-miR-21, hsa-miR-655, hsa-miR-485-5p,hsa-miR-1278, hsa-miR-888*, hsa-miR-577, hsa-miR-300, hsa-miR-219-5p,hsa-miR-556-3p, hsa-miR-126*, hsa-miR-363, hsa-miR-509-5p, hsa-miR-944,hsa-miR-340, hsa-miR-499-5p, hsa-miR-369-3p, hsa-miR-218, hsa-miR-223*,hsa-miR-433, hsa-miR-154, hsa-miR-1205, hsa-miR-671-5p, hsa-miR-584.

Toll-like receptor adaptor molecule2—TICAM2—NM_(—)021649—hsa-miR-576-3p, hsa-miR-376b, hsa-miR-877,hsa-miR-922, hsa-miR-216a, hsa-miR-181a, hsa-miR-302c*, hsa-miR-204,hsa-miR-377, hsa-miR-335, hsa-miR-511, hsa-miR-544, hsa-miR-26a-1*,hsa-miR-335*, hsa-miR-1237, hsa-miR-129-5p, hsa-miR-548n,hsa-miR-342-3p, hsa-miR-298, hsa-miR-587, hsa-miR-1303, hsa-miR-580,hsa-miR-660, hsa-miR-1246, hsa-miR-299-5p, hsa-miR-548p, hsa-miR-23a,hsa-miR-491-5p, hsa-let-7b*, hsa-miR-494, hsa-miR-29a*, hsa-miR-376a,hsa-miR-548f, hsa-miR-590-3p, hsa-miR-513c, hsa-miR-1253, hsa-miR-1200,hsa-miR-579, hsa-miR-26a-2*, hsa-miR-361-5p, hsa-miR-1262, hsa-miR-384,hsa-miR-654-3p, hsa-miR-21*, hsa-miR-624*, hsa-miR-517*, hsa-miR-588,hsa-miR-181d, hsa-miR-935, hsa-miR-9*, hsa-miR-1258, hsa-miR-578,hsa-miR-383, hsa-miR-1206, hsa-miR-23b, hsa-miR-539, hsa-miR-548a-3p,hsa-miR-381, hsa-miR-211, hsa-let-7f-1*, hsa-miR-1300, hsa-miR-181c,hsa-miR-659, hsa-miR-138-2*, hsa-miR-130a*, hsa-miR-106a*, hsa-miR-1264,hsa-miR-548k, hsa-miR-181b, hsa-miR-548e, hsa-miR-577, hsa-miR-300,hsa-miR-485-3p, hsa-let-7a*, hsa-miR-1272, hsa-miR-340,hsa-miR-219-2-3p, hsa-miR-433, hsa-miR-595.

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor3—KDELR3—Variant 1—NM_(—)006855—hsa-miR-34c-5p, hsa-miR-380*,hsa-miR-19b-2*, hsa-miR-766, hsa-miR-181a, hsa-miR-513b, hsa-miR-302c*,hsa-miR-193a-5p, hsa-miR-563, hsa-miR-490-3p, hsa-miR-449a,hsa-miR-29b-1*, hsa-miR-19b, hsa-miR-1277, hsa-miR-19a*, hsa-miR-619,hsa-miR-875-3p, hsa-miR-19b-1*, hsa-miR-543, hsa-miR-449b,hsa-miR-151-3p, hsa-miR-146a*, hsa-miR-582-3p, hsa-miR-548o,hsa-miR-548f, hsa-miR-767-3p, hsa-miR-34a, hsa-miR-1323, hsa-miR-624*,hsa-miR-488, hsa-miR-940, hsa-miR-325, hsa-miR-1261, hsa-miR-432,hsa-miR-593, hsa-miR-34b*, hsa-miR-181d, hsa-miR-636, hsa-miR-578,hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-381, hsa-miR-593*, hsa-miR-1300,hsa-miR-181c, hsa-miR-493, hsa-miR-205, hsa-miR-522, hsa-miR-431,hsa-miR-181b, hsa-miR-548e, hsa-miR-655, hsa-miR-137, hsa-miR-924,hsa-miR-19a, hsa-miR-300, hsa-miR-627, hsa-miR-767-5p, hsa-miR-218,hsa-miR-154, hsa-miR-1275, hsa-miR-1302 MIMAT0005890.

KDELR3—Variant 2—NM_(—)016657—hsa-miR-943, hsa-miR-432*.

Glucosamine-6-phosphate deaminase 1—GNPDA1—NM_(—)005471—hsa-miR-665,hsa-miR-637, hsa-miR-510, hsa-miR-200b, hsa-miR-34c-5p, hsa-miR-32,hsa-miR-645, hsa-miR-27b*, hsa-miR-22, hsa-miR-625, hsa-miR-650,hsa-miR-125a-5p, hsa-miR-337-5p, hsa-miR-28-3p, hsa-miR-532-3p,hsa-miR-638, hsa-miR-1304, hsa-miR-890, hsa-miR-376c, hsa-miR-490-3p,hsa-miR-516a-3p, hsa-miR-320c, hsa-miR-661, hsa-miR-486-3p,hsa-miR-449a, hsa-miR-1237, hsa-miR-561, hsa-miR-938, hsa-miR-128,hsa-miR-342-3p, hsa-miR-92b, hsa-miR-103, hsa-miR-1252, hsa-miR-129*,hsa-miR-367, hsa-miR-30b, hsa-miR-543, hsa-miR-25, hsa-miR-23a,hsa-miR-449b, hsa-miR-491-5p, hsa-miR-218-2*, hsa-miR-516b*,hsa-miR-30a, hsa-miR-200c, hsa-miR-220c, hsa-miR-1286, hsa-miR-765,hsa-miR-296-5p, hsa-miR-320d, hsa-miR-502-5p, hsa-miR-513c,hsa-miR-7-1*, hsa-miR-589*, hsa-miR-34a, hsa-miR-1243, hsa-miR-125b,hsa-miR-214*, hsa-miR-505*, hsa-miR-592, hsa-miR-429, hsa-miR-488,hsa-miR-769-3p, hsa-miR-450b-3p, hsa-miR-198, hsa-miR-514, hsa-miR-200a,hsa-miR-30d, hsa-miR-629*, hsa-miR-518c*, hsa-miR-23b, hsa-miR-1263,hsa-miR-539, hsa-miR-516b, hsa-miR-330-5p, hsa-miR-141, hsa-miR-92a,hsa-miR-744*, hsa-miR-361-3p, hsa-miR-150, hsa-miR-30c, hsa-miR-760,hsa-miR-221*, hsa-miR-185, hsa-miR-378*, hsa-miR-556-5p, hsa-miR-640,hsa-miR-130a*, hsa-miR-758, hsa-miR-320a, hsa-miR-1225-5p,hsa-miR-129-3p, hsa-miR-1827, hsa-miR-320b, hsa-miR-122, hsa-miR-7-2*,hsa-miR-107, hsa-miR-363, hsa-miR-574-5p, hsa-miR-296-3p, hsa-miR-367*,hsa-miR-326, hsa-miR-223*, hsa-miR-1275, hsa-miR-671-5p, hsa-miR-30e.

Thioesterase superfamily member 2—THEM2—NM_(—)018473—hsa-miR-19b-2*,hsa-miR-29b-1*, hsa-miR-19a*, hsa-miR-19b-1*, hsa-miR-664, hsa-miR-26b*.

Debranching enzyme homolog 1—DBR1—NM_(—)016216—hsa-miR-32, hsa-miR-500,hsa-miR-20b*, hsa-miR-650, hsa-miR-550*, hsa-miR-374b, hsa-miR-96,hsa-miR-490-3p, hsa-miR-320c, hsa-miR-142-5p, hsa-miR-658, hsa-miR-128,hsa-miR-508-5p, hsa-miR-92b, hsa-miR-548p, hsa-miR-367, hsa-miR-25*,hsa-miR-524-5p, hsa-miR-25, hsa-miR-10a, hsa-miR-33a*, hsa-miR-302f,hsa-let-7b*, hsa-miR-494, hsa-miR-616*, hsa-miR-552, hsa-miR-373*,hsa-miR-362-5p, hsa-miR-26b, hsa-miR-320d, hsa-miR-495, hsa-miR-1271,hsa-miR-1297, hsa-miR-520f, hsa-miR-768-5p, hsa-miR-1259, hsa-miR-200c*,hsa-miR-122*, hsa-miR-940, hsa-miR-432, hsa-miR-636, hsa-miR-1260,hsa-miR-571, hsa-miR-92a, hsa-let-7f-1*, hsa-miR-1224-3p, hsa-miR-30b*,hsa-miR-320a, hsa-miR-10b, hsa-miR-339-5p, hsa-miR-1827,hsa-miR-548c-3p, hsa-miR-1279, hsa-miR-656, hsa-miR-320b, hsa-miR-1264,hsa-miR-297, hsa-miR-485-5p, hsa-miR-577, hsa-miR-377*, hsa-miR-374a,hsa-miR-1244, hsa-miR-126*, hsa-miR-363, hsa-let-7a*, hsa-miR-340,hsa-miR-369-3p, hsa-miR-26a, hsa-miR-520d-5p.

Solute carrier family 38, member9—SLC38A9—NM_(—)173514—hsa-miR-509-3-5p, hsa-miR-16, hsa-miR-125a-5p,hsa-miR-548m, hsa-miR-129-5p, hsa-miR-623, hsa-miR-103, hsa-miR-580,hsa-miR-548p, hsa-miR-338-5p, hsa-miR-202, hsa-miR-494, hsa-miR-616*,hsa-miR-373*, hsa-miR-628-3p, hsa-miR-15b, hsa-miR-495, hsa-miR-936,hsa-miR-125b, hsa-miR-384, hsa-miR-220b, hsa-miR-195, hsa-miR-323-3p,hsa-miR-607, hsa-miR-200a, hsa-miR-141, hsa-miR-583, hsa-miR-138-2*,hsa-miR-522, hsa-miR-424, hsa-miR-107, hsa-miR-15a, hsa-miR-601,hsa-miR-338-3p, hsa-miR-509-5p, hsa-miR-499-5p, hsa-miR-140-3p,hsa-miR-497, hsa-miR-433, hsa-miR-1205.

N-acetyltrans-ferase 10(GCN5-related)—NAT10—NM_(—)024662—hsa-miR-576-3p, hsa-miR-194*,hsa-miR-518d-5p, hsa-miR-490-5p, hsa-miR-34c-5p, hsa-miR-16,hsa-miR-519a*, hsa-miR-141*, hsa-miR-522*, hsa-miR-520g, hsa-miR-320c,hsa-miR-148a*, hsa-miR-449a, hsa-miR-378, hsa-miR-330-3p, hsa-miR-660,hsa-miR-548p, hsa-miR-449b, hsa-miR-212, hsa-miR-92b*, hsa-miR-1269,hsa-miR-15b, hsa-miR-320d, hsa-miR-132, hsa-miR-1291, hsa-miR-34a,hsa-miR-921, hsa-miR-376a*, hsa-miR-147, hsa-miR-220b, hsa-miR-505*,hsa-miR-1224-5p, hsa-miR-184, hsa-miR-518f*, hsa-miR-1285, hsa-miR-195,hsa-miR-545, hsa-miR-612, hsa-miR-520c-5p, hsa-miR-422a, hsa-miR-526b,hsa-miR-518e*, hsa-miR-593*, hsa-miR-526a, hsa-miR-523*, hsa-miR-149,hsa-miR-520h, hsa-miR-320a, hsa-miR-320b, hsa-miR-424, hsa-miR-15a,hsa-miR-455-3p, hsa-miR-519b-5p, hsa-miR-497, hsa-miR-519c-5p,hsa-miR-1302.

Chromosome 16 open reading frame 33—C16orf33—NM_(—)024571—hsa-miR-194*,hsa-miR-661, hsa-miR-1226*, hsa-miR-892b, hsa-miR-1231, hsa-miR-370,hsa-miR-660, hsa-miR-10a, hsa-miR-296-5p, hsa-miR-1200, hsa-miR-488,hsa-miR-935, hsa-miR-554, hsa-miR-516b, hsa-miR-361-3p, hsa-miR-628-5p,hsa-miR-583, hsa-miR-611, hsa-miR-149, hsa-miR-10b, hsa-miR-339-5p,hsa-miR-296-3p, hsa-let-7f-2*, hsa-miR-346.

Lactate dehydrogenase A—LDHA-NM_(—)005566—hsa-miR-34c-5p,hsa-miR-219-1-3p, hsa-miR-1290, hsa-miR-890, hsa-miR-449a, hsa-miR-30b,hsa-miR-449b, hsa-miR-410, hsa-miR-421, hsa-miR-641, hsa-miR-30a,hsa-miR-489, hsa-miR-1208, hsa-miR-34a, hsa-miR-1243, hsa-miR-505*,hsa-miR-105, hsa-miR-30d, hsa-miR-383, hsa-miR-491-3p, hsa-miR-33b,hsa-miR-203, hsa-miR-30c, hsa-miR-501-5p, hsa-miR-138-2*, hsa-miR-149,hsa-miR-297, hsa-miR-577, hsa-miR-33a, hsa-miR-409-3p, hsa-miR-455-3p,hsa-miR-338-3p, hsa-miR-1265, hsa-miR-193b*, hsa-miR-30e.

Major histocompatib-ility complex, classI-related—MR1—NM_(—)001531—hsa-miR-877, hsa-miR-645, hsa-miR-320c,hsa-miR-885-5p, hsa-miR-875-3p, hsa-miR-212, hsa-miR-320d, hsa-miR-132,hsa-miR-146a, hsa-miR-498, hsa-miR-505*, hsa-miR-146b-5p, hsa-miR-567,hsa-miR-1185, hsa-miR-583, hsa-miR-320a, hsa-miR-320b, hsa-miR-297,hsa-miR-455-3p, hsa-miR-367*, hsa-miR-1275.

Leucyl-tRNA synthetase—LARS—NM_(—)020117—hsa-miR-637, hsa-miR-520b,hsa-miR-515-5p, hsa-miR-625, hsa-miR-520g, hsa-miR-222*, hsa-miR-551b*,hsa-miR-320c, hsa-miR-520a-3p, hsa-miR-148a*, hsa-miR-142-5p,hsa-miR-302e, hsa-miR-134, hsa-miR-342-3p, hsa-miR-130b, hsa-miR-1246,hsa-miR-365, hsa-miR-301b, hsa-miR-302c, hsa-miR-548d-3p, hsa-miR-646,hsa-let-7b*, hsa-miR-411, hsa-miR-371-5p, hsa-miR-373, hsa-miR-1207-3p,hsa-miR-130a, hsa-miR-1286, hsa-miR-32*, hsa-miR-302d, hsa-miR-320d,hsa-miR-936, hsa-miR-186*, hsa-miR-520c-3p, hsa-miR-498, hsa-miR-633,hsa-miR-302a, hsa-miR-125a-3p, hsa-miR-512-3p, hsa-miR-520d-3p,hsa-miR-519d, hsa-miR-9*, hsa-miR-520e, hsa-miR-93, hsa-miR-634,hsa-miR-301a, hsa-miR-526b*, hsa-miR-744*, hsa-miR-519e*, hsa-let-7f-1*,hsa-miR-432*, hsa-miR-150, hsa-miR-205, hsa-miR-659, hsa-miR-20b,hsa-miR-378*, hsa-miR-1224-3p, hsa-miR-106a, hsa-miR-483-5p,hsa-miR-520h, hsa-miR-320a, hsa-miR-17, hsa-miR-106a*, hsa-miR-182,hsa-miR-320b, hsa-miR-454, hsa-miR-1264, hsa-miR-548k, hsa-miR-548l,hsa-miR-302b, hsa-miR-888*, hsa-miR-564, hsa-miR-20a, hsa-miR-183,hsa-let-7a*, hsa-miR-338-3p, hsa-miR-340, hsa-miR-193b*, hsa-miR-106b,hsa-miR-372.

GTP binding protein 1—GTPBP1—NM_(—)004286—hsa-miR-194*, hsa-miR-132*,hsa-miR-453, hsa-miR-637, hsa-miR-490-5p, hsa-miR-1266, hsa-miR-16,hsa-miR-20b*, hsa-miR-515-5p, hsa-miR-380*, hsa-miR-922, hsa-miR-138,hsa-miR-766, hsa-miR-650, hsa-miR-1276, hsa-miR-374b, hsa-miR-182*,hsa-miR-125a-5p, hsa-miR-483-3p, hsa-miR-193a-5p, hsa-miR-563,hsa-miR-214, hsa-miR-890, hsa-miR-490-3p, hsa-miR-92a-2*, hsa-miR-363*,hsa-miR-575, hsa-miR-320c, hsa-miR-511, hsa-miR-661, hsa-miR-544,hsa-miR-143, hsa-miR-1226*, hsa-miR-1237, hsa-miR-658, hsa-let-7c*,hsa-miR-886-3p, hsa-miR-1825, hsa-miR-1268, hsa-miR-298, hsa-miR-508-5p,hsa-miR-619, hsa-miR-370, hsa-miR-1207-5p, hsa-miR-623, hsa-miR-875-3p,hsa-miR-148a, hsa-miR-25*, hsa-miR-23a, hsa-miR-365, hsa-miR-337-3p,hsa-miR-10a, hsa-miR-33 a*, hsa-miR-491-5p, hsa-miR-218-2*,hsa-miR-151-3p, hsa-miR-146a*, hsa-miR-590-5p, hsa-miR-489,hsa-miR-324-3p, hsa-miR-1, hsa-miR-581, hsa-miR-1207-3p, hsa-miR-145,hsa-miR-616*, hsa-miR-874, hsa-miR-148b, hsa-miR-373*, hsa-miR-548f,hsa-miR-220c, hsa-miR-765, hsa-miR-624, hsa-miR-296-5p, hsa-miR-15b,hsa-miR-1324, hsa-miR-320d, hsa-miR-590-3p, hsa-miR-495, hsa-miR-29c,hsa-miR-589*, hsa-miR-1291, hsa-miR-1200, hsa-miR-29b, hsa-miR-135a,hsa-miR-605, hsa-miR-768-5p, hsa-miR-186*, hsa-miR-608, hsa-miR-27a*,hsa-miR-18b, hsa-miR-1226, hsa-miR-185*, hsa-miR-125b, hsa-miR-505*,hsa-miR-596, hsa-miR-29a, hsa-miR-940, hsa-miR-34b, hsa-miR-34b*,hsa-miR-1285, hsa-miR-195, hsa-miR-92a-1*, hsa-miR-612, hsa-miR-135b,hsa-miR-664*, hsa-miR-629*, hsa-miR-1260, hsa-miR-942, hsa-miR-152,hsa-miR-23b, hsa-miR-23a*, hsa-miR-1274a, hsa-miR-545*, hsa-miR-548a-3p,hsa-miR-23b*, hsa-miR-634, hsa-miR-33b*, hsa-miR-149*, hsa-miR-22*,hsa-miR-708*, hsa-miR-597, hsa-miR-519e*, hsa-miR-593*, hsa-miR-432*,hsa-miR-18a, hsa-miR-221*, hsa-miR-185, hsa-miR-378*, hsa-miR-1321,hsa-miR-100*, hsa-miR-149, hsa-miR-18a*, hsa-miR-30b*, hsa-miR-130a*,hsa-miR-519e, hsa-miR-550, hsa-miR-320a, hsa-miR-10b, hsa-miR-339-5p,hsa-miR-1827, hsa-miR-24, hsa-miR-135a*, hsa-miR-196a*, hsa-miR-663b,hsa-miR-500*, hsa-miR-320b, hsa-miR-1274b, hsa-miR-675, hsa-miR-424,hsa-miR-654-5p, hsa-miR-626, hsa-miR-1283, hsa-miR-187*, hsa-miR-548e,hsa-miR-21, hsa-miR-485-5p, hsa-miR-1278, hsa-miR-331-3p, hsa-miR-206,hsa-miR-196a, hsa-miR-377*, hsa-miR-15a, hsa-miR-632, hsa-miR-219-5p,hsa-miR-374a, hsa-miR-423-5p, hsa-miR-455-3p, hsa-miR-196b,hsa-miR-1272, hsa-miR-515-3p, hsa-miR-497, hsa-miR-296-3p, hsa-miR-1197,hsa-miR-346, hsa-miR-505, hsa-miR-541, hsa-miR-135b*, hsa-miR-1293,hsa-miR-613, hsa-miR-671-5p, hsa-miR-340*.

Protease, serine, 16—PRSS16—NM_(—)005865—hsa-miR-140-5p, hsa-miR-665,hsa-miR-1266, hsa-miR-542-3p, hsa-miR-922, hsa-miR-181a, hsa-miR-454*,hsa-miR-195*, hsa-miR-302c*, hsa-miR-214, hsa-miR-16-2*, hsa-miR-320c,hsa-miR-15b*, hsa-miR-28-5p, hsa-miR-19b, hsa-miR-129-5p, hsa-miR-130b,hsa-miR-587, hsa-miR-657, hsa-miR-1252, hsa-miR-580, hsa-miR-148a,hsa-miR-600, hsa-miR-524-5p, hsa-miR-543, hsa-miR-23a, hsa-miR-301b,hsa-miR-641, hsa-miR-708, hsa-miR-130a, hsa-miR-552, hsa-miR-148b,hsa-miR-320d, hsa-miR-591, hsa-miR-767-3p, hsa-miR-1291, hsa-miR-1226,hsa-miR-1224-5p, hsa-miR-624*, hsa-miR-92a-1*, hsa-miR-198, hsa-miR-545,hsa-miR-181d, hsa-miR-192*, hsa-miR-152, hsa-miR-23b, hsa-miR-539,hsa-miR-634, hsa-miR-149*, hsa-miR-301a, hsa-miR-571, hsa-miR-593*,hsa-miR-1300, hsa-miR-181c, hsa-miR-224, hsa-miR-185, hsa-miR-130a*,hsa-miR-320a, hsa-miR-7, hsa-miR-320b, hsa-miR-454, hsa-miR-654-5p,hsa-miR-181b, hsa-miR-137, hsa-miR-577, hsa-miR-19a, hsa-miR-338-3p,hsa-miR-1265, hsa-miR-1197, hsa-miR-541, hsa-miR-520d-5p.

WAP four-disulfide core domain 2—WFDC2—NM_(—)006103—hsa-miR-140-5p,hsa-miR-129-5p, hsa-miR-767-3p, hsa-miR-92a-1*, hsa-miR-149*,hsa-miR-654-5p, hsa-miR-541.

Aurora kinase B—AURKB—NM_(—)004217—hsa-miR-502-3p, hsa-miR-509-3-5p,hsa-miR-490-5p, hsa-miR-493*, hsa-miR-138, hsa-let-7d, hsa-miR-766,hsa-miR-550*, hsa-miR-551b*, hsa-miR-647, hsa-miR-1248, hsa-miR-335,hsa-miR-320c, hsa-miR-661, hsa-miR-31*, hsa-miR-31, hsa-miR-148a*,hsa-miR-142-5p, hsa-miR-379*, hsa-miR-190, hsa-miR-548n, hsa-miR-603,hsa-miR-508-5p, hsa-let-7e, hsa-miR-103, hsa-miR-548p, hsa-miR-33a*,hsa-miR-302f, hsa-miR-520a-5p, hsa-miR-410, hsa-miR-421, hsa-miR-646,hsa-miR-525-5p, hsa-miR-622, hsa-miR-1227, hsa-miR-145, hsa-miR-616*,hsa-miR-373*, hsa-let-7f, hsa-miR-32*, hsa-miR-765, hsa-miR-320d,hsa-miR-29c, hsa-miR-7-1*, hsa-miR-1208, hsa-miR-589*, hsa-miR-26b*,hsa-miR-1253, hsa-miR-190b, hsa-miR-29b, hsa-miR-579, hsa-miR-411*,hsa-miR-200c*, hsa-miR-147, hsa-miR-633, hsa-miR-1224-5p, hsa-miR-888,hsa-miR-29a, hsa-miR-503, hsa-miR-488, hsa-let-7g, hsa-miR-1285,hsa-miR-15a*, hsa-miR-612, hsa-miR-9*, hsa-miR-607, hsa-miR-200a,hsa-miR-548b-3p, hsa-let-7i, hsa-miR-1255a, hsa-miR-634, hsa-miR-526b,hsa-let-7b, hsa-miR-141, hsa-miR-223, hsa-let-7a, hsa-miR-98,hsa-miR-203, hsa-miR-583, hsa-miR-17*, hsa-miR-30b*, hsa-miR-758,hsa-miR-320a, hsa-let-7c, hsa-miR-1228, hsa-miR-24, hsa-miR-548c-3p,hsa-miR-1279, hsa-miR-320b, hsa-miR-548l, hsa-miR-1283, hsa-miR-485-5p,hsa-miR-7-2*, hsa-miR-107, hsa-miR-338-3p, hsa-miR-509-5p, hsa-miR-944,hsa-miR-501-3p, hsa-miR-16-1*, hsa-miR-649, hsa-miR-1183, hsa-miR-1255b,hsa-miR-1205.

3-hydroxybutyrate dehydrogenase, type 2—BDH2—NM_(—)020139—hsa-miR-376b,hsa-miR-509-3-5p, hsa-miR-642, hsa-miR-27b*, hsa-miR-130b*, hsa-miR-648,hsa-miR-1276, hsa-miR-1184, hsa-miR-520g, hsa-miR-519b-3p, hsa-miR-195*,hsa-miR-302c*, hsa-miR-487a, hsa-miR-193a-5p, hsa-miR-1304,hsa-miR-92a-2*, hsa-miR-16-2*, hsa-miR-148a*, hsa-miR-143,hsa-miR-26a-1*, hsa-miR-142-5p, hsa-miR-335*, hsa-miR-519c-3p,hsa-miR-129-5p, hsa-miR-1178, hsa-miR-217, hsa-miR-519a, hsa-miR-1182,hsa-miR-651, hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-143*, hsa-miR-186,hsa-miR-33a*, hsa-miR-590-5p, hsa-miR-371-5p, hsa-miR-489, hsa-miR-376a,hsa-miR-874, hsa-miR-26b, hsa-miR-573, hsa-miR-32*, hsa-miR-590-3p,hsa-miR-495, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-635, hsa-miR-767-3p,hsa-miR-589*, hsa-miR-579, hsa-miR-26a-2*, hsa-miR-605, hsa-miR-1243,hsa-miR-186*, hsa-miR-509-3p, hsa-miR-1262, hsa-miR-384, hsa-miR-34b,hsa-miR-1270, hsa-miR-18b*, hsa-miR-519d, hsa-miR-200a, hsa-miR-93,hsa-miR-554, hsa-miR-1260, hsa-miR-620, hsa-miR-141, hsa-miR-526b*,hsa-miR-1185, hsa-miR-150, hsa-miR-1284, hsa-miR-20b, hsa-miR-556-5p,hsa-miR-106a, hsa-miR-1245, hsa-miR-30b*, hsa-miR-520h, hsa-miR-431,hsa-miR-17, hsa-miR-106a*, hsa-miR-656, hsa-miR-548l, hsa-miR-21,hsa-miR-485-5p, hsa-miR-888*, hsa-miR-7-2*, hsa-miR-377*, hsa-miR-601,hsa-miR-20a, hsa-miR-425, hsa-miR-126*, hsa-miR-509-5p, hsa-miR-944,hsa-miR-106b, hsa-miR-505, hsa-miR-26a, hsa-miR-142-3p, hsa-miR-520d-5p,hsa-miR-154*.

Dehydrogenase/reductase (SDR family) member4—DHRS4—NM_(—)021004—hsa-miR-194*, hsa-miR-557, hsa-miR-665,hsa-miR-1266, hsa-miR-922, hsa-miR-513a-5p, hsa-miR-214, hsa-miR-507,hsa-miR-28-5p, hsa-miR-508-5p, hsa-miR-1207-5p, hsa-miR-1287,hsa-miR-379, hsa-miR-208a, hsa-miR-708, hsa-miR-29a*, hsa-miR-220c,hsa-miR-29c, hsa-miR-29b, hsa-miR-579, hsa-miR-605, hsa-miR-1262,hsa-miR-214*, hsa-miR-29a, hsa-miR-450b-5p, hsa-miR-20a*, hsa-miR-452*,hsa-miR-10b*, hsa-miR-942, hsa-miR-1257, hsa-miR-208b, hsa-miR-663b,hsa-miR-500*, hsa-miR-382, hsa-miR-626, hsa-miR-512-5p.

Abhydrolase domain containing 14B—ABHD14B—NM_(—)032750—hsa-miR-637,hsa-miR-520b, hsa-miR-380, hsa-miR-562, hsa-let-7d, hsa-miR-1184,hsa-miR-615-5p, hsa-miR-204, hsa-miR-1289, hsa-miR-532-3p,hsa-miR-30c-1*, hsa-miR-92a-2*, hsa-miR-575, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-661, hsa-miR-302e, hsa-let-7c*, hsa-miR-298,hsa-let-7e, hsa-miR-1252, hsa-miR-1246, hsa-miR-576-5p, hsa-miR-30c-2*,hsa-miR-302c, hsa-miR-491-5p, hsa-miR-520a-5p, hsa-miR-145*,hsa-miR-525-5p, hsa-miR-373, hsa-miR-581, hsa-let-7f, hsa-miR-302d,hsa-miR-765, hsa-miR-320d, hsa-miR-1253, hsa-miR-1200, hsa-miR-520f,hsa-miR-147, hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-517b,hsa-miR-302a, hsa-let-7g, hsa-miR-940, hsa-miR-1294, hsa-miR-588,hsa-miR-1285, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-198, hsa-miR-612,hsa-miR-299-3p, hsa-miR-636, hsa-miR-520e, hsa-miR-1258,hsa-miR-548b-3p, hsa-miR-1260, hsa-let-7i, hsa-miR-609, hsa-let-7b,hsa-miR-149*, hsa-miR-328, hsa-let-7a, hsa-miR-98, hsa-miR-211,hsa-miR-583, hsa-miR-527, hsa-miR-185, hsa-miR-100*, hsa-miR-1224-3p,hsa-miR-149, hsa-miR-30b*, hsa-miR-320a, hsa-miR-555, hsa-let-7c,hsa-miR-663b, hsa-miR-320b, hsa-miR-297, hsa-miR-302b, hsa-miR-455-3p,hsa-miR-649, hsa-miR-372, hsa-miR-367*.

EF-hand calcium binding domain 4A—EFCAB4A—NM_(—)173584—hsa-miR-194*,hsa-miR-637, hsa-miR-645, hsa-miR-16, hsa-miR-1184, hsa-miR-1301,hsa-miR-483-3p, hsa-miR-668, hsa-miR-214, hsa-miR-661, hsa-miR-93*,hsa-miR-148a, hsa-miR-615-3p, hsa-miR-143*, hsa-miR-148b, hsa-miR-15b,hsa-miR-1200, hsa-miR-185*, hsa-miR-596, hsa-miR-940, hsa-miR-588,hsa-miR-195, hsa-miR-504, hsa-miR-152, hsa-miR-551a, hsa-miR-205,hsa-miR-424, hsa-miR-654-5p, hsa-miR-15a, hsa-miR-193b*, hsa-miR-887,hsa-miR-497, hsa-miR-551b, hsa-miR-602, hsa-miR-541.

Enoyl Coenzyme A hydratase domain containing2—ECHDC2—NM_(—)018281—hsa-miR-141*, hsa-miR-218-1*, hsa-miR-127-5p,hsa-miR-330-3p, hsa-miR-1237, hsa-miR-576-5p, hsa-miR-362-5p,hsa-miR-26b, hsa-miR-1297, hsa-miR-588, hsa-miR-516b, hsa-miR-203,hsa-miR-659, hsa-miR-1272, hsa-miR-26a.

Golgi autoantigen, golgin subfamilya,8B—GOLGA8B—NM_(—)001023567—hsa-miR-557, hsa-miR-200b, hsa-miR-520b,hsa-miR-32, hsa-miR-130b*, hsa-miR-192, hsa-miR-1184, hsa-miR-374b,hsa-miR-1301, hsa-miR-181a, hsa-miR-551b*, hsa-miR-513b, hsa-miR-487a,hsa-miR-193a-5p, hsa-miR-96, hsa-miR-532-3p, hsa-miR-377,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-1267, hsa-miR-548b-5p,hsa-miR-520a-3p, hsa-miR-513a-3p, hsa-miR-507, hsa-miR-1226*,hsa-miR-302a*, hsa-miR-19b, hsa-miR-302e, hsa-miR-548c-5p, hsa-miR-603,hsa-miR-128, hsa-miR-92b, hsa-miR-130b, hsa-miR-651, hsa-miR-148a,hsa-miR-586, hsa-miR-367, hsa-miR-582-5p, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-543, hsa-miR-25, hsa-miR-23a, hsa-miR-301b, hsa-miR-1305,hsa-miR-33a*, hsa-miR-302c, hsa-miR-548i, hsa-miR-646, hsa-miR-153,hsa-miR-30a*, hsa-miR-30a, hsa-miR-373, hsa-miR-200c, hsa-miR-130a,hsa-miR-145, hsa-miR-148b, hsa-let-7i*, hsa-miR-664, hsa-miR-1269,hsa-miR-302d, hsa-miR-628-3p, hsa-miR-590-3p, hsa-miR-1271, hsa-miR-215,hsa-miR-589*, hsa-miR-936, hsa-miR-520c-3p, hsa-miR-518a-5p,hsa-miR-498, hsa-miR-1226, hsa-miR-144, hsa-miR-302a, hsa-miR-30d*,hsa-miR-30e*, hsa-miR-429, hsa-miR-105, hsa-miR-548d-5p, hsa-miR-1270,hsa-miR-520d-3p, hsa-miR-331-5p, hsa-miR-450b-5p, hsa-miR-181d,hsa-miR-935, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607, hsa-miR-520e,hsa-miR-30d, hsa-miR-629, hsa-miR-934, hsa-miR-548b-3p, hsa-miR-1260,hsa-miR-152, hsa-miR-23b, hsa-miR-101, hsa-miR-1257, hsa-miR-634,hsa-miR-526b, hsa-miR-620, hsa-miR-139-5p, hsa-miR-301a, hsa-miR-223,hsa-miR-203, hsa-miR-548h, hsa-miR-92a, hsa-miR-708*, hsa-miR-597,hsa-miR-1238, hsa-miR-30c, hsa-miR-181c, hsa-miR-224, hsa-miR-527,hsa-miR-877*, hsa-miR-18a*, hsa-miR-130a*, hsa-miR-202*, hsa-miR-1249,hsa-miR-1279, hsa-miR-656, hsa-miR-182, hsa-miR-454, hsa-miR-1264,hsa-miR-302b, hsa-miR-181b, hsa-miR-655, hsa-miR-485-5p, hsa-miR-137,hsa-miR-196 a, hsa-miR-19a, hsa-miR-485-3p, hsa-miR-374a, hsa-miR-601,hsa-miR-876-3p, hsa-miR-196b, hsa-miR-363, hsa-miR-1265,hsa-miR-219-2-3p, hsa-miR-369-3p, hsa-miR-16-1*, hsa-miR-372,hsa-miR-154, hsa-miR-520d-5p, hsa-miR-1302, hsa-miR-154*, hsa-miR-30e.

ATPase type 13A3—ATP13A3—NM_(—)024524—hsa-miR-376b, hsa-miR-200b,hsa-miR-34c-5p, hsa-miR-380, hsa-miR-16, hsa-miR-513a-5p, hsa-miR-133a,hsa-miR-519b-3p, hsa-miR-182*, hsa-miR-195*, hsa-miR-125a-5p,hsa-miR-548g, hsa-let-7g*, hsa-miR-532-3p, hsa-miR-548a-5p,hsa-miR-376c, hsa-miR-559, hsa-miR-548b-5p, hsa-miR-452, hsa-miR-16-2*,hsa-miR-320c, hsa-miR-511, hsa-miR-15b*, hsa-miR-31, hsa-miR-513a-3p,hsa-miR-142-5p, hsa-miR-335*, hsa-miR-449a, hsa-miR-190, hsa-miR-302a*,hsa-miR-519c-3p, hsa-miR-129-5p, hsa-miR-194, hsa-miR-548n,hsa-miR-892b, hsa-miR-548c-5p, hsa-miR-519a, hsa-miR-130b, hsa-miR-1287,hsa-miR-875-3p, hsa-miR-103, hsa-miR-1246, hsa-miR-600, hsa-miR-338-5p,hsa-miR-543, hsa-miR-34a*, hsa-miR-186, hsa-miR-365, hsa-miR-301b,hsa-miR-449b, hsa-miR-618, hsa-miR-33a*, hsa-miR-548i, hsa-miR-606,hsa-miR-520a-5p, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-151-3p,hsa-miR-153, hsa-miR-525-5p, hsa-miR-494, hsa-miR-30a*, hsa-miR-376a,hsa-miR-200c, hsa-miR-130a, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f,hsa-miR-1286, hsa-miR-664, hsa-miR-32*, hsa-miR-532-5p, hsa-miR-15b,hsa-miR-320d, hsa-miR-590-3p, hsa-miR-495, hsa-miR-513c, hsa-miR-7-1*,hsa-miR-1208, hsa-miR-589, hsa-miR-1253, hsa-miR-190b, hsa-miR-1200,hsa-miR-34a, hsa-miR-643, hsa-miR-579, hsa-miR-361-5p, hsa-miR-1243,hsa-miR-498, hsa-miR-125b, hsa-miR-384, hsa-miR-653, hsa-miR-505*,hsa-miR-888, hsa-miR-30d*, hsa-miR-802, hsa-miR-568, hsa-miR-30e*,hsa-miR-21*, hsa-miR-429, hsa-miR-570, hsa-miR-105, hsa-miR-517*,hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-1261, hsa-miR-1270, hsa-miR-34b*,hsa-miR-195, hsa-miR-9*, hsa-miR-548j, hsa-miR-607, hsa-miR-1258,hsa-miR-629*, hsa-miR-383, hsa-miR-155*, hsa-miR-518c*, hsa-miR-1260,hsa-miR-548a-3p, hsa-miR-526b, hsa-miR-133b, hsa-miR-620, hsa-miR-301a,hsa-miR-548h, hsa-miR-625*, hsa-miR-708*, hsa-let-7f-1*,hsa-miR-181a-2*, hsa-miR-760, hsa-miR-640, hsa-miR-100*,hsa-miR-1224-3p, hsa-miR-1245, hsa-miR-149, hsa-miR-320a,hsa-miR-486-5p, hsa-miR-202*, hsa-miR-1228, hsa-miR-1299,hsa-miR-548c-3p, hsa-miR-135a*, hsa-miR-1279, hsa-miR-656, hsa-miR-182,hsa-miR-320b, hsa-miR-454, hsa-miR-297, hsa-miR-548l, hsa-miR-424,hsa-miR-1283, hsa-miR-548e, hsa-miR-655, hsa-miR-137, hsa-miR-7-2*,hsa-miR-107, hsa-miR-15a, hsa-miR-409-3p, hsa-miR-183, hsa-let-7a*,hsa-miR-340, hsa-miR-497, hsa-miR-296-3p, hsa-let-7f-2*, hsa-miR-16-1*,hsa-miR-223*.

Prolyl endopeptidase-like—PREPL—Variant C, Variant D and VariantE—NM_(—)006036, NM_(—)001042386 and NM_(—)001042385—hsa-miR-194*,hsa-miR-376b, hsa-miR-877, hsa-miR-1254, hsa-miR-642, hsa-miR-500,hsa-miR-27b*, hsa-miR-19b-2*, hsa-miR-875-5p, hsa-miR-150*,hsa-miR-551b*, hsa-let-7g*, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-1248,hsa-miR-138-1*, hsa-miR-548b-5p, hsa-miR-511, hsa-miR-31, hsa-miR-143,hsa-miR-379*, hsa-miR-29b-1*, hsa-miR-28-5p, hsa-miR-129-5p,hsa-miR-548n, hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-128,hsa-miR-199a-5p, hsa-miR-1287, hsa-miR-580, hsa-miR-548p, hsa-miR-586,hsa-miR-621, hsa-miR-338-5p, hsa-miR-19b-1*, hsa-miR-524-5p,hsa-miR-30b, hsa-miR-543, hsa-miR-618, hsa-miR-1305, hsa-miR-33a*,hsa-miR-548i, hsa-miR-708, hsa-miR-590-5p, hsa-miR-494, hsa-miR-411,hsa-miR-30a*, hsa-miR-30a, hsa-miR-29a*, hsa-miR-376a, hsa-miR-1286,hsa-miR-26b, hsa-miR-569, hsa-miR-32*, hsa-miR-590-3p, hsa-miR-495,hsa-miR-513c, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-1208, hsa-miR-767-3p,hsa-miR-589*, hsa-miR-26b*, hsa-miR-135a, hsa-miR-411*, hsa-miR-1259,hsa-miR-185*, hsa-miR-384, hsa-miR-888, hsa-miR-30d*, hsa-miR-654-3p,hsa-miR-30e*, hsa-miR-21 *, hsa-miR-624*, hsa-miR-488, hsa-miR-105,hsa-miR-508-3p, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-210, hsa-miR-34b*,hsa-miR-935, hsa-miR-135b, hsa-miR-548j, hsa-miR-200a, hsa-miR-30d,hsa-miR-192*, hsa-miR-934, hsa-miR-545*, hsa-miR-149*, hsa-miR-302d*,hsa-miR-141, hsa-miR-548h, hsa-miR-381, hsa-miR-744*, hsa-miR-432*,hsa-miR-30c, hsa-miR-451, hsa-miR-583, hsa-miR-501-5p, hsa-miR-199b-5p,hsa-miR-205, hsa-miR-185, hsa-miR-556-5p, hsa-miR-1321, hsa-miR-1827,hsa-miR-548c-3p, hsa-miR-196a*, hsa-miR-1279, hsa-miR-656, hsa-miR-182,hsa-miR-1283, hsa-miR-21, hsa-miR-655, hsa-miR-7-2*, hsa-miR-300,hsa-miR-485-3p, hsa-miR-632, hsa-miR-944, hsa-miR-499-5p, hsa-miR-1197,hsa-miR-218, hsa-miR-302b*, hsa-miR-367*, hsa-miR-26a, hsa-miR-520d-5p,hsa-miR-512-5p, hsa-miR-30e.

Cytochrome P450, family 4, subfamily V, polypeptide2—CYP4V2—NM_(—)207352—hsa-miR-194*, hsa-miR-510, hsa-miR-200b,hsa-miR-520b, hsa-miR-20b*, hsa-miR-130b*, hsa-miR-766, hsa-miR-9,hsa-miR-374b, hsa-miR-101*, hsa-miR-519b-3p, hsa-miR-125a-5p,hsa-miR-483-3p, hsa-miR-548g, hsa-miR-28-3p, hsa-miR-1826,hsa-miR-490-3p, hsa-miR-1267, hsa-miR-516a-3p, hsa-miR-520a-3p,hsa-miR-661, hsa-miR-148a*, hsa-miR-548m, hsa-miR-183*, hsa-miR-519c-3p,hsa-miR-194, hsa-miR-548n, hsa-miR-302e, hsa-miR-134, hsa-miR-519a,hsa-miR-1268, hsa-miR-298, hsa-miR-587, hsa-miR-216b, hsa-miR-103,hsa-miR-660, hsa-miR-576-5p, hsa-miR-582-5p, hsa-miR-1296, hsa-miR-34a*,hsa-miR-1236, hsa-miR-618, hsa-miR-10a, hsa-miR-33a*, hsa-miR-302c,hsa-miR-302f, hsa-miR-606, hsa-miR-641, hsa-miR-516b*, hsa-miR-145*,hsa-miR-582-3p, hsa-miR-371-5p, hsa-miR-29a*, hsa-miR-622, hsa-miR-548o,hsa-miR-373, hsa-miR-200c, hsa-miR-145, hsa-miR-616*, hsa-miR-373*,hsa-miR-548f, hsa-miR-573, hsa-miR-1269, hsa-miR-302d, hsa-miR-1202,hsa-miR-495, hsa-miR-513c, hsa-miR-1200, hsa-miR-135a, hsa-miR-520c-3p,hsa-miR-498, hsa-miR-1323, hsa-miR-125b, hsa-miR-302a, hsa-miR-888,hsa-miR-802, hsa-miR-429, hsa-miR-570, hsa-miR-124, hsa-miR-517*,hsa-miR-940, hsa-miR-34b, hsa-miR-1270, hsa-miR-769-3p, hsa-miR-450b-3p,hsa-miR-520d-3p, hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-144*,hsa-miR-135b, hsa-miR-9*, hsa-miR-607, hsa-miR-520e, hsa-miR-578,hsa-miR-93, hsa-miR-566, hsa-miR-548a-3p, hsa-miR-516b, hsa-miR-526b,hsa-miR-620, hsa-miR-223, hsa-miR-526b*, hsa-miR-708*, hsa-miR-628-5p,hsa-miR-1273, hsa-miR-205, hsa-miR-185, hsa-miR-20b, hsa-miR-106a,hsa-miR-877*, hsa-miR-30b*, hsa-miR-758, hsa-miR-10b, hsa-miR-197,hsa-miR-339-5p, hsa-miR-1827, hsa-miR-17, hsa-miR-1279, hsa-miR-297,hsa-miR-548k, hsa-miR-1274b, hsa-miR-548l, hsa-miR-506, hsa-miR-302b,hsa-miR-548e, hsa-miR-485-5p, hsa-miR-377*, hsa-miR-107, hsa-miR-374a,hsa-miR-556-3p, hsa-miR-601, hsa-miR-20a, hsa-miR-425, hsa-miR-340,hsa-miR-140-3p, hsa-miR-106b, hsa-miR-369-3p, hsa-miR-649, hsa-miR-372,hsa-miR-1183, hsa-miR-223*, hsa-miR-433, hsa-miR-154, hsa-miR-135b*.

JTV1—JTV1—NM_(—)006303—hsa-miR-1276, hsa-miR-549, hsa-miR-29c,hsa-miR-29b, hsa-miR-193a-3p, hsa-miR-29a, hsa-miR-935, hsa-miR-514,hsa-miR-193b, hsa-miR-1322, hsa-miR-381, hsa-miR-345, hsa-miR-655,hsa-miR-300, hsa-miR-767-5p.

Isoprenyl-cysteine carboxylmethyltransferase—ICMT—NM_(—)012405—hsa-miR-194*, hsa-miR-510,hsa-miR-34c-5p, hsa-miR-645, hsa-miR-380, hsa-miR-16, hsa-miR-515-5p,hsa-miR-22, hsa-miR-922, hsa-miR-138, hsa-miR-216a, hsa-miR-219-1-3p,hsa-let-7d, hsa-miR-513a-5, hsa-miR-766, hsa-miR-650, hsa-miR-1276,hsa-miR-1184, hsa-miR-9, hsa-miR-101*, hsa-miR-181a, hsa-miR-551b*,hsa-miR-519b-3p, hsa-miR-644, hsa-miR-204, hsa-miR-193 a-5p,hsa-miR-532-3p, hsa-miR-377, hsa-miR-549, hsa-miR-92a-2*,hsa-miR-516a-3p, hsa-miR-496, hsa-miR-661, hsa-miR-99a, hsa-miR-24-1*,hsa-miR-486-3p, hsa-miR-449a, hsa-miR-29b-1*, hsa-miR-330-3p,hsa-miR-28-5p, hsa-miR-1226*, hsa-miR-1237, hsa-miR-519c-3p,hsa-miR-19b, hsa-miR-541*, hsa-miR-217, hsa-miR-146b-3p, hsa-let-7c*,hsa-miR-519a, hsa-miR-1268, hsa-miR-508-5p, hsa-miR-130b, hsa-miR-1231,hsa-let-7e, hsa-miR-1280, hsa-miR-875-3p, hsa-miR-216b, hsa-miR-580,hsa-miR-586, hsa-miR-524-5p, hsa-miR-143*, hsa-miR-186, hsa-miR-23a,hsa-miR-301b, hsa-miR-449b, hsa-miR-33a*, hsa-miR-302f, hsa-miR-1201,hsa-miR-410, hsa-miR-421, hsa-miR-24-2*, hsa-miR-516b*, hsa-miR-646,hsa-miR-708, hsa-miR-1281, hsa-miR-1, hsa-miR-1227, hsa-miR-1207-3p,hsa-miR-130a, hsa-miR-220c, hsa-miR-664, hsa-let-7f, hsa-miR-573,hsa-miR-32*, hsa-miR-15b, hsa-miR-1324, hsa-miR-188-3p, hsa-miR-96*,hsa-miR-502-5p, hsa-miR-495, hsa-miR-513c, hsa-miR-589*, hsa-miR-1291,hsa-miR-1200, hsa-miR-885-3p, hsa-miR-34a, hsa-miR-605, hsa-miR-518a-5p,hsa-miR-608, hsa-miR-886-5p, hsa-miR-1224-5p, hsa-miR-888,hsa-miR-654-3p, hsa-miR-21*, hsa-miR-503, hsa-miR-488, hsa-miR-570,hsa-let-7g, hsa-miR-940, hsa-miR-34b, hsa-miR-1294, hsa-miR-210,hsa-miR-148b*, hsa-miR-1285, hsa-miR-195, hsa-miR-331-5p, hsa-miR-519d,hsa-miR-198, hsa-miR-545, hsa-miR-181d, hsa-miR-612, hsa-miR-9*,hsa-miR-200a, hsa-miR-629*, hsa-miR-93, hsa-miR-1206, hsa-miR-554,hsa-miR-200b*, hsa-miR-518c*, hsa-miR-1260, hsa-let-7i, hsa-miR-23b,hsa-miR-101, hsa-miR-1229, hsa-miR-516b, hsa-miR-526b, hsa-let-7b,hsa-miR-330-5p, hsa-miR-301a, hsa-miR-141, hsa-let-7a, hsa-miR-526b*,hsa-miR-22*, hsa-miR-98, hsa-miR-203, hsa-miR-708*, hsa-miR-744*,hsa-miR-211, hsa-miR-519e*, hsa-miR-361-3p, hsa-miR-628-5p, hsa-miR-150,hsa-miR-181c, hsa-miR-583, hsa-miR-501-5p, hsa-miR-527, hsa-miR-20b,hsa-miR-1256, hsa-miR-640, hsa-miR-106a, hsa-miR-877*, hsa-miR-18a*,hsa-miR-30b*, hsa-miR-99b, hsa-miR-130a*, hsa-miR-483-5p, hsa-miR-522,hsa-let-7c, hsa-miR-202*, hsa-miR-1827, hsa-miR-100, hsa-miR-17,hsa-miR-663b, hsa-miR-106a*, hsa-miR-454, hsa-miR-1274b, hsa-miR-424,hsa-miR-654-5p, hsa-miR-181b, hsa-miR-1283, hsa-miR-485-5p, hsa-miR-614,hsa-miR-137, hsa-miR-331-3p, hsa-miR-888*, hsa-miR-206, hsa-miR-122,hsa-miR-377*, hsa-miR-19a, hsa-miR-188-5p, hsa-miR-15a, hsa-miR-485-3p,hsa-miR-632, hsa-miR-564, hsa-miR-601, hsa-miR-20a, hsa-miR-338-3p,hsa-miR-340, hsa-miR-193b*, hsa-miR-106b, hsa-miR-497, hsa-miR-16-1*,hsa-miR-346, hsa-miR-367*, hsa-miR-326, hsa-miR-497*, hsa-miR-433,hsa-miR-1234, hsa-miR-1275, hsa-miR-541, hsa-miR-520d-5p, hsa-miR-200a*,hsa-miR-1205, hsa-miR-613, hsa-miR-512-5p, hsa-miR-340*.

DNA (cytosine-5-)-methyltransferase 3 alpha—DNMT3A—Variant 1, Variant 2and Variant 3—NM_(—)175629, NM_(—)153759 and NM_(—)022552—hsa-miR-200b,hsa-miR-130b*, hsa-miR-19b-2*, hsa-miR-548g, hsa-miR-204, hsa-let-7g*,hsa-miR-532-3p, hsa-miR-490-3p, hsa-miR-1248, hsa-miR-920,hsa-miR-92a-2*, hsa-miR-148a*, hsa-miR-143, hsa-miR-129-5p, hsa-miR-943,hsa-miR-194, hsa-miR-19a*, hsa-miR-298, hsa-miR-370, hsa-miR-1280,hsa-miR-1207-5p, hsa-miR-19b-1*, hsa-miR-30b, hsa-miR-548d-3p,hsa-miR-146a*, hsa-miR-30a*, hsa-miR-30a, hsa-miR-29a*, hsa-miR-200c,hsa-miR-581, hsa-miR-362-5p, hsa-miR-720, hsa-miR-188-3p, hsa-miR-599,hsa-miR-495, hsa-miR-29c, hsa-miR-589, hsa-miR-29b, hsa-miR-147,hsa-miR-1233, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-429, hsa-miR-29a,hsa-miR-570, hsa-miR-148b*, hsa-miR-578, hsa-miR-30d, hsa-miR-518c*,hsa-miR-523, hsa-miR-1260, hsa-miR-942, hsa-miR-101, hsa-miR-567,hsa-miR-149*, hsa-miR-211, hsa-miR-150, hsa-miR-30c, hsa-miR-1224-3p,hsa-miR-199a-3p, hsa-miR-149, hsa-miR-30b*, hsa-miR-548c-3p,hsa-miR-297, hsa-miR-626, hsa-miR-199b-3p, hsa-miR-1244, hsa-miR-627,hsa-miR-767-5p, hsa-miR-193b*, hsa-miR-1183, hsa-miR-30e.

DNMT3A—Variant 4—NM_(—)175630—hsa-miR-510, hsa-miR-200b, hsa-miR-1266,hsa-miR-518a-3p, hsa-miR-1306, hsa-miR-518e, hsa-miR-650, hsa-miR-487a,hsa-miR-548g, hsa-miR-30c-1*, hsa-miR-490-3p, hsa-miR-575, hsa-miR-661,hsa-miR-513a-3p, hsa-miR-335*, hsa-miR-217, hsa-miR-146b-3p,hsa-miR-508-5p, hsa-miR-370, hsa-miR-1207-5p, hsa-miR-875-3p,hsa-miR-1252, hsa-miR-630, hsa-miR-30c-2*, hsa-miR-33a*, hsa-miR-302f,hsa-miR-548o, hsa-miR-200c, hsa-miR-145, hsa-miR-518b, hsa-miR-1291,hsa-miR-873, hsa-miR-1323, hsa-miR-429, hsa-miR-105, hsa-miR-1285,hsa-miR-423-3p, hsa-miR-15a*, hsa-miR-612, hsa-miR-328, hsa-miR-551a,hsa-miR-518c, hsa-miR-492, hsa-miR-744*, hsa-miR-361-3p, hsa-miR-1300,hsa-miR-221*, hsa-miR-1321, hsa-miR-18a*, hsa-miR-30b*, hsa-miR-486-5p,hsa-miR-24, hsa-miR-1299, hsa-miR-518f, hsa-miR-7, hsa-miR-182,hsa-miR-345, hsa-miR-654-5p, hsa-miR-1283, hsa-miR-187*,hsa-miR-518d-3p, hsa-miR-485-3p, hsa-miR-183, hsa-miR-551b,hsa-miR-367*, hsa-miR-541, hsa-miR-891b, hsa-miR-558, hsa-miR-154*.

Histamine N-methyltransferase—HNMT—Variant 1 and Variant 2—NM_(—)006985and NM_(—)001024074—hsa-miR-124*, hsa-miR-557, hsa-miR-32,hsa-miR-542-3p, hsa-miR-222*, hsa-miR-374b, hsa-miR-487a, hsa-miR-221,hsa-miR-127-5p, hsa-miR-516a-3p, hsa-miR-452, hsa-miR-320c,hsa-miR-513a-3p, hsa-miR-142-5p, hsa-miR-335*, hsa-miR-507,hsa-miR-1226*, hsa-miR-129-5p, hsa-miR-943, hsa-miR-1288, hsa-miR-134,hsa-miR-92b, hsa-miR-619, hsa-miR-587, hsa-miR-199a-5p, hsa-miR-623,hsa-miR-1252, hsa-miR-630, hsa-miR-580, hsa-miR-148a, hsa-miR-299-5p,hsa-miR-576-5p, hsa-miR-548p, hsa-miR-586, hsa-miR-367, hsa-miR-524-5p,hsa-miR-543, hsa-miR-34a*, hsa-miR-25, hsa-miR-186, hsa-miR-33a*,hsa-miR-516b*, hsa-let-7b*, hsa-miR-590-5p, hsa-miR-494, hsa-miR-548o,hsa-miR-148b, hsa-miR-362-5p, hsa-miR-664, hsa-miR-1269, hsa-miR-765,hsa-miR-624, hsa-miR-320d, hsa-miR-96*, hsa-miR-590-3p, hsa-miR-7-1*,hsa-miR-1208, hsa-miR-643, hsa-miR-579, hsa-miR-361-5p, hsa-miR-520f,hsa-miR-18b, hsa-miR-1323, hsa-miR-384, hsa-miR-653, hsa-miR-802,hsa-miR-596, hsa-miR-21*, hsa-miR-570, hsa-miR-124, hsa-miR-325,hsa-miR-1261, hsa-miR-222, hsa-miR-768-3p, hsa-miR-125a-3p,hsa-miR-15a*, hsa-miR-20a*, hsa-miR-545, hsa-miR-664*, hsa-miR-323-3p,hsa-miR-200a, hsa-miR-629, hsa-miR-155*, hsa-miR-152, hsa-miR-1255a,hsa-miR-33b, hsa-miR-634, hsa-miR-526b, hsa-miR-139-5p, hsa-miR-141,hsa-miR-22*, hsa-miR-92a, hsa-miR-593*, hsa-let-7f-1*, hsa-miR-1300,hsa-miR-628-5p, hsa-let-7e*, hsa-miR-199b-5p, hsa-miR-493, hsa-miR-18a,hsa-miR-556-5p, hsa-miR-100*, hsa-miR-199a-3p, hsa-miR-758,hsa-miR-320a, hsa-miR-548c-3p, hsa-miR-196a*, hsa-miR-382, hsa-miR-656,hsa-miR-320b, hsa-miR-1264, hsa-miR-548, hsa-miR-506, hsa-miR-21,hsa-miR-199b-3p, hsa-miR-577, hsa-miR-7-2*, hsa-miR-33a, hsa-miR-188-5p,hsa-miR-485-3p, hsa-miR-374a, hsa-miR-455-3p, hsa-miR-126*, hsa-miR-363,hsa-let-7a*, hsa-miR-767-5p, hsa-miR-944, hsa-miR-340, hsa-miR-218,hsa-miR-223*, hsa-miR-602, hsa-miR-1255b, hsa-miR-520d-5p, hsa-miR-154*,hsa-miR-671-5p.

HNMT—Variant 3—NM_(—)001024075—hsa-miR-182*, hsa-miR-330-3p,hsa-miR-1305, hsa-miR-590-3p, hsa-miR-7-1*, hsa-miR-325,hsa-miR-450b-5p, hsa-miR-323-3p, hsa-miR-1206, hsa-miR-656,hsa-miR-892a, hsa-miR-7-2*, hsa-miR-425, hsa-miR-140-3p, hsa-miR-433.

Methyltransferase like 7A—METTL7A—NM_(—)014033—hsa-miR-665, hsa-miR-510,hsa-miR-200b, hsa-miR-520b, hsa-miR-32, hsa-miR-141*, hsa-miR-130b*,hsa-miR-19b-2*, hsa-miR-766, hsa-miR-9, hsa-miR-520g, hsa-miR-616,hsa-miR-195*, hsa-miR-644, hsa-miR-548g, hsa-miR-204, hsa-miR-532-3p,hsa-miR-30c-1*, hsa-miR-549, hsa-miR-335, hsa-miR-138-1*, hsa-miR-363*,hsa-miR-127-5p, hsa-miR-452, hsa-miR-16-2*, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-661, hsa-miR-513a-3p, hsa-miR-26a-1*,hsa-miR-335*, hsa-miR-302a*, hsa-miR-1237, hsa-miR-548n, hsa-miR-1178,hsa-miR-302e, hsa-miR-19a*, hsa-miR-128, hsa-miR-342-3p, hsa-miR-298,hsa-miR-508-5p, hsa-miR-92b, hsa-miR-587, hsa-miR-660, hsa-miR-548p,hsa-miR-367, hsa-miR-338-5p, hsa-miR-19b-1*, hsa-miR-25, hsa-miR-30c-2*,hsa-miR-10a, hsa-miR-598, hsa-miR-302c, hsa-miR-491-5p, hsa-miR-410,hsa-miR-421, hsa-miR-641, hsa-miR-548d-3p, hsa-miR-411, hsa-miR-548o,hsa-miR-373, hsa-miR-200c, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f,hsa-miR-26b, hsa-miR-32*, hsa-miR-302d, hsa-miR-1202, hsa-miR-628-3p,hsa-miR-320d, hsa-miR-495, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-1253,hsa-miR-643, hsa-miR-26a-2*, hsa-miR-520f, hsa-miR-146a, hsa-miR-376a*,hsa-miR-186*, hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-608,hsa-miR-1323, hsa-miR-214*, hsa-miR-220b, hsa-miR-302a, hsa-miR-21*,hsa-miR-429, hsa-miR-570, hsa-miR-940, hsa-miR-34b, hsa-miR-125a-3p,hsa-miR-1285, hsa-miR-520d-3p, hsa-miR-519d, hsa-miR-545, hsa-miR-504,hsa-miR-612, hsa-miR-9*, hsa-miR-664*, hsa-miR-520e, hsa-miR-10b*,hsa-miR-629*, hsa-miR-93, hsa-miR-155*, hsa-miR-548b-3p, hsa-miR-1274a,hsa-miR-548a-3p, hsa-miR-146b-5p, hsa-miR-567, hsa-miR-302d*,hsa-miR-526b*, hsa-miR-92a, hsa-miR-211, hsa-miR-150, hsa-miR-527,hsa-miR-20b, hsa-miR-1321, hsa-miR-640, hsa-miR-106a, hsa-miR-138-2*,hsa-miR-30b*, hsa-miR-520h, hsa-miR-320a, hsa-miR-10b, hsa-miR-431,hsa-miR-339-5p, hsa-miR-1228, hsa-miR-1827, hsa-miR-548c-3p, hsa-miR-17,hsa-miR-196a*, hsa-miR-320b, hsa-miR-1264, hsa-miR-297, hsa-miR-548k,hsa-miR-675, hsa-miR-548l, hsa-miR-654-5p, hsa-miR-302b, hsa-miR-1283,hsa-miR-548e, hsa-miR-485-5p, hsa-miR-924, hsa-miR-577, hsa-miR-7-2*,hsa-miR-377*, hsa-miR-556-3p, hsa-miR-20a, hsa-miR-126*, hsa-miR-363,hsa-miR-944, hsa-miR-499-5p, hsa-miR-106b, hsa-miR-302b*, hsa-miR-372,hsa-miR-26a, hsa-miR-541, hsa-miR-340*.

Methyltransferase like 2A—METTL2A—NM_(—)181725.3—hsa-miR-502-3p,hsa-miR-520b, hsa-miR-515-5p, hsa-miR-22, hsa-miR-625, hsa-miR-216a,hsa-miR-562, hsa-miR-520g, hsa-miR-214, hsa-miR-548a-5p, hsa-miR-559,hsa-miR-548b-5p, hsa-miR-520a-3p, hsa-miR-513a-3p, hsa-miR-379*,hsa-miR-1288, hsa-miR-302e, hsa-miR-769-5p, hsa-miR-548c-5p,hsa-miR-603, hsa-miR-1825, hsa-miR-1287, hsa-miR-1182, hsa-miR-129*,hsa-miR-299-5p, hsa-miR-524-5p, hsa-miR-143*, hsa-miR-302c,hsa-miR-548i, hsa-miR-30a*, hsa-miR-1227, hsa-miR-373, hsa-miR-616*,hsa-miR-552, hsa-miR-373*, hsa-miR-1269, hsa-miR-302d, hsa-miR-1200,hsa-miR-411*, hsa-miR-186*, hsa-miR-520c-3p, hsa-miR-498, hsa-miR-384,hsa-miR-302a, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-21*, hsa-miR-548d-5p,hsa-miR-588, hsa-miR-768-3p, hsa-miR-512-3p, hsa-miR-520d-3p,hsa-miR-519d, hsa-miR-548j, hsa-miR-520e, hsa-miR-93, hsa-miR-941,hsa-miR-526b*, hsa-miR-548h, hsa-miR-744*, hsa-miR-519e*, hsa-miR-150,hsa-miR-20b, hsa-miR-378*, hsa-miR-556-5p, hsa-miR-106a, hsa-miR-483-5p,hsa-miR-550, hsa-miR-520h, hsa-miR-431, hsa-miR-129-3p, hsa-miR-17,hsa-miR-297, hsa-miR-302b, hsa-miR-187*, hsa-miR-924, hsa-miR-20a,hsa-miR-876-3p, hsa-miR-126*, hsa-miR-501-3p, hsa-miR-193b*,hsa-miR-219-2-3p, hsa-miR-106b, hsa-miR-372, hsa-miR-367*,hsa-miR-520d-5p, hsa-miR-558, hsa-miR-135b*, hsa-miR-512-5p.

Methyltransferase like 2B—METTL2B—NM_(—)018396—hsa-miR-502-3p,hsa-miR-520b, hsa-miR-216a, hsa-miR-520g, hsa-miR-214, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-548b-5p, hsa-miR-520a-3p, hsa-miR-513a-3p,hsa-miR-378, hsa-miR-302e, hsa-miR-769-5p, hsa-miR-548c-5p,hsa-miR-1287, hsa-miR-1182, hsa-miR-129*, hsa-miR-299-5p,hsa-miR-524-5p, hsa-miR-302c, hsa-miR-548i, hsa-miR-410, hsa-miR-421,hsa-miR-329, hsa-miR-30a*, hsa-miR-373, hsa-miR-616*, hsa-miR-552,hsa-miR-373*, hsa-miR-99a*, hsa-miR-302d, hsa-miR-1200, hsa-miR-186*,hsa-miR-520c-3p, hsa-miR-384, hsa-miR-302a, hsa-miR-30d*, hsa-miR-30e*,hsa-miR-21*, hsa-miR-548d-5p, hsa-miR-588, hsa-miR-125a-3p,hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-519d, hsa-miR-548j,hsa-miR-520e, hsa-miR-578, hsa-miR-10b*, hsa-miR-93, hsa-miR-422a,hsa-miR-362-3p, hsa-miR-526b*, hsa-miR-548h, hsa-miR-744*, hsa-miR-150,hsa-miR-20b, hsa-miR-378*, hsa-miR-106a, hsa-miR-483-5p, hsa-miR-550,hsa-miR-520h, hsa-miR-522, hsa-miR-431, hsa-miR-129-3p, hsa-miR-17,hsa-miR-297, hsa-miR-99b*, hsa-miR-302b, hsa-miR-626, hsa-miR-1283,hsa-miR-187*, hsa-miR-924, hsa-miR-20a, hsa-miR-876-3p, hsa-miR-338-3p,hsa-miR-767-5p, hsa-miR-501-3p, hsa-miR-193b*, hsa-miR-219-2-3p,hsa-miR-106b, hsa-miR-372, hsa-miR-1250, hsa-miR-520d-5p.

Ezrin—EZR—NM_(—)003379—hsa-miR-376b, hsa-miR-509-3-5p, hsa-miR-380,hsa-miR-22, hsa-miR-138, hsa-miR-1228*, hsa-miR-648, hsa-miR-1184,hsa-miR-133a, hsa-miR-551b*, hsa-miR-548g, hsa-miR-204, hsa-miR-96,hsa-miR-214, hsa-miR-377, hsa-miR-218-1*, hsa-miR-890, hsa-miR-335*,hsa-miR-548m, hsa-miR-129-5p, hsa-miR-885-5p, hsa-miR-134, hsa-miR-663,hsa-miR-1252, hsa-miR-630, hsa-miR-148a, hsa-miR-548p, hsa-miR-524-5p,hsa-miR-33a*, hsa-let-7b*, hsa-miR-153, hsa-miR-1281, hsa-miR-548o,hsa-miR-376a, hsa-miR-1207-3p, hsa-miR-148b, hsa-miR-548f, hsa-miR-1202,hsa-miR-765, hsa-miR-495, hsa-miR-1271, hsa-miR-589*, hsa-miR-885-3p,hsa-miR-643, hsa-miR-520f, hsa-miR-518a-5p, hsa-miR-185*, hsa-miR-1323,hsa-miR-384, hsa-miR-654-3p, hsa-miR-568, hsa-miR-596, hsa-miR-570,hsa-miR-940, hsa-miR-34b, hsa-miR-432, hsa-miR-769-3p, hsa-miR-450b-3p,hsa-miR-15a*, hsa-miR-450b-5p, hsa-miR-566, hsa-miR-152, hsa-miR-1322,hsa-miR-548a-3p, hsa-miR-133b, hsa-miR-211, hsa-let-7f-1*,hsa-miR-628-5p, hsa-miR-205, hsa-miR-527, hsa-miR-18a*, hsa-miR-548c-3p,hsa-miR-345, hsa-miR-548e, hsa-miR-892a, hsa-miR-632, hsa-miR-183,hsa-let-7a*, hsa-miR-338-3p, hsa-miR-509-5p, hsa-let-7f-2*, hsa-miR-595,hsa-miR-499-3p, hsa-miR-520d-5p, hsa-miR-744.

Tumor protein D52—TPD52—Variant 1, Variant 2 and Variant3—NM_(—)001025252, NM_(—)001025253 and NM_(—)005079—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-124*, hsa-miR-376b, hsa-miR-665, hsa-miR-34c-5p,hsa-miR-448, hsa-miR-648, hsa-miR-219-1-3p, hsa-miR-374b, hsa-miR-101*,hsa-miR-181a, hsa-miR-182*, hsa-miR-195*, hsa-miR-302c*, hsa-miR-483-3p,hsa-miR-204, hsa-miR-668, hsa-miR-218-1*, hsa-miR-490-3p, hsa-miR-452,hsa-miR-16-2*, hsa-miR-26a-1*, hsa-miR-486-3p, hsa-miR-335*,hsa-miR-449a, hsa-miR-548m, hsa-miR-1237, hsa-let-7c*, miR-129*,hsa-miR-1246, hsa-miR-299-5p, hsa-miR-586, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-186, hsa-miR-449b, hsa-miR-1236, hsa-miR-618,hsa-miR-33a*, hsa-miR-218-2*, hsa-miR-410, hsa-miR-421, hsa-miR-548d-3p,hsa-let-7b*, hsa-miR-151-3p, hsa-miR-145*, hsa-miR-411, hsa-miR-622,hsa-miR-548o, hsa-miR-376a, hsa-miR-145, hsa-miR-220c, hsa-miR-532-5p,hsa-miR-188-3p, hsa-miR-590-3p, hsa-miR-495, hsa-miR-513c, hsa-miR-7-1*,hsa-miR-767-3p, hsa-miR-589*, hsa-miR-34a, hsa-miR-936, hsa-miR-26a-2*,hsa-miR-146a, hsa-miR-768-5p, hsa-miR-873, hsa-miR-144, hsa-miR-1323,hsa-miR-653, hsa-miR-553, hsa-miR-570, hsa-miR-325, hsa-miR-432,hsa-miR-34b*, hsa-miR-15a*, hsa-miR-452*, hsa-miR-181d, hsa-miR-9*,hsa-miR-636, hsa-miR-548b-3p, hsa-miR-1257, hsa-miR-609,hsa-miR-146b-5p, hsa-miR-516b, hsa-miR-136, hsa-miR-139-5p, hsa-miR-203,hsa-miR-571, hsa-miR-211, hsa-let-7f-1*, hsa-miR-181c, hsa-miR-181a-2*,hsa-miR-583, hsa-miR-205, hsa-miR-224, hsa-miR-1284, hsa-miR-221*,hsa-miR-185, hsa-miR-100*, hsa-miR-1224-3p, hsa-miR-138-2*, hsa-miR-522,hsa-miR-129-3p, hsa-miR-663b, hsa-miR-1279, hsa-miR-656, hsa-miR-548k,hsa-miR-181b, hsa-miR-1251, hsa-miR-7-2*, hsa-miR-107, hsa-miR-374a,hsa-miR-1244, hsa-let-7a*, hsa-miR-1272, hsa-let-7f-2*, hsa-miR-218,hsa-miR-142-3p, hsa-miR-1250, hsa-miR-512-5p.

Actin related protein 2/3 complex, subunit 5 16kDa—ARPC5—NM_(—)005717—hsa-miR-557, hsa-miR-642, hsa-miR-380,hsa-miR-22, hsa-miR-562, hsa-miR-19b-2*, hsa-miR-875-5p, hsa-miR-650,hsa-miR-644, hsa-miR-549, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-548b-5p,hsa-miR-320c, hsa-miR-544, hsa-miR-335*, hsa-miR-507, hsa-miR-190,hsa-miR-302a*, hsa-miR-561, hsa-miR-129-5p, hsa-miR-548c-5p,hsa-miR-19a*, hsa-miR-216b, hsa-miR-548p, hsa-miR-19b-1*, hsa-miR-30b,hsa-miR-548i, hsa-miR-641, hsa-miR-548d-3p, hsa-miR-146a*, hsa-miR-30a,hsa-miR-29a*, hsa-miR-548o, hsa-miR-145, hsa-miR-548f, hsa-miR-220c,hsa-miR-320d, hsa-miR-589*, hsa-miR-190b, hsa-miR-885-3p,hsa-miR-193a-3p, hsa-miR-146a, hsa-miR-374b*, hsa-miR-147,hsa-miR-509-3p, hsa-miR-1262, hsa-miR-1323, hsa-miR-568, hsa-miR-488,hsa-miR-570, hsa-miR-548d-5p, hsa-miR-450b-5p, hsa-miR-610, hsa-miR-545,hsa-miR-548j, hsa-miR-200a, hsa-miR-30d, hsa-miR-193b, hsa-miR-1206,hsa-miR-101, hsa-miR-548a-3p, hsa-miR-146b-5p, hsa-miR-634, hsa-miR-141,hsa-miR-203, hsa-miR-548h, hsa-miR-30c, hsa-miR-378*, hsa-miR-556-5p,hsa-miR-320a, hsa-miR-522, hsa-miR-1827, hsa-miR-106a*, hsa-miR-656,hsa-miR-320b, hsa-miR-548e, hsa-miR-655, hsa-miR-485-5p, hsa-miR-888*,hsa-miR-876-3p, hsa-miR-423-5p, hsa-miR-340, hsa-miR-369-3p,hsa-let-7f-2*, hsa-miR-16-1*, hsa-miR-223*, hsa-miR-499-3p, hsa-miR-30e.

Nucleolar protein 8—NOL8—NM_(—)017948—hsa-miR-510, hsa-miR-520b,hsa-miR-645, hsa-miR-181a, hsa-miR-548g, hsa-miR-377, hsa-miR-452,hsa-miR-520a-3p, hsa-miR-513a-3p, hsa-miR-548n, hsa-miR-302e,hsa-miR-875-3p, hsa-miR-374a*, hsa-miR-23a, hsa-miR-302c, hsa-let-7b*,hsa-miR-146a*, hsa-miR-373, hsa-miR-548f, hsa-miR-302d, hsa-miR-1253,hsa-miR-520f, hsa-miR-520c-3p, hsa-miR-302a, hsa-miR-520d-3p,hsa-miR-181d, hsa-miR-607, hsa-miR-520e, hsa-miR-23b, hsa-miR-548a-3p,hsa-miR-223, hsa-miR-22*, hsa-miR-381, hsa-let-7f-1*, hsa-miR-1300,hsa-miR-181c, hsa-miR-130a*, hsa-miR-548l, hsa-miR-302b, hsa-miR-181b,hsa-miR-548e, hsa-miR-300, hsa-miR-409-3p, hsa-let-7a*, hsa-miR-372,hsa-miR-223*.

N-ehylmaleimide-sensitive factor—NSF—N_(—)006178—hsa-miR-124*,hsa-miR-877, hsa-miR-32, hsa-miR-16, hsa-miR-513a-5p, hsa-miR-192,hsa-miR-125b-2*, hsa-miR-181a, hsa-miR-195*, hsa-miR-28-3p,hsa-miR-1179, hsa-miR-30c-1*, hsa-miR-218-1*, hsa-miR-890,hsa-miR-516a-3p, hsa-miR-16-2*, hsa-miR-31, hsa-miR-143, hsa-miR-548n,hsa-miR-769-5p, hsa-miR-1308, hsa-miR-92b, hsa-miR-587, hsa-miR-1303,hsa-miR-623, hsa-miR-103, hsa-miR-1252, hsa-miR-651, hsa-miR-576-5p,hsa-miR-367, hsa-miR-582-5p, hsa-miR-338-5p, hsa-miR-543, hsa-miR-25,hsa-miR-30c-2*, hsa-miR-302f, hsa-miR-218-2*, hsa-miR-641,hsa-miR-516b*, hsa-let-7b*, hsa-miR-489, hsa-miR-1227, hsa-miR-616*,hsa-miR-373*, hsa-miR-26b, hsa-miR-628-3p, hsa-miR-532-5p, hsa-miR-15b,hsa-miR-502-5p, hsa-miR-1297, hsa-miR-215, hsa-miR-135a, hsa-miR-579,hsa-miR-193a-3p, hsa-miR-1243, hsa-miR-147, hsa-miR-653, hsa-miR-505*,hsa-miR-1224-5p, hsa-miR-596, hsa-miR-570, hsa-miR-34b, hsa-miR-325,hsa-miR-1294, hsa-miR-588, hsa-miR-432, hsa-miR-1270, hsa-miR-768-3p,hsa-miR-512-3p, hsa-miR-195, hsa-miR-15a*, hsa-miR-452*, hsa-miR-181d,hsa-miR-135b, hsa-miR-514, hsa-miR-607, hsa-miR-193b, hsa-miR-1260,hsa-miR-412, hsa-miR-516b, hsa-miR-526b, hsa-miR-620, hsa-miR-302d*,hsa-miR-223, hsa-miR-571, hsa-miR-92a, hsa-let-7f-1*, hsa-miR-432*,hsa-miR-181c, hsa-miR-583, hsa-miR-205, hsa-miR-224, hsa-miR-185,hsa-miR-1228, hsa-miR-656, hsa-miR-548l, hsa-miR-424, hsa-miR-181b,hsa-miR-1278, hsa-miR-892a, hsa-miR-377*, hsa-miR-107, hsa-miR-15a,hsa-miR-425, hsa-miR-363, hsa-let-7a*, hsa-miR-140-3p, hsa-miR-497,hsa-miR-346, hsa-miR-302b*, hsa-miR-595, hsa-miR-26a, hsa-miR-142-3p,hsa-miR-891b, hsa-miR-95.

RAD23 homolog B—RAD23B—NM_(—)002874—hsa-miR-510, hsa-miR-877,hsa-miR-520b, hsa-miR-34c-5p, hsa-miR-16, hsa-miR-562, hsa-miR-875-5p,hsa-miR-520g, hsa-miR-181a, hsa-miR-195*, hsa-miR-302c*, hsa-miR-204,hsa-let-7g*, hsa-miR-532-3p, hsa-miR-516a-3p, hsa-miR-452,hsa-miR-16-2*, hsa-miR-575, hsa-miR-496, hsa-miR-320c, hsa-miR-520a-3p,hsa-miR-513a-3p, hsa-miR-143, hsa-miR-335*, hsa-miR-449a, hsa-miR-1237,hsa-miR-19b, hsa-miR-146b-3p, hsa-miR-302e, hsa-miR-93*, hsa-miR-603,hsa-miR-199a-5p, hsa-miR-1287, hsa-miR-1182, hsa-miR-548p,hsa-miR-524-5p, hsa-miR-30b, hsa-miR-34a*, hsa-miR-186, hsa-miR-23a,hsa-miR-449b, hsa-miR-302c, hsa-miR-410, hsa-miR-421, hsa-miR-516b*,hsa-miR-494, hsa-miR-411, hsa-miR-30a, hsa-miR-29a*, hsa-miR-324-3p,hsa-miR-548o, hsa-miR-373, hsa-miR-145, hsa-miR-874, hsa-miR-548f,hsa-miR-573, hsa-miR-302d, hsa-miR-624, hsa-miR-15b, hsa-miR-320d,hsa-miR-188-3p, hsa-miR-96*, hsa-miR-590-3p, hsa-miR-1200, hsa-miR-34a,hsa-miR-361-5p, hsa-miR-1259, hsa-miR-186*, hsa-miR-147,hsa-miR-520c-3p, hsa-miR-770-5p, hsa-miR-498, hsa-miR-144, hsa-miR-1323,hsa-miR-214*, hsa-miR-302a, hsa-miR-570, hsa-miR-508-3p, hsa-miR-124,hsa-miR-517*, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-195,hsa-miR-519d, hsa-miR-20a*, hsa-miR-545, hsa-miR-181d, hsa-miR-664*,hsa-miR-520e, hsa-miR-200a, hsa-miR-30d, hsa-miR-629*, hsa-miR-93,hsa-miR-383, hsa-miR-192*, hsa-miR-491-3p, hsa-miR-1260, hsa-miR-23b,hsa-miR-539, hsa-miR-1257, hsa-miR-548a-3p, hsa-miR-136, hsa-miR-141,hsa-miR-526b*, hsa-miR-744*, hsa-miR-211, hsa-miR-150, hsa-miR-30c,hsa-miR-181c, hsa-miR-199b-5p, hsa-miR-20b, hsa-miR-640,hsa-miR-1224-3p, hsa-miR-106a, hsa-miR-1245, hsa-miR-138-2*,hsa-miR-18a*, hsa-miR-130a*, hsa-miR-483-5p, hsa-miR-520h, hsa-miR-320a,hsa-miR-548c-3p, hsa-miR-17, hsa-miR-106a*, hsa-miR-656, hsa-miR-320b,hsa-miR-548k, hsa-miR-424, hsa-miR-506, hsa-miR-302b, hsa-miR-626,hsa-miR-181b, hsa-miR-1283, hsa-miR-187*, hsa-miR-548e, hsa-miR-655,hsa-miR-485-5p, hsa-miR-892a, hsa-miR-577, hsa-miR-19a, hsa-miR-15a,hsa-miR-20a, hsa-miR-944, hsa-miR-340, hsa-miR-193b*, hsa-miR-140-3p,hsa-miR-106b, hsa-miR-497, hsa-miR-1197, hsa-miR-372, hsa-miR-595,hsa-miR-154, hsa-miR-520d-5p, hsa-miR-30e.

Signal recognition particle 54 kDa—SRP54—NM_(—)003136—hsa-miR-452hsa-miR-1252, hsa-miR-606, hsa-miR-548d-3p, hsa-miR-494, hsa-miR-590-3p,hsa-miR-1253, hsa-miR-570, hsa-miR-105, hsa-miR-331-5p, hsa-miR-545,hsa-miR-629*, hsa-miR-223, hsa-miR-1321, hsa-miR-106a*, hsa-miR-433.

Heat shock 70 kDa protein 2—HSPA2—NM_(—)021979—hsa-miR-448,hsa-miR-302c*, hsa-miR-96, hsa-miR-452, hsa-miR-19b, hsa-miR-548n,hsa-miR-130b, hsa-miR-299-5p, hsa-miR-586, hsa-miR-301b, hsa-miR-337-3p,hsa-miR-33a*, hsa-miR-371-5p, hsa-miR-130a, hsa-miR-552, hsa-miR-617,hsa-miR-495, hsa-miR-1271, hsa-miR-7-1*, hsa-miR-589*, hsa-miR-579,hsa-miR-450b-5p, hsa-miR-545, hsa-miR-323-3p, hsa-miR-491-3p,hsa-miR-301a, hsa-miR-583, hsa-miR-500*, hsa-miR-106a*, hsa-miR-382,hsa-miR-454, hsa-miR-548, hsa-miR-7-2*, hsa-miR-19a.

Mediator complex subunit 1—MED1—NM_(—)004774—hsa-miR-376b, hsa-miR-200b,hsa-miR-877, hsa-miR-1266, hsa-miR-642, hsa-miR-16, hsa-miR-515-5p,hsa-miR-141*, hsa-miR-922, hsa-miR-493*, hsa-miR-875-5p, hsa-miR-1290,hsa-miR-513b, hsa-miR-221, hsa-miR-483-3p, hsa-miR-548g, hsa-miR-204,hsa-miR-96, hsa-miR-604, hsa-miR-668, hsa-miR-1179, hsa-miR-532-3p,hsa-miR-549, hsa-miR-548a-5p, hsa-miR-490-3p, hsa-miR-647, hsa-miR-559,hsa-miR-1248, hsa-miR-920, hsa-miR-548b-5p, hsa-miR-452, hsa-miR-320c,hsa-miR-486-3p, hsa-miR-335*, hsa-miR-29b-1*, hsa-miR-561, hsa-miR-541*,hsa-miR-1178, hsa-miR-217, hsa-miR-892b, hsa-miR-146b-3p,hsa-miR-885-5p, hsa-miR-548c-5p, hsa-miR-128, hsa-miR-298, hsa-miR-587,hsa-miR-1207-5p, hsa-miR-657, hsa-miR-1252, hsa-miR-1182, hsa-miR-651,hsa-miR-580, hsa-miR-129*, hsa-miR-148a, hsa-miR-576-5p, hsa-miR-876-5p,hsa-miR-618, hsa-miR-10a, hsa-miR-33a*, hsa-miR-548i, hsa-miR-641,hsa-miR-212, hsa-miR-548d-3p, hsa-miR-146a*, hsa-miR-371-5p,hsa-miR-489, hsa-miR-29a*, hsa-miR-324-3p, hsa-miR-548o, hsa-miR-1,hsa-miR-376a, hsa-miR-200c, hsa-miR-616*, hsa-miR-148b, hsa-miR-373*,hsa-miR-548f, hsa-miR-765, hsa-miR-532-5p, hsa-miR-15b, hsa-miR-320d,hsa-miR-188-3p, hsa-miR-617, hsa-miR-590-3p, hsa-miR-502-5p,hsa-miR-495, hsa-miR-1271, hsa-miR-132, hsa-miR-591, hsa-miR-7-1*,hsa-miR-939, hsa-miR-635, hsa-miR-589*, hsa-miR-1291, hsa-miR-1253,hsa-miR-579, hsa-miR-146a, hsa-miR-605, hsa-miR-1259, hsa-miR-186*,hsa-miR-873, hsa-miR-27a*, hsa-miR-1226, hsa-miR-144, hsa-miR-1323,hsa-miR-220b, hsa-miR-888, hsa-miR-654-3p, hsa-miR-568, hsa-miR-429,hsa-miR-488, hsa-miR-570, hsa-miR-105, hsa-miR-940, hsa-miR-548d-5p,hsa-miR-222, hsa-miR-195, hsa-miR-9*, hsa-miR-548j, hsa-miR-323-3p,hsa-miR-200a, hsa-miR-629*, hsa-miR-629, hsa-miR-29b-2*, hsa-miR-155*,hsa-miR-548b-3p, hsa-miR-1260, hsa-miR-152, hsa-miR-1274a, hsa-miR-539,hsa-miR-548a-3p, hsa-miR-146b-5p, hsa-miR-634, hsa-miR-328,hsa-miR-139-5p, hsa-miR-141, hsa-miR-548h, hsa-miR-597, hsa-miR-211,hsa-miR-519e*, hsa-miR-181a*, hsa-miR-361-3p, hsa-miR-628-5p,hsa-miR-760, hsa-miR-205, hsa-miR-224, hsa-miR-1321, hsa-miR-138-2*,hsa-miR-877*, hsa-miR-149, hsa-miR-320a, hsa-miR-10b, hsa-miR-202*,hsa-miR-129-3p, hsa-miR-548c-3p, hsa-miR-182, hsa-miR-320b, hsa-miR-345,hsa-miR-1274b, hsa-miR-548l, hsa-miR-424, hsa-miR-548e, hsa-miR-485-5p,hsa-miR-137, hsa-miR-888*, hsa-miR-577, hsa-miR-206, hsa-miR-7-2*,hsa-miR-15a, hsa-miR-556-3p, hsa-miR-183, hsa-miR-876-3p, hsa-miR-1272,hsa-miR-497, hsa-miR-16-1*, hsa-miR-367*, hsa-miR-497*, hsa-miR-433,hsa-miR-154, hsa-miR-499-3p, hsa-miR-1275, hsa-miR-1302, hsa-miR-425*,hsa-miR-613.

THAP domain containing, apoptosis associated protein2—THAP2—N_(—)031435—hsa-miR-140-5p, hsa-miR-124*, hsa-miR-517a,hsa-miR-200b, hsa-miR-520b, hsa-miR-380, hsa-miR-16, hsa-miR-141*,hsa-miR-922, hsa-miR-562, hsa-miR-875-5p, hsa-miR-650, hsa-miR-9,hsa-miR-520g, hsa-miR-150*, hsa-miR-101*, hsa-miR-181a, hsa-miR-513b,hsa-miR-195*, hsa-miR-96, hsa-miR-28-3p, hsa-miR-1304, hsa-miR-890,hsa-miR-490-3p, hsa-miR-27a, hsa-miR-16-2*, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-513a-3p, hsa-miR-99a, hsa-miR-142-5p,hsa-miR-335*, hsa-miR-183*, hsa-miR-1226*, hsa-miR-561, hsa-miR-146b-3p,hsa-miR-302e, hsa-miR-1825, hsa-miR-128, hsa-miR-508-5p, hsa-miR-587,hsa-miR-1303, hsa-miR-1287, hsa-miR-103, hsa-let-7d*, hsa-miR-630,hsa-miR-379, hsa-miR-576-5p, hsa-miR-548p, hsa-miR-586, hsa-miR-876-5p,hsa-miR-582-5p, hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-143*,hsa-miR-543, hsa-miR-374a*, hsa-miR-186, hsa-miR-23a, hsa-miR-365,hsa-miR-1305, hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-302c, hsa-miR-202,hsa-miR-548d-3p, hsa-miR-146a*, hsa-miR-411, hsa-miR-30a*, hsa-miR-373,hsa-miR-200c, hsa-miR-874, hsa-miR-26b, hsa-miR-302d, hsa-miR-15b,hsa-miR-320d, hsa-miR-590-3p, hsa-miR-1271, hsa-miR-29c, hsa-miR-1297,hsa-miR-7-1*, hsa-miR-26b*, hsa-miR-1253, hsa-miR-936, hsa-miR-29b,hsa-miR-361-5p, hsa-miR-520f, hsa-miR-520c-3p, hsa-miR-518a-5p,hsa-miR-653, hsa-miR-505*, hsa-miR-302a, hsa-miR-30d*, hsa-miR-30e*,hsa-miR-21*, hsa-miR-429, hsa-miR-29a, hsa-miR-624*, hsa-miR-570,hsa-miR-105, hsa-miR-124, hsa-MiR-768-3p, hsa-miR-148b*, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-195, hsa-miR-15a*, hsa-miR-450b-5p,hsa-miR-519d, hsa-miR-181d, hsa-miR-9*, hsa-miR-27b, hsa-miR-607,hsa-miR-520e, hsa-miR-629, hsa-miR-93, hsa-miR-192*, hsa-miR-934,hsa-miR-491-3p, hsa-miR-1260, hsa-miR-942, hsa-miR-23b, hsa-miR-23a*,hsa-miR-545*, hsa-miR-539, hsa-miR-1257, hsa-miR-23b*, hsa-miR-567,hsa-miR-136, hsa-miR-139-5p, hsa-miR-889, hsa-miR-526b*, hsa-miR-625*,hsa-miR-150, hsa-miR-181c, hsa-miR-527, hsa-miR-20b, hsa-miR-100*,hsa-miR-1224-3p, hsa-miR-199a-3p, hsa-miR-106a, hsa-miR-138-2*,hsa-miR-30b*, hsa-miR-99b, hsa-miR-130a*, hsa-miR-758, hsa-miR-520h,hsa-miR-320a, hsa-miR-486-5p, hsa-miR-548c-3p, hsa-miR-135a*,hsa-miR-100, hsa-miR-17, hsa-miR-1279, hsa-miR-656, hsa-miR-182,hsa-miR-320b, hsa-miR-1264, hsa-miR-297, hsa-miR-548k, hsa-miR-424,hsa-miR-506, hsa-miR-302b, hsa-miR-181b, hsa-miR-1283, hsa-miR-655,hsa-miR-199b-3p, hsa-miR-577, hsa-miR-7-2*, hsa-miR-377*, hsa-miR-107,hsa-miR-15a, hsa-miR-1244, hsa-miR-20a, hsa-miR-409-3p, hsa-miR-1272,hsa-miR-944, hsa-miR-340, hsa-miR-1265, hsa-miR-219-2-3p, hsa-miR-106b,hsa-miR-497, hsa-miR-369-3p, hsa-miR-517c, hsa-miR-372, hsa-miR-1183,hsa-miR-497*, hsa-miR-595, hsa-miR-26a, hsa-miR-520d-5p, hsa-miR-891b,hsa-miR-584.

Cold inducible RNA binding protein—CIRBP—NN_(—)001280—hsa-miR-1266,hsa-miR-1276, hsa-miR-615-5p, hsa-miR-532-3p, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-548b-5p, hsa-miR-548n,hsa-miR-548c-5p, hsa-miR-338-5p, hsa-miR-33a*, hsa-miR-548i,hsa-miR-548d-3p, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f,hsa-miR-628-3p, hsa-miR-188-3p, hsa-miR-185*, hsa-miR-548d-5p,hsa-miR-15a*, hsa-miR-27b, hsa-miR-548j, hsa-miR-383, hsa-miR-934,hsa-miR-548b-3p, hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-526b,hsa-miR-571, hsa-miR-548h, hsa-miR-381, hsa-miR-548e, hsa-miR-300.

Small nuclear ribonucleoprotein polypeptide N—SNRPN—Variant 1, Variant2, Variant 3, Variant 4 and Variant 5—NM_(—)003097, NM_(—)022805,NM_(—)022806, N_(—)022807 and NM_(—)022808—hsa-miR-513b, hsa-miR-134,hsa-miR-586, hsa-miR-302f, hsa-miR-144, hsa-miR-126*.

Superkiller viralicidic activity 2-like2—SKIV2L2—N_(—)015360—hsa-miR-140-5p, hsa-miR-557, hsa-miR-380,hsa-miR-493*, hsa-miR-216a, hsa-miR-374b, hsa-miR-214, hsa-miR-30c-1*,hsa-miR-1826, hsa-miR-1267, hsa-miR-127-5p, hsa-miR-31*, hsa-miR-31,hsa-miR-507, hsa-miR-330-3p, hsa-miR-651, hsa-miR-876-5p, hsa-miR-23a,hsa-miR-30c-2*, hsa-miR-552, hsa-miR-589, hsa-miR-34c-3p, hsa-miR-605,hsa-miR-1226, hsa-miR-323-5p, hsa-miR-568, hsa-miR-21*, hsa-miR-488,hsa-miR-155, hsa-miR-34b, hsa-miR-125a-3p, hsa-miR-23b, hsa-miR-302d*,hsa-miR-583, hsa-miR-501-5p, hsa-miR-1224-3p, hsa-miR-130a*,hsa-miR-548c-3p, hsa-miR-182, hsa-miR-297, hsa-miR-548l, hsa-miR-655,hsa-miR-485-3p, hsa-miR-374a, hsa-miR-369-3p, hsa-miR-16-1*,hsa-miR-302b*, hsa-miR-1183.

Dual specificity phosphatase 10—DUSP10—Variant 1, Variant 2 and Variant3—NM_(—)007207, NM_(—)144728 and NM₁₃ 144729—hsa-miR-557, hsa-miR-32,hsa-miR-16, hsa-miR-500, hsa-miR-515-5p, hsa-miR-22, hsa-miR-216a,hsa-miR-551b*, hsa-miR-575, hsa-miR-511, hsa-miR-142-5p, hsa-miR-379*,hsa-miR-507, hsa-miR-548m, hsa-miR-302a*, hsa-miR-129-5p, hsa-miR-541*,hsa-miR-92b, hsa-miR-216b, hsa-miR-1252, hsa-miR-367, hsa-miR-25,hsa-miR-186, hsa-miR-618, hsa-miR-520a-5p, hsa-miR-548d-3p, hsa-miR-329,hsa-miR-525-5p, hsa-miR-874, hsa-miR-1202, hsa-miR-450a, hsa-miR-624,hsa-miR-15b, hsa-miR-411*, hsa-miR-147, hsa-miR-653, hsa-miR-195,hsa-miR-92a-1*, hsa-miR-942, hsa-miR-362-3p, hsa-miR-302d*, hsa-miR-223,hsa-miR-92 a, hsa-miR-519e*, hsa-miR-150, hsa-miR-501-5p, hsa-miR-659,hsa-miR-138-2*, hsa-miR-18a*, hsa-miR-30b*, hsa-miR-548c-3p,hsa-miR-382, hsa-miR-656, hsa-miR-548l, hsa-miR-424, hsa-miR-1283,hsa-miR-15a, hsa-miR-183, hsa-miR-363, hsa-miR-497, hsa-miR-302b*,hsa-miR-595.

Signal sequence receptor, alpha—SSR1—NM_(—)003144—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-376b, hsa-miR-502-3p, hsa-miR-665, hsa-miR-510,hsa-miR-200b, hsa-miR-509-3-5p, hsa-miR-520b, hsa-miR-1266,hsa-miR-34c-5p, hsa-miR-1254, hsa-miR-645, hsa-miR-16, hsa-miR-500,hsa-miR-27b*, hsa-miR-141*, hsa-miR-22, hsa-miR-922, hsa-miR-625,hsa-miR-138, hsa-miR-648, hsa-miR-562, hsa-miR-19b-2*, hsa-miR-513a-5p,hsa-miR-766, hsa-miR-650, hsa-miR-192, hsa-miR-1276, hsa-miR-1184,hsa-miR-125b-2*, hsa-miR-520g, hsa-miR-1290, hsa-miR-1301, hsa-miR-181a,hsa-miR-551b*, hsa-miR-182*, hsa-miR-195*, hsa-miR-302c*,hsa-miR-125a-5p, hsa-miR-487a, hsa-miR-548g, hsa-miR-214, hsa-miR-377,hsa-miR-218-1*, hsa-miR-1304, hsa-miR-890, hsa-miR-376c, hsa-miR-490-3p,hsa-miR-27a, hsa-miR-1248, hsa-miR-335, hsa-miR-138-1*, hsa-miR-363*,hsa-miR-127-5p, hsa-miR-16-2*, hsa-miR-496, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-511, hsa-miR-661, hsa-miR-15b*, hsa-miR-31,hsa-miR-513a-3p, hsa-miR-143, hsa-miR-449a, hsa-miR-548m, hsa-miR-183*,hsa-miR-378, hsa-miR-28-5p, hsa-miR-190, hsa-miR-302a*, hsa-miR-191,hsa-miR-129-5p, hsa-miR-541*, hsa-miR-548n, hsa-miR-1178, hsa-miR-217,hsa-miR-302e, hsa-miR-19a*, hsa-miR-1825, hsa-miR-128, hsa-miR-342-3p,hsa-miR-409-5p, hsa-miR-298, hsa-miR-508-5p, hsa-miR-1308,hsa-miR-542-5p, hsa-miR-455-5p, hsa-miR-587, hsa-miR-1207-5p,hsa-miR-623, hsa-miR-875-3p, hsa-miR-657, hsa-miR-216b, hsa-miR-1252,hsa-miR-1182, hsa-miR-630, hsa-miR-580, hsa-miR-148a, hsa-miR-548p,hsa-miR-586, hsa-miR-621, hsa-miR-582-5p, hsa-miR-19b-1*, hsa-miR-143*,hsa-miR-543, hsa-miR-186, hsa-miR-23 a, hsa-miR-449b, hsa-miR-1236,hsa-miR-618, hsa-miR-337-3p, hsa-miR-10a, hsa-miR-33a*, hsa-miR-302c,hsa-miR-606, hsa-miR-520a-5p, hsa-miR-641, hsa-miR-548d-3p, hsa-miR-646,hsa-miR-329, hsa-let-7b*, hsa-miR-151-3p, hsa-miR-708, hsa-miR-590-5p,hsa-miR-145*, hsa-miR-525-5p, hsa-miR-582-3p, hsa-miR-30a*,hsa-miR-371-5p, hsa-miR-29a*, hsa-miR-622, hsa-miR-548o, hsa-miR-1,hsa-miR-376a, hsa-miR-1227, hsa-miR-373, hsa-miR-200c, hsa-miR-581,hsa-miR-616*, hsa-miR-552, hsa-miR-874, hsa-miR-148b, hsa-miR-373*,hsa-miR-548f, hsa-miR-1286, hsa-miR-26b, hsa-miR-720, hsa-miR-664,hsa-miR-484, hsa-miR-573, hsa-miR-32*, hsa-miR-1269, hsa-miR-302d,hsa-miR-1202, hsa-miR-624, hsa-miR-15b, hsa-miR-1324, hsa-miR-320d,hsa-miR-188-3p, hsa-miR-590-3p, hsa-miR-495, hsa-miR-513c, hsa-miR-1297,hsa-miR-591, hsa-miR-7-1*, hsa-miR-589, hsa-miR-215, hsa-miR-767-3p,hsa-miR-589*, hsa-miR-26b*, hsa-miR-1253, hsa-miR-190b, hsa-miR-34a,hsa-miR-135a, hsa-miR-193a-3p, hsa-miR-146a, hsa-miR-768-5p,hsa-miR-1259, hsa-miR-1243, hsa-miR-186*, hsa-miR-147, hsa-miR-873,hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-608, hsa-miR-498,hsa-miR-1226, hsa-miR-1262, hsa-miR-144, hsa-miR-1323, hsa-miR-125b,hsa-miR-323-5p, hsa-miR-653, hsa-miR-220b, hsa-miR-302a, hsa-miR-888,hsa-miR-30d*, hsa-miR-802, hsa-miR-568, hsa-miR-30e*, hsa-miR-592,hsa-miR-21*, hsa-miR-429, hsa-miR-624*, hsa-miR-570, hsa-miR-105,hsa-miR-124, hsa-miR-517*, hsa-miR-940, hsa-miR-34b, hsa-miR-325,hsa-miR-588, hsa-miR-1261, hsa-miR-34b*, hsa-miR-125a-3p, hsa-miR-1285,hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-195, hsa-miR-15 a*,hsa-miR-450b-5p, hsa-miR-610, hsa-miR-519d, hsa-miR-198, hsa-miR-144*,hsa-miR-20a*, hsa-miR-545, hsa-miR-181d, hsa-miR-935, hsa-miR-612,hsa-miR-135b, hsa-miR-27b, hsa-miR-664*, hsa-miR-636, hsa-miR-323-3p,hsa-miR-607, hsa-miR-520e, hsa-miR-200a, hsa-miR-578, hsa-miR-10b*,hsa-miR-629*, hsa-miR-93, hsa-miR-383, hsa-miR-29b-2*, hsa-miR-192*,hsa-miR-193b, hsa-miR-566, hsa-miR-518c*, hsa-miR-942, hsa-miR-152,hsa-miR-422a, hsa-miR-23b, hsa-miR-1322, hsa-miR-362-3p, hsa-miR-1263,hsa-miR-539, hsa-miR-548a-3p, hsa-miR-1255a, hsa-miR-146b-5p,hsa-miR-412, hsa-miR-516b, hsa-miR-526b, hsa-miR-33b*, hsa-miR-149*,hsa-miR-302d*, hsa-miR-330-5p, hsa-miR-141, hsa-miR-526b*, hsa-miR-22*,hsa-miR-203, hsa-miR-708*, hsa-miR-597, hsa-miR-744*, hsa-let-7f-1*,hsa-miR-1238, hsa-miR-628-5p, hsa-miR-150, hsa-miR-181c, hsa-miR-501-5p,hsa-miR-205, hsa-miR-224, hsa-miR-1284, hsa-miR-221*, hsa-miR-659,hsa-miR-527, hsa-miR-185, hsa-miR-20b, hsa-miR-378*, hsa-miR-556-5p,hsa-miR-640, hsa-miR-100*, hsa-miR-1224-3p, hsa-miR-199a-3p,hsa-miR-106a, hsa-miR-1245, hsa-miR-138-2*, hsa-miR-877*, hsa-miR-149,hsa-miR-30b*, hsa-miR-130a*, hsa-miR-483-5p, hsa-miR-519e, hsa-miR-520h,hsa-miR-320a, hsa-miR-1225-5p, hsa-miR-10b, hsa-miR-197, hsa-miR-1228,hsa-miR-1827, hsa-miR-24, hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-17,hsa-miR-196a*, hsa-miR-382, hsa-miR-656, hsa-miR-182, hsa-miR-320b,hsa-miR-548k, hsa-miR-675, hsa-miR-424, hsa-miR-506, hsa-miR-302b,hsa-miR-181b, hsa-miR-1283, hsa-miR-548e, hsa-miR-21, hsa-miR-655,hsa-miR-485-5p, hsa-miR-199b-3p, hsa-miR-137, hsa-miR-331-3p,hsa-miR-888*, hsa-miR-488*, hsa-miR-577, hsa-miR-206, hsa-miR-7-2*,hsa-miR-196a, hsa-miR-188-5p, hsa-miR-15a, hsa-miR-485-3p, hsa-miR-632,hsa-miR-1244, hsa-miR-601, hsa-miR-20a, hsa-miR-409-3p, hsa-miR-876-3p,hsa-miR-455-3p, hsa-miR-196b, hsa-let-7a*, hsa-miR-1272, hsa-miR-509-5p,hsa-miR-944, hsa-miR-501-3p, hsa-miR-1265, hsa-miR-193b*,hsa-miR-219-2-3p, hsa-miR-515-3p, hsa-miR-140-3p, hsa-miR-106b,hsa-miR-497, hsa-miR-16-1*, hsa-miR-218, hsa-miR-302b*, hsa-miR-372,hsa-miR-326, hsa-miR-497*, hsa-miR-223*, hsa-miR-433, hsa-miR-505,hsa-miR-595, hsa-miR-154, hsa-miR-26a, hsa-miR-1275, hsa-miR-1255b,hsa-miR-1205, hsa-miR-1302, hsa-miR-891b, hsa-miR-1293, hsa-miR-613,hsa-miR-1225-3p, hsa-miR-154*, hsa-miR-671-5p, hsa-miR-512-5p,hsa-miR-340*, hsa-miR-584.

v-erb-a erythroblastic leukemia viral oncogene homolog4—ERBB4—NM_(—)001042599—hsa-miR-140-5p, hsa-miR-376b, hsa-miR-557,hsa-miR-665, hsa-miR-637, hsa-miR-200b, hsa-miR-509-3-5p,hsa-miR-490-5p, hsa-miR-642, hsa-miR-448, hsa-miR-500, hsa-miR-515-5p,hsa-miR-141*, hsa-miR-542-3p, hsa-miR-22, hsa-miR-625, hsa-miR-130b*,hsa-miR-216a, hsa-miR-19b-2*, hsa-miR-513a-5p, hsa-miR-650,hsa-miR-1276, hsa-miR-133a, hsa-miR-125b-2*, hsa-miR-520g, hsa-miR-1290,hsa-miR-222*, hsa-miR-374b, hsa-miR-181a, hsa-miR-551b*,hsa-miR-519b-3p, hsa-miR-513b, hsa-miR-182*, hsa-miR-195*,hsa-miR-302c*, hsa-miR-125a-5p, hsa-miR-221, hsa-miR-483-3p,hsa-miR-204, hsa-let-7g*, hsa-miR-377, hsa-miR-30c-1*, hsa-miR-218-1*,hsa-miR-890, hsa-miR-1248, hsa-miR-335, hsa-miR-138-1*, hsa-miR-92a-2*,hsa-miR-452, hsa-miR-16-2*, hsa-miR-496, hsa-miR-320c, hsa-miR-511,hsa-miR-661, hsa-miR-31, hsa-miR-513a-3p, hsa-miR-148a*, hsa-miR-544,hsa-miR-143, hsa-miR-142-5p, hsa-miR-379*, hsa-miR-220a, hsa-miR-24-1*,hsa-miR-335*, hsa-miR-507, hsa-miR-29b-1*, hsa-miR-378, hsa-miR-330-3p,hsa-miR-28-5p, hsa-miR-302a*, hsa-miR-561, hsa-miR-191, hsa-miR-519c-3p,hsa-miR-19b, hsa-miR-129-5p, hsa-miR-943, hsa-miR-541*, hsa-miR-548n,hsa-let-7c*, hsa-miR-603, hsa-miR-19a*, hsa-miR-519a, hsa-miR-342-3p,hsa-miR-1308, hsa-miR-130b, hsa-miR-587, hsa-miR-199a-5p, hsa-miR-1303,hsa-miR-1207-5p, hsa-miR-875-3p, hsa-miR-424*, hsa-miR-216b,hsa-miR-103, hsa-let-7d*, hsa-miR-1252, hsa-miR-630, hsa-miR-660,hsa-miR-1246, hsa-miR-379, hsa-miR-600, hsa-miR-576-5p, hsa-miR-548p,hsa-miR-876-5p, hsa-miR-19b-1*, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-374a*, hsa-miR-186, hsa-miR-23a, hsa-miR-365, hsa-miR-301b,hsa-miR-30c-2*, hsa-miR-1305, hsa-miR-337-3p, hsa-miR-33a*,hsa-miR-491-5p, hsa-miR-302f, hsa-miR-1201, hsa-miR-218-2*, hsa-miR-202,hsa-miR-606, hsa-miR-520a-5p, hsa-miR-410, hsa-miR-421, hsa-miR-24-2*,hsa-miR-548d-3p, hsa-miR-646, hsa-miR-329, hsa-let-7b*, hsa-miR-708,hsa-miR-146a*, hsa-miR-145*, hsa-miR-525-5p, hsa-miR-494, hsa-miR-411,hsa-miR-30a*, hsa-miR-371-5p, hsa-miR-30a, hsa-miR-548o, hsa-miR-376a,hsa-miR-200c, hsa-miR-581, hsa-miR-1207-3p, hsa-miR-130a, hsa-miR-145,hsa-miR-548f, hsa-miR-362-5p, hsa-miR-220c, hsa-miR-26b, hsa-miR-664,hsa-miR-765, hsa-miR-624, hsa-miR-296-5p, hsa-miR-320d, hsa-miR-599,hsa-miR-590-3p, hsa-miR-502-5p, hsa-miR-495, hsa-miR-1297, hsa-miR-7-1*,hsa-miR-939, hsa-miR-589*, hsa-miR-1253, hsa-miR-936, hsa-miR-921,hsa-miR-643, hsa-miR-135a, hsa-miR-579, hsa-miR-411*, hsa-miR-193a-3p,hsa-miR-361-5p, hsa-miR-146a, hsa-miR-768-5p, hsa-miR-1259,hsa-miR-1243, hsa-miR-1233, hsa-miR-518a-5p, hsa-miR-608, hsa-miR-27a*,hsa-miR-498, hsa-miR-1226, hsa-miR-1262, hsa-miR-633, hsa-miR-144,hsa-miR-1323, hsa-miR-125b, hsa-miR-384, hsa-miR-653, hsa-miR-888,hsa-miR-30d*, hsa-miR-568, hsa-miR-30e*, hsa-miR-592, hsa-miR-429,hsa-miR-624*, hsa-miR-570, hsa-miR-105, hsa-miR-508-3p, hsa-miR-517*,hsa-miR-940, hsa-miR-155, hsa-miR-34b, hsa-miR-325, hsa-miR-1261,hsa-miR-222, hsa-miR-432, hsa-miR-1270, hsa-miR-769-3p, hsa-miR-593,hsa-miR-768-3p, hsa-miR-450b-3p, hsa-miR-512-3p, hsa-miR-15a*,hsa-miR-331-5p, hsa-miR-450b-5p, hsa-miR-20a*, hsa-miR-452*,hsa-miR-181d, hsa-miR-135b, hsa-miR-323-3p, hsa-miR-607, hsa-miR-578,hsa-miR-30d, hsa-miR-10b*, hsa-miR-629*, hsa-miR-383, hsa-miR-155*,hsa-miR-193b, hsa-miR-200b*, hsa-miR-518c*, hsa-miR-942, hsa-miR-422a,hsa-miR-23b, hsa-miR-101, hsa-miR-1274a, hsa-miR-362-3p, hsa-miR-545*,hsa-miR-539, hsa-miR-609, hsa-miR-548a-3p, hsa-miR-1255a, hsa-miR-1229,hsa-miR-146b-5p, hsa-miR-634, hsa-miR-133b, hsa-miR-620, hsa-miR-302d*,hsa-miR-330-5p, hsa-miR-551a, hsa-miR-301a, hsa-miR-889, hsa-miR-571,hsa-miR-625*, hsa-miR-708*, hsa-miR-211, hsa-miR-519e*, hsa-let-7f-1*,hsa-miR-432*, hsa-miR-1300, hsa-miR-30c, hsa-miR-181c, hsa-miR-181a-2*,hsa-miR-583, hsa-miR-501-5p, hsa-miR-199b-5p, hsa-miR-205, hsa-miR-527,hsa-miR-378*, hsa-miR-1321, hsa-miR-640, hsa-miR-199a-3p, hsa-miR-18a*,hsa-miR-130a*, hsa-miR-758, hsa-miR-520h, hsa-miR-320a, hsa-miR-339-5p,hsa-miR-1827, hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-135a*,hsa-miR-663b, hsa-miR-1279, hsa-miR-7, hsa-miR-656, hsa-miR-320b,hsa-miR-454, hsa-miR-1264, hsa-miR-297, hsa-miR-548k, hsa-miR-548l,hsa-miR-181b, hsa-miR-1283, hsa-miR-187*, hsa-miR-548e, hsa-miR-1251,hsa-miR-199b-3p, hsa-miR-137, hsa-miR-1278, hsa-miR-331-3p,hsa-miR-888*, hsa-miR-577, hsa-miR-7-2*, hsa-miR-377*, hsa-miR-107,hsa-miR-19a, hsa-miR-188-5p, hsa-miR-485-3p, hsa-miR-374a, hsa-miR-1244,hsa-miR-556-3p, hsa-miR-425, hsa-miR-409-3p, hsa-miR-876-3p,hsa-let-7a*, hsa-miR-509-5p, hsa-miR-944, hsa-miR-340, hsa-miR-1265,hsa-miR-499-5p, hsa-miR-219-2-3p, hsa-miR-140-3p, hsa-let-7f-2*,hsa-miR-1197, hsa-miR-302b*, hsa-miR-551b, hsa-miR-326, hsa-miR-497*,hsa-miR-433, hsa-miR-505, hsa-miR-499-3p, hsa-miR-26a, hsa-miR-1275,hsa-miR-1255b, hsa-miR-142-3p, hsa-miR-520d-5p, hsa-miR-200a*,hsa-miR-558, hsa-miR-1293, hsa-miR-584, hsa-miR-30e.

Epithelial membrane protein 1—EMP1—NM_(—)001423—hsa-miR-557,hsa-miR-877, hsa-miR-1266, hsa-miR-500, hsa-miR-141*, hsa-miR-22,hsa-miR-922, hsa-miR-138, hsa-miR-130b*, hsa-miR-19b-2*,hsa-miR-513a-5p, hsa-miR-1290, hsa-miR-454*, hsa-miR-195*,hsa-miR-337-5p, hsa-miR-204, hsa-let-7g*, hsa-miR-548a-5p, hsa-miR-376c,hsa-miR-647, hsa-miR-559, hsa-miR-1248, hsa-miR-138-1*, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-16-2*, hsa-miR-496, miR-31, hsa-miR-507,hsa-miR-548m, hsa-miR-330-3p, hsa-miR-190, hsa-miR-129-5p, hsa-miR-548n,hsa-miR-217, hsa-let-7c*, hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-508-5p,hsa-miR-1303, hsa-miR-1207-5p, hsa-miR-424*, hsa-miR-216b, hsa-miR-148a,hsa-miR-299-5p, hsa-miR-19b-1*, hsa-miR-143*, hsa-miR-34a*,hsa-miR-548i, hsa-miR-606, hsa-miR-548d-3p, hsa-miR-516b*,hsa-miR-324-3p, hsa-miR-548o, hsa-miR-1, hsa-miR-1207-3p, hsa-miR-616*,hsa-miR-148b, hsa-miR-373*, hsa-miR-573, hsa-miR-296-5p, hsa-miR-1324,hsa-miR-188-3p, hsa-miR-96*, hsa-miR-591, hsa-miR-1208, hsa-miR-26b*,hsa-miR-190b, hsa-miR-936, hsa-miR-135a, hsa-miR-1259, hsa-miR-147,hsa-miR-1233, hsa-miR-1226, hsa-miR-185*, hsa-miR-144, hsa-miR-1323,hsa-miR-654-3p, hsa-miR-592, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-1294,hsa-miR-610, hsa-miR-20a*, hsa-miR-135b, hsa-miR-548j, hsa-miR-200a,hsa-miR-10b*, hsa-miR-629*, hsa-miR-518c*, hsa-miR-152, hsa-miR-101,hsa-miR-539, hsa-miR-1255a, hsa-miR-33b, hsa-miR-634, hsa-miR-567,hsa-miR-141, hsa-miR-203, hsa-miR-548h, hsa-miR-708*, hsa-miR-597,hsa-miR-211, hsa-miR-361-3p, hsa-miR-181a-2*, hsa-miR-760, hsa-miR-583,hsa-miR-501-5p, hsa-miR-1321, hsa-miR-486-5p, hsa-miR-548c-3p,hsa-miR-548k, hsa-miR-187*, hsa-miR-206, hsa-miR-33a, hsa-miR-183,hsa-miR-338-3p, hsa-miR-219-2-3p, hsa-miR-367*, hsa-miR-1255b,hsa-miR-1205, hsa-miR-558, hsa-miR-613, hsa-miR-95.

Low Density Lipoprotein receptor-related protein associated protein1—LRPAP1—NM_(—)002337—hsa-miR-576-3p, hsa-miR-200b, hsa-miR-500,hsa-miR-335, hsa-miR-146b-3p, hsa-miR-1825, hsa-miR-134, hsa-miR-1236,hsa-miR-646, hsa-miR-200c, hsa-miR-1207-3p, hsa-miR-1202,hsa-miR-885-3p, hsa-miR-361-5p, hsa-miR-374b*, hsa-miR-608,hsa-miR-220b, hsa-miR-429, hsa-miR-105, hsa-miR-33b*, hsa-miR-17*,hsa-miR-877*, hsa-miR-519e, hsa-miR-515-3p, hsa-miR-1293,hsa-miR-671-5p.

SCY1-like binding protein 1—SCYL1BP1—NM_(—)152281—hsa-miR-665,hsa-miR-562, hsa-miR-125b-2*, hsa-miR-1290, hsa-miR-101*, hsa-miR-55 1b*, hsa-miR-513b, hsa-miR-195*, hsa-miR-16-2*, hsa-miR-511,hsa-miR-29b-1*, hsa-miR-191, hsa-miR-194, hsa-miR-548n, hsa-miR-657,hsa-miR-582-5p, hsa-miR-338-5p, hsa-miR-34a*, hsa-miR-186, hsa-miR-618,hsa-miR-33a*, hsa-miR-494, hsa-miR-30a*, hsa-miR-145, hsa-miR-616*,hsa-miR-373*, hsa-miR-26b, hsa-miR-628-3p, hsa-miR-617, hsa-miR-495,hsa-miR-1297, hsa-miR-768-5p, hsa-miR-30d*, hsa-miR-802, hsa-miR-30e*,hsa-miR-34b, hsa-miR-768-3p, hsa-miR-331-5p, hsa-miR-607, hsa-miR-200a,hsa-miR-548b-3p, hsa-miR-545*, hsa-miR-141, hsa-miR-889, hsa-miR-22*,hsa-miR-203, hsa-miR-501-5p, hsa-miR-224, hsa-miR-659, hsa-miR-548c-3p,hsa-miR-382, hsa-miR-656, hsa-miR-548l, hsa-miR-488*, hsa-miR-595,hsa-miR-26a, hsa-miR-891b.

Cleavage stimulation factor, 3′ pre-RNA, subunit 1, 50 kDa—CSTF1—Variant1, Variant 2 and Variant 3—NM_(—)001033521, NM_(—)001324 andNM_(—)001033522—hsa-miR-510, hsa-miR-509-3-5p, hsa-miR-922, hsa-miR-192,hsa-miR-1184, hsa-miR-1301, hsa-miR-454*, hsa-miR-142-5p, hsa-miR-619,hsa-miR-424*, hsa-miR-548p, hsa-miR-582-5p, hsa-miR-374a*, hsa-miR-365,hsa-miR-337-3p, hsa-miR-410, hsa-miR-421, hsa-let-7b*, hsa-miR-548f,hsa-miR-765, hsa-miR-590-3p, hsa-miR-215, hsa-miR-193a-3p,hsa-miR-361-5p, hsa-miR-653, hsa-miR-545, hsa-miR-935, hsa-miR-607,hsa-miR-193b, hsa-miR-200b*, hsa-miR-548b-3p, hsa-miR-1257,hsa-miR-548a-3p, hsa-miR-567, hsa-let-7f-1*, hsa-miR-583,hsa-miR-486-5p, hsa-miR-196a*, hsa-miR-548e, hsa-miR-1298, hsa-let-7a*,hsa-miR-509-5p, hsa-miR-1275, hsa-miR-200a*, hsa-miR-558, hsa-miR-135b*.

Kelch-like 20—KLHL20—NM_(—)014458—hsa-miR-500, hsa-miR-20b*,hsa-miR-219-1-3p, hsa-miR-19b-2*, hsa-miR-519b-3p, hsa-miR-548g,hsa-miR-30c-1*, hsa-miR-1304, hsa-miR-548a-5p, hsa-miR-559,hsa-miR-548b-5p, hsa-miR-15b*, hsa-miR-544, hsa-miR-29b-1*,hsa-miR-548m, hsa-miR-1237, hsa-miR-519c-3p, hsa-miR-19b,hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-938, hsa-miR-519a, hsa-miR-130b,hsa-miR-370, hsa-miR-623, hsa-miR-580, hsa-miR-129*, hsa-miR-576-5p,hsa-miR-548p, hsa-miR-19b-1*, hsa-miR-524-5p, hsa-miR-30b, hsa-miR-301b,hsa-miR-30c-2*, hsa-miR-618, hsa-miR-33a*, hsa-miR-548i, hsa-miR-641,hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-30a, hsa-miR-130a, hsa-miR-548f,hsa-miR-362-5p, hsa-miR-664, hsa-miR-96*, hsa-miR-513c, hsa-miR-1253,hsa-miR-768-5p, hsa-miR-18b, hsa-miR-802, hsa-miR-568, hsa-miR-570,hsa-miR-508-3p, hsa-miR-517*, hsa-miR-548d-5p, hsa-miR-432,hsa-miR-125a-3p, hsa-miR-519d, hsa-miR-548j, hsa-miR-578, hsa-miR-30d,hsa-miR-629*, hsa-miR-93, hsa-miR-548b-3p, hsa-miR-942, hsa-miR-548a-3p,hsa-miR-302d*, hsa-miR-301 a, hsa-miR-526b*, hsa-miR-548h, hsa-miR-381,hsa-miR-744*, hsa-let-7f-1*, hsa-miR-432*, hsa-miR-30c, hsa-miR-18a,hsa-miR-20b, hsa-miR-106a, hsa-miR-18a*, hsa-miR-30b*, hsa-miR-129-3p,hsa-miR-17, hsa-miR-656, hsa-miR-454, hsa-miR-1264, hsa-miR-548e,hsa-miR-655, hsa-miR-485-5p, hsa-miR-122, hsa-miR-19a, hsa-miR-188-5p,hsa-miR-300, hsa-miR-20a, hsa-miR-876-3p, hsa-let-7a*, hsa-miR-944,hsa-miR-219-3p, hsa-miR-106b, hsa-miR-302b*, hsa-miR-367*, hsa-miR-1183,hsa-miR-154, hsa-miR-142-3p, hsa-miR-520d-5p, hsa-miR-558, hsa-miR-30e.

DnaJ (Hsp40) homolog, subfamily C, member13—DNAJC13—NM_(—)015268—hsa-miR-557, hsa-miR-665, hsa-miR-493*,hsa-miR-181a, hsa-miR-204, hsa-miR-96, hsa-miR-27a, hsa-miR-92a-2*,hsa-miR-575, hsa-miR-511, hsa-miR-335*, hsa-miR-507, hsa-miR-330-3p,hsa-miR-561, hsa-miR-129-5p, hsa-miR-943, hsa-miR-651, hsa-miR-30b,hsa-miR-30a, hsa-miR-489, hsa-miR-1, hsa-miR-581, hsa-miR-1207-3p,hsa-miR-569, hsa-miR-590-3p, hsa-miR-1271, hsa-miR-7-1*,hsa-miR-193a-3p, hsa-miR-520f, hsa-miR-633, hsa-miR-568, hsa-miR-588,hsa-miR-34b*, hsa-miR-181d, hsa-miR-27b, hsa-miR-200a, hsa-miR-578,hsa-miR-30d, hsa-miR-193b, hsa-miR-139-5p, hsa-miR-141, hsa-miR-211,hsa-miR-432*, hsa-miR-30c, hsa-miR-181c, hsa-miR-640, hsa-miR-181b,hsa-miR-206, hsa-miR-7-2*, hsa-miR-340, hsa-miR-218, hsa-miR-1183,hsa-miR-613, hsa-miR-30e.

Amyloid beta (A4) precursor-like protein2—APLP2—NM_(—)001642—hsa-miR-665, hsa-miR-200b, hsa-miR-1254,hsa-miR-16, hsa-miR-448, hsa-miR-1180, hsa-miR-141*, hsa-miR-542-3p,hsa-miR-493*, hsa-miR-219-1-3p, hsa-miR-513a-5p, hsa-miR-513b,hsa-miR-548g, hsa-miR-377, hsa-miR-363*, hsa-miR-335*, hsa-miR-378,hsa-miR-885-5p, hsa-miR-128, hsa-miR-409-5p, hsa-miR-298, hsa-miR-216b,hsa-miR-1252, hsa-miR-1182, hsa-miR-660, hsa-miR-582-5p, hsa-miR-524-5p,hsa-miR-30b, hsa-miR-186, hsa-miR-520a-5p, hsa-miR-212, hsa-miR-153,hsa-miR-525-5p, hsa-miR-582-3p, hsa-miR-30a, hsa-miR-200c, hsa-miR-450a,hsa-miR-765, hsa-miR-532-5p, hsa-miR-15b, hsa-miR-1324, hsa-miR-495,hsa-miR-132, hsa-miR-885-3p, hsa-miR-1243, hsa-miR-608, hsa-miR-592,hsa-miR-596, hsa-miR-429, hsa-miR-503, hsa-miR-570, hsa-miR-517*,hsa-miR-324-5p, hsa-miR-769-3p, hsa-miR-450b-3p, hsa-miR-195,hsa-miR-198, hsa-miR-452*, hsa-miR-200a, hsa-miR-30d, hsa-miR-155*,hsa-miR-942, hsa-miR-422a, hsa-miR-1257, hsa-miR-33b*, hsa-miR-302d*,hsa-miR-139-5p, hsa-miR-141, hsa-miR-30c, hsa-miR-221 *,hsa-miR-1224-3p, hsa-miR-199a-3p, hsa-miR-519e, hsa-miR-548l,hsa-miR-424, hsa-miR-485-5p, hsa-miR-199b-3p, hsa-miR-331-3p,hsa-miR-892a, hsa-miR-15a, hsa-miR-556-3p, hsa-miR-455-3p, hsa-miR-1265,hsa-miR-193b*, hsa-miR-515-3p, hsa-miR-140-3p, hsa-miR-887, hsa-miR-497,hsa-miR-302b*, hsa-miR-520d-5p, hsa-miR-891b, hsa-miR-30e.

Sorbin and SH3 domain containing 2—SORBS2—Variant 1 and Variant2—NM_(—)003603 and NM_(—)021069—hsa-miR-376b, hsa-miR-557,hsa-miR-518d-5p, hsa-miR-637, hsa-miR-448, hsa-miR-519a*, hsa-miR-500,hsa-miR-522*, hsa-miR-493*, hsa-miR-138, hsa-miR-216a, hsa-miR-1276,hsa-miR-222*, hsa-miR-181a, hsa-miR-551b*, hsa-miR-302c*, hsa-miR-1179,hsa-miR-1248, hsa-miR-127-5p, hsa-miR-452, hsa-miR-320c, hsa-miR-661,hsa-miR-513a-3p, hsa-miR-507, hsa-miR-190, hsa-miR-561, hsa-miR-129-5p,hsa-miR-93*, hsa-miR-603, hsa-miR-128, hsa-miR-619, hsa-miR-587,hsa-miR-623, hsa-miR-1246, hsa-miR-600, hsa-miR-548p, hsa-miR-582-5p,hsa-miR-524-5p, hsa-miR-34a*, hsa-miR-374a*, hsa-miR-186, hsa-miR-23a,hsa-miR-329, hsa-miR-1281, hsa-miR-376a, hsa-miR-548f, hsa-miR-362-5p,hsa-miR-664, hsa-miR-484, hsa-miR-320d, hsa-miR-188-3p, hsa-miR-502-5p,hsa-miR-7-1*, hsa-miR-190b, hsa-miR-936, hsa-miR-643, hsa-miR-579,hsa-miR-518a-5p, hsa-miR-18b, hsa-miR-384, hsa-miR-653, hsa-miR-505*,hsa-miR-596, hsa-miR-503, hsa-miR-34b, hsa-miR-1270, hsa-miR-518f*,hsa-miR-768-3p, hsa-miR-519d, hsa-miR-545, hsa-miR-181d, hsa-miR-935,hsa-miR-636, hsa-miR-520c-5p, hsa-miR-200a, hsa-miR-93, hsa-miR-1206,hsa-miR-200b*, hsa-miR-491-3p, hsa-miR-23b, hsa-miR-1322,hsa-miR-362-3p, hsa-miR-609, hsa-miR-548a-3p, hsa-miR-33b*, hsa-miR-620,hsa-miR-141, hsa-miR-526b*, hsa-miR-203, hsa-miR-518e*, hsa-miR-181c,hsa-miR-526a, hsa-miR-342-5p, hsa-miR-18a, hsa-miR-527, hsa-miR-20b,hsa-miR-523*, hsa-miR-106a, hsa-miR-138-2*, hsa-miR-130a*, hsa-miR-519e,hsa-miR-320a, hsa-miR-17, hsa-miR-196a*, hsa-miR-500*, hsa-miR-1279,hsa-miR-320b, hsa-miR-1264, hsa-miR-297, hsa-miR-548k, hsa-miR-1274b,hsa-miR-181b, hsa-miR-548e, hsa-miR-485-5p, hsa-miR-137, hsa-miR-577,hsa-miR-7-2*, hsa-miR-485-3p, hsa-miR-556-3p, hsa-miR-20a,hsa-miR-876-3p, hsa-miR-126*, hsa-miR-519b-5p, hsa-miR-944, hsa-miR-340,hsa-miR-515-3p, hsa-miR-140-3p, hsa-miR-106b, hsa-miR-519c-5p,hsa-miR-497*, hsa-miR-433, hsa-miR-1275, hsa-miR-520d-5p, hsa-miR-200a*,hsa-miR-891b, hsa-miR-671-5p.

DnaJ (Hsp40) homolog, subfamily B, member1—DNAJB1—NM_(—)006145—hsa-miR-194*, hsa-miR-665, hsa-miR-509-3-5p,hsa-miR-34c-5p, hsa-miR-500, hsa-miR-380*, hsa-miR-648, hsa-miR-9,hsa-miR-133a, hsa-miR-520g, hsa-miR-181a, hsa-miR-204, hsa-let-7g*,hsa-miR-668, hsa-miR-563, hsa-miR-532-3p, hsa-miR-377, hsa-miR-30c-1*,hsa-miR-647, hsa-miR-920, hsa-miR-544, hsa-miR-486-3p, hsa-miR-449a,hsa-miR-378, hsa-miR-19b, hsa-miR-892b, hsa-miR-603, hsa-miR-128,hsa-miR-370, hsa-miR-623, hsa-miR-875-3p, hsa-miR-657, hsa-miR-1182,hsa-miR-600, hsa-miR-543, hsa-miR-30c-2*, hsa-miR-449b, hsa-miR-202,hsa-miR-641, hsa-miR-548d-3p, hsa-miR-582-3p, hsa-miR-362-5p,hsa-miR-484, hsa-miR-1269, hsa-miR-765, hsa-miR-532-5p, hsa-miR-939,hsa-miR-1253, hsa-miR-34a, hsa-miR-193a-3p, hsa-miR-186*, hsa-miR-220b,hsa-miR-505*, hsa-miR-1224-5p, hsa-miR-570, hsa-miR-508-3p, hsa-miR-155,hsa-miR-34b*, hsa-miR-148b*, hsa-miR-198, hsa-miR-181d, hsa-miR-299-3p,hsa-miR-383, hsa-miR-193b, hsa-miR-518c*, hsa-miR-1260, hsa-miR-422a,hsa-miR-1229, hsa-miR-133b, hsa-miR-149*, hsa-miR-328, hsa-miR-211,hsa-miR-181c, hsa-miR-181a-2*, hsa-miR-1284, hsa-miR-149, hsa-miR-520h,hsa-miR-1299, hsa-miR-181b, hsa-miR-485-5p, hsa-miR-137, hsa-miR-331-3p,hsa-miR-122, hsa-miR-19a, hsa-miR-188-5p, hsa-miR-627, hsa-miR-509-5p,hsa-miR-574-5p, hsa-let-7f-2*, hsa-miR-346, hsa-miR-497*, hsa-miR-662,hsa-miR-1205, hsa-miR-891b.

Nebulette—NEBL—Variant 1 and Variant 2—NM_(—)006393 andNM_(—)213569—hsa-miR-518d-5p, hsa-miR-509-3-5p, hsa-miR-877,hsa-miR-380, hsa-miR-16, hsa-miR-519a*, hsa-miR-500, hsa-miR-542-3p,hsa-miR-522*, hsa-miR-22, hsa-miR-138, hsa-miR-130b*, hsa-miR-216a,hsa-miR-19b-2*, hsa-miR-513a-5p, hsa-miR-766, hsa-miR-9, hsa-miR-133a,hsa-miR-520g, hsa-miR-150*, hsa-miR-1301, hsa-miR-181a, hsa-miR-551b*,hsa-miR-195*, hsa-miR-302c*, hsa-miR-221, hsa-miR-548g, hsa-miR-214,hsa-miR-532-3p, hsa-miR-377, hsa-miR-549, hsa-miR-1826, hsa-miR-647,hsa-miR-27a, hsa-miR-1248, hsa-miR-335, hsa-miR-127-5p, hsa-miR-516a-3p,hsa-miR-452, hsa-miR-16-2*, hsa-miR-496, hsa-miR-320c, hsa-miR-661,hsa-miR-31*, hsa-miR-513a-3p, hsa-miR-99a, hsa-miR-148a*, hsa-miR-335*,hsa-miR-29b-1*, hsa-miR-378, hsa-miR-302a*, hsa-miR-1237, hsa-miR-191,hsa-miR-129-5p, hsa-miR-541*, hsa-miR-548n, hsa-miR-892b, hsa-miR-1288,hsa-let-7c*, hsa-miR-769-5p, hsa-miR-19a*, hsa-miR-508-5p, hsa-miR-619,hsa-miR-1303, hsa-miR-1207-5p, hsa-miR-623, hsa-miR-216b, hsa-miR-148a,hsa-miR-548p, hsa-miR-621, hsa-miR-582-5p, hsa-miR-338-5p,hsa-miR-19b-1*, hsa-miR-524-5p, hsa-miR-30b, hsa-miR-543, hsa-miR-34a*,hsa-miR-374a*, hsa-miR-618, hsa-miR-1305, hsa-miR-337-3p, hsa-miR-33a*,hsa-miR-218-2*, hsa-miR-606, hsa-miR-410, hsa-miR-421, hsa-miR-641,hsa-miR-548d-3p, hsa-miR-516b*, hsa-miR-30a*, hsa-miR-30a, hsa-miR-548o,hsa-miR-581, hsa-miR-616*, hsa-miR-148b, hsa-miR-373*, hsa-miR-548f,hsa-miR-362-5p, hsa-miR-220c, hsa-miR-26b, hsa-miR-569, hsa-miR-664,hsa-miR-484, hsa-miR-573, hsa-miR-1269, hsa-miR-628-3p, hsa-miR-624,hsa-miR-532-5p, hsa-miR-15b, hsa-miR-320d, hsa-miR-96*, hsa-miR-590-3p,hsa-miR-29c, hsa-miR-513c, hsa-miR-1297, hsa-miR-1208, hsa-miR-635,hsa-miR-1200, hsa-miR-29b, hsa-miR-579, hsa-miR-193a-3p, hsa-miR-361-5p,hsa-miR-605, hsa-miR-1243, hsa-miR-374b*, hsa-miR-147, hsa-miR-518a-5p,hsa-miR-18b, hsa-miR-1226, hsa-miR-185*, hsa-miR-1262, hsa-miR-1323,hsa-miR-888, hsa-miR-30d*, hsa-miR-802, hsa-miR-30e*, hsa-miR-596,hsa-miR-29a, hsa-miR-570, hsa-miR-105, hsa-miR-124, hsa-miR-324-5p,hsa-miR-222, hsa-miR-1270, hsa-miR-769-3p, hsa-miR-518f*,hsa-miR-450b-3p, hsa-miR-195, hsa-miR-331-5p, hsa-miR-198, hsa-miR-20a*,hsa-miR-181d, hsa-miR-9*, hsa-miR-27b, hsa-miR-636, hsa-miR-520c-5p,hsa-miR-30d, hsa-miR-383, hsa-miR-155*, hsa-miR-193b, hsa-miR-200b*,hsa-miR-518c*, hsa-miR-548b-3p, hsa-miR-523, hsa-miR-1260, hsa-miR-942,hsa-miR-152, hsa-miR-422a, hsa-miR-1322, hsa-miR-1263, hsa-miR-545*,hsa-miR-539, hsa-miR-1257, hsa-miR-548a-3p, hsa-miR-634, hsa-miR-133b,hsa-miR-567, hsa-miR-149*, hsa-miR-620, hsa-miR-302d*, hsa-miR-223,hsa-miR-889, hsa-miR-203, hsa-miR-625*, hsa-miR-708*, hsa-miR-1185,hsa-miR-744*, hsa-miR-518e*, hsa-miR-1238, hsa-miR-30c, hsa-miR-181c,hsa-miR-526a, hsa-miR-18a, hsa-miR-205, hsa-miR-224, hsa-miR-151-5p,hsa-miR-1284, hsa-miR-527, hsa-miR-378*, hsa-miR-556-5p, hsa-miR-100*,hsa-miR-523*, hsa-miR-631, hsa-miR-1224-3p, hsa-miR-30b*, hsa-miR-99b,hsa-miR-520h, hsa-miR-320a, hsa-miR-486-5p, hsa-miR-202*,hsa-miR-548c-3p, hsa-miR-135a*, hsa-miR-100, hsa-miR-382, hsa-miR-320b,hsa-miR-1264, hsa-miR-548k, hsa-miR-5481, hsa-miR-424, hsa-miR-506,hsa-miR-181b, hsa-miR-1283, hsa-miR-548e, hsa-miR-577, hsa-miR-188-5p,hsa-miR-15a, hsa-miR-485-3p, hsa-miR-423-5p, hsa-miR-126*,hsa-miR-519b-5p, hsa-miR-509-5p, hsa-miR-944, hsa-miR-1265,hsa-miR-193b*, hsa-miR-140-3p, hsa-miR-497, hsa-miR-296-3p,hsa-let-7f-2*, hsa-miR-519c-5p, hsa-miR-218, hsa-miR-302b*,hsa-miR-367*, hsa-miR-595, hsa-miR-26a, hsa-miR-520d-5p, hsa-miR-200a*,hsa-miR-891b, hsa-miR-30e.

SH3 domain binding glutamic acid-rich proteinlike—SH3BGRL—NM_(—)003022—hsa-miR-448, hsa-miR-130b*, hsa-miR-216a,hsa-miR-221, hsa-miR-890, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-548b-5p,hsa-miR-511, hsa-miR-26a-1*, hsa-miR-548m, hsa-miR-129-5p, hsa-miR-548n,hsa-let-7c*, hsa-miR-548c-5p, hsa-miR-128, hsa-miR-298, hsa-miR-216b,hsa-miR-586, hsa-miR-524-5p, hsa-miR-186, hsa-miR-1305, hsa-miR-33a*,hsa-miR-548i, hsa-miR-606, hsa-miR-548o, hsa-miR-1, hsa-miR-664,hsa-miR-590-3p, hsa-miR-135a, hsa-miR-26a-2*, hsa-miR-520f,hsa-miR-1259, hsa-miR-1323, hsa-miR-488, hsa-miR-548d-5p,hsa-miR-324-5p, hsa-miR-222, hsa-miR-210, hsa-miR-15a*, hsa-miR-135b,hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607, hsa-miR-578, hsa-miR-1206,hsa-miR-609, hsa-miR-634, hsa-miR-889, hsa-miR-203, hsa-miR-548h,hsa-miR-181a-2*, hsa-miR-1284, hsa-miR-138-2*, hsa-miR-106a*,hsa-miR-182, hsa-miR-1264, hsa-miR-548k, hsa-miR-1283, hsa-miR-655,hsa-miR-137, hsa-miR-1278, hsa-miR-206, hsa-miR-196a, hsa-miR-485-3p,hsa-miR-196b, hsa-miR-338-3p, hsa-let-7f-2*, hsa-miR-649, hsa-miR-433,hsa-miR-154, hsa-miR-142-3p, hsa-miR-520d-5p, hsa-miR-891b, hsa-miR-558,hsa-miR-613.

Nudix (nucleoside diphosphate linked moiety X)-type motif5—NUDT5—NM_(—)014142—hsa-miR-199a-5p, hsa-miR-524-5p, hsa-miR-26b*,hsa-miR-323-5p, hsa-miR-199b-5p, hsa-miR-1264, hsa-miR-218,hsa-miR-520d-5p.

GABA(A) receptor-associated protein like1—GABARAPL1—NM_(—)031412—hsa-miR-194*, hsa-miR-140-5p, hsa-miR-200b,hsa-miR-877, hsa-miR-16, hsa-miR-130b*, hsa-miR-1276, hsa-miR-133a,hsa-miR-125b-2*, hsa-miR-1301, hsa-miR-551b*, hsa-miR-1179,hsa-miR-532-3p, hsa-miR-30c-1*, hsa-miR-513a-3p, hsa-miR-143,hsa-miR-335*, hsa-miR-548m, hsa-miR-378, hsa-miR-1237, hsa-miR-19b,hsa-miR-1288, hsa-miR-130b, hsa-miR-657, hsa-miR-216b, hsa-miR-103,hsa-miR-548p, hsa-miR-301b, hsa-miR-30c-2*, hsa-miR-33a*, hsa-miR-1201,hsa-miR-646, hsa-miR-329, hsa-let-7b*, hsa-miR-200c, hsa-miR-1207-3p,hsa-miR-130a, hsa-miR-145, hsa-miR-220c, hsa-miR-1269, hsa-miR-15b,hsa-miR-96*, hsa-miR-502-5p, hsa-miR-605, hsa-miR-374b*, hsa-miR-186*,hsa-miR-147, hsa-miR-608, hsa-miR-505*, hsa-miR-654-3p, hsa-miR-429,hsa-miR-155, hsa-miR-768-3p, hsa-miR-195, hsa-miR-545, hsa-miR-629*,hsa-miR-934, hsa-miR-548b-3p, hsa-miR-1260, hsa-miR-422a, hsa-miR-1274a,hsa-miR-362-3p, hsa-miR-412, hsa-miR-133b, hsa-miR-301a, hsa-miR-203,hsa-miR-381, hsa-miR-593*, hsa-let-7f-1*, hsa-miR-205, hsa-miR-17*,hsa-miR-378*, hsa-miR-1256, hsa-miR-339-5p, hsa-miR-454, hsa-miR-424,hsa-miR-331-3p, hsa-miR-888*, hsa-miR-107, hsa-miR-19a, hsa-miR-300,hsa-miR-15a, hsa-let-7a*, hsa-miR-944, hsa-miR-497, hsa-miR-595,hsa-miR-1293.

Microtubule-associated protein tau—MAPT—Variant 1, Variant 2, Variant 3and Variant 4—NM_(—)016835, NM_(—)005910, NM_(—)016834 andNM_(—)016841—hsa-miR-132*, hsa-miR-453, hsa-miR-518d-5p, hsa-miR-637,hsa-miR-510, hsa-miR-509-3-5p, hsa-miR-520b, hsa-miR-1266,hsa-miR-34c-5p, hsa-miR-1254, hsa-miR-642, hsa-miR-519a*, hsa-miR-500,hsa-miR-380*, hsa-miR-522*, hsa-miR-22, hsa-miR-922, hsa-miR-625,hsa-miR-19b-2*, hsa-miR-766, hsa-miR-650, hsa-miR-125b-2*, hsa-miR-520g,hsa-miR-615-5p, hsa-miR-181a, hsa-miR-513b, hsa-miR-337-5p,hsa-miR-548g, hsa-miR-204, hsa-miR-96, hsa-miR-604, hsa-miR-668,hsa-miR-563, hsa-miR-214, hsa-miR-532-3p, hsa-miR-377, hsa-miR-30c-1*,hsa-miR-923, hsa-miR-890, hsa-miR-647, hsa-miR-335, hsa-miR-920,hsa-miR-363*, hsa-miR-516a-3p, hsa-miR-575, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-661, hsa-miR-142-5p, hsa-miR-486-3p,hsa-miR-449a, hsa-miR-378, hsa-miR-330-3p, hsa-miR-892b, hsa-miR-1288,hsa-miR-302e, hsa-miR-93*, hsa-miR-603, hsa-miR-19a*, hsa-miR-1825,hsa-miR-134, hsa-miR-342-3p, hsa-miR-508-5p, hsa-miR-1231, hsa-miR-663,hsa-miR-370, hsa-miR-199a-5p, hsa-miR-1207-5p, hsa-miR-623, hsa-miR-657,hsa-miR-876-5p, hsa-miR-615-3p, hsa-miR-19b-1*, hsa-miR-524-5p,hsa-miR-186, hsa-miR-30c-2*, hsa-miR-449b, hsa-miR-33a*, hsa-miR-302c,hsa-miR-302f, hsa-miR-520a-5p, hsa-miR-641, hsa-miR-212, hsa-miR-516b*,hsa-miR-646, hsa-miR-329, hsa-miR-525-5p, hsa-miR-582-3p, hsa-miR-489,hsa-miR-29a*, hsa-miR-622, hsa-miR-324-3p, hsa-miR-548o, hsa-miR-1227,hsa-miR-373, hsa-miR-1207-3p, hsa-miR-874, hsa-miR-220c, hsa-miR-302d,hsa-miR-1202, hsa-miR-765, hsa-miR-624, hsa-miR-1324, hsa-miR-320d,hsa-miR-188-3p, hsa-miR-617, hsa-miR-1271, hsa-miR-513c, hsa-miR-132,hsa-miR-589, hsa-miR-635, hsa-miR-767-3p, hsa-miR-589*, hsa-miR-1291,hsa-miR-34a, hsa-miR-135a, hsa-miR-579, hsa-miR-146a, hsa-miR-605,hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-608, hsa-miR-27a*,hsa-miR-144, hsa-miR-1323, hsa-miR-214*, hsa-miR-220b, hsa-miR-505*,hsa-miR-302a, hsa-miR-596, hsa-miR-503, hsa-miR-517*, hsa-miR-940,hsa-miR-432, hsa-miR-593, hsa-miR-136*, hsa-miR-518f*, hsa-miR-34b*,hsa-miR-148b*, hsa-miR-125a-3p, hsa-miR-512-3p, hsa-miR-520d-3p,hsa-miR-18b*, hsa-miR-450b-5p, hsa-miR-181d, hsa-miR-135b, hsa-miR-1204,hsa-miR-9*, hsa-miR-607, hsa-miR-520e, hsa-miR-520c-5p, hsa-miR-578,hsa-miR-629*, hsa-miR-934, hsa-miR-200b*, hsa-miR-548b-3p, hsa-miR-942,hsa-miR-422a, hsa-miR-362-3p, hsa-miR-539, hsa-miR-1255a, hsa-miR-1229,hsa-miR-146b-5p, hsa-miR-516b, hsa-miR-149*, hsa-miR-302d*, hsa-miR-492,hsa-miR-211, hsa-miR-361-3p, hsa-miR-518e*, hsa-miR-593*, hsa-miR-1300,hsa-miR-150, hsa-miR-181c, hsa-miR-526a, hsa-miR-181a-2*, hsa-miR-760,hsa-miR-583, hsa-miR-501-5p, hsa-miR-199b-5p, hsa-miR-151-5p,hsa-miR-527, hsa-miR-17*, hsa-miR-378*, hsa-miR-1321, hsa-miR-523*,hsa-miR-1245, hsa-miR-877*, hsa-miR-149, hsa-miR-18a*, hsa-miR-30b*,hsa-miR-191*, hsa-miR-550, hsa-miR-758, hsa-miR-520h, hsa-miR-320a,hsa-miR-197, hsa-miR-1827, hsa-miR-24, hsa-miR-196a*, hsa-miR-663b,hsa-miR-500*, hsa-miR-320b, hsa-miR-302b, hsa-miR-626, hsa-miR-181b,hsa-miR-187*, hsa-miR-1251, hsa-miR-485-5p, hsa-miR-888*, hsa-miR-377*,hsa-miR-188-5p, hsa-miR-219-5p, hsa-miR-409-3p, hsa-miR-876-3p,hsa-miR-519b-5p, hsa-miR-509-5p, hsa-miR-944, hsa-miR-887,hsa-miR-296-3p, hsa-miR-1197, hsa-miR-519c-5p, hsa-miR-346, hsa-miR-218,hsa-miR-302b*, hsa-miR-372, hsa-miR-505, hsa-miR-1275, hsa-miR-1255b,hsa-miR-520d-5p, hsa-miR-200a*, hsa-miR-1205, hsa-miR-1302, hsa-miR-558,hsa-miR-1293, hsa-miR-1225-3p, hsa-miR-671-5p, hsa-miR-512-5p.

Discoidin, CUB and LCCL domain containing1—DCBLD1—NM_(—)173674—hsa-miR-658, hsa-miR-93*, hsa-miR-370,hsa-miR-524-5p, hsa-miR-517*, hsa-miR-18a*, hsa-miR-520d-5p, hsa-miR-95.

Serine threonine kinase 39—STK39—NM_(—)013233—hsa-miR-517a, hsa-miR-877,hsa-miR-32, hsa-miR-642, hsa-miR-22, hsa-miR-1276, hsa-miR-616,hsa-miR-1301, hsa-miR-302c*, hsa-miR-1179, hsa-miR-27a, hsa-miR-92a-2*,hsa-miR-513a-3p, hsa-miR-544, hsa-miR-561, hsa-miR-92b, hsa-miR-587,hsa-miR-630, hsa-miR-299-5p, hsa-miR-548p, hsa-miR-367, hsa-miR-30b,hsa-miR-25, hsa-miR-186, hsa-miR-520a-5p, hsa-miR-212, hsa-miR-525-5p,hsa-miR-30a, hsa-miR-489, hsa-miR-29a*, hsa-miR-548o, hsa-miR-26b,hsa-miR-32*, hsa-miR-590-3p, hsa-miR-132, hsa-miR-1297, hsa-miR-7-1*,hsa-miR-1259, hsa-miR-608, hsa-miR-1323, hsa-miR-653, hsa-miR-553,hsa-miR-488, hsa-miR-508-3p, hsa-miR-124, hsa-miR-517*, hsa-miR-34b*,hsa-miR-450b-5p, hsa-miR-27b, hsa-miR-578, hsa-miR-30d, hsa-miR-10b*,hsa-miR-192*, hsa-miR-1263, hsa-miR-539, hsa-miR-149*, hsa-miR-223,hsa-miR-92a, hsa-miR-708*, hsa-miR-744*, hsa-miR-150, hsa-miR-30c,hsa-miR-583, hsa-miR-1321, hsa-miR-1224-3p, hsa-miR-877*, hsa-miR-30b*,hsa-miR-1827, hsa-miR-196a*, hsa-miR-5481, hsa-miR-506, hsa-miR-122,hsa-miR-7-2*, hsa-miR-363, hsa-miR-944, hsa-miR-296-3p, hsa-let-7f-2*,hsa-miR-517c, hsa-miR-16-1*, hsa-miR-223*, hsa-miR-26a, hsa-miR-558,hsa-miR-30e.

Protein kinase N2—PKN2—NM_(—)006256—hsa-miR-576-3p, hsa-miR-124*,hsa-miR-376b, hsa-miR-518d-5p, hsa-miR-510, hsa-miR-200b,hsa-miR-509-3-5p, hsa-miR-520b, hsa-miR-16, hsa-miR-519a*, hsa-miR-1306,hsa-miR-515-5p, hsa-miR-542-3p, hsa-miR-522*, hsa-miR-922, hsa-miR-625,hsa-miR-130b*, hsa-miR-648, hsa-miR-216a, hsa-miR-766, hsa-miR-1276,hsa-miR-1184, hsa-miR-9, hsa-miR-520g, hsa-miR-1290, hsa-miR-374b,hsa-miR-1301, hsa-miR-551b*, hsa-miR-513b, hsa-miR-221, hsa-miR-96,hsa-miR-28-3p, hsa-miR-377, hsa-miR-218-1*, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-548b-5p, hsa-miR-452, hsa-miR-496,hsa-miR-520a-3p, hsa-miR-511, hsa-miR-661, hsa-miR-513 a-3p,hsa-miR-148a*, hsa-miR-379*, hsa-miR-335*, hsa-miR-548m, hsa-miR-28-5p,hsa-miR-1237, hsa-miR-561, hsa-miR-129-5p, hsa-miR-658, hsa-miR-302e,hsa-miR-93*, hsa-miR-548c-5p, hsa-miR-886-3p, hsa-miR-603,hsa-miR-342-3p, hsa-miR-298, hsa-miR-508-5p, hsa-miR-455-5p,hsa-miR-216b, hsa-miR-580, hsa-miR-129*, hsa-miR-576-5p, hsa-miR-548p,hsa-miR-582-5p, hsa-miR-524-5p, hsa-miR-143*, hsa-miR-543, hsa-miR-186,hsa-miR-23a, hsa-miR-1305, hsa-miR-33a*, hsa-miR-302c, hsa-miR-302f,hsa-miR-548i, hsa-miR-606, hsa-miR-520a-5p, hsa-miR-641, hsa-miR-212,hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-151-3p, hsa-miR-708,hsa-miR-146a*, hsa-miR-525-5p, hsa-miR-29a*, hsa-miR-548o, hsa-miR-376a,hsa-miR-373, hsa-miR-200c, hsa-miR-1207-3p, hsa-miR-616*, hsa-miR-373*,hsa-miR-548f, hsa-miR-26b, hsa-miR-569, hsa-miR-302d, hsa-miR-1202,hsa-miR-15b, hsa-miR-96*, hsa-miR-590-3p, hsa-miR-495, hsa-miR-1271,hsa-miR-132, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-34c-3p, hsa-miR-26b*,hsa-miR-1291, hsa-miR-1253, hsa-miR-579, hsa-miR-411*, hsa-miR-361-5p,hsa-miR-605, hsa-miR-186*, hsa-miR-1233, hsa-miR-520c-3p, hsa-miR-144,hsa-miR-1323, hsa-miR-384, hsa-miR-653, hsa-miR-302a, hsa-miR-888,hsa-miR-568, hsa-miR-429, hsa-miR-503, hsa-miR-570, hsa-miR-105,hsa-miR-155, hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-1294, hsa-miR-222,hsa-miR-769-3p, hsa-miR-518f*, hsa-miR-34b*, hsa-miR-148b*,hsa-miR-1285, hsa-miR-450b-3p, hsa-miR-520d-3p, hsa-miR-18b*,hsa-miR-195, hsa-miR-450b-5p, hsa-miR-545, hsa-miR-612, hsa-miR-514,hsa-miR-27b, hsa-miR-664*, hsa-miR-636, hsa-miR-548j, hsa-miR-520e,hsa-miR-520c-5p, hsa-miR-578, hsa-miR-383, hsa-miR-554, hsa-miR-491-3p,hsa-miR-942, hsa-miR-23b, hsa-miR-1257, hsa-miR-548a-3p, hsa-miR-33b*,hsa-miR-149*, hsa-miR-328, hsa-miR-139-5p, hsa-miR-223, hsa-miR-571,hsa-miR-548h, hsa-miR-519e*, hsa-miR-518e*, hsa-let-7f-1*,hsa-miR-628-5p, hsa-miR-526a, hsa-miR-224, hsa-miR-1284, hsa-miR-659,hsa-miR-185, hsa-miR-1321, hsa-miR-523*, hsa-miR-631, hsa-miR-138-2*,hsa-miR-30b*, hsa-miR-130a*, hsa-miR-519e, hsa-miR-550, hsa-miR-520h,hsa-miR-129-3p, hsa-miR-548c-3p, hsa-miR-7, hsa-miR-656, hsa-miR-5481,hsa-miR-424, hsa-miR-654-5p, hsa-miR-302b, hsa-miR-1283, hsa-miR-548e,hsa-miR-485-5p, hsa-miR-137, hsa-miR-888*, hsa-miR-7-2*, hsa-miR-196a,hsa-miR-377*, hsa-miR-15a, hsa-miR-374a, hsa-miR-425, hsa-miR-876-3p,hsa-miR-455-3p, hsa-miR-196b, hsa-miR-126*, hsa-miR-519b-5p,hsa-let-7a*, hsa-miR-509-5p, hsa-miR-944, hsa-miR-515-3p,hsa-miR-140-3p, hsa-miR-887, hsa-miR-497, hsa-miR-369-3p, hsa-let-7f-2*,hsa-miR-519c-5p, hsa-miR-218, hsa-miR-372, hsa-miR-497*, hsa-miR-433,hsa-miR-505, hsa-miR-595, hsa-miR-154, hsa-miR-26a, hsa-miR-1275,hsa-miR-541, hsa-miR-520d-5p, hsa-miR-1205.

Casein kinase 2, alpha 1 polypeptide—CSNK2A1—Variant 1, Variant 2 andVariant 3—NM_(—)177559, NM_(—)001895 and NM_(—)177560—hsa-miR-642,hsa-miR-518e, hsa-miR-644, hsa-miR-125a-5p, hsa-miR-221, hsa-let-7g*,hsa-miR-30c-1*, hsa-miR-1304, hsa-miR-1248, hsa-miR-335, hsa-miR-363*,hsa-miR-661, hsa-miR-143, hsa-miR-379*, hsa-miR-29b-1*, hsa-miR-548n,hsa-miR-603, hsa-miR-663, hsa-miR-216b, hsa-miR-1296, hsa-miR-34a*,hsa-miR-186, hsa-miR-30c-2*, hsa-miR-1305, hsa-miR-337-3p, hsa-miR-33a*,hsa-miR-606, hsa-miR-641, hsa-miR-92b*, hsa-miR-573, hsa-miR-188-3p,hsa-miR-513c, hsa-miR-767-3p, hsa-miR-1253, hsa-miR-411*, hsa-miR-1243,hsa-miR-608, hsa-miR-185*, hsa-miR-125b, hsa-miR-588, hsa-miR-222,hsa-miR-1270, hsa-miR-20a*, hsa-miR-200a, hsa-miR-518c*, hsa-miR-634,hsa-miR-516b, hsa-miR-149*, hsa-miR-620, hsa-miR-141, hsa-miR-571,hsa-miR-432*, hsa-miR-1300, hsa-miR-181a-2*, hsa-miR-760,hsa-miR-1224-3p, hsa-miR-30b*, hsa-miR-486-5p, hsa-miR-5481,hsa-miR-1251, hsa-miR-485-5p, hsa-miR-632, hsa-miR-455-3p, hsa-miR-649,hsa-miR-595, hsa-miR-1250, hsa-miR-1205, hsa-miR-744.

Paired immunoglobin-like type 2 receptor beta—PILRB—Variant 1 andVariant 3—NM_(—)013440 and NM_(—)178238—hsa-miR-140-5p, hsa-miR-557,hsa-miR-1266, hsa-miR-16, hsa-miR-374b, hsa-miR-513b, hsa-miR-507,hsa-miR-1237, hsa-miR-103, hsa-miR-548p, hsa-miR-337-3p, hsa-miR-362-5p,hsa-miR-15b, hsa-miR-105, hsa-miR-195, hsa-miR-629*, hsa-miR-192*,hsa-miR-1292, hsa-miR-1185, hsa-miR-151-5p, hsa-miR-424, hsa-miR-655,hsa-miR-107, hsa-miR-188-5p, hsa-miR-15a, hsa-miR-374a, hsa-miR-574-5p,hsa-miR-497, hsa-miR-499-3p.

PILRB—Variant 2—NM_(—)175047—hsa-miR-140-5p, hsa-miR-557, hsa-miR-1266,hsa-miR-16, hsa-miR-374b, hsa-miR-513b, hsa-miR-507, hsa-miR-1237,hsa-miR-103, hsa-miR-548p, hsa-miR-337-3p, hsa-miR-362-5p, hsa-miR-15b,hsa-miR-105, hsa-miR-195, hsa-miR-629*, hsa-miR-192*, hsa-miR-1292,hsa-miR-1185, hsa-miR-224, hsa-miR-151-5p, hsa-miR-424, hsa-miR-655,hsa-miR-107, hsa-miR-188-5p, hsa-miR-15a, hsa-miR-374a, hsa-miR-574-5p,hsa-miR-497, hsa-miR-499-3p.

Endoplasmic reticulum to nucleus signaling1—ERN1—NM_(—)001433—hsa-miR-665, hsa-miR-637, hsa-miR-509-3-5p,hsa-miR-642, hsa-miR-141*, hsa-miR-216a, hsa-miR-650, hsa-miR-193a-5p,hsa-miR-532-3p, hsa-miR-24-1*, hsa-miR-769-5p, hsa-miR-342-3p,hsa-miR-1231, hsa-miR-370, hsa-miR-548p, hsa-miR-24-2*, hsa-miR-329,hsa-miR-151-3p, hsa-miR-146a*, hsa-miR-153, hsa-miR-1207-3p,hsa-miR-1286, hsa-miR-720, hsa-miR-1202, hsa-miR-29c, hsa-miR-1208,hsa-miR-589*, hsa-miR-26b*, hsa-miR-1200, hsa-miR-936, hsa-miR-29b,hsa-miR-518a-5p, hsa-miR-220b, hsa-miR-29a, hsa-miR-488, hsa-miR-124,hsa-miR-324-5p, hsa-miR-588, hsa-miR-593, hsa-miR-1285, hsa-miR-612,hsa-miR-629*, hsa-miR-1274a, hsa-miR-362-3p, hsa-miR-539,hsa-miR-330-5p, hsa-miR-342-5p, hsa-miR-527, hsa-miR-631,hsa-miR-1224-3p, hsa-miR-877*, hsa-miR-339-5p, hsa-miR-1228,hsa-miR-506, hsa-miR-626, hsa-miR-888*, hsa-miR-423-5p, hsa-miR-338-3p,hsa-miR-509-5p, hsa-miR-639, hsa-miR-326, hsa-miR-1205, hsa-miR-671-5p.

Serum/gluco-corticoid regulated kinase family, member 3—SGK3—Variant 1,Variant 2 and Variant 3—NM_(—)013257, NM_(—)170709 andNM_(—)001033578—hsa-miR-520b, hsa-miR-32, hsa-miR-645, hsa-miR-20b*,hsa-miR-515-5p, hsa-miR-562, hsa-miR-1276, hsa-miR-520g, hsa-miR-550*,hsa-miR-181a, hsa-miR-519b-3p, hsa-miR-195*, hsa-miR-487a, hsa-miR-548g,hsa-miR-377, hsa-miR-376c, hsa-miR-16-2*, hsa-miR-496, hsa-miR-520a-3p,hsa-miR-148a*, hsa-miR-142-5p, hsa-miR-335*, hsa-miR-548m,hsa-miR-302a*, hsa-miR-519c-3p, hsa-miR-129-5p, hsa-miR-943,hsa-miR-302e, hsa-miR-93*, hsa-let-7c*, hsa-miR-519a, hsa-miR-92b,hsa-miR-130b, hsa-miR-1231, hsa-miR-455-5p, hsa-miR-1182, hsa-miR-600,hsa-miR-548p, hsa-miR-367, hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-143*,hsa-miR-543, hsa-miR-25, hsa-miR-365, hsa-miR-301b, hsa-miR-1305,hsa-miR-33a*, hsa-miR-302c, hsa-miR-1201, hsa-miR-520a-5p, hsa-miR-641,hsa-miR-212, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-153, hsa-miR-590-5p,hsa-miR-525-5p, hsa-miR-1281, hsa-miR-494, hsa-miR-582-3p, hsa-miR-30a*,hsa-miR-371-5p, hsa-miR-29a*, hsa-miR-548o, hsa-miR-1227, hsa-miR-373,hsa-miR-130a, hsa-miR-548f, hsa-miR-569, hsa-miR-720, hsa-miR-664,hsa-miR-302d, hsa-miR-590-3p, hsa-miR-513c, hsa-miR-132, hsa-miR-7-1*,hsa-miR-1200, hsa-miR-1259, hsa-miR-186*, hsa-miR-200c*,hsa-miR-520c-3p, hsa-miR-770-5p, hsa-miR-498, hsa-miR-144, hsa-miR-1323,hsa-miR-302a, hsa-miR-30d*, hsa-miR-654-3p, hsa-miR-30e*, hsa-miR-940,hsa-miR-155, hsa-miR-432, hsa-miR-1270, hsa-miR-125a-3p, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-181d,hsa-miR-664*, hsa-miR-520e, hsa-miR-1258, hsa-miR-578, hsa-miR-93,hsa-miR-29b-2*, hsa-miR-192*, hsa-miR-1263, hsa-miR-539,hsa-miR-548a-3p, hsa-miR-620, hsa-miR-301a, hsa-miR-526b*, hsa-miR-22*,hsa-miR-203, hsa-miR-92a, hsa-miR-381, hsa-miR-708*, hsa-miR-597,hsa-miR-744*, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-150, hsa-miR-181c,hsa-miR-224, hsa-miR-20b, hsa-miR-378*, hsa-miR-199a-3p, hsa-miR-106a,hsa-miR-1245, hsa-miR-483-5p, hsa-miR-520h, hsa-miR-548c-3p, hsa-miR-17,hsa-miR-106a*, hsa-miR-656, hsa-miR-454, hsa-miR-1264, hsa-miR-302b,hsa-miR-181b, hsa-miR-548e, hsa-miR-21, hsa-miR-199b-3p, hsa-miR-7-2*,hsa-miR-300, hsa-miR-485-3p, hsa-miR-556-3p, hsa-miR-20a, hsa-miR-126*,hsa-miR-363, hsa-let-7a*, hsa-miR-193b*, hsa-miR-106b, hsa-miR-218,hsa-miR-372, hsa-miR-223*, hsa-miR-1234, hsa-miR-520d-5p, hsa-miR-89 1b, hsa-miR-154*.

WEE1 homolog—WEE1—NM_(—)003390—hsa-miR-194*, hsa-miR-140-5p,hsa-miR-124*, hsa-miR-520b, hsa-miR-16, hsa-miR-138, hsa-miR-875-5p,hsa-miR-125b-2*, hsa-miR-520g, hsa-miR-519b-3p, hsa-miR-513b,hsa-miR-204, hsa-let-7g*, hsa-miR-1179, hsa-miR-890, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-548b-5p, hsa-miR-516a-3p, hsa-miR-575,hsa-miR-520a-3p, hsa-miR-15b*, hsa-miR-335*, hsa-miR-519c-3p,hsa-miR-19b, hsa-miR-302e, hsa-miR-548c-5p, hsa-miR-128, hsa-miR-519a,hsa-miR-130b, hsa-miR-875-3p, hsa-miR-129*, hsa-miR-524-5p,hsa-miR-301b, hsa-miR-1305, hsa-miR-302c, hsa-miR-548i, hsa-miR-218-2*,hsa-miR-606, hsa-miR-548d-3p, hsa-miR-516b*, hsa-miR-646, hsa-let-7b*,hsa-miR-548o, hsa-miR-1, hsa-miR-373, hsa-miR-130a, hsa-miR-26b,hsa-miR-302d, hsa-miR-15b, hsa-miR-495, hsa-miR-1297, hsa-miR-589*,hsa-miR-1243, hsa-miR-520c-3p, hsa-miR-144, hsa-miR-1323, hsa-miR-220b,hsa-miR-302a, hsa-miR-654-3p, hsa-miR-570, hsa-miR-155, hsa-miR-548d-5p,hsa-miR-520d-3p, hsa-miR-195, hsa-miR-519d, hsa-miR-545, hsa-miR-27b,hsa-miR-548j, hsa-miR-323-3p, hsa-miR-520e, hsa-miR-93, hsa-miR-155*,hsa-miR-192*, hsa-miR-1206, hsa-miR-545*, hsa-miR-149*, hsa-miR-301a,hsa-miR-526b*, hsa-miR-548h, hsa-miR-381, hsa-miR-211, hsa-let-7f-1*,hsa-miR-1284, hsa-miR-20b, hsa-miR-1321, hsa-miR-106a, hsa-miR-520h,hsa-miR-129-3p, hsa-miR-17, hsa-miR-106a*, hsa-miR-454, hsa-miR-424,hsa-miR-302b, hsa-miR-1283, hsa-miR-187*, hsa-miR-655, hsa-miR-888*,hsa-miR-924, hsa-miR-577, hsa-miR-206, hsa-miR-19a, hsa-miR-300,hsa-miR-15a, hsa-miR-20a, hsa-miR-627, hsa-miR-126*, hsa-let-7a*,hsa-miR-944, hsa-miR-140-3p, hsa-miR-106b, hsa-miR-497, hsa-miR-369-3p,hsa-miR-16-1*, hsa-miR-372, hsa-miR-26a, hsa-miR-520d-5p, hsa-miR-613.

Microtubule associated serine/threonine kinase family member4—MAST4—Variant 1—NM_(—)015183—hsa-miR-511, hsa-miR-29b-1*,hsa-miR-548m, hsa-miR-194, hsa-miR-128, hsa-miR-324-3p, hsa-miR-188-3p,hsa-miR-488, hsa-miR-512-3p, hsa-miR-493, hsa-miR-339-5p, hsa-miR-1299,hsa-miR-331-3p, hsa-miR-196a, hsa-miR-196b.

MAST4—Variant 2—NM_(—)198828—hsa-miR-190, hsa-miR-190b.

Chromosome 11 open reading frame 17—- C11orf17—Variant 1—Variant2—NM_(—)182901—NM_(—)020642—hsa-miR-34c-5p, hsa-miR-20b*, hsa-miR-766,hsa-miR-487a, hsa-miR-890, hsa-miR-363*, hsa-miR-661, hsa-miR-15b*,hsa-miR-449a, hsa-miR-886-3p, hsa-miR-508-5p, hsa-miR-216b,hsa-miR-449b, hsa-miR-548d-3p, hsa-miR-145, hsa-miR-616*, hsa-miR-373*,hsa-miR-1202, hsa-miR-1324, hsa-miR-495, hsa-miR-34a, hsa-miR-124,hsa-miR-940, hsa-miR-1285, hsa-miR-612, hsa-miR-545*, hsa-miR-30b*,hsa-miR-550, hsa-miR-1827, hsa-miR-196a*, hsa-miR-506, hsa-miR-485-5p,hsa-miR-485-3p, hsa-miR-649, hsa-miR-505, hsa-miR-154*, hsa-miR-340*.

Nucleoproin 37 kDa—NUP37—NM_(—)024057—hsa-miR-561, hsa-miR-524-5p,hsa-miR-570, hsa-miR-625*, hsa-let-7e*, hsa-miR-5481, hsa-miR-520d-5p.

Clathrin, heavy chain (Hc)—CLTC—NM_(—)004859—hsa-miR-140-5p,hsa-miR-557, hsa-miR-520b, hsa-miR-1266, hsa-miR-27b*, hsa-miR-625,hsa-miR-219-1-3p, hsa-miR-513a-5p, hsa-miR-1276, hsa-miR-520g,hsa-miR-616, hsa-miR-1290, hsa-miR-551b*, hsa-miR-519b-3p, hsa-miR-182*,hsa-miR-195*, hsa-miR-302c*, hsa-miR-204, hsa-miR-96, hsa-miR-532-3p,hsa-miR-377, hsa-miR-647, hsa-miR-1248, hsa-miR-335, hsa-miR-92a-2*,hsa-miR-516a-3p, hsa-miR-16-2*, hsa-miR-496, hsa-miR-520a-3p,hsa-miR-511, hsa-miR-15b*, hsa-miR-513a-3p, hsa-miR-335*, hsa-miR-507,hsa-miR-548m, hsa-miR-330-3p, hsa-miR-561, hsa-miR-519c-3p, hsa-miR-19b,hsa-miR-129-5p, hsa-miR-892b, hsa-miR-302e, hsa-miR-574-3p,hsa-miR-519a, hsa-miR-130b, hsa-miR-199a-5p, hsa-miR-1287, hsa-miR-1182,hsa-miR-630, hsa-miR-148a, hsa-miR-576-5p, hsa-miR-548p, hsa-miR-586,hsa-miR-338-5p, hsa-miR-30b, hsa-miR-143*, hsa-miR-543, hsa-miR-34a*,hsa-miR-23a, hsa-miR-301b, hsa-miR-1236, hsa-miR-33a*, hsa-miR-302c,hsa-miR-491-5p, hsa-miR-606, hsa-miR-410, hsa-miR-421, hsa-miR-548d-3p,hsa-miR-516b*, hsa-miR-646, hsa-miR-151-3p, hsa-miR-153, hsa-miR-590-5p,hsa-miR-30a*, hsa-miR-30a, hsa-miR-29a*, hsa-miR-548o, hsa-miR-1,hsa-miR-373, hsa-miR-130a, hsa-miR-148b, hsa-miR-548f, hsa-miR-220c,hsa-miR-569, hsa-miR-664, hsa-miR-573, hsa-miR-302d, hsa-miR-188-3p,hsa-miR-1271, hsa-miR-29c, hsa-miR-513c, hsa-miR-589*, hsa-miR-26b*,hsa-miR-1200, hsa-miR-29b, hsa-miR-193a-3p, hsa-miR-186*,hsa-miR-520c-3p, hsa-miR-608, hsa-miR-1323, hsa-miR-384, hsa-miR-302a,hsa-miR-30d*, hsa-miR-30e*, hsa-miR-21 *, hsa-miR-29a, hsa-miR-503,hsa-miR-768-3p, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-519d,hsa-miR-452*, hsa-miR-935, hsa-miR-607, hsa-miR-520e, hsa-miR-578,hsa-miR-30d, hsa-miR-93, hsa-miR-193b, hsa-miR-152, hsa-miR-23b,hsa-miR-1322, hsa-miR-1257, hsa-miR-548a-3p, hsa-miR-301a,hsa-miR-526b*, hsa-miR-22*, hsa-miR-203, hsa-miR-625*, hsa-miR-597,hsa-miR-1185, hsa-miR-211, hsa-miR-593*, hsa-miR-1300, hsa-miR-150,hsa-miR-30c, hsa-miR-181a-2*, hsa-miR-583, hsa-miR-199b-5p, hsa-miR-205,hsa-miR-20b, hsa-miR-640, hsa-miR-106a, hsa-miR-1245, hsa-miR-138-2*,hsa-miR-877*, hsa-miR-149, hsa-miR-130a*, hsa-miR-520h, hsa-miR-431,hsa-miR-1228, hsa-miR-1827, hsa-miR-24, hsa-miR-548c-3p, hsa-miR-17,hsa-miR-382, hsa-miR-454, hsa-miR-5481, hsa-miR-654-5p, hsa-miR-302b,hsa-miR-1283, hsa-miR-548e, hsa-miR-21, hsa-miR-655, hsa-miR-888*,hsa-miR-206, hsa-miR-196a, hsa-miR-19a, hsa-miR-20a, hsa-miR-183,hsa-miR-455-3p, hsa-miR-196b, hsa-miR-126*, hsa-miR-1272,hsa-miR-767-5p, hsa-miR-499-5p, hsa-miR-106b, hsa-miR-369-3p,hsa-miR-372, hsa-miR-433, hsa-miR-541, hsa-miR-1302, hsa-miR-613,hsa-miR-584, hsa-miR-30e.

Coatomer protein complex, subunit beta 2 (betaprime)—COPB2—NM_(—)004766—hsa-miR-374b, hsa-miR-551b*, hsa-miR-330-3p,hsa-miR-128, hsa-miR-633, hsa-miR-654-3p, hsa-miR-570, hsa-miR-299-3p,hsa-miR-1256, hsa-miR-548c-3p, hsa-miR-374a.

Solute carrier family 25 (mitochondrial carrier; phosphate carrier)member 25—SLC25A25—Variant 1, Variant 2, Variant 3 and Variant4—NM_(—)052901, NM_(—)001006641, NM_(—)001006642 andNM_(—)001007743—hsa-miR-576-3p, hsa-miR-194*, hsa-miR-132*, hsa-miR-453,hsa-miR-637, hsa-miR-509-3-5p, hsa-miR-490-5p, hsa-miR-642, hsa-miR-922,hsa-miR-1228*, hsa-miR-766, hsa-miR-1184, hsa-miR-125b-2*, hsa-miR-181a, hsa-miR-519b-3p, hsa-miR-96, hsa-miR-604, hsa-miR-214,hsa-miR-532-3p, hsa-miR-549, hsa-miR-647, hsa-miR-27a, hsa-miR-92a-2*,hsa-miR-575, hsa-miR-661, hsa-miR-1237, hsa-miR-519c-3p, hsa-miR-129-5p,hsa-miR-93*, hsa-miR-886-3p, hsa-miR-128, hsa-miR-134, hsa-miR-519a,hsa-miR-298, hsa-miR-508-5p, hsa-miR-130b, hsa-miR-370, hsa-miR-1207-5p,hsa-miR-1182, hsa-miR-129*, hsa-miR-1246, hsa-miR-1203, hsa-miR-615-3p,hsa-miR-301b, hsa-miR-1236, hsa-miR-491-5p, hsa-miR-410, hsa-miR-421,hsa-miR-212, hsa-miR-92b*, hsa-miR-371-5p, hsa-miR-1, hsa-miR-1207-3p,hsa-miR-130a, hsa-miR-145, hsa-miR-220c, hsa-miR-1286, hsa-miR-99a*,hsa-miR-484, hsa-miR-1202, hsa-miR-1324, hsa-miR-1271, hsa-miR-29c,hsa-miR-132, hsa-miR-7-1*, hsa-miR-589*, hsa-miR-29b, hsa-miR-579,hsa-miR-1243, hsa-miR-873, hsa-miR-608, hsa-miR-185*, hsa-miR-505*,hsa-miR-596, hsa-miR-29a, hsa-miR-940, hsa-miR-1294, hsa-miR-184,hsa-miR-92a-1*, hsa-miR-181d, hsa-miR-504, hsa-miR-1204, hsa-miR-27b,hsa-miR-299-3p, hsa-miR-607, hsa-miR-1258, hsa-miR-518c*, hsa-miR-1260,hsa-miR-33b, hsa-miR-149*, hsa-miR-301a, hsa-miR-203, hsa-miR-361-3p,hsa-miR-628-5p, hsa-miR-150, hsa-miR-181c, hsa-miR-501-5p, hsa-miR-659,hsa-miR-378*, hsa-miR-1256, hsa-miR-1224-3p, hsa-miR-877*, hsa-miR-18a*,hsa-miR-30b*, hsa-miR-129-3p, hsa-miR-24, hsa-miR-1299, hsa-miR-454,hsa-miR-99b*, hsa-miR-181b, hsa-miR-206, hsa-miR-7-2*, hsa-miR-33a,hsa-miR-455-3p, hsa-miR-509-5p, hsa-miR-767-5p, hsa-miR-154,hsa-miR-613, hsa-miR-1225-3p.

EGFR-coamplified and overexpressedprotein—ECOP—NM_(—)030796—hsa-miR-576-3p, hsa-miR-557, hsa-miR-665,hsa-miR-510, hsa-miR-34c-5p, hsa-miR-515-5p, hsa-miR-22, hsa-miR-648,hsa-miR-766, hsa-miR-1184, hsa-miR-520g, hsa-miR-302c*, hsa-miR-532-3p,hsa-miR-377, hsa-miR-27a, hsa-miR-1248, hsa-miR-335, hsa-miR-516a-3p,hsa-miR-511, hsa-miR-661, hsa-miR-486-3p, hsa-miR-335*, hsa-miR-507,hsa-miR-449a, hsa-miR-28-5p, hsa-miR-129-5p, hsa-miR-194, hsa-miR-217,hsa-miR-938, hsa-miR-342-3p, hsa-miR-298, hsa-miR-508-5p,hsa-miR-455-5p, hsa-miR-619, hsa-miR-587, hsa-miR-370, hsa-miR-103,hsa-miR-651, hsa-miR-580, hsa-miR-148a, hsa-miR-576-5p, hsa-miR-30b,hsa-miR-143*, hsa-miR-365, hsa-miR-449b, hsa-miR-1201, hsa-miR-606,hsa-miR-641, hsa-miR-212, hsa-miR-516b*, hsa-miR-329, hsa-miR-708,hsa-miR-146a*, hsa-miR-153, hsa-miR-145*, hsa-miR-494, hsa-miR-30a,hsa-miR-29a*, hsa-miR-622, hsa-miR-1, hsa-miR-1207-3p, hsa-miR-145,hsa-miR-874, hsa-miR-148b, hsa-miR-1286, hsa-miR-32*, hsa-miR-628-3p,hsa-miR-188-3p, hsa-miR-617, hsa-miR-495, hsa-miR-513c, hsa-miR-132,hsa-miR-7-1*, hsa-miR-34a, hsa-miR-361-5p, hsa-miR-374b*, hsa-miR-1233,hsa-miR-323-5p, hsa-miR-802, hsa-miR-570, hsa-miR-34b, hsa-miR-432,hsa-miR-768-3p, hsa-miR-34b*, hsa-miR-144*, hsa-miR-20a*, hsa-miR-27b,hsa-miR-636, hsa-miR-30d, hsa-miR-566, hsa-miR-139-3p, hsa-miR-152,hsa-miR-362-3p, hsa-miR-1185, hsa-miR-519e*, hsa-miR-30c, hsa-miR-760,hsa-miR-631, hsa-miR-1224-3p, hsa-miR-18a*, hsa-miR-30b*, hsa-miR-520h,hsa-miR-197, hsa-miR-1827, hsa-miR-24, hsa-miR-1299, hsa-miR-500*,hsa-miR-106a*, hsa-miR-7, hsa-miR-626, hsa-miR-206, hsa-miR-122,hsa-miR-7-2*, hsa-miR-107, hsa-miR-218, hsa-miR-595, hsa-miR-1234,hsa-miR-558, hsa-miR-1293, hsa-miR-613, hsa-miR-30e.

Phosphodiesterase 8A—PDE8A—Variant 1 and Variant 2—NM_(—)002605 andNM_(—)173454—hsa-miR-376b, hsa-miR-520b, hsa-miR-32, hsa-miR-513a-5p,hsa-miR-1184, hsa-miR-222*, hsa-miR-519b-3p, hsa-miR-182*,hsa-miR-302c*, hsa-miR-668, hsa-miR-214, hsa-miR-647, hsa-miR-1248,hsa-miR-520a-3p, hsa-miR-15b*, hsa-miR-31*, hsa-miR-513a-3p,hsa-miR-335*, hsa-miR-183*, hsa-miR-28-5p, hsa-miR-561, hsa-miR-519c-3p,hsa-miR-302e, hsa-miR-519a, hsa-miR-298, hsa-miR-508-5p, hsa-miR-92b,hsa-miR-455-5p, hsa-miR-1280, hsa-miR-1252, hsa-miR-367, hsa-miR-143*,hsa-miR-25, hsa-miR-302c, hsa-miR-548d-3p, hsa-miR-708, hsa-miR-146a*,hsa-miR-411, hsa-miR-376a, hsa-miR-373, hsa-miR-581, hsa-miR-145,hsa-miR-664, hsa-miR-573, hsa-miR-302d, hsa-miR-450a, hsa-miR-96*,hsa-miR-590-3p, hsa-miR-26b*, hsa-miR-936, hsa-miR-1233,hsa-miR-520c-3p, hsa-miR-185*, hsa-miR-144, hsa-miR-302a, hsa-miR-488,hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-450b-5p, hsa-miR-452*,hsa-miR-607, hsa-miR-520e, hsa-miR-1260, hsa-miR-545*, hsa-miR-330-5p,hsa-miR-139-5p, hsa-miR-203, hsa-miR-92a, hsa-miR-432*, hsa-miR-760,hsa-miR-224, hsa-miR-1284, hsa-miR-1256, hsa-miR-199a-3p, hsa-miR-18a*,hsa-miR-522, hsa-miR-500*, hsa-miR-302b, hsa-miR-199b-3p, hsa-miR-1278,hsa-miR-577, hsa-miR-363, hsa-miR-219-2-3p, hsa-let-7f-2*, hsa-miR-372,hsa-miR-326, hsa-miR-497*, hsa-miR-142-3p, hsa-miR-1293.

Signal tranducing adaptor molecule (SH3 domain and ITAM motif)1—STAM—NM_(—)003473—hsa-miR-32, hsa-miR-625, hsa-miR-493*, hsa-miR-138,hsa-miR-216a, hsa-miR-9, hsa-miR-1267, hsa-miR-1248, hsa-miR-575,hsa-miR-513a-3p, hsa-miR-544, hsa-miR-548m, hsa-miR-128, hsa-miR-92b,hsa-miR-663, hsa-miR-619, hsa-miR-299-5p, hsa-miR-367, hsa-miR-25,hsa-miR-186, hsa-miR-337-3p, hsa-miR-641, hsa-miR-146a*, hsa-miR-145*,hsa-miR-494, hsa-miR-145, hsa-miR-32*, hsa-miR-188-3p, hsa-miR-643,hsa-miR-579, hsa-miR-374b*, hsa-miR-144, hsa-miR-488, hsa-miR-588,hsa-miR-487b, hsa-miR-935, hsa-miR-548b-3p, hsa-miR-539, hsa-miR-203,hsa-miR-92a, hsa-miR-597, hsa-miR-1185, hsa-miR-205, hsa-miR-185,hsa-miR-631, hsa-miR-199a-3p, hsa-miR-197, hsa-miR-656, hsa-miR-199b-3p,hsa-miR-1244, hsa-miR-409-3p, hsa-miR-363, hsa-let-7f-2*, hsa-miR-649,hsa-miR-142-3p, hsa-miR-1205.

Tubulin, beta—TUBB_—NM_(—)178014—hsa-miR-124*, hsa-miR-200b,hsa-miR-1254, hsa-miR-642, hsa-miR-16, hsa-miR-515-5p, hsa-miR-625,hsa-miR-130b*, hsa-miR-216a, hsa-let-7d, hsa-miR-181a, hsa-miR-182*,hsa-miR-204, hsa-miR-92a-2*, hsa-miR-127-5p, hsa-miR-24-1*,hsa-miR-486-3p, hsa-miR-28-5p, hsa-miR-541*, hsa-miR-93*,hsa-miR-508-5p, hsa-miR-455-5p, hsa-let-7e, hsa-miR-623, hsa-miR-339-3p,hsa-miR-651, hsa-miR-548p, hsa-miR-876-5p, hsa-miR-208a, hsa-miR-491-5p,hsa-miR-520a-5p, hsa-miR-24-2*, hsa-miR-708, hsa-miR-525-5p,hsa-miR-371-5p, hsa-miR-548o, hsa-miR-200c, hsa-let-7f, hsa-miR-32*,hsa-miR-765, hsa-miR-15b, hsa-miR-495, hsa-miR-1208, hsa-miR-26b*,hsa-miR-605, hsa-miR-768-5p, hsa-miR-27a*, hsa-miR-1323, hsa-miR-888,hsa-miR-429, hsa-let-7g, hsa-miR-432, hsa-miR-1270, hsa-miR-769-3p,hsa-miR-450b-3p, hsa-miR-195, hsa-miR-545, hsa-miR-181d, hsa-miR-200a,hsa-let-7i, hsa-miR-23a*, hsa-miR-609, hsa-miR-23b*, hsa-miR-516b,hsa-let-7b, hsa-miR-620, hsa-miR-330-5p, hsa-miR-141, hsa-let-7a,hsa-miR-98, hsa-miR-571, hsa-miR-211, hsa-miR-519e*, hsa-miR-361-3p,hsa-miR-593*, hsa-miR-1300, hsa-miR-628-5p, hsa-miR-150, hsa-miR-181c,hsa-miR-760, hsa-miR-659, hsa-miR-1321, hsa-miR-208b, hsa-let-7c,hsa-miR-1827, hsa-miR-345, hsa-miR-424, hsa-miR-181b, hsa-miR-188-5p,hsa-miR-15a, hsa-miR-497, hsa-miR-369-3p, hsa-miR-326, hsa-miR-595,hsa-miR-1302.

Sorting nexin 6—SNX6—Variant 1 and Variant 2—NM_(—)021249 andNM_(—)152233—hsa-miR-642, hsa-miR-16, hsa-miR-515-5p, hsa-miR-542-3p,hsa-miR-922, hsa-miR-130b*, hsa-miR-219-1-3p, hsa-let-7d, hsa-miR-644,hsa-miR-302c*, hsa-miR-487a, hsa-miR-1179, hsa-miR-661, hsa-miR-375,hsa-miR-15b*, hsa-miR-31, hsa-miR-513a-3p, hsa-miR-548m, hsa-miR-330-3p,hsa-miR-191, hsa-let-7c*, hsa-miR-128, hsa-miR-1268, hsa-miR-619,hsa-let-7e, hsa-miR-424*, hsa-miR-1252, hsa-miR-630, hsa-miR-129*,hsa-miR-586, hsa-miR-25*, hsa-miR-30b, hsa-miR-1305, hsa-miR-33a*,hsa-miR-606, hsa-miR-520a-5p, hsa-miR-410, hsa-miR-421, hsa-miR-521,hsa-miR-525-5p, hsa-miR-30a, hsa-miR-874, hsa-miR-26b, hsa-let-7f,hsa-miR-15b, hsa-miR-495, hsa-miR-513c, hsa-miR-1297, hsa-miR-1208,hsa-miR-146a, hsa-miR-27a*, hsa-miR-509-3p, hsa-miR-624*, hsa-miR-570,hsa-miR-105, hsa-let-7g, hsa-miR-1294, hsa-miR-195, hsa-miR-30d,hsa-let-7i, hsa-miR-146b-5p, hsa-let-7b, hsa-miR-223, hsa-let-7a,hsa-miR-98, hsa-miR-519e*, hsa-miR-30c, hsa-miR-583, hsa-miR-631,hsa-miR-18a*, hsa-miR-522, hsa-let-7c, hsa-miR-129-3p, hsa-miR-1827,hsa-miR-548c-3p, hsa-miR-424, hsa-miR-655, hsa-miR-122, hsa-miR-15a,hsa-miR-338-3p, hsa-miR-944, hsa-miR-574-5p, hsa-miR-340, hsa-miR-497,hsa-miR-369-3p, hsa-miR-497*, hsa-miR-595, hsa-miR-499-3p, hsa-miR-26a,hsa-miR-154*, hsa-miR-512-5p, hsa-miR-30e.

RAB23, member RAS oncogene family—RAB23—Variant 1 and Variant2—NM_(—)016277 and NM_(—)183227—hsa-miR-576-3p, hsa-miR-518d-5p,hsa-miR-200b, hsa-miR-509-3-5p, hsa-miR-520b, hsa-miR-32, hsa-miR-380,hsa-miR-16, hsa-miR-519a*, hsa-miR-522*, hsa-miR-493*, hsa-miR-513a-5p,hsa-miR-125b-2*, hsa-miR-374b, hsa-miR-195*, hsa-miR-221, hsa-miR-96,hsa-miR-1289, hsa-miR-1179, hsa-miR-30c-1*, hsa-miR-1826, hsa-miR-1248,hsa-miR-16-2*, hsa-miR-320c, hsa-miR-520a-3p, hsa-miR-31,hsa-miR-513a-3p, hsa-miR-183*, hsa-miR-330-3p, hsa-miR-28-5p,hsa-miR-302e, hsa-miR-93*, hsa-miR-508-5p, hsa-miR-92b, hsa-miR-1287,hsa-miR-875-3p, hsa-miR-299-5p, hsa-miR-548p, hsa-miR-586, hsa-miR-367,hsa-miR-338-5p, hsa-miR-30b, hsa-miR-25, hsa-miR-186, hsa-miR-30c-2*,hsa-miR-337-3p, hsa-miR-302c, hsa-miR-548d-3p, hsa-miR-329, hsa-let-7b*,hsa-miR-708, hsa-miR-30a*, hsa-miR-30a, hsa-miR-622, hsa-miR-373,hsa-miR-200c, hsa-miR-1207-3p, hsa-miR-548f, hsa-miR-220c, hsa-miR-573,hsa-miR-302d, hsa-miR-624, hsa-miR-15b, hsa-miR-320d, hsa-miR-590-3p,hsa-miR-1271, hsa-miR-579, hsa-miR-520c-3p, hsa-miR-770-5p,hsa-miR-1262, hsa-miR-144, hsa-miR-653, hsa-miR-302a, hsa-miR-30d*,hsa-miR-30e*, hsa-miR-429, hsa-miR-624*, hsa-miR-488, hsa-miR-222,hsa-miR-518f*, hsa-miR-768-3p, hsa-miR-520d-3p, hsa-miR-195,hsa-miR-331-5p, hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-545,hsa-miR-299-3p, hsa-miR-323-3p, hsa-miR-607, hsa-miR-520e,hsa-miR-520c-5p, hsa-miR-30d, hsa-miR-10b*, hsa-miR-629, hsa-miR-93,hsa-miR-362-3p, hsa-miR-548a-3p, hsa-miR-1255a, hsa-miR-33b,hsa-miR-526b, hsa-miR-526b*, hsa-miR-92a, hsa-miR-518e*, hsa-let-7f-1*,hsa-miR-432*, hsa-miR-150, hsa-miR-30c, hsa-miR-526a, hsa-miR-1284,hsa-miR-20b, hsa-miR-378*, hsa-miR-640, hsa-miR-523*, hsa-miR-106a,hsa-miR-138-2*, hsa-miR-320a, hsa-miR-522, hsa-miR-197, hsa-miR-17,hsa-miR-106a*, hsa-miR-320b, hsa-miR-297, hsa-miR-5481, hsa-miR-424,hsa-miR-302b, hsa-miR-548e, hsa-miR-1251, hsa-miR-888*, hsa-miR-577,hsa-miR-33a, hsa-miR-15a, hsa-miR-374a, hsa-miR-20a, hsa-miR-409-3p,hsa-miR-363, hsa-miR-519b-5p, hsa-let-7a*, hsa-miR-338-3p,hsa-miR-509-5p, hsa-miR-499-5p, hsa-miR-106b, hsa-miR-497, hsa-miR-1197,hsa-miR-519c-5p, hsa-miR-16-1*, hsa-miR-649, hsa-miR-372, hsa-miR-154,hsa-miR-1255b, hsa-miR-30e.

Phospholipase A2-activating protein—PLAA—Variant1—NM_(—)001031689—hsa-miR-642, hsa-miR-19b, hsa-miR-130b, hsa-miR-630,hsa-miR-148a, hsa-miR-374a*, hsa-miR-301b, hsa-miR-1236, hsa-miR-130a,hsa-miR-148b, hsa-miR-590-3p, hsa-miR-152, hsa-miR-301 a, hsa-miR-877*,hsa-miR-454, hsa-miR-19a.

PLAA—Variant 2—NM_(—)004253—hsa-miR-124*, hsa-miR-200b, hsa-miR-1254,hsa-miR-642, hsa-miR-493 *, hsa-miR-216a, hsa-miR-616, hsa-miR-101*,hsa-miR-551b*, hsa-miR-182*, hsa-miR-204, hsa-miR-376c, hsa-miR-27a,hsa-miR-138-1*, hsa-miR-26a-1*, hsa-miR-379*, hsa-miR-19b, hsa-miR-194,hsa-miR-541*, hsa-miR-892b, hsa-miR-769-5p, hsa-miR-130b, hsa-miR-630,hsa-miR-129*, hsa-miR-148a, hsa-miR-582-5p, hsa-miR-374a*, hsa-miR-301b,hsa-miR-1236, hsa-miR-590-5p, hsa-miR-548o, hsa-miR-200c, hsa-miR-130a,hsa-miR-616*, hsa-miR-148b, hsa-miR-373*, hsa-miR-590-3p, hsa-miR-7-1*,hsa-miR-411*, hsa-miR-26a-2*, hsa-miR-193a-3p, hsa-miR-1259,hsa-miR-1323, hsa-miR-802, hsa-miR-429, hsa-miR-769-3p, hsa-miR-450b-3p,hsa-miR-512-3p, hsa-miR-15a*, hsa-miR-27b, hsa-miR-607, hsa-miR-193b,hsa-miR-934, hsa-miR-152, hsa-miR-328, hsa-miR-301a, hsa-miR-203,hsa-miR-708*, hsa-miR-211, hsa-miR-877*, hsa-miR-129-3p, hsa-miR-454,hsa-miR-21, hsa-miR-655, hsa-miR-7-2*, hsa-miR-19a, hsa-miR-1244,hsa-miR-944, hsa-miR-193b*, hsa-miR-369-3p.

Stanniocalcin 2—STC2—NM_(—)003714—hsa-miR-140-5p, hsa-miR-124*,hsa-miR-665, hsa-miR-637, hsa-miR-200b, hsa-miR-509-3-5p,hsa-miR-490-5p, hsa-miR-448, hsa-miR-141*, hsa-miR-625,hsa-miR-219-1-3p, hsa-miR-1184, hsa-miR-133a, hsa-miR-222*,hsa-miR-181a, hsa-miR-519b-3p, hsa-miR-644, hsa-miR-125a-5p,hsa-miR-483-3p, hsa-miR-548g, hsa-miR-204, hsa-let-7g*, hsa-miR-96,hsa-miR-1289, hsa-miR-377, hsa-miR-376c, hsa-miR-647, hsa-miR-335,hsa-miR-92a-2*, hsa-miR-513a-3p, hsa-miR-29b-1*, hsa-miR-548m,hsa-miR-330-3p, hsa-miR-28-5p, hsa-miR-190, hsa-miR-519c-3p,hsa-miR-19b, hsa-miR-129-5p, hsa-miR-93*, hsa-miR-769-5p, hsa-miR-519a,hsa-miR-298, hsa-miR-508-5p, hsa-miR-1231, hsa-miR-663, hsa-miR-1303,hsa-miR-1287, hsa-miR-623, hsa-miR-875-3p, hsa-miR-651, hsa-miR-299-5p,hsa-miR-524-5p, hsa-miR-34a*, hsa-miR-33a*, hsa-miR-410, hsa-miR-421,hsa-miR-212, hsa-miR-329, hsa-let-7b*, hsa-miR-708, hsa-miR-146a*,hsa-miR-30a*, hsa-miR-489, hsa-miR-324-3p, hsa-miR-1, hsa-miR-200c,hsa-miR-1207-3p, hsa-miR-616*, hsa-miR-874, hsa-miR-373*,hsa-miR-532-5p, hsa-miR-1324, hsa-miR-617, hsa-miR-1271, hsa-miR-29c,hsa-miR-132, hsa-miR-26b*, hsa-miR-1291, hsa-miR-190b, hsa-miR-29b,hsa-miR-1243, hsa-miR-147, hsa-miR-873, hsa-miR-1226, hsa-miR-185*,hsa-miR-125b, hsa-miR-505*, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-429,hsa-miR-29a, hsa-miR-570, hsa-miR-588, hsa-miR-1261, hsa-miR-1270,hsa-miR-769-3p, hsa-miR-34b*, hsa-miR-148b*, hsa-miR-450b-3p,hsa-miR-20a*, hsa-miR-181d, hsa-miR-504, hsa-miR-1204, hsa-miR-607,hsa-miR-629*, hsa-miR-383, hsa-miR-29b-2*, hsa-miR-192*, hsa-miR-942,hsa-miR-101, hsa-miR-362-3p, hsa-miR-545*, hsa-miR-1229, hsa-miR-133b,hsa-miR-620, hsa-miR-328, hsa-miR-330-5p, hsa-miR-941, hsa-miR-625*,hsa-miR-1185, hsa-miR-744*, hsa-miR-211, hsa-miR-361-3p, hsa-miR-593*,hsa-let-7f-1*, hsa-miR-1238, hsa-miR-628-5p, hsa-miR-181c,hsa-miR-181a-2*, hsa-miR-659, hsa-miR-138-2*, hsa-miR-483-5p,hsa-miR-550, hsa-miR-1228, hsa-miR-24, hsa-miR-1299, hsa-miR-548c-3p,hsa-miR-663b, hsa-miR-106a*, hsa-miR-656, hsa-miR-345, hsa-miR-548k,hsa-miR-181b, hsa-miR-891a, hsa-miR-485-5p, hsa-miR-137, hsa-miR-1278,hsa-miR-892a, hsa-miR-206, hsa-miR-19a, hsa-miR-1244, hsa-miR-425,hsa-miR-455-3p, hsa-let-7a*, hsa-miR-509-5p, hsa-miR-340, hsa-miR-193b*,hsa-miR-367*, hsa-miR-326, hsa-miR-223*, hsa-miR-520d-5p, hsa-miR-1205,hsa-miR-613, hsa-miR-512-5p.

Lactotransferrin—LTF—NM_(—)002343—hsa-miR-637, hsa-miR-34c-5p,hsa-miR-214, hsa-miR-920, hsa-miR-513a-3p, hsa-miR-486-3p, hsa-miR-449a,hsa-miR-208a, hsa-miR-449b, hsa-miR-329, hsa-miR-939, hsa-miR-1253,hsa-miR-34a, hsa-miR-362-3p, hsa-miR-1257, hsa-miR-432*, hsa-miR-185,hsa-miR-1224-3p, hsa-miR-208b, hsa-miR-1228, hsa-miR-219-2-3p.

Interferon regulator factor 9—IRF9—NM_(—)006084—hsa-miR-520b,hsa-miR-130b*, hsa-miR-1290, hsa-miR-549, hsa-miR-138-1*, hsa-miR-575,hsa-miR-520a-3p, hsa-miR-585, hsa-miR-142-5p, hsa-miR-302e,hsa-miR-199a-5p, hsa-miR-580, hsa-miR-600, hsa-miR-302c, hsa-miR-606,hsa-miR-373, hsa-miR-616*, hsa-miR-373*, hsa-miR-302d, hsa-miR-590-3p,hsa-miR-520f, hsa-miR-520c-3p, hsa-miR-1226, hsa-miR-384, hsa-miR-302a,hsa-miR-1294, hsa-miR-520d-3p, hsa-miR-519d, hsa-miR-636, hsa-miR-520e,hsa-miR-93, hsa-miR-934, hsa-miR-554, hsa-miR-526b*, hsa-miR-571,hsa-miR-361-3p, hsa-miR-583, hsa-miR-199b-5p, hsa-miR-20b, hsa-miR-106a,hsa-miR-30b*, hsa-miR-17, hsa-miR-302b, hsa-miR-331-3p, hsa-miR-20a,hsa-miR-627, hsa-miR-340, hsa-miR-106b, hsa-miR-1197, hsa-miR-372.

Ataxin 3—ATXN3—Variant 1 and Variant 2—NM_(—)004993 andNM_(—)030660—hsa-miR-576-3p, hsa-miR-124*, hsa-miR-665, hsa-miR-520b,hsa-miR-32, hsa-miR-645, hsa-miR-448, hsa-miR-922, hsa-miR-493*,hsa-miR-130b*, hsa-miR-766, hsa-miR-1276, hsa-miR-1184, hsa-miR-520g,hsa-miR-616, hsa-miR-1290, hsa-miR-181a, hsa-miR-551b*, hsa-miR-195*,hsa-miR-302c*, hsa-miR-487a, hsa-let-7g*, hsa-miR-96, hsa-miR-377,hsa-miR-30c-1*, hsa-miR-890, hsa-miR-376c, hsa-miR-27a, hsa-miR-516a-3p,hsa-miR-16-2*, hsa-miR-320c, hsa-miR-520a-3p, hsa-miR-511, hsa-miR-661,hsa-miR-513a-3p, hsa-miR-26a-1*, hsa-miR-142-5p, hsa-miR-379*,hsa-miR-335*, hsa-miR-29b-1*, hsa-miR-548m, hsa-miR-302a*, hsa-miR-561,hsa-miR-1178, hsa-miR-217, hsa-miR-885-5p, hsa-miR-302e, hsa-miR-603,hsa-miR-128, hsa-miR-342-3p, hsa-miR-508-5p, hsa-miR-92b, hsa-miR-130b,hsa-miR-199a-5p, hsa-miR-623, hsa-miR-129*, hsa-miR-148a,hsa-miR-299-5p, hsa-miR-548p, hsa-miR-367, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-543, hsa-miR-25, hsa-miR-186,hsa-miR-23a, hsa-miR-365, hsa-miR-301b, hsa-miR-30c-2*, hsa-miR-618,hsa-miR-33 a*, hsa-miR-302c, hsa-miR-302f, hsa-miR-641, hsa-miR-212,hsa-miR-516b*, hsa-miR-329, hsa-miR-590-5p, hsa-miR-494, hsa-miR-582-3p,hsa-miR-30a*, hsa-miR-371-5p, hsa-miR-489, hsa-miR-29a*, hsa-miR-622,hsa-miR-324-3p, hsa-miR-548o, hsa-miR-373, hsa-miR-130a, hsa-miR-616*,hsa-miR-552, hsa-miR-148b, hsa-miR-373*, hsa-miR-548f, hsa-miR-1286,hsa-miR-26b, hsa-miR-573, hsa-miR-32*, hsa-miR-302d, hsa-miR-1324,hsa-miR-320d, hsa-miR-617, hsa-miR-590-3p, hsa-miR-495, hsa-miR-1271,hsa-miR-29c, hsa-miR-513c, hsa-miR-132, hsa-miR-1297, hsa-miR-7-1*,hsa-miR-589*, hsa-miR-1253, hsa-miR-1200, hsa-miR-921, hsa-miR-643,hsa-miR-29b, hsa-miR-411*, hsa-miR-26a-2*, hsa-miR-193a-3p,hsa-miR-520f, hsa-miR-146a, hsa-miR-1259, hsa-miR-374b*, hsa-miR-186*,hsa-miR-1233, hsa-miR-520c-3p, hsa-miR-27a*, hsa-miR-498, hsa-miR-144,hsa-miR-1323, hsa-miR-220b, hsa-miR-302a, hsa-miR-888, hsa-miR-30d*,hsa-miR-568, hsa-miR-30e*, hsa-miR-29a, hsa-miR-488, hsa-miR-570,hsa-miR-940, hsa-miR-125a-3p, hsa-miR-1285, hsa-miR-520d-3p,hsa-miR-18b*, hsa-miR-450b-5p, hsa-miR-610, hsa-miR-545, hsa-miR-181d,hsa-miR-612, hsa-miR-9*, hsa-miR-514, hsa-miR-27b, hsa-miR-323-3p,hsa-miR-607, hsa-miR-520e, hsa-miR-200a, hsa-miR-578, hsa-miR-629,hsa-miR-383, hsa-miR-155*, hsa-miR-192*, hsa-miR-193b, hsa-miR-566,hsa-miR-518c*, hsa-miR-491-3p, hsa-miR-942, hsa-miR-152, hsa-miR-23b,hsa-miR-1322, hsa-miR-362-3p, hsa-miR-545*, hsa-miR-548a-3p,hsa-miR-146b-5p, hsa-miR-516b, hsa-miR-526b, hsa-miR-567, hsa-miR-302d*,hsa-miR-301a, hsa-miR-141, hsa-miR-92a, hsa-miR-625*, hsa-miR-744*,hsa-miR-593*, hsa-miR-628-5p, hsa-miR-150, hsa-miR-181c, hsa-miR-760,hsa-miR-501-5p, hsa-miR-199b-5p, hsa-miR-378*, hsa-miR-640,hsa-miR-1224-3p, hsa-miR-877*, hsa-miR-18a*, hsa-miR-525-3p,hsa-miR-30b*, hsa-miR-130a*, hsa-miR-550, hsa-miR-520h, hsa-miR-320a,hsa-miR-1225-5p, hsa-miR-197, hsa-miR-129-3p, hsa-miR-1827,hsa-miR-548c-3p, hsa-miR-135a*, hsa-miR-663b, hsa-miR-500*,hsa-miR-1279, hsa-miR-106a*, hsa-miR-382, hsa-miR-656, hsa-miR-320b,hsa-miR-454, hsa-miR-1264, hsa-miR-297, hsa-miR-5481, hsa-miR-654-5p,hsa-miR-302b, hsa-miR-181b, hsa-miR-548e, hsa-miR-1251, hsa-miR-21,hsa-miR-655, hsa-miR-485-5p, hsa-miR-614, hsa-miR-1278, hsa-miR-7-2*,hsa-miR-377*, hsa-miR-188-5p, hsa-miR-485-3p, hsa-miR-632,hsa-miR-409-3p, hsa-miR-183, hsa-miR-876-3p, hsa-miR-363, hsa-miR-1272,hsa-miR-767-5p, hsa-miR-944, hsa-miR-340, hsa-miR-499-5p, hsa-miR-193b*,hsa-miR-219-2-3p, hsa-miR-524-3p, hsa-let-7f-2*, hsa-miR-302b*,hsa-miR-372, hsa-miR-595, hsa-miR-26a, hsa-miR-541, hsa-miR-520d-5p,hsa-miR-1205, hsa-miR-154*, hsa-miR-671-5p, hsa-miR-340*, hsa-miR-584.

General transcription factor IIIC, polypeptide 3, 102kDa—GTF3C3—NM_(—)012086—hsa-miR-448, hsa-miR-22, hsa-miR-125a-5p,hsa-miR-377, hsa-miR-452, hsa-miR-342-3p, hsa-miR-646, hsa-miR-1208,hsa-miR-26b*, hsa-miR-125b, hsa-miR-203, hsa-miR-522, hsa-miR-433,hsa-miR-1250.

Glycogen synthase kinase 3 beta—GSK3B—NM_(—)002093—hsa-miR-1301,hsa-miR-647, hsa-miR-199a-5p, hsa-miR-582-3p, hsa-miR-1207-3p,hsa-miR-26b, hsa-miR-1297, hsa-miR-199b-5p, hsa-miR-876-3p, hsa-miR-26a.

Kruppel-like factor 10—KLF10—Variant 1—NM_(—)005655—hsa-miR-200b,hsa-miR-509-3-5p, hsa-miR-19b-2*, hsa-miR-520g, hsa-miR-1290,hsa-miR-101*, hsa-miR-519b-3p, hsa-miR-513b, hsa-miR-195*,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-1248, hsa-miR-548b-5p,hsa-miR-16-2*, hsa-miR-31*, hsa-miR-142-5p, hsa-miR-548m,hsa-miR-330-3p, hsa-miR-519c-3p, hsa-miR-19b, hsa-miR-541*,hsa-miR-548n, hsa-miR-892b, hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-1825,hsa-miR-519a, hsa-miR-663, hsa-miR-875-3p, hsa-miR-129*, hsa-miR-576-5p,hsa-miR-548p, hsa-miR-338-5p, hsa-miR-19b-1*, hsa-miR-30b, hsa-miR-143*,hsa-miR-23a, hsa-miR-618, hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-548i,hsa-miR-410, hsa-miR-421, hsa-let-7b*, hsa-miR-30a, hsa-miR-200c,hsa-miR-26b, hsa-miR-513c, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-34c-3p,hsa-miR-579, hsa-miR-520f, hsa-miR-802, hsa-miR-654-3p, hsa-miR-429,hsa-miR-570, hsa-miR-517*, hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-148b*,hsa-miR-519d, hsa-miR-545, hsa-miR-452*, hsa-miR-548j, hsa-miR-607,hsa-miR-30d, hsa-miR-10b*, hsa-miR-93, hsa-miR-23b, hsa-miR-539,hsa-miR-1257, hsa-miR-889, hsa-miR-526b*, hsa-miR-203, hsa-miR-548h,hsa-let-7f-1 *, hsa-miR-30c, hsa-miR-224, hsa-miR-20b, hsa-miR-106a,hsa-miR-149, hsa-miR-130a*, hsa-miR-520h, hsa-miR-197, hsa-miR-129-3p,hsa-miR-17, hsa-miR-345, hsa-miR-548k, hsa-miR-655, hsa-miR-892a,hsa-miR-7-2*, hsa-miR-19a, hsa-miR-188-5p, hsa-miR-20a, hsa-let-7a*,hsa-miR-509-5p, hsa-miR-340, hsa-miR-106b, hsa-miR-369-3p,hsa-let-7f-2*, hsa-miR-499-3p, hsa-miR-662, hsa-miR-26a, hsa-miR-1205,hsa-miR-744, hsa-miR-30e.

KLF10—Variant 2—NM_(—)001032282—hsa-miR-200b, hsa-miR-509-3-5p,hsa-miR-19b-2*, hsa-miR-520g, hsa-miR-1290, hsa-miR-101*,hsa-miR-519b-3p, hsa-miR-513b, hsa-miR-195*, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-1248, hsa-miR-548b-5p, hsa-miR-16-2*, hsa-miR-31*,hsa-miR-142-5p, hsa-miR-548m, hsa-miR-330-3p, hsa-miR-519c-3p,hsa-miR-19b, hsa-miR-541*, hsa-miR-548n, hsa-miR-892b, hsa-miR-548c-5p,hsa-miR-19a*, hsa-miR-1825, hsa-miR-519a, hsa-miR-875-3p, hsa-miR-129*,hsa-miR-576-5p, hsa-miR-548p, hsa-miR-338-5p, hsa-miR-19b-1*,hsa-miR-30b, hsa-miR-143*, hsa-miR-23a, hsa-miR-618, hsa-miR-337-3p,hsa-miR-33a*, hsa-miR-548i, hsa-miR-410, hsa-miR-421, hsa-let-7b*,hsa-miR-30a, hsa-miR-200c, hsa-miR-26b, hsa-miR-513c, hsa-miR-1297,hsa-miR-7-1*, hsa-miR-34c-3p, hsa-miR-579, hsa-miR-520f, hsa-miR-802,hsa-miR-654-3p, hsa-miR-429, hsa-miR-570, hsa-miR-517*, hsa-miR-548d-5p,hsa-miR-34b, hsa-miR-148b*, hsa-miR-519d, hsa-miR-545, hsa-miR-452*,hsa-miR-548j, hsa-miR-607, hsa-miR-30d, hsa-miR-10b*, hsa-miR-93,hsa-miR-23b, hsa-miR-539, hsa-miR-1257, hsa-miR-889, hsa-miR-526b*,hsa-miR-203, hsa-miR-548h, hsa-let-7f-1*, hsa-miR-30c, hsa-miR-224,hsa-miR-20b, hsa-miR-106a, hsa-miR-149, hsa-miR-130a*, hsa-miR-483-5p,hsa-miR-520h, hsa-miR-197, hsa-miR-129-3p, hsa-miR-17, hsa-miR-345,hsa-miR-548k, hsa-miR-655, hsa-miR-892a, hsa-miR-7-2*, hsa-miR-19a,hsa-miR-188-5p, hsa-miR-20a, hsa-let-7a*, hsa-miR-509-5p, hsa-miR-340,hsa-miR-106b, hsa-miR-369-3p, hsa-let-7f-2*, hsa-miR-499-3p,hsa-miR-662, hsa-miR-26a, hsa-miR-1205, hsa-miR-30e.

Elongation factor, RNA polymerase II,2—ELL2—NM_(—)012081—hsa-miR-576-3p,hsa-miR-557, hsa-miR-518d-5p, hsa-miR-510, hsa-miR-200b, hsa-miR-520b,hsa-miR-34c-5p, hsa-miR-16, hsa-miR-448, hsa-miR-519a*, hsa-miR-500,hsa-miR-20b*, hsa-miR-141*, hsa-miR-542-3p, hsa-miR-522*,hsa-miR-219-1-3p, hsa-miR-562, hsa-miR-875-5p, hsa-miR-766,hsa-miR-1276, hsa-miR-125b-2*, hsa-miR-520g, hsa-miR-551b*,hsa-miR-302c*, hsa-miR-221, hsa-miR-548g, hsa-miR-204, hsa-let-7g*,hsa-miR-28-3p, hsa-miR-890, hsa-miR-548a-5p, hsa-miR-376c,hsa-miR-490-3p, hsa-miR-559, hsa-miR-27a, hsa-miR-92a-2*,hsa-miR-548b-5p, hsa-miR-320c, hsa-miR-520a-3p, hsa-miR-513a-3p,hsa-miR-24-1*, hsa-miR-335*, hsa-miR-507, hsa-miR-449a, hsa-miR-29b-1*,hsa-miR-28-5p, hsa-miR-561, hsa-miR-19b, hsa-miR-129-5p, hsa-miR-541*,hsa-miR-548n, hsa-miR-892b, hsa-miR-885-5p, hsa-miR-302e, hsa-miR-93*,hsa-miR-548c-5p, hsa-miR-603, hsa-miR-574-3p, hsa-miR-409-5p,hsa-miR-130b, hsa-miR-619, hsa-miR-370, hsa-miR-1287, hsa-miR-299-5p,hsa-miR-576-5p, hsa-miR-876-5p, hsa-miR-30b, hsa-miR-186, hsa-miR-301b,hsa-miR-449b, hsa-miR-1305, hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-302c,hsa-miR-491-5p, hsa-miR-548i, hsa-miR-218-2*, hsa-miR-24-2*,hsa-miR-646, hsa-let-7b*, hsa-miR-708, hsa-miR-590-5p, hsa-miR-30a*,hsa-miR-30a, hsa-miR-29a*, hsa-miR-548o, hsa-miR-373, hsa-miR-200c,hsa-miR-130a, hsa-miR-145, hsa-miR-616*, hsa-miR-373*, hsa-miR-548f,hsa-miR-569, hsa-miR-664, hsa-miR-1269, hsa-miR-302d, hsa-miR-624,hsa-miR-15b, hsa-miR-320d, hsa-miR-188-3p, hsa-miR-590-3p, hsa-miR-495,hsa-miR-29c, hsa-miR-513c, hsa-miR-635, hsa-miR-34a, hsa-miR-29b,hsa-miR-579, hsa-miR-1243, hsa-miR-520c-3p, hsa-miR-518a-5p,hsa-miR-608, hsa-miR-770-5p, hsa-miR-144, hsa-miR-1323, hsa-miR-220b,hsa-miR-302a, hsa-miR-30d*, hsa-miR-802, hsa-miR-30e*, hsa-miR-21*,hsa-miR-429, hsa-miR-29a, hsa-miR-508-3p, hsa-miR-155, hsa-miR-548d-5p,hsa-miR-588, hsa-miR-222, hsa-miR-518f*, hsa-miR-34b*, hsa-miR-125a-3p,hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-195, hsa-miR-450b-5p,hsa-miR-519d, hsa-miR-9*, hsa-miR-27b, hsa-miR-664*, hsa-miR-548j,hsa-miR-323-3p, hsa-miR-607, hsa-miR-520e, hsa-miR-520c-5p, hsa-miR-30d,hsa-miR-10b*, hsa-miR-93, hsa-miR-383, hsa-miR-1322, hsa-miR-548a-3p,hsa-miR-567, hsa-miR-139-5p, hsa-miR-301a, hsa-miR-223, hsa-miR-526b*,hsa-miR-203, hsa-miR-571, hsa-miR-548h, hsa-miR-625*, hsa-miR-708*,hsa-miR-211, hsa-miR-518e*, hsa-miR-593*, hsa-let-7f-1*, hsa-miR-628-5p,hsa-miR-30c, hsa-miR-526a, hsa-miR-205, hsa-miR-224, hsa-miR-1284,hsa-miR-221*, hsa-miR-527, hsa-miR-20b, hsa-miR-640, hsa-miR-523*,hsa-miR-106a, hsa-miR-520h, hsa-miR-320a, hsa-miR-522, hsa-miR-555,hsa-miR-431, hsa-miR-548c-3p, hsa-miR-17, hsa-miR-500*, hsa-miR-106a*,hsa-miR-656, hsa-miR-182, hsa-miR-320b, hsa-miR-454, hsa-miR-1264,hsa-miR-297, hsa-miR-5481, hsa-miR-424, hsa-miR-302b, hsa-miR-548e,hsa-miR-21, hsa-miR-888*, hsa-miR-577, hsa-miR-19a, hsa-miR-15a,hsa-miR-20a, hsa-miR-519b-5p, hsa-let-7a*, hsa-miR-944, hsa-miR-340,hsa-miR-1265, hsa-miR-140-3p, hsa-miR-106b, hsa-miR-497,hsa-miR-519c-5p, hsa-miR-649, hsa-miR-372, hsa-miR-1183, hsa-miR-505,hsa-miR-595, hsa-miR-1293, hsa-miR-584, hsa-miR-30e.

Zinc finger and BTB domain containing20—ZBTB20—NM_(—)015642—hsa-miR-380, hsa-miR-214, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-548b-5p, hsa-miR-548c-5p, hsa-miR-548i,hsa-miR-548d-5p, hsa-miR-548j, hsa-miR-634, hsa-miR-22*, hsa-miR-548h,hsa-miR-296-3p.

Iroquois homeobox 3—IRX3—NM_(—)024336—hsa-miR-493*, hsa-miR-19b-2*,hsa-miR-520g, hsa-miR-551b*, hsa-miR-377, hsa-miR-29b-1*, hsa-miR-561,hsa-miR-19a*, hsa-miR-19b-1*, hsa-miR-646, hsa-let-7b*, hsa-miR-1227,hsa-miR-495, hsa-miR-331-5p, hsa-miR-149*, hsa-let-7f-1*,hsa-miR-342-5p, hsa-miR-1284, hsa-miR-659, hsa-miR-520h, hsa-miR-382,hsa-miR-125b-1*, hsa-miR-126*, hsa-let-7a*, hsa-miR-944, hsa-let-7f-2*.

v-ets erythroblastosis virus E26 oncogene homolog1—ETS1—NM_(—)005238—hsa-miR-124*, hsa-miR-200b, hsa-miR-509-3-5p,hsa-miR-490-5p, hsa-miR-642, hsa-miR-431*, hsa-miR-1180, hsa-miR-515-5p,hsa-miR-27b*, hsa-miR-141*, hsa-miR-542-3p, hsa-miR-187, hsa-miR-922,hsa-miR-625, hsa-miR-130b*, hsa-miR-216a, hsa-miR-19b-2*, hsa-miR-766,hsa-miR-650, hsa-miR-125b-2*, hsa-miR-520g, hsa-miR-181a, hsa-miR-182*,hsa-miR-125a-5p, hsa-miR-221, hsa-miR-214, hsa-miR-532-3p, hsa-miR-377,hsa-miR-218-1*, hsa-miR-1248, hsa-miR-320c, hsa-miR-335*, hsa-miR-19b,hsa-miR-129-5p, hsa-miR-548n, hsa-miR-658, hsa-miR-19a*, hsa-miR-1825,hsa-miR-455-5p, hsa-miR-587, hsa-miR-199a-5p, hsa-miR-1303,hsa-miR-875-3p, hsa-miR-657, hsa-miR-630, hsa-miR-660, hsa-miR-148a,hsa-miR-576-5p, hsa-miR-548p, hsa-miR-586, hsa-miR-338-5p,hsa-miR-19b-1*, hsa-miR-25*, hsa-miR-543, hsa-miR-34a*, hsa-miR-208a,hsa-miR-23a, hsa-miR-365, hsa-miR-1236, hsa-miR-1305, hsa-miR-10a,hsa-miR-218-2*, hsa-miR-410, hsa-miR-421, hsa-miR-641, hsa-miR-646,hsa-miR-329, hsa-miR-146a*, hsa-miR-30a*, hsa-miR-489, hsa-miR-29a*,hsa-miR-548o, hsa-miR-1, hsa-miR-200c, hsa-miR-1207-3p, hsa-miR-148b,hsa-miR-569, hsa-miR-664, hsa-miR-1202, hsa-miR-765, hsa-miR-320d,hsa-miR-590-3p, hsa-miR-495, hsa-miR-513c, hsa-miR-7-1*, hsa-miR-1291,hsa-miR-605, hsa-miR-1259, hsa-miR-498, hsa-miR-144, hsa-miR-1323,hsa-miR-125b, hsa-miR-30d*, hsa-miR-654-3p, hsa-miR-568, hsa-miR-30e*,hsa-miR-429, hsa-miR-570, hsa-miR-124, hsa-miR-940, hsa-miR-155,hsa-miR-324-5p, hsa-miR-222, hsa-miR-769-3p, hsa-miR-593, hsa-miR-34b*,hsa-miR-148b*, hsa-miR-1285, hsa-miR-450b-3p, hsa-miR-545, hsa-miR-181d,hsa-miR-612, hsa-miR-607, hsa-miR-10b*, hsa-miR-629*, hsa-miR-548b-3p,hsa-miR-1260, hsa-miR-942, hsa-miR-152, hsa-miR-23b, hsa-miR-362-3p,hsa-miR-1229, hsa-miR-634, hsa-miR-136, hsa-miR-330-5p, hsa-miR-139-5p,hsa-miR-941, hsa-miR-203, hsa-miR-571, hsa-miR-492, hsa-miR-625*,hsa-miR-381, hsa-miR-708*, hsa-miR-519e*, hsa-miR-1300, hsa-miR-181c,hsa-miR-181 a-2*, hsa-miR-501-5p, hsa-miR-199b-5p, hsa-miR-342-5p,hsa-miR-493, hsa-miR-224, hsa-miR-221*, hsa-miR-17*, hsa-miR-1224-3p,hsa-miR-208b, hsa-miR-130a*, hsa-miR-758, hsa-miR-520h, hsa-miR-320a,hsa-miR-10b, hsa-miR-522, hsa-miR-486-5p, hsa-miR-1228, hsa-miR-1827,hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-369-5p, hsa-miR-320b,hsa-miR-5481, hsa-miR-506, hsa-miR-626, hsa-miR-181b, hsa-miR-1283,hsa-miR-655, hsa-miR-206, hsa-miR-7-2*, hsa-miR-19a, hsa-miR-300,hsa-miR-632, hsa-miR-1244, hsa-miR-338-3p, hsa-miR-509-5p,hsa-miR-369-3p, hsa-miR-16-1*, hsa-miR-326, hsa-miR-497*, hsa-miR-223*,hsa-miR-1275, hsa-miR-1205, hsa-miR-135b*, hsa-miR-613, hsa-miR-512-5p,hsa-miR-584.

SERTA domain containing 1—SERTAD1—NM_(—)013376—hsa-miR-105*,hsa-miR-515-5p, hsa-miR-133a, hsa-miR-520g, hsa-miR-125a-5p,hsa-miR-28-3p, hsa-miR-214, hsa-miR-511, hsa-miR-892b, hsa-miR-146b-3p,hsa-miR-1252, hsa-miR-1236, hsa-miR-10a, hsa-miR-484, hsa-miR-1202,hsa-miR-34c-3p, hsa-miR-26b*, hsa-miR-361-5p, hsa-miR-376a*,hsa-miR-125b, hsa-miR-184, hsa-miR-504, hsa-miR-133b, hsa-miR-519e*,hsa-miR-611, hsa-miR-520h, hsa-miR-10b, hsa-miR-339-5p, hsa-miR-24,hsa-miR-548c-3p, hsa-miR-663b, hsa-miR-1274b, hsa-miR-671-5p.

Trans-membrane protein 101—TMEM101—NM_(—)032376—hsa-miR-194*,hsa-miR-509-3-5p, hsa-miR-1266, hsa-miR-642, hsa-miR-518e, hsa-miR-20b*,hsa-miR-515-5p, hsa-miR-141*, hsa-miR-542-3p, hsa-miR-22, hsa-miR-222*,hsa-miR-125a-5p, hsa-let-7g*, hsa-miR-214, hsa-miR-532-3p, hsa-miR-27a,hsa-miR-452, hsa-miR-320c, hsa-miR-1178, hsa-miR-603, hsa-miR-1207-5p,hsa-miR-1182, hsa-miR-548p, hsa-miR-23a, hsa-miR-33a*, hsa-miR-1201,hsa-miR-548d-3p, hsa-miR-646, hsa-miR-324-3p, hsa-miR-1207-3p,hsa-miR-320d, hsa-miR-590-3p, hsa-miR-495, hsa-miR-513c, hsa-miR-589,hsa-miR-589*, hsa-miR-768-5p, hsa-miR-147, hsa-miR-125b, hsa-miR-592,hsa-miR-940, hsa-miR-324-5p, hsa-miR-588, hsa-miR-27b, hsa-miR-23b,hsa-miR-1274a, hsa-miR-149*, hsa-miR-519e*, hsa-miR-150, hsa-miR-583,hsa-miR-221*, hsa-miR-556-5p, hsa-miR-640, hsa-miR-18a*, hsa-miR-30b*,hsa-miR-130a*, hsa-miR-320a, hsa-miR-486-5p, hsa-miR-320b,hsa-miR-331-3p, hsa-miR-892a, hsa-miR-509-5p, hsa-miR-649, hsa-miR-505,hsa-miR-558.

v-maf musculo-aponeurotic fibrosarcoma oncogene homolog F—MAFF—Variant 1and Variant 2—NM_(—)012323 and NM_(—)152878—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-665, hsa-miR-510, hsa-miR-509-3-5p, hsa-miR-520b,hsa-miR-1266, hsa-miR-34c-5p, hsa-miR-642, hsa-miR-20b*, hsa-miR-562,hsa-miR-133a, hsa-miR-520g, hsa-miR-1290, hsa-miR-195*, hsa-miR-96,hsa-miR-214, hsa-miR-532-3p, hsa-miR-647, hsa-miR-1248, hsa-miR-920,hsa-miR-92a-2*, hsa-miR-16-2*, hsa-miR-520a-3p, hsa-miR-486-3p,hsa-miR-449a, hsa-miR-378, hsa-miR-28-5p, has-miR-302a*, hsa-miR-1237,hsa-miR-1288, hsa-miR-302e, hsa-miR-1825, hsa-miR-128, hsa-miR-1268,hsa-miR-508-5p, hsa-miR-130b, hsa-miR-663, hsa-miR-1207-5p, hsa-miR-623,hsa-miR-1182, hsa-miR-148a, hsa-miR-143*, hsa-miR-186, hsa-miR-301b,hsa-miR-449b, hsa-miR-1236, hsa-miR-302c, hsa-miR-491-5p, hsa-miR-708,hsa-miR-371-5p, hsa-miR-324-3p, hsa-miR-1, hsa-miR-373, hsa-miR-130a,hsa-miR-148b, hsa-miR-1286, hsa-miR-302d, hsa-miR-1324, hsa-miR-1271,hsa-miR-26b*, hsa-miR-34a, hsa-miR-193a-3p, hsa-miR-768-5p,hsa-miR-186*, hsa-miR-520c-3p, hsa-miR-27a*, hsa-miR-185*, hsa-miR-302a,hsa-miR-1224-5p, hsa-miR-940, hsa-miR-1285, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-519d, hsa-miR-612, hsa-miR-520e, hsa-miR-629*,hsa-miR-93, hsa-miR-193b, hsa-miR-1260, hsa-miR-942, hsa-miR-152,hsa-miR-422a, hsa-miR-1274a, hsa-miR-539, hsa-miR-133b, hsa-miR-149*,hsa-miR-301a, hsa-miR-526b*, hsa-miR-203, hsa-miR-492, hsa-miR-597,hsa-miR-744*, hsa-miR-361-3p, hsa-miR-150, hsa-miR-760, hsa-miR-342-5p,hsa-miR-224, hsa-miR-20b, hsa-miR-1321, hsa-miR-631, hsa-miR-106a,hsa-miR-1245, hsa-miR-877*, hsa-miR-30b*, hsa-miR-483-5p, hsa-miR-520h,hsa-miR-339-5p, hsa-miR-17, hsa-miR-1279, hsa-miR-7, hsa-miR-454,hsa-miR-302b, hsa-miR-1283, hsa-miR-888*, hsa-miR-577, hsa-miR-206,hsa-miR-1298, hsa-miR-20a, hsa-miR-423-5p, hsa-miR-455-3p,hsa-miR-509-5p, hsa-miR-340, hsa-miR-193b*, hsa-miR-106b, hsa-miR-1197,hsa-miR-372, hsa-miR-1183, hsa-miR-1275, hsa-miR-1205, hsa-miR-613.

Splicing factor proline/glutamine-rich (polypyrimidine tract bindingprotein associated)—SFPQ—NM_(—)005066—hsa-miR-150*, hsa-miR-550*,hsa-miR-195*, hsa-miR-302c*, hsa-miR-138-1*, hsa-miR-516a-3p,hsa-miR-16-2*, hsa-miR-335*, hsa-miR-217, hsa-miR-660, hsa-miR-586,hsa-miR-582-5p, hsa-miR-1296, hsa-miR-337-3p, hsa-miR-606,hsa-miR-516b*, hsa-miR-153, hsa-miR-26b, hsa-miR-624, hsa-miR-590-3p,hsa-miR-495, hsa-miR-29c, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-29b,hsa-miR-200c*, hsa-miR-509-3p, hsa-miR-1226, hsa-miR-29a, hsa-miR-20a*,hsa-miR-607, hsa-miR-200a, hsa-miR-545*, hsa-miR-141, hsa-miR-381,hsa-miR-656, hsa-miR-655, hsa-miR-7-2*, hsa-miR-300, hsa-miR-944,hsa-let-7f-2*, hsa-miR-26a.

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminaldomain, 4—CITED4—NM_(—)133467—hsa-miR-1254, hsa-miR-625, hsa-miR-130b*,hsa-miR-650, hsa-miR-548g, hsa-miR-214, hsa-miR-127-5p, hsa-miR-320c,hsa-miR-486-3p, hsa-miR-658, hsa-miR-1281, hsa-miR-220c, hsa-miR-1324,hsa-miR-320d, hsa-miR-1291, hsa-miR-885-3p, hsa-miR-768-5p, hsa-miR-608,hsa-miR-548b-3p, hsa-miR-330-5p, hsa-miR-760, hsa-miR-151-5p,hsa-miR-185, hsa-miR-1256, hsa-miR-30b*, hsa-miR-320a, hsa-miR-24,hsa-miR-106a*, hsa-miR-320b, hsa-miR-485-5p, hsa-miR-140-3p,hsa-miR-1197, hsa-miR-326, hsa-miR-1275, hsa-miR-744.

CCAAT/enhancer binding protein (C/EBP),delta—CEBPD—NM_(—)005195—hsa-miR-200b, hsa-miR-509-3-5p, hsa-miR-1184,hsa-miR-604, hsa-miR-647, hsa-miR-29b-1*, hsa-miR-885-5p,hsa-miR-1207-5p, hsa-miR-524-5p, hsa-miR-202, hsa-miR-200c, hsa-miR-429,hsa-miR-105, hsa-miR-607, hsa-miR-942, hsa-miR-572, hsa-miR-941,hsa-miR-760, hsa-miR-202*, hsa-miR-627, hsa-miR-509-5p, hsa-miR-520d-5p.

Eukaryotic translation initiation factor 4E family member2—EIF4E2—NM_(—)004846—hsa-miR-141*, hsa-miR-1236, hsa-miR-520a-5p,hsa-miR-525-5p, hsa-miR-29c, hsa-miR-589*, hsa-miR-26b*, hsa-miR-29b,hsa-miR-29a, hsa-miR-1245, hsa-miR-767-5p.

Heparan sulfate 2-O-sulfotransferase1—HS2ST1—NM_(—)012262—hsa-miR-576-3p, hsa-miR-140-5p, hsa-miR-502-3p,hsa-miR-518d-5p, hsa-miR-200b, hsa-miR-520b, hsa-miR-105*,hsa-miR-34c-5p, hsa-miR-518a-3p, hsa-miR-380, hsa-miR-16, hsa-miR-448,hsa-miR-519a*, hsa-miR-515-5p, hsa-miR-380*, hsa-miR-141*,hsa-miR-542-3p, hsa-miR-522*, hsa-miR-922, hsa-miR-625, hsa-miR-216a,hsa-miR-219-1-3p, hsa-let-7d, hsa-miR-513a-5p, hsa-miR-650,hsa-miR-1276, hsa-miR-133a, hsa-miR-520g, hsa-miR-222*, hsa-miR-374b,hsa-miR-181a, hsa-miR-551 b*, hsa-miR-513b, hsa-miR-182*, hsa-miR-195*,hsa-miR-487a, hsa-miR-548g, hsa-miR-204, hsa-miR-563, hsa-miR-214,hsa-miR-377, hsa-miR-30c-1*, hsa-miR-1304, hsa-miR-548a-5p, hsa-miR-559,hsa-miR-1267, hsa-miR-138-1*, hsa-miR-127-5p, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-452, hsa-miR-16-2*, hsa-miR-575, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-15b*, hsa-miR-31*, hsa-miR-513a-3p,hsa-miR-544, hsa-miR-26a-1*, hsa-miR-142-5p, hsa-miR-449a, hsa-miR-548m,hsa-miR-330-3p, hsa-miR-28-5p, hsa-miR-190, hsa-miR-302a*, hsa-miR-561,hsa-miR-19b, hsa-miR-541*, hsa-miR-548n, hsa-miR-1178, hsa-miR-146b-3p,hsa-miR-302e, hsa-let-7c*, hsa-miR-548c-5p, hsa-miR-603, hsa-miR-1825,hsa-miR-298, hsa-miR-508-5p, hsa-miR-130b, hsa-miR-619, hsa-let-7e,hsa-miR-1207-5p, hsa-miR-875-3p, hsa-miR-216b, hsa-miR-630,hsa-miR-129*, hsa-miR-148a, hsa-miR-600, hsa-miR-576-5p, hsa-miR-548p,hsa-miR-586, hsa-miR-876-5p, hsa-miR-338-5p, hsa-miR-524-5p,hsa-miR-30b, hsa-miR-543, hsa-miR-186, hsa-miR-23a, hsa-miR-365,hsa-miR-301b, hsa-miR-30c-2*, hsa-miR-449b, hsa-miR-1236, hsa-miR-1305,hsa-miR-33a*, hsa-miR-302c, hsa-miR-548i, hsa-miR-520a-5p,hsa-miR-516b*, hsa-miR-646, hsa-miR-708, hsa-miR-146a*, hsa-miR-153,hsa-miR-525-5p, hsa-miR-494, hsa-miR-582-3p, hsa-miR-30a*, hsa-miR-30a,hsa-miR-489, hsa-miR-373, hsa-miR-200c, hsa-miR-130a, hsa-miR-145,hsa-miR-148b, hsa-miR-548f, hsa-miR-569, hsa-miR-518b, hsa-miR-664,hsa-let-7f, hsa-miR-573, hsa-miR-302d, hsa-miR-1202, hsa-miR-15b,hsa-miR-320d, hsa-miR-590-3p, hsa-miR-29c, hsa-miR-513c, hsa-miR-7-1*,hsa-miR-1208, hsa-miR-767-3p, hsa-miR-589*, hsa-miR-26b*, hsa-miR-1253,hsa-miR-190b, hsa-miR-34a, hsa-miR-936, hsa-miR-921, hsa-miR-29b,hsa-miR-579, hsa-miR-26a-2*, hsa-miR-361-5p, hsa-miR-520f,hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-770-5p, hsa-miR-633,hsa-miR-144, hsa-miR-653, hsa-miR-302a, hsa-miR-888, hsa-miR-30d*,hsa-miR-568, hsa-miR-30e*, hsa-miR-596, hsa-miR-429, hsa-miR-29a,hsa-miR-570, hsa-miR-105, hsa-let-7g, hsa-miR-124, hsa-miR-940,hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-1294, hsa-miR-518f*,hsa-miR-520d-3p, hsa-miR-195, hsa-miR-331-5p, hsa-miR-519d, hsa-miR-198,hsa-miR-452*, hsa-miR-181d, hsa-miR-514, hsa-miR-548j, hsa-miR-607,hsa-miR-520e, hsa-miR-520c-5p, hsa-miR-1258, hsa-miR-200a, hsa-miR-30d,hsa-miR-629*, hsa-miR-93, hsa-miR-383, hsa-miR-29b-2*, hsa-let-7i,hsa-miR-942, hsa-miR-152, hsa-miR-23b, hsa-miR-545*, hsa-miR-539,hsa-miR-548a-3p, hsa-miR-634, hsa-miR-133b, hsa-let-7b, hsa-miR-149*,hsa-miR-328, hsa-miR-301a, hsa-miR-141, hsa-let-7a, hsa-miR-526b*,hsa-miR-518c, hsa-miR-98, hsa-miR-203, hsa-miR-548h, hsa-miR-492,hsa-miR-381, hsa-miR-1185, hsa-miR-211, hsa-miR-519e*, hsa-miR-518e*,hsa-miR-593*, hsa-miR-30c, hsa-miR-181c, hsa-miR-526a, hsa-miR-583,hsa-miR-527, hsa-miR-185, hsa-miR-20b, hsa-miR-523*, hsa-miR-1224-3p,hsa-miR-106a, hsa-miR-1245, hsa-miR-138-2*, hsa-miR-130a*, hsa-miR-520h,hsa-miR-320a, hsa-miR-522, hsa-let-7c, hsa-miR-1228, hsa-miR-129-3p,hsa-miR-1827, hsa-miR-548c-3p, hsa-miR-17, hsa-miR-518f, hsa-miR-196a*,hsa-miR-500*, hsa-miR-1279, hsa-miR-106a*, hsa-miR-656, hsa-miR-320b,hsa-miR-454, hsa-miR-345, hsa-miR-548k, hsa-miR-5481, hsa-miR-424,hsa-miR-506, hsa-miR-302b, hsa-miR-181b, hsa-miR-1283, hsa-miR-187*,hsa-miR-548e, hsa-miR-1251, hsa-miR-518d-3p, hsa-miR-137, hsa-miR-1278,hsa-miR-888*, hsa-miR-892a, hsa-miR-488*, hsa-miR-577, hsa-miR-7-2*,hsa-miR-196a, hsa-miR-19a, hsa-miR-188-5p, hsa-miR-300, hsa-miR-15a,hsa-miR-485-3p, hsa-miR-374a, hsa-miR-556-3p, hsa-miR-20a, hsa-miR-183,hsa-miR-455-3p, hsa-miR-196b, hsa-miR-126*, hsa-miR-519b-5p,hsa-miR-767-5p, hsa-miR-944, hsa-miR-501 -3p, hsa-miR-340,hsa-miR-140-3p, hsa-miR-106b, hsa-miR-497, hsa-miR-369-3p,hsa-miR-296-3p, hsa-miR-1197, hsa-miR-519c-5p, hsa-miR-16-1*,hsa-miR-372, hsa-miR-497*, hsa-miR-223*, hsa-miR-433, hsa-miR-154,hsa-miR-499-3p, hsa-miR-1275, hsa-miR-520d-5p, hsa-miR-1205,hsa-miR-891b, hsa-miR-154*, hsa-miR-30e.

Alkylglycerone phosphate synthase—AGPS—NM_(—)003659—hsa-miR-124*,hsa-miR-557, hsa-miR-518d-5p, hsa-miR-637, hsa-miR-510, hsa-miR-200b,hsa-miR-520b, hsa-miR-1266, hsa-miR-32, hsa-miR-448, hsa-miR-519a*,hsa-miR-500, hsa-miR-20b*, hsa-miR-141*, hsa-miR-522*, hsa-miR-625,hsa-miR-562, hsa-miR-513a-5p, hsa-miR-125b-2*, hsa-miR-616,hsa-miR-222*, hsa-miR-551b*, hsa-miR-513b, hsa-miR-182*, hsa-miR-195*,hsa-miR-221, hsa-miR-483-3p, hsa-miR-204, hsa-miR-1289, hsa-miR-1179,hsa-miR-532-3p, hsa-miR-377, hsa-miR-1304, hsa-miR-890, hsa-miR-548a-5p,hsa-miR-1826, hsa-miR-647, hsa-miR-559, hsa-miR-138-1*, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-452, hsa-miR-16-2*, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-511, hsa-miR-15b*, hsa-miR-31*,hsa-miR-513a-3p, hsa-miR-544, hsa-miR-26a-1*, hsa-miR-142-5p,hsa-miR-220a, hsa-miR-24-1*, hsa-miR-486-3p, hsa-miR-335*, hsa-miR-507,hsa-miR-548m, hsa-miR-183*, hsa-miR-190, hsa-miR-302a*, hsa-miR-1237,hsa-miR-943, hsa-miR-541*, hsa-miR-548n, hsa-miR-1178, hsa-miR-217,hsa-miR-302e, hsa-miR-93*, hsa-miR-548c-5p, hsa-miR-603, hsa-miR-342-3p,hsa-miR-92b, hsa-miR-587, hsa-miR-199a-5p, hsa-miR-216b, hsa-miR-1252,hsa-miR-1182, hsa-miR-129*, hsa-miR-1246, hsa-miR-600, hsa-miR-576-5p,hsa-miR-548p, hsa-miR-586, hsa-miR-876-5p, hsa-miR-367, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-30b, hsa-miR-543, hsa-miR-25, hsa-miR-186,hsa-miR-302c, hsa-miR-548i, hsa-miR-218-2*, hsa-miR-606, hsa-miR-410,hsa-miR-421, hsa-miR-24-2*, hsa-miR-641, hsa-miR-516b*, hsa-miR-646,hsa-miR-329, hsa-miR-494, hsa-miR-30a, hsa-miR-29a*, hsa-miR-373,hsa-miR-200c, hsa-miR-581, hsa-miR-1207-3p, hsa-miR-616*, hsa-miR-373*,hsa-miR-26b, hsa-miR-664, hsa-miR-302d, hsa-miR-624, hsa-miR-1324,hsa-miR-320d, hsa-miR-590-3p, hsa-miR-502-5p, hsa-miR-495, hsa-miR-29c,hsa-miR-1297, hsa-miR-7-1*, hsa-miR-1208, hsa-miR-589*, hsa-miR-26b*,hsa-miR-1253, hsa-miR-190b, hsa-miR-921, hsa-miR-643, hsa-miR-29b,hsa-miR-135a, hsa-miR-579, hsa-miR-26a-2*, hsa-miR-361-5p, hsa-miR-520f,hsa-miR-605, hsa-miR-768-5p, hsa-miR-1259, hsa-miR-374b*, hsa-miR-186*,hsa-miR-1233, hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-27a*,hsa-miR-1226, hsa-miR-185*, hsa-miR-633, hsa-miR-144, hsa-miR-384,hsa-miR-302a, hsa-miR-429, hsa-miR-29a, hsa-miR-570, hsa-miR-105,hsa-miR-124, hsa-miR-548d-5p, hsa-miR-222, hsa-miR-432, hsa-miR-593,hsa-miR-518f*, hsa-miR-520d-3p, hsa-miR-18b*, hsa-miR-331-5p,hsa-miR-610, hsa-miR-92a-1*, hsa-miR-198, hsa-miR-20a*, hsa-miR-935,hsa-miR-135b, hsa-miR-9*, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607,hsa-miR-520e, hsa-miR-520c-5p, hsa-miR-200a, hsa-miR-578, hsa-miR-30d,hsa-miR-29b-2*, hsa-miR-1206, hsa-miR-518c*, hsa-miR-491-3p,hsa-miR-942, hsa-miR-101, hsa-miR-362-3p, hsa-miR-634, hsa-miR-526b,hsa-miR-139-5p, hsa-miR-141, hsa-miR-889, hsa-miR-22*, hsa-miR-203,hsa-miR-548h, hsa-miR-92a, hsa-miR-381, hsa-miR-708*, hsa-miR-211,hsa-miR-518e*, hsa-miR-593*, hsa-miR-150, hsa-miR-30c, hsa-miR-526a,hsa-miR-181a-2*, hsa-miR-583, hsa-miR-501-5p, hsa-miR-199b-5p,hsa-miR-221*, hsa-miR-527, hsa-miR-378*, hsa-miR-556-5p, hsa-miR-523*,hsa-miR-199a-3p, hsa-miR-320a, hsa-miR-129-3p, hsa-miR-1827, hsa-miR-24,hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-196a*, hsa-miR-1279,hsa-miR-106a*, hsa-miR-7, hsa-miR-382, hsa-miR-656, hsa-miR-320b,hsa-miR-1264, hsa-miR-5481, hsa-miR-506, hsa-miR-302b, hsa-miR-1283,hsa-miR-187*, hsa-miR-655, hsa-miR-199b-3p, hsa-miR-1278, hsa-miR-888*,hsa-miR-924, hsa-miR-892a, hsa-miR-7-2*, hsa-miR-377*, hsa-miR-300,hsa-miR-1244, hsa-miR-627, hsa-miR-876-3p, hsa-miR-126*, hsa-miR-363,hsa-miR-519b-5p, hsa-miR-1272, hsa-miR-767-5p, hsa-miR-944, hsa-miR-340,hsa-miR-1265, hsa-miR-499-5p, hsa-miR-219-2-3p, hsa-miR-140-3p,hsa-let-7f-2*, hsa-miR-519c-5p, hsa-miR-649, hsa-miR-372, hsa-miR-367*,hsa-miR-497*, hsa-miR-154, hsa-miR-26a, hsa-miR-1275, hsa-miR-891b,hsa-miR-30e.

Phosphoglycerate kinase 1—PGK1—NM_(—)000291—hsa-miR-219-1-3p,hsa-miR-452, hsa-miR-26a-1*, hsa-miR-142-5p, hsa-miR-1178, hsa-miR-217,hsa-miR-338-5p, hsa-miR-143*, hsa-miR-186, hsa-miR-202, hsa-miR-494,hsa-miR-324-3p, hsa-miR-548o, hsa-miR-96*, hsa-miR-767-3p,hsa-miR-26a-2*, hsa-miR-146a, hsa-miR-873, hsa-miR-185*, hsa-miR-1323,hsa-miR-654-3p, hsa-miR-517*, hsa-miR-940, hsa-miR-588, hsa-miR-1270,hsa-miR-769-3p, hsa-miR-768-3p, hsa-miR-450b-3p, hsa-miR-607,hsa-miR-200a, hsa-miR-23a*, hsa-miR-23b*, hsa-miR-1229, hsa-miR-146b-5p,hsa-miR-620, hsa-miR-330-5p, hsa-miR-141, hsa-miR-221*, hsa-miR-556-5p,hsa-miR-30b*, hsa-miR-758, hsa-miR-548c-3p, hsa-miR-5481, hsa-miR-1283,hsa-miR-632, hsa-miR-346, hsa-miR-326.

5-aminoimidazole-4-carboxamide ribonucleotide formyltrans-ferase/IMPcyclohydrolase—ATIC—NM_(—)004044—hsa-miR-101*, hsa-miR-452, hsa-miR-561,hsa-miR-943, hsa-miR-134, hsa-miR-147.

Ethanolamine kinase 1—ETNK1—Variant 1—NM_(—)018638—hsa-miR-642,hsa-miR-380, hsa-miR-16, hsa-miR-448, hsa-miR-20b*, hsa-miR-515-5p,hsa-miR-27b*, hsa-miR-542-3p, hsa-miR-625, hsa-miR-493*, hsa-miR-562,hsa-let-7d, hsa-miR-513a-5p, hsa-miR-125b-2*, hsa-miR-150*,hsa-miR-222*, hsa-miR-374b, hsa-miR-181a, hsa-miR-551b*,hsa-miR-519b-3p, hsa-miR-513b, hsa-miR-182*, hsa-miR-195*,hsa-miR-302c*, hsa-miR-487a, hsa-miR-337-5p, hsa-miR-548g,hsa-miR-193a-5p, hsa-miR-532-3p, hsa-miR-377, hsa-miR-218-1*,hsa-miR-548a-5p, hsa-miR-376c, hsa-miR-559, hsa-miR-138-1*,hsa-miR-127-5p, hsa-miR-548b-5p, hsa-miR-16-2*, hsa-miR-496,hsa-miR-511, hsa-miR-15b*, hsa-miR-31*, hsa-miR-513a-3p, hsa-miR-148a*,hsa-miR-544, hsa-miR-142-5p, hsa-miR-379*, hsa-miR-335*, hsa-miR-330-3p,hsa-miR-28-5p, hsa-miR-561, hsa-miR-519c-3p, hsa-miR-19b, hsa-miR-217,hsa-miR-548c-5p, hsa-miR-519a, hsa-miR-130b, hsa-miR-587, hsa-let-7e,hsa-miR-1303, hsa-miR-216b, hsa-miR-103, hsa-miR-580, hsa-miR-600,hsa-miR-576-5p, hsa-miR-548p, hsa-miR-876-5p, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-30b, hsa-miR-23 a, hsa-miR-365,hsa-miR-301b, hsa-miR-1305, hsa-miR-33a*, hsa-miR-548i, hsa-miR-218-2*,hsa-miR-202, hsa-miR-606, hsa-miR-410, hsa-miR-421, hsa-miR-641,hsa-miR-212, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-708, hsa-miR-146a*,hsa-miR-153, hsa-miR-494, hsa-miR-30a*, hsa-miR-371-5p, hsa-miR-30a,hsa-miR-489, hsa-miR-130a, hsa-miR-145, hsa-miR-548f, hsa-miR-26b,hsa-miR-664, hsa-let-7f, hsa-miR-32*, hsa-miR-15b, hsa-miR-1324,hsa-miR-188-3p, hsa-miR-590-3p, hsa-miR-132, hsa-miR-1297, hsa-miR-7-1*,hsa-miR-1208, hsa-miR-767-3p, hsa-miR-589*, hsa-miR-579, hsa-miR-411*,hsa-miR-1259, hsa-miR-376a*, hsa-miR-518a-5p, hsa-miR-144, hsa-miR-384,hsa-miR-888, hsa-miR-30d*, hsa-miR-802, hsa-miR-568, hsa-miR-30e*,hsa-miR-592, hsa-miR-596, hsa-miR-570, hsa-let-7g, hsa-miR-517*,hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-325, hsa-miR-768-3p,hsa-miR-125a-3p, hsa-miR-512-3p, hsa-miR-18b*, hsa-miR-195,hsa-miR-331-5p, hsa-miR-610, hsa-miR-545, hsa-miR-181d, hsa-miR-935,hsa-miR-9*, hsa-miR-548j, hsa-miR-607, hsa-miR-1258, hsa-miR-200a,hsa-miR-30d, hsa-miR-200b*, hsa-miR-518c*, hsa-let-7i, hsa-miR-942,hsa-miR-23b, hsa-miR-101, hsa-miR-545*, hsa-miR-539, hsa-miR-1257,hsa-miR-548a-3p, hsa-miR-526b, hsa-let-7b, hsa-miR-301a, hsa-miR-141,hsa-let-7a, hsa-miR-98, hsa-miR-203, hsa-miR-548h, hsa-miR-381,hsa-miR-708*, hsa-miR-597, hsa-miR-1185, hsa-miR-519e*, hsa-let-7f-1*,hsa-miR-30c, hsa-miR-181c, hsa-miR-205, hsa-miR-1284, hsa-miR-659,hsa-miR-527, hsa-miR-185, hsa-miR-556-5p, hsa-miR-100*, hsa-miR-199a-3p,hsa-miR-138-2*, hsa-miR-130a*, hsa-miR-522, hsa-miR-555, hsa-let-7c,hsa-miR-24, hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-196a*, hsa-miR-1279,hsa-miR-656, hsa-miR-454, hsa-miR-1264, hsa-miR-5481, hsa-miR-424,hsa-miR-181b, hsa-miR-1283, hsa-miR-548e, hsa-miR-655, hsa-miR-485-5p,hsa-miR-199b-3p, hsa-miR-1278, hsa-miR-888*, hsa-miR-892a, hsa-miR-577,hsa-miR-7-2*, hsa-miR-107, hsa-miR-19a, hsa-miR-188-5p, hsa-miR-300,hsa-miR-15a, hsa-miR-485-3p, hsa-miR-374a, hsa-miR-556-3p, hsa-miR-425,hsa-miR-876-3p, hsa-miR-126*, hsa-let-7a*, hsa-miR-767-5p, hsa-miR-944,hsa-miR-340, hsa-miR-140-3p, hsa-miR-497, hsa-let-7f-2*, hsa-miR-16-1*,hsa-miR-367*, hsa-miR-1183, hsa-miR-10a*, hsa-miR-223*, hsa-miR-433,hsa-miR-505, hsa-miR-154, hsa-miR-499-3p, hsa-miR-26a, hsa-miR-1275,hsa-miR-520d-5p, hsa-miR-200a*, hsa-miR-1302, hsa-miR-154*, hsa-miR-584,hsa-miR-30e.

ETNK1—Variant 2—NM_(—)001039481—hsa-miR-31, hsa-miR-146a*,hsa-miR-371-5p, hsa-miR-590-3p, hsa-miR-888, hsa-miR-568, hsa-miR-570.

Asparagine-linked glycosylation 2homolog—ALG2—NM_(—)033087—hsa-miR-200b, hsa-miR-625, hsa-miR-648,hsa-miR-219-1-3p, hsa-miR-192, hsa-miR-150*, hsa-miR-181a, hsa-miR-195*,hsa-miR-548g, hsa-miR-96, hsa-miR-138-1*, hsa-miR-452, hsa-miR-16-2*,hsa-miR-15b*, hsa-miR-544, hsa-miR-28-5p, hsa-miR-302a*, hsa-miR-19b,hsa-miR-93*, hsa-miR-603, hsa-miR-875-3p, hsa-miR-103, hsa-miR-660,hsa-miR-576-5p, hsa-miR-338-5p, hsa-miR-30b, hsa-miR-23a,hsa-miR-337-3p, hsa-miR-202, hsa-miR-606, hsa-miR-641, hsa-miR-708,hsa-miR-30a, hsa-miR-29a*, hsa-miR-548o, hsa-miR-200c, hsa-miR-145,hsa-miR-548f, hsa-miR-32*, hsa-miR-628-3p, hsa-miR-599, hsa-miR-1271,hsa-miR-513c, hsa-miR-215, hsa-miR-376a*, hsa-miR-144, hsa-miR-1323,hsa-miR-653, hsa-miR-429, hsa-miR-124, hsa-miR-1270, hsa-miR-20a*,hsa-miR-181d, hsa-miR-200a, hsa-miR-30d, hsa-miR-29b-2*, hsa-miR-23b,hsa-miR-548a-3p, hsa-miR-567, hsa-miR-620, hsa-miR-141, hsa-miR-597,hsa-miR-30c, hsa-miR-181c, hsa-miR-1321, hsa-miR-30b*, hsa-miR-130a*,hsa-miR-1299, hsa-miR-656, hsa-miR-506, hsa-miR-181b, hsa-miR-548e,hsa-miR-577, hsa-miR-107, hsa-miR-19a, hsa-miR-425, hsa-miR-1225-3p,hsa-miR-30e.

Ubiquitin-conjugating enzyme E2F—UBE2F—NM_(—)080678—hsa-miR-513a-5p,hsa-miR-548g, hsa-miR-549, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-27a,hsa-miR-548b-5p, hsa-miR-548n, hsa-miR-548c-5p, hsa-miR-1303,hsa-miR-1207-5p, hsa-miR-580, hsa-miR-586, hsa-miR-30b, hsa-miR-543,hsa-miR-548i, hsa-let-7b*, hsa-miR-30a, hsa-miR-653, hsa-miR-1224-5p,hsa-miR-940, hsa-miR-548d-5p, hsa-miR-27b, hsa-miR-548j, hsa-miR-30d,hsa-miR-192*, hsa-miR-101, hsa-miR-1257, hsa-miR-139-5p, hsa-miR-548h,hsa-let-7f-1*, hsa-miR-30c, hsa-miR-1284, hsa-miR-30b*, hsa-miR-196a*,hsa-miR-632, hsa-miR-455-3p, hsa-let-7a*, hsa-miR-219-2-3p, hsa-let-7f-2*, hsa-miR-30e.

Membrane-associated ring finger (C3HC4) 8—MARCH8—Variant 6, Variant 7and Variant 8—NM_(—)001002265, NM_(—)001002266 andNM_(—)145021—hsa-miR-520b, hsa-miR-490-5p, hsa-miR-22, hsa-miR-650,hsa-miR-1290, hsa-miR-193a-5p, hsa-miR-335, hsa-miR-520a-3p,hsa-miR-661, hsa-miR-15b*, hsa-miR-548m, hsa-miR-129-5p, hsa-miR-302e,hsa-miR-623, hsa-miR-103, hsa-miR-1246, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-186, hsa-miR-1236, hsa-miR-302c, hsa-let-7b*, hsa-miR-153,hsa-miR-30a, hsa-miR-373, hsa-miR-1286, hsa-miR-302d, hsa-miR-765,hsa-miR-188-3p, hsa-miR-29c, hsa-miR-591, hsa-miR-767-3p, hsa-miR-29b,hsa-miR-873, hsa-miR-520c-3p, hsa-miR-302a, hsa-miR-29a, hsa-miR-940,hsa-miR-1285, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-519d,hsa-miR-612, hsa-miR-520e, hsa-miR-30d, hsa-miR-629, hsa-miR-93,hsa-miR-545*, hsa-miR-526b*, hsa-let-7f-1*, hsa-miR-30c, hsa-miR-20b,hsa-miR-106a, hsa-miR-877*, hsa-miR-149, hsa-miR-1827, hsa-miR-17,hsa-miR-302b, hsa-miR-107, hsa-miR-20a, hsa-miR-627, hsa-let-7a*,hsa-miR-767-5p, hsa-miR-140-3p, hsa-miR-106b, hsa-miR-372, hsa-miR-433,hsa-miR-520d-5p, hsa-miR-558, hsa-miR-30e.

CCR4-NOT transcription complex, subunit 4—CNOT4—Variant1—NM_(—)013316—hsa-miR-200b, hsa-miR-216a, hsa-miR-181a, hsa-miR-668,hsa-miR-1826, hsa-miR-490-3p, hsa-miR-920, hsa-miR-320c, hsa-miR-511,hsa-miR-544, hsa-miR-143, hsa-miR-335*, hsa-miR-29b-1*, hsa-miR-1287,hsa-miR-576-5p, hsa-miR-586, hsa-miR-543, hsa-miR-186, hsa-miR-337-3p,hsa-miR-10a, hsa-miR-494, hsa-miR-200c, hsa-let-7i*, hsa-miR-320d,hsa-miR-502-5p, hsa-miR-589*, hsa-miR-1243, hsa-miR-888, hsa-miR-429,hsa-miR-570, hsa-miR-105, hsa-miR-125a-3p, hsa-miR-331-5p, hsa-miR-198,hsa-miR-20a*, hsa-miR-181d, hsa-miR-504, hsa-miR-935, hsa-miR-383,hsa-miR-1229, hsa-miR-381, hsa-miR-597, hsa-miR-1300, hsa-miR-181c,hsa-miR-583, hsa-miR-17*, hsa-miR-18a*, hsa-miR-320a, hsa-miR-10b,hsa-miR-656, hsa-miR-320b, hsa-miR-654-5p, hsa-miR-181b, hsa-miR-300,hsa-miR-425, hsa-miR-126*, hsa-miR-154, hsa-miR-541, hsa-miR-1205,hsa-miR-1302, hsa-miR-1293.

CNOT4—Variant 2—NM_(—)001008225—hsa-miR-34c-5p, hsa-miR-380,hsa-miR-448, hsa-miR-216a, hsa-miR-519b-3p, hsa-miR-549, hsa-miR-1304,hsa-miR-15b*, hsa-miR-148a*, hsa-miR-449a, hsa-miR-1237,hsa-miR-519c-3p, hsa-miR-19b, hsa-miR-885-5p, hsa-miR-519a,hsa-miR-130b, hsa-miR-651, hsa-miR-630, hsa-miR-148a, hsa-miR-548p,hsa-miR-338-5p, hsa-miR-186, hsa-miR-301b, hsa-miR-449b, hsa-miR-33a*,hsa-miR-130a, hsa-miR-145, hsa-miR-148b, hsa-miR-26b, hsa-miR-513c,hsa-miR-1297, hsa-miR-34a, hsa-miR-220b, hsa-miR-568, hsa-miR-570,hsa-miR-769-3p, hsa-miR-34b*, hsa-miR-148b*, hsa-miR-450b-3p,hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-93, hsa-miR-152, hsa-miR-1229,hsa-miR-301a, hsa-miR-526b*, hsa-miR-20b, hsa-miR-106a, hsa-miR-548c-3p,hsa-miR-17, hsa-miR-656, hsa-miR-454, hsa-miR-187*, hsa-miR-19a,hsa-miR-20a, hsa-miR-425, hsa-miR-126*, hsa-miR-944, hsa-miR-106b,hsa-miR-26a.

Ring finger protein 8—RNF8—Variant 1—NM_(—)003958—hsa-miR-124*,hsa-miR-509-3-5p, hsa-miR-520b, hsa-miR-32, hsa-miR-1254, hsa-miR-16,hsa-miR-20b*, hsa-miR-515-5p, hsa-miR-922, hsa-miR-625, hsa-miR-493*,hsa-miR-138, hsa-miR-130b*, hsa-miR-216a, hsa-let-7d, hsa-miR-513a-5p,hsa-miR-766, hsa-miR-192, hsa-miR-1276, hsa-miR-1184, hsa-miR-520g,hsa-miR-150*, hsa-miR-1301, hsa-miR-181a, hsa-miR-551b*, hsa-miR-302c*,hsa-miR-483-3p, hsa-miR-96, hsa-miR-668, hsa-miR-28-3p, hsa-miR-214,hsa-miR-532-3p, hsa-miR-377, hsa-miR-548a-5p, hsa-miR-1826, hsa-miR-647,hsa-miR-559, hsa-miR-27a, hsa-miR-1248, hsa-miR-127-5p, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-496, hsa-miR-320c, hsa-miR-520a-3p,hsa-miR-511, hsa-miR-31*, hsa-miR-143, hsa-miR-24-1*, hsa-miR-548m,hsa-miR-183*, hsa-miR-330-3p, hsa-miR-1226*, hsa-miR-19b,hsa-miR-129-5p, hsa-miR-548n, hsa-miR-302e, hsa-miR-548c-5p,hsa-miR-938, hsa-miR-134, hsa-miR-342-3p, hsa-miR-1268, hsa-miR-298,hsa-miR-508-5p, hsa-miR-92b, hsa-miR-1231, hsa-let-7e, hsa-miR-370,hsa-miR-1303, hsa-miR-875-3p, hsa-miR-657, hsa-miR-103, hsa-miR-1252,hsa-miR-129*, hsa-miR-576-5p, hsa-miR-367, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-30b, hsa-miR-543, hsa-miR-25,hsa-miR-365, hsa-miR-10a, hsa-miR-302c, hsa-miR-491-5p, hsa-miR-548i,hsa-miR-202, hsa-miR-24-2*, hsa-miR-516b*, hsa-miR-646, hsa-let-7b*,hsa-miR-146a*, hsa-miR-494, hsa-miR-411, hsa-miR-30a, hsa-miR-622,hsa-miR-1, hsa-miR-373, hsa-miR-145, hsa-miR-616*, hsa-miR-373*,hsa-miR-484, hsa-let-7f, hsa-miR-32*, hsa-miR-302d, hsa-miR-1202,hsa-miR-624, hsa-miR-15b, hsa-miR-320d, hsa-miR-188-3p, hsa-miR-495,hsa-miR-1271, hsa-miR-7-1 *, hsa-miR-215, hsa-miR-635, hsa-miR-589*,hsa-miR-921, hsa-miR-643, hsa-miR-135a, hsa-miR-361-5p, hsa-miR-520f,hsa-miR-146a, hsa-miR-605, hsa-miR-1243, hsa-miR-1233, hsa-miR-520c-3p,hsa-miR-518a-5p, hsa-miR-18b, hsa-miR-185*, hsa-miR-144, hsa-miR-384,hsa-miR-302a, hsa-miR-888, hsa-miR-802, hsa-miR-654-3p, hsa-miR-122*,hsa-miR-503, hsa-miR-488, hsa-miR-105, hsa-let-7g, hsa-miR-940,hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-1294, hsa-miR-588, hsa-miR-593,hsa-miR-768-3p, hsa-miR-34b*, hsa-miR-520d-3p, hsa-miR-195,hsa-miR-519d, hsa-miR-20a*, hsa-miR-452*, hsa-miR-181d, hsa-miR-935,hsa-miR-135b, hsa-miR-27b, hsa-miR-548j, hsa-miR-607, hsa-miR-520e,hsa-miR-30d, hsa-miR-629*, hsa-miR-93, hsa-miR-1206, hsa-miR-518c*,hsa-miR-548b-3p, hsa-miR-1260, hsa-let-7i, hsa-miR-942, hsa-miR-609,hsa-miR-1255a, hsa-miR-146b-5p, hsa-let-7b, hsa-let-7a, hsa-miR-889,hsa-miR-526b*, hsa-miR-98, hsa-miR-548h, hsa-miR-92a, hsa-miR-625*,hsa-miR-381, hsa-miR-744*, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-432*,hsa-miR-30c, hsa-miR-181c, hsa-miR-760, hsa-miR-18a, hsa-miR-221*,hsa-miR-527, hsa-miR-185, hsa-miR-20b, hsa-miR-556-5p, hsa-miR-1224-3p,hsa-miR-106a, hsa-miR-30b*, hsa-miR-758, hsa-miR-520h, hsa-miR-320a,hsa-miR-10b, hsa-let-7c, hsa-miR-339-5p, hsa-miR-1228, hsa-miR-129-3p,hsa-miR-1827, hsa-miR-24, hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-17,hsa-miR-196a*, hsa-miR-1279, hsa-miR-106a*, hsa-miR-382, hsa-miR-182,hsa-miR-320b, hsa-miR-297, hsa-miR-424, hsa-miR-654-5p, hsa-miR-302b,hsa-miR-181b, hsa-miR-655, hsa-miR-485-5p, hsa-miR-137, hsa-miR-888*,hsa-miR-488*, hsa-miR-577, hsa-miR-206, hsa-miR-7-2*, hsa-miR-377*,hsa-miR-107, hsa-miR-19a, hsa-miR-300, hsa-miR-15a, hsa-miR-20a,hsa-miR-627, hsa-miR-409-3p, hsa-miR-423-5p, hsa-miR-363, hsa-let-7a*,hsa-miR-338-3p, hsa-miR-509-5p, hsa-miR-106b, hsa-miR-497, hsa-miR-1197,hsa-miR-16-1*, hsa-miR-372, hsa-miR-367*, hsa-miR-223*, hsa-miR-1255b,hsa-miR-541, hsa-miR-520d-5p, hsa-miR-1302, hsa-miR-558, hsa-miR-613,hsa-miR-95, hsa-miR-30e.

RNF8—Variant 2—NM_(—)183078—hsa-miR-124*, hsa-miR-509-3-5p,hsa-miR-520b, hsa-miR-32, hsa-miR-1254, hsa-miR-16, hsa-miR-20b*,hsa-miR-515-5p, hsa-miR-922, hsa-miR-625, hsa-miR-493*, hsa-miR-138,hsa-miR-130b*, hsa-miR-216a, hsa-let-7d, hsa-miR-513a-5p, hsa-miR-766,hsa-miR-192, hsa-miR-1276, hsa-miR-1184, hsa-miR-520g, hsa-miR-150*,hsa-miR-1301, hsa-miR-181a, hsa-miR-551b*, hsa-miR-302c*,hsa-miR-483-3p, hsa-miR-96, hsa-miR-668, hsa-miR-28-3p, hsa-miR-214,hsa-miR-532-3p, hsa-miR-377, hsa-miR-548a-5p, hsa-miR-1826, hsa-miR-647,hsa-miR-559, hsa-miR-27a, hsa-miR-1248, hsa-miR-127-5p, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-496, hsa-miR-320c, hsa-miR-520a-3p,hsa-miR-511, hsa-miR-31*, hsa-miR-143, hsa-miR-24-1*, hsa-miR-548m,hsa-miR-183*, hsa-miR-330-3p, hsa-miR-1226*, hsa-miR-19b,hsa-miR-129-5p, hsa-miR-548n, hsa-miR-302e, hsa-miR-548c-5p,hsa-miR-134, hsa-miR-342-3p, hsa-miR-1268, hsa-miR-298, hsa-miR-508-5p,hsa-miR-92b, hsa-miR-1231, hsa-let-7e, hsa-miR-370, hsa-miR-1303,hsa-miR-875-3p, hsa-miR-657, hsa-miR-103, hsa-miR-1252, hsa-miR-129*,hsa-miR-576-5p, hsa-miR-367, hsa-miR-582-5p, hsa-miR-338-5p,hsa-miR-524-5p, hsa-miR-30b, hsa-miR-543, hsa-miR-25, hsa-miR-10a,hsa-miR-302c, hsa-miR-491-5p, hsa-miR-548i, hsa-miR-202, hsa-miR-24-2*,hsa-miR-516b*, hsa-miR-646, hsa-let-7b*, hsa-miR-146a*, hsa-miR-494,hsa-miR-411, hsa-miR-30a, hsa-miR-622, hsa-miR-1, hsa-miR-373,hsa-miR-145, hsa-miR-616*, hsa-miR-373*, hsa-miR-484, hsa-let-7f,hsa-miR-32*, hsa-miR-302d, hsa-miR-1202, hsa-miR-624, hsa-miR-15b,hsa-miR-320d, hsa-miR-188-3p, hsa-miR-495, hsa-miR-1271, hsa-miR-7-1*,hsa-miR-215, hsa-miR-635, hsa-miR-589*, hsa-miR-921, hsa-miR-643,hsa-miR-135a, hsa-miR-361-5p, hsa-miR-520f, hsa-miR-146a, hsa-miR-605,hsa-miR-1243, hsa-miR-1233, hsa-miR-520c-3p, hsa-miR-518a-5p,hsa-miR-18b, hsa-miR-185*, hsa-miR-144, hsa-miR-384, hsa-miR-302a,hsa-miR-888, hsa-miR-802, hsa-miR-654-3p, hsa-miR-122*, hsa-miR-488,hsa-miR-105, hsa-let-7g, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-34b,hsa-miR-1294, hsa-miR-588, hsa-miR-593, hsa-miR-768-3p, hsa-miR-34b*,hsa-miR-520d-3p, hsa-miR-195, hsa-miR-519d, hsa-miR-20a*, hsa-miR-452*,hsa-miR-181d, hsa-miR-935, hsa-miR-135b, hsa-miR-27b, hsa-miR-548j,hsa-miR-607, hsa-miR-520e, hsa-miR-30d, hsa-miR-629*, hsa-miR-93,hsa-miR-1206, hsa-miR-518c*, hsa-miR-548b-3p, hsa-miR-1260, hsa-let-7i,hsa-miR-942, hsa-miR-609, hsa-miR-1255a, hsa-miR-146b-5p, hsa-let-7b,hsa-let-7a, hsa-miR-889, hsa-miR-526b*, hsa-miR-98, hsa-miR-548h,hsa-miR-92a, hsa-miR-625*, hsa-miR-381, hsa-miR-744*, hsa-miR-519e*,hsa-let-7f-1*, hsa-miR-432*, hsa-miR-30c, hsa-miR-181c, hsa-miR-760,hsa-miR-18a, hsa-miR-527, hsa-miR-185, hsa-miR-20b, hsa-miR-556-5p,hsa-miR-1224-3p, hsa-miR-106a, hsa-miR-30b*, hsa-miR-758, hsa-miR-520h,hsa-miR-320a, hsa-miR-10b, hsa-let-7c, hsa-miR-339-5p, hsa-miR-1228,hsa-miR-129-3p, hsa-miR-1827, hsa-miR-24, hsa-miR-1299, hsa-miR-548c-3p,hsa-miR-17, hsa-miR-196a*, hsa-miR-1279, hsa-miR-106a*, hsa-miR-382,hsa-miR-182, hsa-miR-320b, hsa-miR-297, hsa-miR-424, hsa-miR-654-5p,hsa-miR-302b, hsa-miR-181b, hsa-miR-655, hsa-miR-485-5p, hsa-miR-137,hsa-miR-888*, hsa-miR-488*, hsa-miR-577, hsa-miR-206, hsa-miR-7-2*,hsa-miR-377*, hsa-miR-107, hsa-miR-19a, hsa-miR-300, hsa-miR-15a,hsa-miR-20a, hsa-miR-627, hsa-miR-409-3p, hsa-miR-423-5p, hsa-miR-363,hsa-let-7a*, hsa-miR-338-3p, hsa-miR-509-5p, hsa-miR-106b, hsa-miR-497,hsa-miR-1197, hsa-miR-16-1*, hsa-miR-372, hsa-miR-367*, hsa-miR-223*,hsa-miR-1255b, hsa-miR-541, hsa-miR-520d-5p, hsa-miR-1302, hsa-miR-558,hsa-miR-613, hsa-miR-95, hsa-miR-30e.

Proteasome (prosome, macropain) subunit, alpha type,5—PSMA5—NM_(—)002790—hsa-let-7g*, hsa-miR-148a*, hsa-miR-28-5p,hsa-miR-875-3p, hsa-miR-708, hsa-miR-1270, hsa-miR-148b*, hsa-miR-620,hsa-miR-126*.

Alport syndrome, mental retardation, midface hypoplasia andelliptocytosis chromosomal region gene 1—AMMERCR1—Variant 1 and Variant2—NM_(—)015365 and NM_(—)001025580—hsa-miR-517a, hsa-miR-637,hsa-miR-510, hsa-miR-645, hsa-miR-380, hsa-miR-16, hsa-miR-448,hsa-miR-515-5p, hsa-miR-141*, hsa-miR-542-3p, hsa-miR-922, hsa-miR-138,hsa-miR-513a-5p, hsa-miR-650, hsa-miR-1184, hsa-miR-9, hsa-miR-520g,hsa-miR-150*, hsa-miR-1290, hsa-miR-550*, hsa-miR-101*, hsa-miR-551b*,hsa-miR-454*, hsa-miR-182*, hsa-miR-195*, hsa-miR-302c*, hsa-miR-221,hsa-miR-548g, hsa-miR-204, hsa-miR-28-3p, hsa-miR-548a-5p, hsa-miR-559,hsa-miR-27a, hsa-miR-1267, hsa-miR-92a-2*, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-16-2*, hsa-miR-513a-3p, hsa-miR-544,hsa-miR-143, hsa-miR-142-5p, hsa-miR-548m, hsa-miR-183*, hsa-miR-378,hsa-miR-330-3p, hsa-miR-28-5p, hsa-miR-190, hsa-miR-561, hsa-miR-191,hsa-miR-129-5p, hsa-miR-541*, hsa-miR-548n, hsa-miR-1178, hsa-miR-892b,hsa-miR-885-5p, hsa-miR-548c-5p, hsa-miR-134, hsa-miR-342-3p,hsa-miR-298, hsa-miR-508-5p, hsa-miR-130b, hsa-miR-1303,hsa-miR-1207-5p, hsa-miR-216b, hsa-miR-103, hsa-let-7d*, hsa-miR-1252,hsa-miR-1182, hsa-miR-1246, hsa-miR-600, hsa-miR-548p, hsa-miR-876-5p,hsa-miR-582-5p, hsa-miR-338-5p, hsa-mik-524-5-p, hsa-miR-143*,hsa-miR-23a, hsa-miR-365, hsa-miR-301b, hsa-miR-1236, hsa-miR-618,hsa-miR-1305, hsa-miR-33a*, hsa-miR-548i, hsa-miR-606, hsa-miR-641,hsa-miR-548d-3p, hsa-miR-516b*, hsa-let-7b*, hsa-miR-708, hsa-miR-622,hsa-miR-548o, hsa-miR-130a, hsa-miR-616*, hsa-miR-552, hsa-miR-373*,hsa-miR-548f, hsa-miR-26b, hsa-miR-147b, hsa-miR-664, hsa-miR-32*,hsa-miR-1269, hsa-miR-765, hsa-miR-15b, hsa-miR-495, hsa-miR-1297,hsa-miR-7-1*, hsa-miR-34c-3p, hsa-miR-767-3p, hsa-miR-190b, hsa-miR-605,hsa-miR-200c*, hsa-miR-608, hsa-miR-498, hsa-miR-1323, hsa-miR-653,hsa-miR-888, hsa-miR-568, hsa-miR-596, hsa-miR-488, hsa-miR-570,hsa-miR-105, hsa-miR-124, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-34b,hsa-miR-1261, hsa-miR-222, hsa-miR-34b*, hsa-miR-1285, hsa-miR-195,hsa-miR-450b-5p, hsa-miR-610, hsa-miR-545, hsa-miR-935, hsa-miR-612,hsa-miR-27b, hsa-miR-664*, hsa-miR-548j, hsa-miR-607, hsa-miR-10b*,hsa-miR-1206, hsa-miR-200b*, hsa-miR-422a, hsa-miR-23b, hsa-miR-1263,hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-1229, hsa-miR-412, hsa-miR-634,hsa-miR-136, hsa-miR-301a, hsa-miR-548h, hsa-miR-625*, hsa-miR-708*,hsa-miR-211, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-628-5p, hsa-miR-150,hsa-miR-583, hsa-miR-501-5p, hsa-miR-493, hsa-miR-224, hsa-miR-151-5p,hsa-miR-659, hsa-miR-556-5p, hsa-miR-1321, hsa-miR-138-2*,hsa-miR-130a*, hsa-miR-520h, hsa-miR-522, hsa-miR-555, hsa-miR-1827,hsa-miR-24, hsa-miR-548c-3p, hsa-miR-135a*, hsa-miR-7, hsa-miR-656,hsa-miR-454, hsa-miR-1264, hsa-miR-297, hsa-miR-548k, hsa-miR-5481,hsa-miR-424, hsa-miR-506, hsa-miR-1283, hsa-miR-548e, hsa-miR-1251,hsa-miR-137, hsa-miR-7-2*, hsa-miR-196a, hsa-miR-107, hsa-miR-188-5p,hsa-miR-15a, hsa-miR-485-3p, hsa-miR-601, hsa-miR-876-3p, hsa-miR-196b,hsa-let-7a*, hsa-miR-1272, hsa-miR-340, hsa-miR-193b*, hsa-miR-497,hsa-miR-517c, hsa-miR-649, hsa-miR-499-3p, hsa-miR-26a, hsa-miR-1275,hsa-miR-520d-5p, hsa-miR-200a*, hsa-miR-1205, hsa-miR-135b*,hsa-miR-671-5p.

Integrator complex subunit 2—INTS2—NM_(—)020748—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-376b, hsa-miR-665, hsa-miR-510, hsa-miR-500,hsa-miR-130b*, hsa-let-7d, hsa-miR-766, hsa-miR-1276, hsa-miR-125b-2*,hsa-miR-195*, hsa-miR-302c*, hsa-miR-204, hsa-miR-214, hsa-miR-377,hsa-miR-1304, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-27a, hsa-miR-1248,hsa-miR-335, hsa-miR-92a-2*, hsa-miR-548b-5p, hsa-miR-16-2*,hsa-miR-661, hsa-miR-31, hsa-miR-513a-3p, hsa-miR-148a*, hsa-miR-142-5p,hsa-miR-183*, hsa-miR-217, hsa-miR-1288, hsa-miR-548c-5p,hsa-miR-342-3p, hsa-miR-298, hsa-miR-508-5p, hsa-miR-455-5p, hsa-let-7e,hsa-miR-623, hsa-miR-657, hsa-miR-299-5p, hsa-miR-338-5p, hsa-miR-1296,hsa-miR-524-5p, hsa-miR-30b, hsa-miR-186, hsa-miR-23a, hsa-miR-33a*,hsa-miR-491-5p, hsa-miR-548i, hsa-miR-202, hsa-miR-494, hsa-miR-30a,hsa-miR-622, hsa-miR-548o, hsa-miR-1, hsa-miR-376a, hsa-miR-581,hsa-miR-616*, hsa-miR-552, hsa-miR-373*, hsa-miR-548f, hsa-miR-26b,hsa-let-7f, hsa-miR-590-3p, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-135a,hsa-miR-146a, hsa-miR-608, hsa-miR-1323, hsa-miR-653, hsa-miR-888,hsa-miR-654-3p, hsa-miR-570, hsa-let-7g, hsa-miR-548d-5p, hsa-miR-1285,hsa-miR-20a*, hsa-miR-545, hsa-miR-452*, hsa-miR-612, hsa-miR-135b,hsa-miR-27b, hsa-miR-548j, hsa-miR-200a, hsa-miR-30d, hsa-miR-10b*,hsa-miR-629, hsa-miR-192*, hsa-let-7i, hsa-miR-23b, hsa-miR-548a-3p,hsa-miR-146b-5p, hsa-miR-526b, hsa-let-7b, hsa-miR-302d*, hsa-miR-141,hsa-let-7a, hsa-miR-22*, hsa-miR-98, hsa-miR-548h, hsa-miR-381,hsa-miR-708*, hsa-miR-211, hsa-miR-30c, hsa-miR-205, hsa-miR-17*,hsa-miR-640, hsa-miR-199a-3p, hsa-miR-30b*, hsa-miR-130a*, hsa-miR-550,hsa-miR-758, hsa-let-7c, hsa-miR-1228, hsa-miR-196a*, hsa-miR-7,hsa-miR-1264, hsa-miR-675, hsa-miR-654-5p, hsa-miR-1283, hsa-miR-187*,hsa-miR-548e, hsa-miR-199b-3p, hsa-miR-137, hsa-miR-888*, hsa-miR-206,hsa-miR-7-2*, hsa-miR-377*, hsa-miR-188-5p, hsa-miR-300, hsa-miR-632,hsa-miR-944, hsa-miR-219-2-3p, hsa-miR-346, hsa-miR-302b*, hsa-miR-433,hsa-miR-595, hsa-miR-154, hsa-miR-26a, hsa-miR-541, hsa-miR-520d-5p,hsa-miR-613, hsa-miR-340*, hsa-miR-30e.

Family with sequence similarity 152, memberA—FAM152A—NM_(—)016076—hsa-miR-576-3p, hsa-miR-490-5p, hsa-miR-1266,hsa-miR-380, hsa-miR-515-5p, hsa-miR-542-3p, hsa-miR-922, hsa-miR-493*,hsa-miR-138, hsa-miR-130b*, hsa-miR-216a, hsa-miR-19b-2*, hsa-miR-1184,hsa-miR-150*, hsa-miR-1290, hsa-miR-222*, hsa-miR-1301, hsa-miR-181a,hsa-miR-551b*, hsa-miR-513b, hsa-miR-195*, hsa-miR-487a, hsa-miR-483-3p,hsa-miR-548g, hsa-miR-1289, hsa-miR-377, hsa-miR-890, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-548b-5p, hsa-miR-452, hsa-miR-16-2*, hsa-miR-320c,hsa-miR-31, hsa-miR-148a*, hsa-miR-24-1*, hsa-miR-548m, hsa-miR-183*,hsa-miR-1237, hsa-miR-561, hsa-miR-541*, hsa-miR-548n, hsa-miR-217,hsa-miR-93*, hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-342-3p,hsa-miR-1287, hsa-miR-875-3p, hsa-miR-651, hsa-miR-580, hsa-miR-379,hsa-miR-600, hsa-miR-548p, hsa-miR-582-5p, hsa-miR-19b-1*,hsa-miR-524-5p, hsa-miR-30b, hsa-miR-34a*, hsa-miR-374a*, hsa-miR-23a,hsa-miR-548i, hsa-miR-606, hsa-miR-24-2*, hsa-miR-641, hsa-miR-212,hsa-miR-548d-3p, hsa-miR-646, hsa-let-7b*, hsa-miR-151-3p,hsa-miR-590-5p, hsa-miR-145*, hsa-miR-1281, hsa-miR-411, hsa-miR-30a,hsa-miR-622, hsa-miR-324-3p, hsa-miR-581, hsa-miR-1207-3p, hsa-miR-548f,hsa-miR-569, hsa-miR-664, hsa-miR-1324, hsa-miR-320d, hsa-miR-188-3p,hsa-miR-590-3p, hsa-miR-502-5p, hsa-miR-495, hsa-miR-132, hsa-miR-7-1*,hsa-miR-589*, hsa-miR-1253, hsa-miR-1200, hsa-miR-643, hsa-miR-376a*,hsa-miR-509-3p, hsa-miR-653, hsa-miR-568, hsa-miR-592, hsa-miR-570,hsa-miR-105, hsa-miR-155, hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-1261,hsa-miR-184, hsa-miR-768-3p, hsa-miR-148b*, hsa-miR-125a-3p,hsa-miR-198, hsa-miR-181d, hsa-miR-935, hsa-miR-9*, hsa-miR-664*,hsa-miR-548j, hsa-miR-200a, hsa-miR-30d, hsa-miR-10b*, hsa-miR-629*,hsa-miR-629, hsa-miR-155*, hsa-miR-518c*, hsa-miR-548b-3p, hsa-miR-942,hsa-miR-23b, hsa-miR-101, hsa-miR-23a*, hsa-miR-545*, hsa-miR-1257,hsa-miR-548a-3p, hsa-miR-23b*, hsa-miR-412, hsa-miR-567, hsa-miR-302d*,hsa-miR-141, hsa-miR-223, hsa-miR-203, hsa-miR-548h, hsa-miR-625*,hsa-miR-381, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-1300, hsa-miR-628-5p,hsa-miR-30c, hsa-miR-181c, hsa-miR-224, hsa-miR-659, hsa-miR-138-2*,hsa-miR-130a*, hsa-miR-320a, hsa-miR-1299, hsa-miR-7, hsa-miR-320b,hsa-miR-297, hsa-miR-5481, hsa-miR-626, hsa-miR-181b, hsa-miR-548e,hsa-miR-21, hsa-miR-137, hsa-miR-892a, hsa-miR-7-2*, hsa-miR-300,hsa-miR-485-3p, hsa-miR-409-3p, hsa-miR-126*, hsa-let-7a*, hsa-miR-340,hsa-miR-1197, hsa-miR-218, hsa-miR-302b*, hsa-miR-1183, hsa-miR-223*,hsa-miR-1275, hsa-miR-520d-5p, hsa-miR-154*, hsa-miR-30e.

Integrator complex subunit 8—INTS8—NM_(—)017864—hsa-miR-200b,hsa-miR-493*, hsa-miR-204, hsa-miR-28-3p, hsa-miR-452, hsa-miR-190,hsa-miR-216b, hsa-miR-374a*, hsa-miR-30a*, hsa-miR-200c, hsa-miR-190b,hsa-miR-361-5p, hsa-miR-30d*, hsa-miR-30e*, hsa-miR-21*, hsa-miR-429,hsa-miR-570, hsa-miR-629*, hsa-miR-708*, hsa-miR-211, hsa-miR-1284,hsa-miR-1264, hsa-miR-16-1*.

THUMP domain containing 3—THUMPD3—NM_(—)015453—hsa-miR-557, hsa-miR-665,hsa-miR-509-3-5p, hsa-miR-34c-5p, hsa-miR-380, hsa-miR-515-5p,hsa-miR-216a, hsa-miR-19b-2*, hsa-miR-1276, hsa-miR-133a, hsa-miR-374b,hsa-miR-181a, hsa-miR-377, hsa-miR-548a-5p, hsa-miR-559, hsa-miR-92a-2*,hsa-miR-363*, hsa-miR-548b-5p, hsa-miR-516a-3p, hsa-miR-320c,hsa-miR-148a*, hsa-miR-26a-1*, hsa-miR-335*, hsa-miR-507, hsa-miR-449a,hsa-miR-330-3p, hsa-miR-302a*, hsa-miR-561, hsa-miR-129-5p,hsa-miR-548n, hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-938, hsa-miR-130b,hsa-miR-370, hsa-miR-875-3p, hsa-miR-19b-1*, hsa-miR-186, hsa-miR-23a,hsa-miR-301b, hsa-miR-449b, hsa-miR-1305, hsa-miR-337-3p,hsa-miR-491-5p, hsa-miR-548i, hsa-miR-606, hsa-miR-410, hsa-miR-421,hsa-miR-641, hsa-miR-548d-3p, hsa-miR-516b*, hsa-miR-646, hsa-miR-329,hsa-miR-622, hsa-miR-548o, hsa-miR-130a, hsa-miR-26b, hsa-miR-664,hsa-miR-573, hsa-miR-320d, hsa-miR-188-3p, hsa-miR-599, hsa-miR-29c,hsa-miR-513c, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-1200, hsa-miR-34a,hsa-miR-29b, hsa-miR-26a-2*, hsa-miR-1243, hsa-miR-518a-5p, hsa-miR-608,hsa-miR-144, hsa-miR-1323, hsa-miR-384, hsa-miR-802, hsa-miR-21*,hsa-miR-29a, hsa-miR-570, hsa-miR-155, hsa-miR-548d-5p, hsa-miR-325,hsa-miR-768-3p, hsa-miR-125a-3p, hsa-miR-15a*, hsa-miR-181d, hsa-miR-9*,hsa-miR-514, hsa-miR-664*, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-629*,hsa-miR-383, hsa-miR-29b-2*, hsa-miR-23b, hsa-miR-362-3p, hsa-miR-133b,hsa-miR-301a, hsa-miR-203, hsa-miR-548h, hsa-miR-597, hsa-miR-519e*,hsa-miR-150, hsa-miR-181c, hsa-miR-205, hsa-miR-1284, hsa-miR-527,hsa-miR-17*, hsa-miR-640, hsa-miR-18a*, hsa-miR-130a*, hsa-miR-550,hsa-miR-320a, hsa-miR-522, hsa-miR-1228, hsa-miR-106a*, hsa-miR-320b,hsa-miR-454, hsa-miR-297, hsa-miR-5481, hsa-miR-181b, hsa-miR-1251,hsa-miR-7-2*, hsa-miR-374a, hsa-miR-1244, hsa-miR-1272, hsa-miR-509-5p,hsa-miR-767-5p, hsa-miR-369-3p, hsa-let-7f-2*, hsa-miR-16-1*,hsa-miR-223*, hsa-miR-595, hsa-miR-26a, hsa-miR-512-5p.

Centrosomal protein 350 kDa—CEP350—NM_(—)014810—hsa-miR-140-5p,hsa-miR-665, hsa-miR-200b, hsa-miR-877, hsa-miR-32, hsa-miR-1254,hsa-miR-20b*, hsa-miR-493*, hsa-miR-648, hsa-miR-219-1-3p,hsa-miR-875-5p, hsa-miR-650, hsa-miR-9, hsa-miR-133a, hsa-miR-616,hsa-miR-222*, hsa-miR-374b, hsa-miR-181 a, hsa-miR-519b-3p,hsa-miR-513b, hsa-miR-195*, hsa-miR-487a, hsa-let-7g*, hsa-miR-335,hsa-miR-127-5p, hsa-miR-452, hsa-miR-16-2*, hsa-miR-511, hsa-miR-26a-1*,hsa-miR-335*, hsa-miR-29b-1*, hsa-miR-183*, hsa-miR-302a*, hsa-miR-561,hsa-miR-191, hsa-miR-519c-3p, hsa-miR-19b, hsa-miR-129-5p, hsa-miR-194,hsa-miR-93*, hsa-let-7c*, hsa-miR-769-5p, hsa-miR-603, hsa-miR-519a,hsa-miR-508-5p, hsa-miR-92b, hsa-miR-587, hsa-miR-1303, hsa-miR-1207-5p,hsa-miR-875-3p, hsa-miR-216b, hsa-miR-103, hsa-miR-1252, hsa-miR-630,hsa-miR-660, hsa-miR-1246, hsa-miR-299-5p, hsa-miR-576-5p, hsa-miR-548p,hsa-miR-586, hsa-miR-367, hsa-miR-338-5p, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-543, hsa-miR-25, hsa-miR-186, hsa-miR-23a, hsa-miR-1305,hsa-miR-10a, hsa-miR-33a*, hsa-miR-302f, hsa-miR-1201, hsa-miR-641,hsa-miR-646, hsa-miR-153, hsa-miR-582-3p, hsa-miR-30a*, hsa-miR-30a,hsa-miR-29a*, hsa-miR-200c, hsa-miR-1207-3p, hsa-miR-548f, hsa-miR-26b,hsa-miR-664, hsa-miR-450a, hsa-miR-624, hsa-miR-617, hsa-miR-1297,hsa-miR-7-1*, hsa-miR-767-3p, hsa-miR-1200, hsa-miR-936, hsa-miR-643,hsa-miR-26a-2*, hsa-miR-520f, hsa-miR-768-5p, hsa-miR-1243,hsa-miR-518a-5p, hsa-miR-633, hsa-miR-888, hsa-miR-30d*, hsa-miR-802,hsa-miR-654-3p, hsa-miR-30e*, hsa-miR-429, hsa-miR-940, hsa-miR-155,hsa-miR-325, hsa-miR-588, hsa-miR-125a-3p, hsa-miR-450b-5p,hsa-miR-487b, hsa-miR-198, hsa-miR-20a*, hsa-miR-181d, hsa-miR-30d,hsa-miR-629, hsa-miR-155*, hsa-miR-548b-3p, hsa-miR-942, hsa-miR-23b,hsa-miR-101, hsa-miR-545*, hsa-miR-609, hsa-miR-548a-3p, hsa-miR-1255a,hsa-miR-33b, hsa-miR-516b, hsa-miR-133b, hsa-miR-567, hsa-miR-328,hsa-miR-330-5p, hsa-miR-139-5p, hsa-miR-92a, hsa-miR-1300, hsa-miR-30c,hsa-miR-181c, hsa-miR-181a-2*, hsa-miR-583, hsa-miR-527, hsa-miR-640,hsa-miR-130a*, hsa-miR-10b, hsa-miR-522, hsa-miR-486-5p, hsa-miR-202*,hsa-miR-1827, hsa-miR-1299, hsa-miR-135a*, hsa-miR-106a*, hsa-miR-297,hsa-miR-5481, hsa-miR-181b, hsa-miR-1283, hsa-miR-187*, hsa-miR-548e,hsa-miR-655, hsa-miR-485-5p, hsa-miR-577, hsa-miR-122, hsa-miR-7-2*,hsa-miR-33a, hsa-miR-196a, hsa-miR-107, hsa-miR-19a, hsa-miR-632,hsa-miR-374a, hsa-miR-627, hsa-miR-455-3p, hsa-miR-196b, hsa-miR-363,hsa-miR-944, hsa-miR-574-5p, hsa-miR-1265, hsa-miR-499-5p,hsa-miR-193b*, hsa-miR-140-3p, hsa-miR-887, hsa-miR-369-3p, hsa-miR-326,hsa-miR-497*, hsa-miR-223*, hsa-miR-499-3p, hsa-miR-26a, hsa-miR-1255b,hsa-miR-520d-5p, hsa-miR-135b*, hsa-miR-154*, hsa-miR-512-5p,hsa-miR-30e.

Ewing tumor-associated antigen 1—ETAA1—NM_(—)019002—hsa-miR-374b,hsa-miR-101*, hsa-miR-551b*, hsa-miR-513a-3p, hsa-miR-142-5p,hsa-miR-1277, hsa-miR-374a*, hsa-miR-33a*, hsa-miR-302f, hsa-miR-606,hsa-miR-410, hsa-miR-421, hsa-miR-641, hsa-miR-548o, hsa-miR-1323,hsa-miR-568, hsa-miR-607, hsa-miR-539, hsa-miR-889, hsa-miR-1264,hsa-miR-374a.

WD repeat domain 68—WDR68—NM_(—)005828—hsa-miR-194*, hsa-miR-665,hsa-miR-637, hsa-miR-200b, hsa-miR-509-3-5p, hsa-miR-520b,hsa-miR-490-5p, hsa-miR-34c-5p, hsa-miR-642, hsa-miR-645, hsa-miR-16,hsa-miR-515-5p, hsa-miR-380*, hsa-miR-27b*, hsa-miR-141*, hsa-miR-922,hsa-miR-625, hsa-miR-138, hsa-miR-216a, hsa-miR-562, hsa-miR-766,hsa-miR-1276, hsa-miR-1184, hsa-miR-520g, hsa-miR-374b, hsa-miR-1301,hsa-miR-302c*, hsa-miR-125a-5p, hsa-miR-221, hsa-miR-204, hsa-miR-1289,hsa-miR-563, hsa-miR-214, hsa-miR-532-3p, hsa-miR-377, hsa-miR-549,hsa-miR-1304, hsa-miR-548a-5p, hsa-miR-376c, hsa-miR-647, hsa-miR-559,hsa-miR-27a, hsa-miR-1248, hsa-miR-335, hsa-miR-138-1*, hsa-miR-92a-2*,hsa-miR-363*, hsa-miR-548b-5p, hsa-miR-516a-3p, hsa-miR-452,hsa-miR-575, hsa-miR-520a-3p, hsa-miR-661, hsa-miR-544, hsa-miR-486-3p,hsa-miR-335*, hsa-miR-449a, hsa-miR-330-3p, hsa-miR-28-5p, hsa-miR-561,hsa-miR-19b, hsa-miR-129-5p, hsa-miR-194, hsa-miR-892b, hsa-miR-146b-3p,hsa-miR-302e, hsa-miR-548c-5p, hsa-miR-603, hsa-miR-1825, hsa-miR-128,hsa-miR-134, hsa-miR-1308, hsa-miR-130b, hsa-miR-587, hsa-miR-875-3p,hsa-miR-1252, hsa-miR-1182, hsa-miR-660, hsa-miR-148a, hsa-miR-600,hsa-miR-576-5p, hsa-miR-548p, hsa-miR-582-5p, hsa-miR-25*,hsa-miR-524-5p, hsa-miR-30b, hsa-miR-143*, hsa-miR-186, hsa-miR-365,hsa-miR-301b, hsa-miR-449b, hsa-miR-1236, hsa-miR-33a*, hsa-miR-302c,hsa-miR-491-5p, hsa-miR-1201, hsa-miR-548i, hsa-miR-520a-5p,hsa-miR-410, hsa-miR-421, hsa-miR-641, hsa-miR-548d-3p, hsa-miR-516b*,hsa-miR-646, hsa-let-7b*, hsa-miR-151-3p, hsa-miR-708, hsa-miR-146a*,hsa-miR-590-5p, hsa-miR-525-5p, hsa-miR-494, hsa-miR-30a*,hsa-miR-371-5p, hsa-miR-30a, hsa-miR-489, hsa-miR-622, hsa-miR-324-3p,hsa-miR-373, hsa-miR-200c, hsa-miR-1207-3p, hsa-miR-130a, hsa-miR-616*,hsa-miR-552, hsa-miR-148b, hsa-miR-373*, hsa-miR-220c, hsa-miR-1286,hsa-miR-720, hsa-miR-573, hsa-miR-302d, hsa-miR-15b, hsa-miR-1324,hsa-miR-188-3p, hsa-miR-617, hsa-miR-590-3p, hsa-miR-495, hsa-miR-29c,hsa-miR-513c, hsa-miR-7-1*, hsa-miR-589, hsa-miR-635, hsa-miR-767-3p,hsa-miR-589*, hsa-miR-1253, hsa-miR-1200, hsa-miR-34a, hsa-miR-29b,hsa-miR-135a, hsa-miR-193a-3p, hsa-miR-605, hsa-miR-374b*, hsa-miR-186*,hsa-miR-873, hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-608,hsa-miR-27a*, hsa-miR-770-5p, hsa-miR-18b, hsa-miR-1226, hsa-miR-185*,hsa-miR-1262, hsa-miR-144, hsa-miR-125b, hsa-miR-220b, hsa-miR-505*,hsa-miR-302a, hsa-miR-1224-5p, hsa-miR-888, hsa-miR-30d*,hsa-miR-654-3p, hsa-miR-30e*, hsa-miR-122*, hsa-miR-429, hsa-miR-29a,hsa-miR-624*, hsa-miR-488, hsa-miR-570, hsa-miR-105, hsa-miR-124,hsa-miR-940, hsa-miR-155, hsa-miR-548d-5p, hsa-miR-34b, hsa-miR-588,hsa-miR-222, hsa-miR-1270, hsa-miR-769-3p, hsa-miR-768-3p, hsa-miR-34b*,hsa-miR-148b*, hsa-miR-125a-3p, hsa-miR-1285, hsa-miR-450b-3p,hsa-miR-520d-3p, hsa-miR-18b*, hsa-miR-195, hsa-miR-450b-5p,hsa-miR-144*, hsa-miR-545, hsa-miR-504, hsa-miR-935, hsa-miR-612,hsa-miR-135b, hsa-miR-27b, hsa-miR-299-3p, hsa-miR-664*, hsa-miR-636,hsa-miR-548j, hsa-miR-520e, hsa-miR-30d, hsa-miR-29b-2*, hsa-miR-155*,hsa-miR-193b, hsa-miR-139-3p, hsa-miR-491-3p, hsa-miR-1260, hsa-miR-152,hsa-miR-101, hsa-miR-1274a, hsa-miR-545*, hsa-miR-1229, hsa-miR-634,hsa-miR-516b, hsa-miR-526b, hsa-miR-149*, hsa-miR-620, hsa-miR-136,hsa-miR-328, hsa-miR-330-5p, hsa-miR-301a, hsa-miR-223, hsa-miR-548h,hsa-miR-492, hsa-miR-211, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-432*,hsa-miR-150, hsa-miR-30c, hsa-miR-181a-2*, hsa-miR-583, hsa-miR-493,hsa-miR-18a, hsa-miR-1284, hsa-miR-527, hsa-miR-185, hsa-miR-1321,hsa-miR-631, hsa-miR-138-2*, hsa-miR-877*, hsa-miR-18a*, hsa-miR-520h,hsa-miR-555, hsa-miR-431, hsa-miR-202*, hsa-miR-1827, hsa-miR-1299,hsa-miR-106a*, hsa-miR-7, hsa-miR-382, hsa-miR-454, hsa-miR-5481,hsa-miR-424, hsa-miR-506, hsa-miR-302b, hsa-miR-1283, hsa-miR-187*,hsa-miR-21, hsa-miR-485-5p, hsa-miR-614, hsa-miR-1278, hsa-miR-331-3p,hsa-miR-888*, hsa-miR-924, hsa-miR-7-2*, hsa-miR-19a, hsa-miR-15a,hsa-miR-374a, hsa-miR-627, hsa-miR-876-3p, hsa-miR-455-3p, hsa-miR-126*,hsa-let-7a*, hsa-miR-509-5p, hsa-miR-944, hsa-miR-340, hsa-miR-193b*,hsa-miR-497, hsa-miR-296-3p, hsa-let-7f-2*, hsa-miR-1197, hsa-miR-346,hsa-miR-218, hsa-miR-372, hsa-miR-326, hsa-miR-1183, hsa-miR-505,hsa-miR-499-3p, hsa-miR-662, hsa-miR-1234, hsa-miR-1275, hsa-miR-1250,hsa-miR-520d-5p, hsa-miR-1205, hsa-miR-1302, hsa-miR-425*,hsa-miR-512-5p, hsa-miR-30e.

Viral DNA polymerase-transactivated protein 6—DNAPTP6—Variant 1, Variant2, Variant 3 and Variant 4—NM_(—)015535, NM_(—)001100422,NM_(—)001100423 and NM_(—)001100424—hsa-miR-140-5p, hsa-miR-557,hsa-miR-665, hsa-miR-200b, hsa-miR-1266, hsa-miR-518a-3p, hsa-miR-32,hsa-miR-1254, hsa-miR-645, hsa-miR-380, hsa-miR-448, hsa-miR-500,hsa-miR-1180, hsa-miR-20b*, hsa-miR-922, hsa-miR-219-1-3p, hsa-miR-562,hsa-miR-766, hsa-miR-616, hsa-miR-181a, hsa-miR-551b*, hsa-miR-454*,hsa-miR-221, hsa-miR-548g, hsa-miR-204, hsa-miR-96, hsa-miR-1179,hsa-miR-490-3p, hsa-miR-1267, hsa-miR-920, hsa-miR-92a-2*, hsa-miR-363*,hsa-miR-127-5p, hsa-miR-452, hsa-miR-661, hsa-miR-507, hsa-miR-548m,hsa-miR-378, hsa-miR-330-3p, hsa-miR-1226*, hsa-miR-190, hsa-miR-561,hsa-miR-191, hsa-miR-19b, hsa-miR-541*, hsa-miR-548n, hsa-miR-146b-3p,hsa-miR-1288, hsa-miR-658, hsa-miR-769-5p, hsa-miR-886-3p, hsa-miR-134,hsa-miR-1268, hsa-miR-508-5p, hsa-miR-92b, hsa-miR-130b,hsa-miR-1207-5p, hsa-miR-216b, hsa-miR-103, hsa-miR-1182, hsa-miR-580,hsa-miR-1246, hsa-miR-548p, hsa-miR-876-5p, hsa-miR-367, hsa-miR-25*,hsa-miR-30b, hsa-miR-25, hsa-miR-186, hsa-miR-23a, hsa-miR-301b,hsa-miR-1236, hsa-miR-10a, hsa-miR-33a*, hsa-miR-491-5p,hsa-miR-548d-3p, hsa-miR-30a*, hsa-miR-30a, hsa-miR-489, hsa-miR-622,hsa-miR-548o, hsa-miR-1, hsa-miR-1227, hsa-miR-200c, hsa-miR-130a,hsa-miR-616*, hsa-miR-874, hsa-miR-373*, hsa-miR-548f, hsa-miR-569,hsa-miR-518b, hsa-miR-664, hsa-miR-484, hsa-miR-1269, hsa-miR-1202,hsa-miR-1324, hsa-miR-96*, hsa-miR-1271, hsa-miR-589, hsa-miR-939,hsa-miR-767-3p, hsa-miR-190b, hsa-miR-885-3p, hsa-miR-921, hsa-miR-135a,hsa-miR-579, hsa-miR-1259, hsa-miR-374b*, hsa-miR-873, hsa-miR-518a-5p,hsa-miR-608, hsa-miR-509-3p, hsa-miR-1262, hsa-miR-144, hsa-miR-1323,hsa-miR-653, hsa-miR-30d*, hsa-miR-802, hsa-miR-654-3p, hsa-miR-30e*,hsa-miR-21*, hsa-miR-429, hsa-miR-488, hsa-miR-105, hsa-miR-508-3p,hsa-miR-940, hsa-miR-34b, hsa-miR-588, hsa-miR-222, hsa-miR-768-3p,hsa-miR-125a-3p, hsa-miR-1285, hsa-miR-450b-5p, hsa-miR-610,hsa-miR-92a-1*, hsa-miR-20a*, hsa-miR-545, hsa-miR-181d, hsa-miR-504,hsa-miR-612, hsa-miR-135b, hsa-miR-514, hsa-miR-664*, hsa-miR-607,hsa-miR-30d, hsa-miR-554, hsa-miR-518c*, hsa-miR-942, hsa-miR-422a,hsa-miR-23b, hsa-miR-101, hsa-miR-1274a, hsa-miR-539, hsa-miR-548a-3p,hsa-miR-634, hsa-miR-149*, hsa-miR-328, hsa-miR-330-5p, hsa-miR-139-5p,hsa-miR-301a, hsa-miR-518c, hsa-miR-92a, hsa-miR-492, hsa-miR-211,hsa-miR-593*, hsa-miR-1300, hsa-miR-30c, hsa-miR-1273, hsa-miR-181c,hsa-miR-181 a-2*, hsa-miR-221*, hsa-miR-527, hsa-miR-378*, hsa-miR-1321,hsa-miR-631, hsa-miR-18a*, hsa-miR-30b*, hsa-miR-130a*, hsa-miR-550,hsa-miR-1225-5p, hsa-miR-10b, hsa-miR-431, hsa-miR-339-5p,hsa-miR-486-5p, hsa-miR-1228, hsa-miR-1827, hsa-miR-24, hsa-miR-518f,hsa-miR-663b, hsa-miR-106a*, hsa-miR-182, hsa-miR-454, hsa-miR-1264,hsa-miR-1274b, hsa-miR-654-5p, hsa-miR-181b, hsa-miR-1283, hsa-miR-187*,hsa-miR-548e, hsa-miR-655, hsa-miR-518d-3p, hsa-miR-485-5p,hsa-miR-888*, hsa-miR-924, hsa-miR-206, hsa-miR-122, hsa-miR-377*,hsa-miR-107, hsa-miR-19a, hsa-miR-425, hsa-miR-627, hsa-miR-409-3p,hsa-miR-126*, hsa-miR-363, hsa-miR-767-5p, hsa-miR-193b*,hsa-miR-371-3p, hsa-miR-16-1*, hsa-miR-326, hsa-miR-433, hsa-miR-505,hsa-miR-499-3p, hsa-miR-1234, hsa-miR-541, hsa-miR-891b, hsa-miR-613,hsa-miR-30e.

Chromosome 7 open reading frame 25-C7orf25—Variant 1 and Variant2—NM_(—)001099858 and NM_(—)024054—hsa-miR-32, hsa-miR-9, hsa-miR-454*,hsa-miR-29b-1*, hsa-miR-92b, hsa-miR-367, hsa-miR-25, hsa-miR-618,hsa-miR-1324, hsa-miR-374b*, hsa-miR-1260, hsa-miR-942, hsa-miR-203,hsa-miR-92a, hsa-miR-625*, hsa-miR-30b*, hsa-miR-106a*, hsa-miR-7,hsa-miR-5481, hsa-miR-488*, hsa-miR-363, hsa-miR-218, hsa-miR-154.

Chromosome 2 open reading frame60—C2orf60—NM_(—)001039693—hsa-miR-576-3p, hsa-miR-376b, hsa-miR-517a,hsa-miR-557, hsa-miR-502-3p, hsa-miR-200b, hsa-miR-509-3-5p,hsa-miR-520b, hsa-miR-1266, hsa-miR-645, hsa-miR-380, hsa-miR-16,hsa-miR-448, hsa-miR-625, hsa-miR-493*, hsa-miR-130b*, hsa-miR-19b-2*,hsa-miR-650, hsa-miR-1276, hsa-miR-1184, hsa-miR-520g, hsa-miR-374b,hsa-miR-101*, hsa-miR-1301, hsa-miR-181a, hsa-miR-483-3p, hsa-miR-548g,hsa-miR-28-3p, hsa-miR-1179, hsa-miR-377, hsa-miR-490-3p,hsa-miR-92a-2*, hsa-miR-516a-3p, hsa-miR-452, hsa-miR-575, hsa-miR-320c,hsa-miR-520a-3p, hsa-miR-511, hsa-miR-15b*, hsa-miR-31, hsa-miR-148a*,hsa-miR-379*, hsa-miR-335*, hsa-miR-507, hsa-miR-29b-1*, hsa-miR-548m,hsa-miR-28-5p, hsa-miR-129-5p, hsa-miR-548n, hsa-miR-892b,hsa-miR-885-5p, hsa-miR-302e, hsa-miR-769-5p, hsa-miR-19a*, hsa-miR-134,hsa-miR-508-5p, hsa-miR-455-5p, hsa-miR-1303, hsa-miR-216b,hsa-miR-1182, hsa-miR-651, hsa-miR-630, hsa-miR-148a, hsa-miR-1246,hsa-miR-576-5p, hsa-miR-582-5p, hsa-miR-19b-1*, hsa-miR-524-5p,hsa-miR-143*, hsa-miR-543, hsa-miR-1236, hsa-miR-337-3p, hsa-miR-10a,hsa-miR-33a*, hsa-miR-302c, hsa-miR-548d-3p, hsa-miR-516b*, hsa-miR-646,hsa-miR-329, hsa-miR-708, hsa-miR-548o, hsa-miR-376a, hsa-miR-373,hsa-miR-200c, hsa-miR-145, hsa-miR-616*, hsa-miR-552, hsa-miR-148b,hsa-miR-373*, hsa-miR-548f, hsa-miR-26b, hsa-miR-569, hsa-miR-664,hsa-miR-484, hsa-miR-302d, hsa-miR-624, hsa-miR-296-5p, hsa-miR-15b,hsa-miR-320d, hsa-miR-590-3p, hsa-miR-495, hsa-miR-29c, hsa-miR-1297,hsa-miR-589*, hsa-miR-1200, hsa-miR-643, hsa-miR-29b, hsa-miR-135a,hsa-miR-579, hsa-miR-411*, hsa-miR-361-5p, hsa-miR-605, hsa-miR-768-5p,hsa-miR-376a*, hsa-miR-186*, hsa-miR-147, hsa-miR-520c-3p, hsa-miR-608,hsa-miR-498, hsa-miR-517b, hsa-miR-1262, hsa-miR-1323, hsa-miR-220b,hsa-miR-302a, hsa-miR-654-3p, hsa-miR-568, hsa-miR-21*, hsa-miR-429,hsa-miR-29a, hsa-miR-488, hsa-miR-1294, hsa-miR-432, hsa-miR-210,hsa-miR-1270, hsa-miR-768-3p, hsa-miR-148b*, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-18b*, hsa-miR-195, hsa-miR-331-5p,hsa-miR-519d, hsa-miR-92a-1*, hsa-miR-20a*, hsa-miR-452*, hsa-miR-181d,hsa-miR-135b, hsa-miR-323-3p, hsa-miR-607, hsa-miR-520e, hsa-miR-200a,hsa-miR-93, hsa-miR-383, hsa-miR-29b-2*, hsa-miR-192*, hsa-miR-518c*,hsa-miR-491-3p, hsa-miR-152, hsa-miR-1322, hsa-miR-23a*, hsa-miR-362-3p,hsa-miR-545*, hsa-miR-539, hsa-miR-548a-3p, hsa-miR-23b*, hsa-miR-33b,hsa-miR-149*, hsa-miR-620, hsa-miR-302d*, hsa-miR-136, hsa-miR-141,hsa-miR-526b*, hsa-miR-203, hsa-miR-492, hsa-miR-708*, hsa-miR-744*,hsa-miR-432*, hsa-miR-1300, hsa-miR-150, hsa-miR-181c, hsa-miR-501-5p,hsa-miR-224, hsa-miR-20b, hsa-miR-378*, hsa-miR-640, hsa-miR-1224-3p,hsa-miR-106a, hsa-miR-1245, hsa-miR-877*, hsa-miR-149, hsa-miR-18a*,hsa-miR-483-5p, hsa-miR-550, hsa-miR-520h, hsa-miR-320a, hsa-miR-10b,hsa-miR-24, hsa-miR-17, hsa-miR-500*, hsa-miR-656, hsa-miR-182,hsa-miR-320b, hsa-miR-345, hsa-miR-548l, hsa-miR-424, hsa-miR-302b,hsa-miR-181b, hsa-miR-1283, hsa-miR-548e, hsa-miR-655, hsa-miR-1278,hsa-miR-577, hsa-miR-33a, hsa-miR-196a, hsa-miR-15a, hsa-miR-374a,hsa-miR-20a, hsa-miR-425, hsa-miR-409-3p, hsa-miR-183, hsa-miR-196b,hsa-miR-509-5p, hsa-miR-944, hsa-miR-501-3p, hsa-miR-193b*,hsa-miR-140-3p, hsa-miR-106b, hsa-miR-497, hsa-miR-369-3p, hsa-miR-517c,hsa-miR-302b*, hsa-miR-372, hsa-miR-497*, hsa-miR-154, hsa-miR-26a,hsa-miR-1275, hsa-miR-520d-5p, hsa-miR-891b.

Chromosome 17 open reading frame 71—C17orf71—NM_(—)018149—hsa-miR-200b,hsa-miR-548n, hsa-miR-892b, hsa-miR-875-3p, hsa-miR-338-5p, hsa-miR-30b,hsa-miR-548d-3p, hsa-miR-30a, hsa-miR-200c, hsa-miR-26b, hsa-miR-1297,hsa-miR-7-1*, hsa-miR-429, hsa-miR-570, hsa-miR-30d, hsa-miR-545*,hsa-miR-30c, hsa-miR-382, hsa-miR-7-2*, hsa-miR-26a, hsa-miR-30e.

Chromosome 7 open reading frame 36—C7orf36'NM_(—)020192—hsa-miR-513a-3p,hsa-miR-335*, hsa-miR-587, hsa-miR-582-5p, hsa-miR-770-5p, hsa-miR-633,hsa-miR-1258, hsa-miR-139-5p.

Elongation protein 4 homolog—ELP4—NM_(—)019040—hsa-miR-376b,hsa-miR-518d-5p, hsa-miR-519a*, hsa-miR-522*, hsa-miR-544, hsa-miR-548n,hsa-miR-1252, hsa-miR-376a, hsa-miR-517*, hsa-miR-518P, hsa-miR-148b*,hsa-miR-520c-5p, hsa-miR-539, hsa-miR-518e*, hsa-miR-593*, hsa-miR-526a,hsa-miR-523*, hsa-miR-548l, hsa-miR-519b-5p, hsa-miR-767-5p,hsa-miR-944, hsa-miR-519c-5p.

nudE nuclear distribution gene E homolog (A. nidulans)-like1—NDEL1—Variant 1—NM_(—)001025579—hsa-miR-665, hsa-miR-22, hsa-miR-922,hsa-miR-650, hsa-miR-519b-3p, hsa-miR-302c*, hsa-miR-548g, hsa-miR-377,hsa-miR-920, hsa-miR-363*, hsa-miR-575, hsa-miR-661, hsa-miR-544,hsa-miR-486-3p, hsa-miR-519c-3p, hsa-miR-217, hsa-miR-658, hsa-miR-603,hsa-miR-519a, hsa-miR-342-3p, hsa-miR-130b, hsa-miR-619,hsa-miR-1207-5p, hsa-miR-103, hsa-miR-1203, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-186, hsa-miR-301b, hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-92b*,hsa-let-7b*, hsa-miR-128l, hsa-miR-30a, hsa-miR-29a*, hsa-miR-130a,hsa-miR-220c, hsa-miR-1247, hsa-miR-1202, hsa-miR-765, hsa-miR-96*,hsa-miR-7-1*, hsa-miR-1253, hsa-miR-146a, hsa-miR-768-5p, hsa-miR-608,hsa-miR-18b, hsa-miR-185*, hsa-miR-596, hsa-miR-570, hsa-miR-1270,hsa-miR-1285, hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-612, hsa-miR-30d,hsa-miR-93, hsa-miR-545*, hsa-miR-146b-5p, hsa-miR-620, hsa-miR-330-5p,hsa-miR-55 1 a, hsa-miR-301a, hsa-miR-941, hsa-miR-526b*, hsa-miR-571,hsa-let-7f-1*, hsa-miR-30c, hsa-miR-18a, hsa-miR-151-5p, hsa-miR-1284,hsa-miR-20b, hsa-miR-378*, hsa-miR-1256, hsa-miR-1224-3p, hsa-miR-106a,hsa-miR-18a*, hsa-miR-30b*, hsa-miR-483-5p, hsa-miR-1225-5p,hsa-miR-1827, hsa-miR-24, hsa-miR-17, hsa-miR-106a*, hsa-miR-454,hsa-miR-345, hsa-miR-1283, hsa-miR-187*, hsa-miR-655, hsa-miR-485-5p,hsa-miR-7-2*, hsa-miR-107, hsa-miR-564, hsa-miR-20a, hsa-miR-423-5p,hsa-miR-455-3p, hsa-let-7a*, hsa-miR-1272, hsa-miR-106b, hsa-let-7f-2*,hsa-miR-1197, hsa-miR-16-1*, hsa-miR-551b, hsa-miR-326, hsa-miR-1275,hsa-miR-520d-5p, hsa-miR-1225-3p, hsa-miR-30e.

NDEL1—Variant 2—NM_(—)030808—hsa-miR-22, hsa-miR-922, hsa-miR-650,hsa-miR-519b-3p, hsa-miR-302c*, hsa-miR-548g, hsa-miR-920, hsa-miR-363*,hsa-miR-575, hsa-miR-661, hsa-miR-544, hsa-miR-486-3p, hsa-miR-519c-3p,hsa-miR-217, hsa-miR-658, hsa-miR-519a, hsa-miR-130b, hsa-miR-619,hsa-miR-1207-5p, hsa-miR-103, hsa-miR-1203, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-186, hsa-miR-301b, hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-92b*,hsa-let-7b*, hsa-miR-1281, hsa-miR-30a, hsa-miR-29a*, hsa-miR-130a,hsa-miR-220c, hsa-miR-1247, hsa-miR-1202, hsa-miR-765, hsa-miR-96*,hsa-miR-7-1*, hsa-miR-1253, hsa-miR-146a, hsa-miR-768-5p, hsa-miR-608,hsa-miR-18b, hsa-miR-185*, hsa-miR-596, hsa-miR-570, hsa-miR-1270,hsa-miR-1285, hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-612, hsa-miR-30d,hsa-miR-93, hsa-miR-545*, hsa-miR-146b-5p, hsa-miR-620, hsa-miR-330-5p,hsa-miR-551a, hsa-miR-301a, hsa-miR-526b*, hsa-miR-571, hsa-let-7f-1*,hsa-miR-30c, hsa-miR-18a, hsa-miR-1284, hsa-miR-20b, hsa-miR-378*,hsa-miR-1256, hsa-miR-1224-3p, hsa-miR-106a, hsa-miR-18a*, hsa-miR-30b*,hsa-miR-483-5p, hsa-miR-1225-5p, hsa-miR-1827, hsa-miR-24, hsa-miR-17,hsa-miR-106a*, hsa-miR-454, hsa-miR-345, hsa-miR-1283, hsa-miR-187*,hsa-miR-655, hsa-miR-485-5p, hsa-miR-7-2*, hsa-miR-107, hsa-miR-564,hsa-miR-20a, hsa-miR-423-5p, hsa-miR-455-3p, hsa-let-7a*, hsa-miR-1272,hsa-miR-106b, hsa-let-7f-2*, hsa-miR-1197, hsa-miR-16-1*, hsa-miR-551b,hsa-miR-326, hsa-miR-1275, hsa-miR-520d-5p, hsa-miR-1225-3p,hsa-miR-30e.

Chromosome 1 open reading frame 63—C1orf63—NM_(—)020317—hsa-miR-9,hsa-miR-133a, hsa-miR-125b-2*, hsa-miR-519b-3p, hsa-miR-195*,hsa-miR-532-3p, hsa-miR-16-2*, hsa-miR-513a-3p, hsa-miR-142-5p,hsa-miR-335*, hsa-miR-519c-3p, hsa-miR-519a, hsa-miR-582-5p,hsa-miR-338-5p, hsa-miR-143*, hsa-let-7b*, hsa-miR-570, hsa-miR-155,hsa-miR-519d, hsa-miR-93, hsa-miR-1260, hsa-miR-133b, hsa-miR-526b*,hsa-let-7f-1*, hsa-miR-20b, hsa-miR-1224-3p, hsa-miR-106a, hsa-miR-17,hsa-miR-892a, hsa-miR-20a, hsa-let-7a*, hsa-miR-106b.

Family with sequence similarity 172, memberA—FAM172A—NM_(—)032042—hsa-miR-140-5p, hsa-miR-1266, hsa-miR-32,hsa-miR-642, hsa-miR-16, hsa-miR-22, hsa-miR-625, hsa-miR-1276,hsa-miR-125b-2*, hsa-miR-150*, hsa-miR-1290, hsa-miR-374b, hsa-miR-513b,hsa-miR-302c*, hsa-miR-483-3p, hsa-miR-548g, hsa-miR-1289, hsa-miR-668,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-27a, hsa-miR-138-1*,hsa-miR-548b-5p, hsa-miR-143, hsa-miR-548m, hsa-miR-330-3p,hsa-miR-541*, hsa-miR-548n, hsa-miR-93*, hsa-miR-548c-5p,hsa-miR-886-3p, hsa-miR-603, hsa-miR-128, hsa-miR-298, hsa-miR-508-5p,hsa-miR-92b, hsa-miR-1207-5p, hsa-miR-1287, hsa-miR-875-3p,hsa-miR-216b, hsa-miR-1252, hsa-miR-299-5p, hsa-miR-548p, hsa-miR-367,hsa-miR-615-3p, hsa-miR-524-5p, hsa-miR-25, hsa-miR-374a*, hsa-miR-186,hsa-miR-337-3p, hsa-miR-33a*, hsa-miR-548i, hsa-miR-212,hsa-miR-548d-3p, hsa-miR-548o, hsa-miR-1, hsa-miR-581, hsa-miR-145,hsa-miR-26b, hsa-miR-32*, hsa-miR-1269, hsa-miR-15b, hsa-miR-96*,hsa-miR-590-3p, hsa-miR-495, hsa-miR-132, hsa-miR-1297, hsa-miR-589*,hsa-miR-1253, hsa-miR-885-3p, hsa-miR-643, hsa-miR-193a-3p, hsa-miR-147,hsa-miR-185*, hsa-miR-1323, hsa-miR-323-5p, hsa-miR-653, hsa-miR-802,hsa-miR-503, hsa-miR-570, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-588,hsa-miR-1261, hsa-miR-195, hsa-miR-450b-5p, hsa-miR-545, hsa-miR-504,hsa-miR-27b, hsa-miR-636, hsa-miR-548j, hsa-miR-323-3p, hsa-miR-607,hsa-miR-200a, hsa-miR-578, hsa-miR-10b*, hsa-miR-629, hsa-miR-383,hsa-miR-155*, hsa-miR-193b, hsa-miR-491-3p, hsa-miR-942, hsa-miR-101,hsa-miR-572, hsa-miR-330-5p, hsa-miR-141, hsa-miR-548h, hsa-miR-92a,hsa-miR-625*, hsa-miR-760, hsa-miR-583, hsa-miR-185, hsa-miR-378*,hsa-miR-100*, hsa-miR-199a-3p, hsa-miR-1225-5p, hsa-miR-197,hsa-miR-1228, hsa-miR-1827, hsa-miR-1299, hsa-miR-548c-3p, hsa-miR-1279,hsa-miR-297, hsa-miR-548l, hsa-miR-424, hsa-miR-654-5p, hsa-miR-199b-3p,hsa-miR-137, hsa-miR-206, hsa-miR-122, hsa-miR-15a, hsa-miR-374a,hsa-miR-1244, hsa-miR-423-5p, hsa-miR-126*, hsa-miR-363, hsa-miR-574-5p,hsa-miR-499-5p, hsa-miR-193b*, hsa-miR-497, hsa-miR-369-3p,hsa-let-7f-2*, hsa-miR-218, hsa-miR-649, hsa-miR-326, hsa-miR-1183,hsa-miR-505, hsa-miR-595, hsa-miR-26a, hsa-miR-541, hsa-miR-520d-5p,hsa-miR-558, hsa-miR-135b*, hsa-miR-613.

Family with sequence similarity 53, member C—FAM53C—Variant 1 andVariant 2—NM_(—)001135647 and NM_(—)016605—hsa-miR-665, hsa-miR-518d-5p,hsa-miR-637, hsa-miR-510, hsa-miR-1266, hsa-miR-1254, hsa-miR-642,hsa-miR-519a*, hsa-miR-500, hsa-miR-522*, hsa-miR-22, hsa-miR-922,hsa-miR-562, hsa-miR-650, hsa-miR-125b-2*, hsa-miR-1290, hsa-miR-222*,hsa-miR-513b, hsa-miR-644, hsa-miR-125a-5p, hsa-miR-96, hsa-miR-28-3p,hsa-miR-214, hsa-miR-377, hsa-miR-218-1*, hsa-miR-890, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-1248, hsa-miR-92a-2*, hsa-miR-548b-5p,hsa-miR-320c, hsa-miR-661, hsa-miR-1226*, hsa-miR-302a*, hsa-miR-561,hsa-miR-129-5p, hsa-miR-548n, hsa-miR-769-5p, hsa-miR-548c-5p,hsa-miR-886-3p, hsa-miR-603, hsa-miR-342-3p, hsa-miR-370,hsa-miR-199a-5p, hsa-miR-1207-5p, hsa-miR-1287, hsa-miR-875-3p,hsa-miR-1182, hsa-miR-1246, hsa-miR-299-5p, hsa-miR-576-5p,hsa-miR-548p, hsa-miR-586, hsa-miR-1296, hsa-miR-365, hsa-miR-618,hsa-miR-491-5p, hsa-miR-548i, hsa-miR-520a-5p, hsa-miR-641, hsa-miR-329,hsa-miR-525-5p, hsa-miR-622, hsa-miR-874, hsa-miR-220c, hsa-miR-484,hsa-miR-1202, hsa-miR-765, hsa-miR-320d, hsa-miR-1271, hsa-miR-29c,hsa-miR-513c, hsa-miR-1253, hsa-miR-936, hsa-miR-29b, hsa-miR-193a-3p,hsa-miR-147, hsa-miR-1233, hsa-miR-608, hsa-miR-1226, hsa-miR-185*,hsa-miR-125b, hsa-miR-886-5p, hsa-miR-654-3p, hsa-miR-29a, hsa-miR-570,hsa-miR-105, hsa-miR-517*, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-34b,hsa-miR-588, hsa-miR-1261, hsa-miR-518f*, hsa-miR-148b*, hsa-miR-1285,hsa-miR-512-3p, hsa-miR-20a*, hsa-miR-612, hsa-miR-27b, hsa-miR-548j,hsa-miR-607, hsa-miR-520c-5p, hsa-miR-629*, hsa-miR-29b-2*,hsa-miR-193b, hsa-miR-518c*, hsa-miR-362-3p, hsa-miR-1255a, hsa-miR-33b,hsa-miR-516b, hsa-miR-149*, hsa-miR-330-5p, hsa-miR-548h,hsa-miR-361-3p, hsa-miR-518e*, hsa-miR-593*, hsa-miR-150, hsa-miR-526a,hsa-miR-583, hsa-miR-501-5p, hsa-miR-199b-5p, hsa-miR-224, hsa-miR-221*,hsa-miR-185, hsa-miR-17*, hsa-miR-378*, hsa-miR-1256, hsa-miR-1321,hsa-miR-523*, hsa-miR-631, hsa-miR-1224-3p, hsa-miR-149, hsa-miR-18a*,hsa-miR-320a, hsa-miR-522, hsa-miR-555, hsa-miR-1228, hsa-miR-1827,hsa-miR-135a*, hsa-miR-663b, hsa-miR-7, hsa-miR-320b, hsa-miR-345,hsa-miR-485-5p, hsa-miR-892a, hsa-miR-33a, hsa-miR-377*, hsa-miR-632,hsa-miR-455-3p, hsa-miR-519b-5p, hsa-miR-519c-5p, hsa-miR-346,hsa-miR-649, hsa-miR-367*, hsa-miR-326, hsa-miR-1183, hsa-miR-433,hsa-miR-1255b, hsa-miR-558, hsa-miR-1225-3p.

Immediate early response 5—IER5—NM_(—)016545—hsa-miR-200b, hsa-miR-642,hsa-miR-513a-5p, hsa-miR-192, hsa-miR-551b*, hsa-miR-483-3p,hsa-miR-30c-1*, hsa-miR-92a-2*, hsa-miR-516a-3p, hsa-miR-486-3p,hsa-miR-302a*, hsa-miR-1277, hsa-miR-216b, hsa-miR-1252, hsa-miR-548p,hsa-miR-374a*, hsa-miR-30c-2*, hsa-miR-1236, hsa-miR-491-5p,hsa-miR-548d-3p, hsa-miR-516b*, hsa-let-7b*, hsa-miR-622,hsa-miR-324-3p, hsa-miR-200c, hsa-miR-147b, hsa-miR-450a, hsa-miR-215,hsa-miR-1291, hsa-miR-605, hsa-miR-384, hsa-miR-429, hsa-miR-593,hsa-miR-629*, hsa-miR-523, hsa-miR-1274a, hsa-miR-149*, hsa-miR-136,hsa-miR-328, hsa-miR-330-5p, hsa-let-7f-1*, hsa-miR-185, hsa-miR-100*,hsa-miR-877*, hsa-miR-339-5p, hsa-miR-3p, hsa-miR-1283, hsa-miR-892a,hsa-miR-488*, hsa-miR-632, hsa-miR-601, hsa-let-7a*, hsa-miR-346,hsa-miR-326.

KIAA0146—KIAA0146—NM_(—)001080394—hsa-miR-200b, hsa-miR-27b*,hsa-miR-625, hsa-miR-548g, hsa-miR-27a, hsa-miR-548m, hsa-miR-302a*,hsa-miR-630, hsa-miR-299-5p, hsa-miR-582-5p, hsa-miR-548o, hsa-miR-1,hsa-miR-200c, hsa-miR-548f, hsa-miR-7-1*, hsa-miR-589*, hsa-miR-518a-5p,hsa-miR-144, hsa-miR-1323, hsa-miR-220b, hsa-miR-429, hsa-miR-27b,hsa-miR-548a-3p, hsa-miR-889, hsa-miR-527, hsa-miR-197, hsa-miR-548c-3p,hsa-miR-548e, hsa-miR-892a, hsa-miR-577, hsa-miR-206, hsa-miR-7-2*,hsa-miR-1183, hsa-miR-1275, hsa-miR-1302, hsa-miR-613.

Transmembrane protein 63A—TMEM63A—NM_(—)014698—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-665, hsa-miR-509-3-5p, hsa-miR-34c-5p,hsa-miR-1254, hsa-miR-650, hsa-miR-1184, hsa-miR-9, hsa-miR-125a-5p,hsa-miR-214, hsa-miR-920, hsa-miR-511, hsa-miR-31*, hsa-miR-486-3p,hsa-miR-449a, hsa-miR-378, hsa-miR-1288, hsa-miR-298, hsa-miR-619,hsa-miR-370, hsa-miR-1207-5p, hsa-miR-1287, hsa-miR-103, hsa-miR-449b,hsa-miR-1236, hsa-miR-618, hsa-miR-324-3p, hsa-miR-1207-3p,hsa-miR-1269, hsa-miR-1202, hsa-miR-765, hsa-miR-296-5p, hsa-miR-599,hsa-miR-502-5p, hsa-miR-591, hsa-miR-1291, hsa-miR-1253, hsa-miR-34a,hsa-miR-193a-3p, hsa-miR-768-5p, hsa-miR-1262, hsa-miR-125b,hsa-miR-596, hsa-miR-940, hsa-miR-324-5p, hsa-miR-588, hsa-miR-432,hsa-miR-1285, hsa-miR-15a*, hsa-miR-612, hsa-miR-629*, hsa-miR-193b,hsa-miR-422a, hsa-miR-1255a, hsa-miR-149*, hsa-miR-328, hsa-miR-492,hsa-miR-361-3p, hsa-miR-1300, hsa-miR-150, hsa-miR-1273, hsa-miR-151-5p,hsa-miR-1321, hsa-miR-100*, hsa-miR-631, hsa-miR-197, hsa-miR-1228,hsa-miR-1827, hsa-miR-656, hsa-miR-1264, hsa-miR-1251, hsa-miR-485-5p,hsa-miR-1278, hsa-miR-331-3p, hsa-miR-488*, hsa-miR-107, hsa-miR-564,hsa-miR-183, hsa-miR-423-5p, hsa-miR-509-5p, hsa-miR-649, hsa-miR-497*,hsa-miR-1255b, hsa-miR-1225-3p, hsa-miR-512-5p.

NEDD4 binding protein 2-like 1—N4BP2L1—Variant 1 and Variant2—NM_(—)052818 and NM_(—)001079691—hsa-miR-124*, hsa-miR-1254,hsa-miR-448, hsa-miR-22, hsa-miR-219-1-3p, hsa-miR-562, hsa-miR-192,hsa-miR-1276, hsa-miR-520g, hsa-miR-222*, hsa-miR-374b, hsa-miR-551b*,hsa-miR-454*, hsa-miR-195*, hsa-miR-302c*, hsa-miR-668, hsa-miR-548a-5p,hsa-miR-376c, hsa-miR-559, hsa-miR-127-5p, hsa-miR-548b-5p, hsa-miR-452,hsa-miR-16-2*, hsa-miR-320c, hsa-miR-544, hsa-miR-143, hsa-miR-26a-1*,hsa-miR-142-5p, hsa-miR-379*, hsa-miR-29b-1*, hsa-miR-28-5p,hsa-miR-1237, hsa-miR-541*, hsa-miR-548n, hsa-miR-93*, hsa-let-7c*,hsa-miR-548c-5p, hsa-miR-370, hsa-miR-875-3p, hsa-miR-657,hsa-miR-299-5p, hsa-miR-586, hsa-miR-23a, hsa-miR-365, hsa-miR-548i,hsa-miR-520a-5p, hsa-miR-641, hsa-miR-212, hsa-miR-548d-3p, hsa-miR-708,hsa-miR-590-5p, hsa-miR-145*, hsa-miR-525-5p, hsa-miR-582-3p,hsa-miR-30a*, hsa-miR-29a*, hsa-miR-548f, hsa-miR-664, hsa-miR-320d,hsa-miR-590-3p, hsa-miR-29c, hsa-miR-513c, hsa-miR-132, hsa-miR-591,hsa-miR-7-1*, hsa-miR-215, hsa-miR-767-3p, hsa-miR-589*, hsa-miR-29b,hsa-miR-135a, hsa-miR-579, hsa-miR-411*, hsa-miR-26a-2*, hsa-miR-376a*,hsa-miR-186*, hsa-miR-653, hsa-miR-220b, hsa-miR-505*, hsa-miR-1224-5p,hsa-miR-888, hsa-miR-30d*, hsa-miR-802, hsa-miR-30e*, hsa-miR-29a,hsa-miR-570, hsa-miR-517*, hsa-miR-940, hsa-miR-548d-5p, hsa-miR-432,hsa-miR-1270, hsa-miR-135b, hsa-miR-636, hsa-miR-548j, hsa-miR-323-3p,hsa-miR-607, hsa-miR-629*, hsa-miR-29b-2*, hsa-miR-934, hsa-miR-942,hsa-miR-23b, hsa-miR-1322, hsa-miR-1274a, hsa-miR-609, hsa-miR-548a-3p,hsa-miR-620, hsa-miR-302d*, hsa-miR-889, hsa-miR-548h, hsa-miR-381,hsa-miR-150, hsa-miR-342-5p, hsa-miR-1256, hsa-miR-199a-3p,hsa-miR-130a*, hsa-miR-520h, hsa-miR-320a, hsa-miR-522, hsa-miR-1279,hsa-miR-320b, hsa-miR-548e, hsa-miR-21, hsa-miR-199b-3p, hsa-miR-7-2*,hsa-miR-300, hsa-miR-219-5p, hsa-miR-374a, hsa-miR-425, hsa-miR-183,hsa-miR-126*, hsa-miR-338-3p, hsa-miR-767-5p, hsa-miR-218,hsa-miR-302b*, hsa-miR-649, hsa-miR-433, hsa-miR-142-3p, hsa-miR-558,hsa-miR-584.

LY6/PLAUR domain containing 6B—LYPD6B—NM_(—)177964—hsa-miR-376b,hsa-miR-1254, hsa-miR-500, hsa-miR-519b-3p, hsa-miR-377, hsa-miR-92a-2*,hsa-miR-335*, hsa-miR-519c-3p, hsa-miR-892b, hsa-miR-519a, hsa-miR-130b,hsa-miR-301b, hsa-miR-491-5p, hsa-miR-376a, hsa-miR-130a, hsa-miR-548f,hsa-miR-1291, hsa-miR-568, hsa-miR-593, hsa-miR-34b*, hsa-miR-450b-5p,hsa-miR-610, hsa-miR-548a-3p, hsa-miR-412, hsa-miR-301a, hsa-miR-501-5p,hsa-miR-221*, hsa-miR-631, hsa-miR-1827, hsa-miR-454, hsa-miR-548e,hsa-miR-485-5p, hsa-miR-218, hsa-miR-497*, hsa-miR-671-5p.

BEX family member 5—BEX5—NM_(—)001012978—hsa-miR-515-5p, hsa-miR-1290,hsa-miR-548m, hsa-miR-298, hsa-miR-600, hsa-miR-23a, hsa-miR-302f,hsa-miR-32*, hsa-miR-144, hsa-miR-23b, hsa-miR-519e*, hsa-miR-877*,hsa-miR-130a*, hsa-miR-126*.

KIAA1217—KIAA1217—Variant 1, Variant 2 and Variant 3—N_(—)019590,NM_(—)001098500 and NM_(—)001098501—hsa-miR-34c-5p, hsa-miR-130b*,hsa-miR-216a, hsa-miR-19b-2*, hsa-miR-9, hsa-miR-487a, hsa-miR-532-3p,hsa-miR-335, hsa-miR-363*, hsa-miR-15b*, hsa-miR-379*, hsa-miR-335*,hsa-miR-449a, hsa-miR-561, hsa-miR-19b, hsa-miR-943, hsa-miR-194,hsa-miR-548n, hsa-miR-217, hsa-miR-603, hsa-miR-19a*, hsa-miR-342-3p,hsa-miR-409-5p, hsa-miR-130b, hsa-miR-1252, hsa-miR-129*, hsa-miR-148a,hsa-miR-299-5p, hsa-miR-621, hsa-miR-19b-1*, hsa-miR-301b, hsa-miR-449b,hsa-miR-33a*, hsa-miR-606, hsa-miR-641, hsa-let-7b*, hsa-miR-151-3p,hsa-miR-371-5p, hsa-miR-581, hsa-miR-130a, hsa-miR-148b, hsa-miR-624,hsa-miR-635, hsa-miR-1253, hsa-miR-34a, hsa-miR-411*, hsa-miR-873,hsa-miR-518a-5p, hsa-miR-144, hsa-miR-214*, hsa-miR-488, hsa-miR-570,hsa-miR-124, hsa-miR-593, hsa-miR-768-3p, hsa-miR-148b*, hsa-miR-331-5p,hsa-miR-450b-5p, hsa-miR-20a*, hsa-miR-935, hsa-miR-9*, hsa-miR-607,hsa-miR-1260, hsa-miR-152, hsa-miR-301a, hsa-miR-625*, hsa-miR-708*,hsa-miR-593*, hsa-let-7f-1*, hsa-miR-527, hsa-miR-129-3p, hsa-miR-1299,hsa-miR-656, hsa-miR-182, hsa-miR-454, hsa-miR-506, hsa-miR-1251,hsa-miR-892a, hsa-miR-19a, hsa-miR-485-3p, hsa-miR-1244, hsa-miR-126*,hsa-let-7a*, hsa-miR-944, hsa-miR-16-1*, hsa-miR-1183, hsa-miR-142-3p,hsa-miR-135b*, hsa-miR-1225-3p, hsa-miR-154*.

Chromosome 4 open reading frame 7—C4orf7—NM_(—)152997—hsa-miR-1248,hsa-miR-34c-3p, hsa-miR-125a-3p, hsa-miR-578, hsa-miR-138-2*.

Chromosome 9 open reading frame64—C9orf64—NM_(—)032307—hsa-miR-509-3-5p, hsa-miR-520b, hsa-miR-645,hsa-miR-625, hsa-miR-1184, hsa-miR-520g, hsa-miR-222*, hsa-miR-548g,hsa-let-7g*, hsa-miR-1179, hsa-miR-532-3p, hsa-miR-520a-3p,hsa-miR-142-5p, hsa-miR-330-3p, hsa-miR-1237, hsa-miR-561, hsa-miR-943,hsa-miR-302e, hsa-miR-128, hsa-miR-134, hsa-miR-130b, hsa-miR-580,hsa-miR-548p, hsa-miR-301b, hsa-miR-337-3p, hsa-miR-302c,hsa-miR-548d-3p, hsa-miR-329, hsa-miR-146a*, hsa-miR-371-5p,hsa-miR-548o, hsa-miR-1227, hsa-miR-373, hsa-miR-130a, hsa-miR-548f,hsa-miR-220c, hsa-miR-302d, hsa-miR-624, hsa-miR-188-3p, hsa-miR-96*,hsa-miR-7-1*, hsa-miR-936, hsa-miR-186*, hsa-miR-520c-3p, hsa-miR-498,hsa-miR-1323, hsa-miR-323-5p, hsa-miR-302a, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-519d, hsa-miR-520e, hsa-miR-93, hsa-miR-362-3p,hsa-miR-548a-3p, hsa-miR-301a, hsa-miR-526b*, hsa-miR-744*, hsa-miR-150,hsa-miR-20b, hsa-miR-378*, hsa-miR-640, hsa-miR-106a, hsa-miR-520h,hsa-miR-1228, hsa-miR-17, hsa-miR-106a*, hsa-miR-656, hsa-miR-454,hsa-miR-302b, hsa-miR-548e, hsa-miR-485-5p, hsa-miR-331-3p,hsa-miR-7-2*, hsa-miR-20a, hsa-miR-509-5p, hsa-miR-193b*, hsa-miR-106b,hsa-miR-372, hsa-miR-367*, hsa-miR-497*, hsa-miR-433.

Zyg-11 homolog B—ZYG11B—NM_(—)024646—hsa-miR-576-3p, hsa-miR-140-5p,hsa-miR-376b, hsa-miR-517a, hsa-miR-637, hsa-miR-877, hsa-miR-520b,hsa-miR-34c-5p, hsa-miR-380, hsa-miR-1306, hsa-miR-20b*, hsa-miR-216a,hsa-miR-513a-5p, hsa-miR-766, hsa-miR-125b-2*, hsa-miR-520g,hsa-miR-222*, hsa-miR-101*, hsa-miR-1301, hsa-miR-513b, hsa-miR-195*,hsa-miR-302c*, hsa-miR-548g, hsa-miR-28-3p, hsa-miR-1267, hsa-miR-1248,hsa-miR-335, hsa-miR-127-5p, hsa-miR-452, hsa-miR-16-2*, hsa-miR-575,hsa-miR-520a-3p, hsa-miR-15b*, hsa-miR-31, hsa-miR-513a-3p,hsa-miR-24-1*, hsa-miR-335*, hsa-miR-449a, hsa-miR-548m, hsa-miR-19b,hsa-miR-541*, hsa-miR-548n, hsa-miR-1178, hsa-miR-217, hsa-miR-892b,hsa-miR-302e, hsa-miR-508-5p, hsa-miR-619, hsa-miR-1303, hsa-miR-875-3p,hsa-miR-216b, hsa-miR-1252, hsa-miR-524-5p, hsa-miR-143*, hsa-miR-543,hsa-miR-186, hsa-miR-23a, hsa-miR-449b, hsa-miR-1305, hsa-miR-33a*,hsa-miR-302c, hsa-miR-202, hsa-miR-520a-5p, hsa-miR-24-2*,hsa-miR-548d-3p, hsa-miR-590-5p, hsa-miR-145*, hsa-miR-525-5p,hsa-miR-30a*, hsa-miR-29a*, hsa-miR-622, hsa-miR-376a, hsa-miR-1227,hsa-miR-373, hsa-miR-552, hsa-miR-548f, hsa-miR-484, hsa-miR-32*,hsa-miR-1269, hsa-miR-302d, hsa-miR-590-3p, hsa-miR-495, hsa-miR-513c,hsa-miR-635, hsa-miR-34c-3p, hsa-miR-767-3p, hsa-miR-26b*, hsa-miR-1253,hsa-miR-1200, hsa-miR-34a, hsa-miR-193a-3p, hsa-miR-361-5p,hsa-miR-376a*, hsa-miR-186*, hsa-miR-873, hsa-miR-520c-3p,hsa-miR-518a-5p, hsa-miR-498, hsa-miR-214*, hsa-miR-323-5p, hsa-miR-384,hsa-miR-653, hsa-miR-302a, hsa-miR-888, hsa-miR-30d*, hsa-miR-553,hsa-miR-30e*, hsa-miR-21*, hsa-miR-570, hsa-miR-508-3p, hsa-miR-124,hsa-miR-34b, hsa-miR-1294, hsa-miR-588, hsa-miR-1270, hsa-miR-769-3p,hsa-miR-450b-3p, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-15a*,hsa-miR-331-5p, hsa-miR-450b-5p, hsa-miR-519d, hsa-miR-9*, hsa-miR-664*,hsa-miR-636, hsa-miR-520e, hsa-miR-200a, hsa-miR-10b*, hsa-miR-93,hsa-miR-383, hsa-miR-155*, hsa-miR-193b, hsa-miR-200b*, hsa-miR-491-3p,hsa-miR-1260, hsa-miR-23b, hsa-miR-548a-3p, hsa-miR-634, hsa-miR-149*,hsa-miR-620, hsa-miR-302d*, hsa-miR-141, hsa-miR-889, hsa-miR-526b*,hsa-miR-625*, hsa-miR-744*, hsa-miR-593*, hsa-miR-150, hsa-miR-1273,hsa-miR-181a-2*, hsa-miR-205, hsa-miR-527, hsa-miR-17*, hsa-miR-20b,hsa-miR-378*, hsa-miR-1321, hsa-miR-640, hsa-miR-631, hsa-miR-1224-3p,hsa-miR-106a, hsa-miR-1245, hsa-miR-130a*, hsa-miR-483-5p, hsa-miR-520h,hsa-miR-555, hsa-miR-197, hsa-miR-548c-3p, hsa-miR-17, hsa-miR-506,hsa-miR-302b, hsa-miR-626, hsa-miR-1283, hsa-miR-548e, hsa-miR-1251,hsa-miR-21, hsa-miR-485-5p, hsa-miR-577, hsa-miR-19a, hsa-miR-188-5p,hsa-miR-20a, hsa-miR-409-3p, hsa-miR-455-3p, hsa-miR-126*,hsa-miR-338-3p, hsa-miR-944, hsa-miR-499-5p, hsa-miR-193b*,hsa-miR-140-3p, hsa-miR-106b, hsa-let-7f-2*, hsa-miR-517c, hsa-miR-218,hsa-miR-302b*, hsa-miR-372, hsa-miR-1183, hsa-miR-505, hsa-miR-520d-5p,hsa-miR-200a*, hsa-miR-891b, hsa-miR-1293, hsa-miR-340*, hsa-miR-584.

Family with sequence similarity 160, memberB1—FAM160B1—NM_(—)020940—hsa-miR-518d-5p, hsa-miR-200b, hsa-miR-520b,hsa-miR-32, hsa-miR-16, hsa-miR-448, hsa-miR-519a*, hsa-miR-500,hsa-miR-542-3p, hsa-miR-522*, hsa-miR-625, hsa-miR-650, hsa-miR-133a,hsa-miR-1301, hsa-miR-551b*, hsa-miR-302c*, hsa-miR-221, hsa-miR-1179,hsa-miR-532-3p, hsa-miR-27a, hsa-miR-363*, hsa-miR-452, hsa-miR-496,hsa-miR-320c, hsa-miR-520a-3p, hsa-miR-15b*, hsa-miR-513a-3p,hsa-miR-142-5p, hsa-miR-335*, hsa-miR-561, hsa-miR-129-5p, hsa-miR-194,hsa-miR-892b, hsa-miR-146b-3p, hsa-miR-302e, hsa-let-7c*, hsa-miR-92b,hsa-miR-587, hsa-miR-216b, hsa-miR-103, hsa-miR-660, hsa-miR-367,hsa-miR-582-5p, hsa-miR-30b, hsa-miR-25, hsa-miR-374a*, hsa-miR-186,hsa-miR-33a*, hsa-miR-302c, hsa-miR-218-2*, hsa-miR-410, hsa-miR-421,hsa-let-7b*, hsa-miR-151-3p, hsa-miR-582-3p, hsa-miR-411, hsa-miR-30a*,hsa-miR-30a, miR-373, hsa-miR-200c, hsa-miR-145, hsa-miR-874,hsa-miR-548f, hsa-miR-26b, hsa-miR-569, hsa-miR-664, hsa-miR-573,hsa-miR-1269, hsa-miR-302d, hsa-miR-532-5p, hsa-miR-15b, hsa-miR-320d,hsa-miR-590-3p, hsa-miR-495, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-34c-3p,hsa-miR-26b*, hsa-miR-643, hsa-miR-520c-3p, hsa-miR-770-5p, hsa-miR-498,hsa-miR-384, hsa-miR-220b, hsa-miR-505*, hsa-miR-302a, hsa-miR-30d*,hsa-miR-802, hsa-miR-30e*, hsa-miR-429, hsa-miR-570, hsa-miR-508-3p,hsa-miR-940, hsa-miR-34b, hsa-miR-222, hsa-miR-518f*, hsa-miR-768-3p,hsa-miR-148b*, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-195,hsa-miR-450b-5p, hsa-miR-610, hsa-miR-519d, hsa-miR-545, hsa-miR-935,hsa-miR-9*, hsa-miR-27b, hsa-miR-323-3p, hsa-miR-520e, hsa-miR-520c-5p,hsa-miR-200a, hsa-miR-30d, hsa-miR-93, hsa-miR-29b-2*, hsa-miR-155*,hsa-miR-545*, hsa-miR-548a-3p, hsa-miR-133b, hsa-miR-567, hsa-miR-302d*,hsa-miR-141, hsa-miR-223, hsa-miR-889, hsa-miR-526b*, hsa-miR-203,hsa-miR-92a, hsa-miR-381, hsa-miR-597, hsa-miR-361-3p, hsa-miR-518e*,hsa-let-7f-1*, hsa-miR-30c, hsa-miR-526a, hsa-miR-501-5p,hsa-miR-151-5p, hsa-miR-20b, hsa-miR-523*, hsa-miR-1224-3p,hsa-miR-199a-3p, hsa-miR-106a, hsa-miR-1245, hsa-miR-149, hsa-miR-320a,hsa-miR-17, hsa-miR-1279, hsa-miR-656, hsa-miR-320b, hsa-miR-297,hsa-miR-424, hsa-miR-302b, hsa-miR-548e, hsa-miR-199b-3p, hsa-miR-1278,hsa-miR-924, hsa-miR-7-2*, hsa-miR-107, hsa-miR-300, hsa-miR-15a,hsa-miR-1244, hsa-miR-20a, hsa-miR-627, hsa-miR-363, hsa-miR-519b-5p,hsa-let-7a*, hsa-miR-340, hsa-miR-219-2-3p, hsa-miR-106b, hsa-miR-497,hsa-miR-519c-5p, hsa-miR-302b*, hsa-miR-372, hsa-miR-505, hsa-miR-26a,hsa-miR-1250, hsa-miR-512-5p, hsa-miR-30e.

Limb region 1 homolog—LMBR1—NM_(—)022458—hsa-miR-576-3p, hsa-miR-376b,hsa-miR-510, hsa-miR-200b, hsa-miR-509-3-5p, hsa-miR-1266, hsa-miR-448,hsa-miR-380*, hsa-miR-542-3p, hsa-miR-922, hsa-miR-625, hsa-miR-493*,hsa-miR-130b*, hsa-miR-1276, hsa-miR-1184, hsa-miR-1301, hsa-miR-551b*,hsa-miR-454*, hsa-miR-302c*, hsa-miR-548g, hsa-miR-563, hsa-miR-106b*,hsa-miR-490-3p, hsa-miR-127-5p, hsa-miR-320c, hsa-miR-513a-3p,hsa-miR-148a*, hsa-miR-142-5p, hsa-miR-379*, hsa-miR-335*, hsa-miR-183*,hsa-miR-28-5p, hsa-miR-561, hsa-miR-19b, hsa-miR-129-5p, hsa-miR-548n,hsa-miR-217, hsa-miR-892b, hsa-miR-1288, hsa-miR-885-5p, hsa-miR-128,hsa-miR-298, hsa-miR-130b, hsa-miR-455-5p, hsa-miR-875-3p, hsa-miR-1252,hsa-miR-1182, hsa-miR-630, hsa-miR-148a, hsa-miR-548p, hsa-miR-586,hsa-miR-30b, hsa-miR-374a*, hsa-miR-186, hsa-miR-23a, hsa-miR-365,hsa-miR-301b, hsa-miR-33a*, hsa-miR-520a-5p, hsa-miR-641,hsa-miR-151-3p, hsa-miR-708, hsa-miR-146a*, hsa-miR-590-5p,hsa-miR-525-5p, hsa-miR-494, hsa-miR-582-3p, hsa-miR-30a, hsa-miR-548o,hsa-miR-1, hsa-miR-376a, hsa-miR-200c, hsa-miR-130a, hsa-miR-148b,hsa-miR-548f, hsa-miR-99a*, hsa-miR-32*, hsa-miR-532-5p, hsa-miR-320d,hsa-miR-590-3p, hsa-miR-513c, hsa-miR-635, hsa-miR-767-3p, hsa-miR-26b*,hsa-miR-1200, hsa-miR-411*, hsa-miR-361-5p, hsa-miR-873, hsa-miR-27a*,hsa-miR-770-5p, hsa-miR-1262, hsa-miR-1323, hsa-miR-1224-5p,hsa-miR-654-3p, hsa-miR-596, hsa-miR-429, hsa-miR-624*, hsa-miR-570,hsa-miR-508-3p, hsa-miR-34b, hsa-miR-324-5p, hsa-miR-210,hsa-miR-125a-3p, hsa-miR-331-5p, hsa-miR-610, hsa-miR-20a*, hsa-miR-9*,hsa-miR-514, hsa-miR-607, hsa-miR-200a, hsa-miR-30d, hsa-miR-629*,hsa-miR-518c*, hsa-miR-491-3p, hsa-miR-152, hsa-miR-23b, hsa-miR-545*,hsa-miR-539, hsa-miR-548a-3p, hsa-miR-33b, hsa-miR-634, hsa-miR-516b,hsa-miR-33b*, hsa-miR-149*, hsa-miR-302d*, hsa-miR-301a, hsa-miR-141,hsa-miR-22*, hsa-miR-361-3p, hsa-miR-432*, hsa-miR-1300, hsa-miR-30c,hsa-miR-583, hsa-miR-501-5p, hsa-miR-224, hsa-miR-221*, hsa-miR-185,hsa-miR-17*, hsa-miR-1321, hsa-miR-100*, hsa-miR-1245, hsa-miR-130a*,hsa-miR-519e, hsa-miR-550, hsa-miR-320a, hsa-miR-1827, hsa-miR-1299,hsa-miR-548c-3p, hsa-miR-320b, hsa-miR-454, hsa-miR-297, hsa-miR-548k,hsa-miR-99b*, hsa-miR-548l, hsa-miR-548e, hsa-miR-21, hsa-miR-655,hsa-miR-485-5p, hsa-miR-206, hsa-miR-33a, hsa-miR-19a, hsa-miR-485-3p,hsa-miR-601, hsa-miR-183, hsa-miR-423-5p, hsa-miR-1272, hsa-miR-509-5p,hsa-miR-944, hsa-miR-340, hsa-miR-219-2-3p, hsa-miR-515-3p,hsa-miR-140-3p, hsa-miR-7f-2*, hsa-miR-302b*, hsa-miR-649, hsa-miR-1183,hsa-miR-223*, hsa-miR-1250, hsa-miR-1205, hsa-miR-1302, hsa-miR-613,hsa-miR-30e.

Nuclear casein kinase and cyclin-dependent kinase substrate1—NUCKS1—NM_(—)022731—hsa-miR-576-3p, hsa-miR-140-5p, hsa-miR-124*,hsa-miR-642, hsa-miR-16, hsa-miR-448, hsa-miR-500, hsa-miR-216a,hsa-miR-513a-5p, hsa-miR-1276, hsa-miR-125b-2*, hsa-miR-520g,hsa-miR-150*, hsa-miR-1301, hsa-miR-181a, hsa-miR-551b*, hsa-miR-454*,hsa-miR-519b-3p, hsa-miR-513b, hsa-miR-195*, hsa-miR-302c*, hsa-miR-96,hsa-miR-668, hsa-miR-214, hsa-miR-490-3p, hsa-miR-335, hsa-miR-920,hsa-miR-16-2*, hsa-miR-575, hsa-miR-320c, hsa-miR-511, hsa-miR-15b*,hsa-miR-513a-3p, hsa-miR-142-5p, hsa-miR-379*, hsa-miR-548m,hsa-miR-183*, hsa-miR-330-3p, hsa-miR-190, hsa-miR-302a*, hsa-miR-1237,hsa-miR-561, hsa-miR-519c-3p, hsa-miR-194, hsa-miR-892b, hsa-miR-885-5p,hsa-miR-93*, hsa-miR-603, hsa-miR-1825, hsa-miR-128, hsa-miR-134,hsa-miR-519a, hsa-miR-342-3p, hsa-miR-298, hsa-miR-130b, hsa-miR-1303,hsa-miR-875-3p, hsa-miR-657, hsa-miR-216b, hsa-miR-103, hsa-miR-1252,hsa-miR-129*, hsa-miR-660, hsa-miR-148a, hsa-miR-1246, hsa-miR-299-5p,hsa-miR-600, hsa-miR-548p, hsa-miR-1296, hsa-miR-524-5p, hsa-miR-30b,hsa-miR-143*, hsa-miR-186, hsa-miR-23a, hsa-miR-365, hsa-miR-301b,hsa-miR-1305, hsa-miR-337-3p, hsa-miR-202, hsa-miR-606, hsa-miR-641,hsa-miR-212, hsa-miR-548d-3p, hsa-miR-329, hsa-let-7b*, hsa-miR-151-3p,hsa-miR-146a*, hsa-miR-494, hsa-miR-582-3p, hsa-miR-30a*,hsa-miR-371-5p, hsa-miR-30a, hsa-miR-489, hsa-miR-1, hsa-miR-581,hsa-miR-130a, hsa-miR-145, hsa-miR-148b, hsa-miR-548f, hsa-miR-220c,hsa-miR-1286, hsa-miR-26b, hsa-miR-569, hsa-miR-664, hsa-miR-628-3p,hsa-miR-624, hsa-miR-532-5p, hsa-miR-15b, hsa-miR-320d, hsa-miR-188-3p,hsa-miR-96*, hsa-miR-599, hsa-miR-590-3p, hsa-miR-495, hsa-miR-1271,hsa-miR-29c, hsa-miR-132, hsa-miR-1297, hsa-miR-7-1*, hsa-miR-1208,hsa-miR-34c-3p, hsa-miR-767-3p, hsa-miR-589*, hsa-miR-26b*,hsa-miR-190b, hsa-miR-1200, hsa-miR-29b, hsa-miR-135a, hsa-miR-411*,hsa-miR-361-5p, hsa-miR-146a, hsa-miR-605, hsa-miR-1259, hsa-miR-1233,hsa-miR-770-5p, hsa-miR-498, hsa-miR-214*, hsa-miR-384, hsa-miR-220b,hsa-miR-30d*, hsa-miR-802, hsa-miR-30e*, hsa-miR-29a, hsa-miR-624*,hsa-miR-570, hsa-miR-105, hsa-miR-940, hsa-miR-588, hsa-miR-195,hsa-miR-610, hsa-miR-181d, hsa-miR-135b, hsa-miR-9*, hsa-miR-607,hsa-miR-200a, hsa-miR-30d, hsa-miR-383, hsa-miR-192*, hsa-miR-1206,hsa-miR-934, hsa-miR-554, hsa-miR-152, hsa-miR-23b, hsa-miR-1322,hsa-miR-362-3p, hsa-miR-545*, hsa-miR-539, hsa-miR-1257,hsa-miR-548a-3p, hsa-miR-146b-5p, hsa-miR-412, hsa-miR-516b,hsa-miR-149*, hsa-miR-302d*, hsa-miR-136, hsa-miR-330-5p, hsa-miR-301a,hsa-miR-141, hsa-miR-223, hsa-miR-203, hsa-miR-492, hsa-miR-381,hsa-miR-708*, hsa-let-7f-1*, hsa-miR-30c, hsa-miR-181c, hsa-miR-583,hsa-miR-221*, hsa-miR-378*, hsa-miR-640, hsa-miR-138-2*, hsa-miR-149,hsa-miR-130a*, hsa-miR-758, hsa-miR-520h, hsa-miR-320a, hsa-miR-197,hsa-miR-202*, hsa-miR-1228, hsa-miR-129-3p, hsa-miR-1299,hsa-miR-548c-3p, hsa-miR-196a*, hsa-miR-7, hsa-miR-320b, hsa-miR-454,hsa-miR-548l, hsa-miR-424, hsa-miR-181b, hsa-miR-548e, hsa-miR-655,hsa-miR-485-5p, hsa-miR-137, hsa-miR-892a, hsa-miR-577, hsa-miR-206,hsa-miR-7-2*, hsa-miR-107, hsa-miR-300, hsa-miR-15a, hsa-miR-876-3p,hsa-miR-455-3p, hsa-let-7a*, hsa-miR-340, hsa-miR-499-5p, hsa-miR-193b*,hsa-miR-219-2-3p, hsa-miR-497, hsa-miR-302b*, hsa-miR-367*, hsa-miR-326,hsa-miR-1183, hsa-miR-497*, hsa-miR-433, hsa-miR-505, hsa-miR-154,hsa-miR-499-3p, hsa-miR-26a, hsa-miR-142-3p, hsa-miR-520d-5p,hsa-miR-613, hsa-miR-30e.

Ankyrin repeat domain 13C—ANKRD13C—NM_(—)030816—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-665, hsa-miR-200b, hsa-miR-520b, hsa-miR-32,hsa-miR-1254, hsa-miR-448, hsa-miR-515-5p, hsa-miR-542-3p, hsa-miR-922,hsa-miR-875-5p, hsa-miR-1290, hsa-miR-374b, hsa-miR-1301, hsa-miR-181a,hsa-miR-551b*, hsa-miR-519b-3p, hsa-miR-513b, hsa-miR-182*,hsa-miR-195*, hsa-miR-302c*, hsa-miR-548g, hsa-miR-204, hsa-miR-890,hsa-miR-548a-5p, hsa-miR-559, hsa-miR-1248, hsa-miR-138-1*,hsa-miR-548b-5p, hsa-miR-16-2*, hsa-miR-520a-3p, miR-31,hsa-miR-513a-3p, hsa-miR-148a*, hsa-miR-544, hsa-miR-379*, hsa-miR-335*,hsa-miR-378, hsa-miR-1237, hsa-miR-561, hsa-miR-519c-3p, hsa-miR-19b,hsa-miR-541*, hsa-miR-548n, hsa-miR-217, hsa-miR-1288, hsa-miR-885-5p,hsa-miR-302e, hsa-let-7c*, hsa-miR-548c-5p, hsa-miR-519a,hsa-miR-409-5p, hsa-miR-298, hsa-miR-92b, hsa-miR-130b, hsa-miR-199a-5p,hsa-miR-875-3p, hsa-let-7d*, hsa-miR-1252, hsa-miR-1182, hsa-miR-660,hsa-miR-299-5p, hsa-miR-548p, hsa-miR-586, hsa-miR-367, hsa-miR-338-5p,hsa-miR-524-5p, hsa-miR-543, hsa-miR-25, hsa-miR-301b, hsa-miR-618,hsa-miR-1305, hsa-miR-33a*, hsa-miR-302c, hsa-miR-548i, hsa-miR-218-2*,hsa-miR-641, hsa-miR-29c*, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-30a*,hsa-miR-371-5p, hsa-miR-373, hsa-miR-200c, hsa-miR-581, hsa-miR-130a,hsa-miR-145, hsa-miR-548f, hsa-miR-569, hsa-miR-99a*, hsa-miR-720,hsa-miR-664, hsa-miR-1269, hsa-miR-302d, hsa-miR-624, hsa-miR-1324,hsa-miR-590-3p, hsa-miR-495, hsa-miR-29c, hsa-miR-7-1*, hsa-miR-589*,hsa-miR-1253, hsa-miR-29b, hsa-miR-579, hsa-miR-411*, hsa-miR-1243,hsa-miR-147, hsa-miR-520c-3p, hsa-miR-27a*, hsa-miR-18b, hsa-miR-302a,hsa-miR-888, hsa-miR-30d*, hsa-miR-802, hsa-miR-30e*, hsa-miR-592,hsa-miR-429, hsa-miR-29a, hsa-miR-488, hsa-miR-570, hsa-miR-124,hsa-miR-548d-5p, hsa-miR-1261, hsa-miR-593, hsa-miR-768-3p,hsa-miR-148b*, hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-450b-5p,hsa-miR-519d, hsa-miR-545, hsa-miR-452*, hsa-miR-181d, hsa-miR-548j,hsa-miR-607, hsa-miR-520e, hsa-miR-1258, hsa-miR-200a, hsa-miR-629,hsa-miR-93, hsa-miR-383, hsa-miR-155*, hsa-miR-518c*, hsa-miR-942,hsa-miR-422a, hsa-miR-548a-3p, hsa-miR-526b, hsa-miR-302d*,hsa-miR-301a, hsa-miR-141, hsa-miR-889, hsa-miR-526b*, hsa-miR-203,hsa-miR-548h, hsa-miR-92a, hsa-miR-211, hsa-miR-519e*, hsa-miR-361-3p,hsa-let-7f-1*, hsa-miR-181c, hsa-miR-181a-2*, hsa-miR-501-5p,hsa-miR-199b-5p, hsa-miR-18a, hsa-miR-1284, hsa-miR-659, hsa-miR-20b,hsa-miR-199a-3p, hsa-miR-106a, hsa-miR-1245, hsa-miR-30b*,hsa-miR-548c-3p, hsa-miR-17, hsa-miR-182, hsa-miR-454, hsa-miR-297,hsa-miR-99b*, hsa-miR-5481, hsa-miR-506, hsa-miR-302b, hsa-miR-181b,hsa-miR-1283, hsa-miR-548e, hsa-miR-1251, hsa-miR-655, hsa-miR-199b-3p,hsa-miR-888*, hsa-miR-122, hsa-miR-7-2*, hsa-miR-19a, hsa-miR-219-5p,hsa-miR-374a, hsa-miR-1244, hsa-miR-20a, hsa-miR-183, hsa-miR-363,hsa-let-7a*, hsa-miR-1272, hsa-miR-944, hsa-miR-106b, hsa-miR-296-3p,hsa-miR-302b*, hsa-miR-372, hsa-miR-497*, hsa-miR-223*, hsa-miR-505,hsa-miR-520d-5p, hsa-miR-135b*, hsa-miR-584.

Coiled-coil domain containing 43—CCDC43—Variant1—NM_(—)144609—hsa-miR-557, hsa-miR-200b, hsa-miR-1266, hsa-miR-515-5p,hsa-miR-542-3p, hsa-miR-625, hsa-miR-216a, hsa-miR-19b-2*,hsa-miR-875-5p, hsa-miR-9, hsa-miR-150*, hsa-miR-374b, hsa-miR-302c*,hsa-miR-548g, hsa-miR-204, hsa-miR-532-3p, hsa-miR-496, hsa-miR-513a-3p,hsa-miR-544, hsa-miR-379*, hsa-miR-507, hsa-miR-548m, hsa-miR-330-3p,hsa-miR-1237, hsa-miR-561, hsa-miR-129-5p, hsa-miR-1178, hsa-miR-19a*,hsa-miR-199a-5p, hsa-miR-216b, hsa-miR-600, hsa-miR-19b-1*, hsa-miR-30b,hsa-miR-186, hsa-miR-302f, hsa-miR-606, hsa-let-7b*, hsa-miR-30a,hsa-miR-200c, hsa-miR-145, hsa-miR-548f, hsa-miR-362-5p, hsa-miR-569,hsa-miR-664, hsa-miR-532-5p, hsa-miR-188-3p, hsa-miR-502-5p,hsa-miR-591, hsa-miR-767-3p, hsa-miR-411*, hsa-miR-374b*, hsa-miR-384,hsa-miR-429, hsa-miR-450b-5p, hsa-miR-30d, hsa-miR-629*, hsa-miR-1206,hsa-miR-539, hsa-miR-548a-3p, hsa-miR-634, hsa-miR-149*, hsa-miR-1185,hsa-miR-211, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-30c, hsa-miR-199b-5p,hsa-miR-1321, hsa-miR-199a-3p, hsa-miR-138-2*, hsa-miR-877*,hsa-miR-758, hsa-miR-548c-3p, hsa-miR-663b, hsa-miR-106a*, hsa-miR-7,hsa-miR-182, hsa-miR-345, hsa-miR-548e, hsa-miR-199b-3p, hsa-miR-331-3p,hsa-miR-122, hsa-miR-196a, hsa-miR-374a, hsa-miR-1244, hsa-miR-876-3p,hsa-miR-196b, hsa-let-7a*, hsa-miR-767-5p, hsa-miR-944, hsa-miR-340,hsa-miR-10a*, hsa-miR-30e.

CCDC43—Variant 2—NM_(—)001099225—hsa-miR-557, hsa-miR-200b,hsa-miR-1266, hsa-miR-642, hsa-miR-515-5p, hsa-miR-542-3p, hsa-miR-625,hsa-miR-216a, hsa-miR-19b-2*, hsa-miR-875-5p, hsa-miR-1184, hsa-miR-9,hsa-miR-150*, hsa-miR-374b, hsa-miR-1301, hsa-miR-302c*, hsa-miR-548g,hsa-miR-204, hsa-miR-532-3p, hsa-miR-1248, hsa-miR-496, hsa-miR-513a-3p,hsa-miR-544, hsa-miR-379*, hsa-miR-507, hsa-miR-548m, hsa-miR-330-3p,hsa-miR-1237, hsa-miR-561, hsa-miR-129-5p, hsa-miR-1178, hsa-miR-19a*,hsa-miR-199a-5p, hsa-miR-216b, hsa-miR-600, hsa-miR-19b-1*, hsa-miR-30b,hsa-miR-186, hsa-miR-302f, hsa-miR-606, hsa-let-7b*, hsa-miR-30a,hsa-miR-200c, hsa-miR-145, hsa-miR-548f, hsa-miR-362-5p, hsa-miR-569,hsa-miR-664, hsa-miR-532-5p, hsa-miR-188-3p, hsa-miR-502-5p,hsa-miR-591, hsa-miR-767-3p, hsa-miR-411*, hsa-miR-374b*, hsa-miR-384,hsa-miR-429, hsa-miR-450b-5p, hsa-miR-30d, hsa-miR-629*, hsa-miR-1206,hsa-miR-539, hsa-miR-548a-3p, hsa-miR-634, hsa-miR-149*, hsa-miR-1185,hsa-miR-211, hsa-miR-519e*, hsa-let-7f-1*, hsa-miR-30c, hsa-miR-199b-5p,hsa-miR-1321, hsa-miR-199a-3p, hsa-miR-138-2*, hsa-miR-877*,hsa-miR-758, hsa-miR-548c-3p, hsa-miR-663b, hsa-miR-106a*, hsa-miR-7,hsa-miR-182, hsa-miR-345, hsa-miR-548e, hsa-miR-199b-3p, hsa-miR-331-3p,hsa-miR-122, hsa-miR-196a, hsa-miR-374a, hsa-miR-1244, hsa-miR-627,hsa-miR-876-3p, hsa-miR-196b, hsa-let-7a*, hsa-miR-767-5p, hsa-miR-944,hsa-miR-340, hsa-miR-10a*, hsa-miR-154, hsa-miR-30e.

UHRF1 binding protein 1—UHRF1BP1—NM_(—)017754—hsa-miR-576-3p,hsa-miR-194*, hsa-miR-124*, hsa-miR-557, hsa-miR-510, hsa-miR-200b,hsa-miR-520b, hsa-miR-1254, hsa-miR-642, hsa-miR-16, hsa-miR-448,hsa-miR-515-5p, hsa-miR-22, hsa-miR-625, hsa-miR-138, hsa-miR-219-1-3p,hsa-miR-562, hsa-miR-875-5p, hsa-miR-513a-5p, hsa-miR-766, hsa-miR-1276,hsa-miR-9, hsa-miR-125b-2*, hsa-miR-520g, hsa-miR-1290, hsa-miR-454*,hsa-miR-195*, hsa-miR-483-3p, hsa-miR-204, hsa-miR-96, hsa-miR-28-3p,hsa-miR-532-3p, hsa-miR-377, hsa-miR-218-1*, hsa-miR-1304,hsa-miR-548a-5p, hsa-miR-490-3p, hsa-miR-559, hsa-miR-1267,hsa-miR-1248, hsa-miR-335, hsa-miR-127-5p, hsa-miR-548b-5p,hsa-miR-16-2*, hsa-miR-575, hsa-miR-496, hsa-miR-320c, hsa-miR-520a-3p,hsa-miR-31, hsa-miR-513a-3p, hsa-miR-142-5p, hsa-miR-379*, hsa-miR-507,hsa-miR-29b-1*, hsa-miR-548m, hsa-miR-378, hsa-miR-190, hsa-miR-302a*,hsa-miR-1237, hsa-miR-561, hsa-miR-541*, hsa-miR-302e, hsa-miR-769-5p,hsa-miR-548c-5p, hsa-miR-603, hsa-miR-128, hsa-miR-508-5p, hsa-miR-130b,hsa-miR-455-5p, hsa-miR-619, hsa-miR-587, hsa-miR-1303, hsa-miR-1207-5p,hsa-miR-875-3p, hsa-miR-1252, hsa-miR-630, hsa-miR-129*, hsa-miR-576-5p,hsa-miR-582-5p, hsa-miR-30b, hsa-miR-143*, hsa-miR-543, hsa-miR-374a*,hsa-miR-23a, hsa-miR-301b, hsa-miR-618, hsa-miR-302c, hsa-miR-302f,hsa-miR-548i, hsa-miR-202, hsa-miR-641, hsa-miR-329, hsa-miR-146a*,hsa-miR-145*, hsa-miR-582-3p, hsa-miR-652, hsa-miR-30a, hsa-miR-29a*,hsa-miR-324-3p, hsa-miR-1227, hsa-miR-373, hsa-miR-200c, hsa-miR-581,hsa-miR-1207-3p, hsa-miR-130a, hsa-miR-362-5p, hsa-miR-220c,hsa-miR-1286, hsa-miR-26b, hsa-miR-573, hsa-miR-302d, hsa-miR-15b,hsa-miR-320d, hsa-miR-96*, hsa-miR-590-3p, hsa-miR-502-5p, hsa-miR-1271,hsa-miR-1297, hsa-miR-7-1*, hsa-miR-939, hsa-miR-34c-3p, hsa-miR-26b*,hsa-miR-1253, hsa-miR-190b, hsa-miR-1200, hsa-miR-643, hsa-miR-135a,hsa-miR-411*, hsa-miR-520f, hsa-miR-146a, hsa-miR-605, hsa-miR-1243,hsa-miR-374b*, hsa-miR-186*, hsa-miR-1233, hsa-miR-873, hsa-miR-520c-3p,hsa-miR-608, hsa-miR-770-5p, hsa-miR-509-3p, hsa-miR-498, hsa-miR-1262,hsa-miR-653, hsa-miR-220b, hsa-miR-505*, hsa-miR-302a, hsa-miR-1224-5p,hsa-miR-888, hsa-miR-802, hsa-miR-568, hsa-miR-21*, hsa-miR-429,hsa-miR-488, hsa-miR-570, hsa-miR-548d-5p, hsa-miR-325, hsa-miR-324-5p,hsa-miR-588, hsa-miR-768-3p, hsa-miR-125a-3p, hsa-miR-512-3p,hsa-miR-520d-3p, hsa-miR-195, hsa-miR-519d, hsa-miR-935, hsa-miR-135b,hsa-miR-548j, hsa-miR-520e, hsa-miR-578, hsa-miR-30d, hsa-miR-10b*,hsa-miR-93, hsa-miR-554, hsa-miR-200b*, hsa-miR-518c*, hsa-miR-1260,hsa-miR-422a, hsa-miR-23b, hsa-miR-1322, hsa-miR-362-3p, hsa-miR-1257,hsa-miR-1255a, hsa-miR-146b-5p, hsa-miR-526b, hsa-miR-136, hsa-miR-328,hsa-miR-330-5p, hsa-miR-139-5p, hsa-miR-301a, hsa-miR-223, hsa-miR-889,hsa-miR-526b*, hsa-miR-203, hsa-miR-548h, hsa-miR-708*, hsa-miR-211,hsa-miR-519e*, hsa-miR-1300, hsa-miR-150, hsa-miR-30c, hsa-miR-181a-2*,hsa-miR-760, hsa-miR-583, hsa-miR-224, hsa-miR-151-5p, hsa-miR-221*,hsa-miR-659, hsa-miR-185, hsa-miR-20b, hsa-miR-556-5p, hsa-miR-1321,hsa-miR-640, hsa-miR-1224-3p, hsa-miR-106a, hsa-miR-1245,hsa-miR-138-2*, hsa-miR-877*, hsa-miR-130a*, hsa-miR-758, hsa-miR-520h,hsa-miR-320a, hsa-miR-1225-5p, hsa-miR-1228, hsa-miR-129-3p, hsa-miR-24,hsa-miR-548c-3p, hsa-miR-135a*, hsa-miR-17, hsa-miR-196a*,hsa-miR-106a*, hsa-miR-382, hsa-miR-656, hsa-miR-320b, hsa-miR-454,hsa-miR-1264, hsa-miR-297, hsa-miR-548l, hsa-miR-424, hsa-miR-302b,hsa-miR-655, hsa-miR-137, hsa-miR-331-3p, hsa-miR-888*, hsa-miR-7-2*,hsa-miR-188-5p, hsa-miR-15a, hsa-miR-1244, hsa-miR-566-3p, hsa-miR-20a,hsa-miR-425, hsa-miR-876-3p, hsa-miR-455-3p, hsa-miR-1272, hsa-miR-944,hsa-miR-340, hsa-miR-499-5p, hsa-miR-140-3p, hsa-miR-106b, hsa-miR-497,hsa-miR-369-3p, hsa-miR-296-3p, hsa-let-7f-2*, hsa-miR-372, hsa-miR-326,hsa-miR-497*, hsa-miR-154, hsa-miR-499-3p, hsa-miR-602, hsa-miR-26a,hsa-miR-1275, hsa-miR-1255b, hsa-miR-200a*, hsa-miR-1302, hsa-miR-1293,hsa-miR-512-5p, hsa-miR-584, hsa-miR-30e.

Chromosome 1 open reading frame163—C1orf163—NM_(—)023077—hsa-miR-576-3p, hsa-miR-34c-5p, hsa-miR-642,hsa-miR-380*, hsa-miR-22, hsa-miR-513a-5p, hsa-miR-766, hsa-let-7g*,hsa-miR-563, hsa-miR-214, hsa-miR-363*, hsa-miR-127-5p, hsa-miR-661,hsa-miR-449a, hsa-miR-28-5p, hsa-miR-129-5p, hsa-miR-943,hsa-miR-508-5p, hsa-miR-657, hsa-miR-1252, hsa-miR-449b, hsa-miR-708,hsa-miR-145*, hsa-miR-29a*, hsa-miR-616*, hsa-miR-373*, hsa-miR-220c,hsa-miR-1202, hsa-miR-502-5p, hsa-miR-589*, hsa-miR-26b*, hsa-miR-34a,hsa-miR-498, hsa-miR-185*, hsa-miR-888, hsa-miR-592, hsa-miR-192*,hsa-miR-567, hsa-miR-149*, hsa-miR-597, hsa-miR-744*, hsa-miR-1321,hsa-miR-30b*, hsa-miR-758, hsa-miR-24, hsa-miR-297, hsa-miR-1283,hsa-miR-187*, hsa-miR-488*, hsa-miR-577, hsa-miR-1272, hsa-miR-558,hsa-miR-1293.

Axin interactor, dorsalizationassociated—AIDA—NM_(—)022831—hsa-miR-576-3p, hsa-miR-32, hsa-miR-448,hsa-miR-27b*, hsa-miR-922, hsa-miR-19b-2*, hsa-miR-1276, hsa-miR-150*,hsa-miR-1290, hsa-miR-519b-3p, hsa-miR-302c*, hsa-miR-1289,hsa-miR-28-3p, hsa-miR-549, hsa-miR-218-1*, hsa-miR-548a-5p,hsa-miR-559, hsa-miR-27a, hsa-miR-1267, hsa-miR-1248, hsa-miR-548b-5p,hsa-miR-516a-3p, hsa-miR-15b*, hsa-miR-24-1*, hsa-miR-335*,hsa-miR-548m, hsa-miR-378, hsa-miR-330-3p, hsa-miR-561, hsa-miR-519c-3p,hsa-miR-548n, hsa-miR-217, hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-519a,hsa-miR-92b, hsa-miR-130b, hsa-miR-1280, hsa-miR-875-3p, hsa-miR-657,hsa-miR-580, hsa-miR-600, hsa-miR-548p, hsa-miR-586, hsa-miR-367,hsa-miR-19b-1*, hsa-miR-30b, hsa-miR-25, hsa-miR-301b, hsa-miR-618,hsa-miR-337-3p, hsa-miR-548i, hsa-miR-218-2*, hsa-miR-202,hsa-miR-24-2*, hsa-miR-641, hsa-miR-516b*, hsa-miR-146a*,hsa-miR-582-3p, hsa-miR-30a, hsa-miR-130a, hsa-miR-220c, hsa-miR-664,hsa-miR-484, hsa-miR-573, hsa-miR-32*, hsa-miR-1269, hsa-miR-628-3p,hsa-miR-1324, hsa-miR-96*, hsa-miR-361-5p, hsa-miR-186*, hsa-miR-144,hsa-miR-653, hsa-miR-802, hsa-miR-488, hsa-miR-124, hsa-miR-548d-5p,hsa-miR-1285, hsa-miR-512-3p, hsa-miR-20a*, hsa-miR-452*, hsa-miR-612,hsa-miR-514, hsa-miR-27b, hsa-miR-299-3p, hsa-miR-548j, hsa-miR-30d,hsa-miR-29b-2*, hsa-miR-422a, hsa-miR-33b, hsa-miR-301a, hsa-miR-548h,hsa-miR-92a, hsa-miR-30c, hsa-miR-17*, hsa-miR-100*, hsa-miR-1225-5p,hsa-miR-1299, hsa-miR-1279, hsa-miR-454, hsa-miR-345, hsa-miR-506,hsa-miR-187*, hsa-miR-1251, hsa-miR-655, hsa-miR-137, hsa-miR-888*,hsa-miR-33a, hsa-miR-425, hsa-miR-409-3p, hsa-miR-363, hsa-miR-944,hsa-miR-369-3p, hsa-miR-16-1*, hsa-miR-649, hsa-miR-584, hsa-miR-30e.

Chromosome 4 open reading frame 32—C4orf32—NM_(—)152400—hsa-miR-645,hsa-miR-493*, hsa-miR-648, hsa-miR-216a, hsa-miR-195*, hsa-let-7g*,hsa-miR-548a-5p, hsa-miR-490-3p, hsa-miR-559, hsa-miR-27a, hsa-miR-920,hsa-miR-92a-2*, hsa-miR-548b-5p, hsa-miR-16-2*, hsa-miR-513a-3p,hsa-miR-143, hsa-miR-335*, hsa-miR-183*, hsa-miR-561, hsa-miR-548n,hsa-miR-885-5p, hsa-miR-548c-5p, hsa-miR-199a-5p, hsa-miR-424*,hsa-miR-651, hsa-miR-576-5p, hsa-miR-548p, hsa-miR-338-5p,hsa-miR-524-5p, hsa-miR-143*, hsa-miR-186, hsa-miR-1305, hsa-miR-10a,hsa-miR-33a*, hsa-miR-491-5p, hsa-miR-548i, hsa-miR-410, hsa-miR-421,hsa-let-7b*, hsa-miR-489, hsa-miR-29a*, hsa-miR-324-3p, hsa-miR-548o,hsa-miR-573, hsa-miR-590-3p, hsa-miR-29c, hsa-miR-34c-3p, hsa-miR-1253,hsa-miR-29b, hsa-miR-518a-5p, hsa-miR-144, hsa-miR-1323, hsa-miR-568,hsa-miR-21*, hsa-miR-29a, hsa-miR-570, hsa-miR-105, hsa-miR-548d-5p,hsa-miR-487b, hsa-miR-144*, hsa-miR-20a*, hsa-miR-545, hsa-miR-504,hsa-miR-27b, hsa-miR-548j, hsa-miR-607, hsa-miR-101, hsa-miR-1274a,hsa-miR-545*, hsa-miR-136, hsa-miR-203, hsa-miR-548h, hsa-miR-381,hsa-miR-744*, hsa-let-7f-1*, hsa-miR-1300, hsa-miR-199b-5p, hsa-miR-527,hsa-miR-199a-3p, hsa-miR-10b, hsa-miR-548c-3p, hsa-miR-656,hsa-miR-1264, hsa-miR-1274b, hsa-miR-199b-3p, hsa-miR-137, hsa-miR-1278,hsa-miR-888*, hsa-miR-122, hsa-miR-196a, hsa-miR-300, hsa-miR-601,hsa-miR-196b, hsa-let-7a*, hsa-miR-574-5p, hsa-miR-340, hsa-miR-142-3p,hsa-miR-520d-5p, hsa-miR-891b.

Nestin—NES—NM_(—)006617—hsa-miR-665, hsa-miR-509-3-5p, hsa-miR-138,hsa-miR-650, hsa-miR-204, hsa-miR-31, hsa-miR-658, hsa-miR-1825,hsa-miR-1268, hsa-miR-1207-5p, hsa-miR-635, hsa-miR-1200,hsa-miR-768-5p, hsa-miR-940, hsa-miR-1294, hsa-miR-432, hsa-miR-512-3p,hsa-miR-155*, hsa-miR-136, hsa-miR-330-5p, hsa-miR-211, hsa-miR-17*,hsa-miR-30b*, hsa-miR-338-3p, hsa-miR-509-5p, hsa-miR-371-3p,hsa-miR-326, hsa-miR-154.

v-kit Hardy Zuckerman 4 feline sarcoma viral oncogenehomolog—KIT—Variant 1 and Variant 2—NM_(—)000222 andNM_(—)001093772—hsa-miR-194*, hsa-miR-124*, hsa-miR-510, hsa-miR-520b,hsa-miR-1266, hsa-miR-34c-5p, hsa-miR-642, hsa-miR-515-5p, hsa-miR-625,hsa-miR-493*, hsa-miR-648, hsa-miR-875-5p, hsa-miR-519b-3p,hsa-miR-195*, hsa-miR-487a, hsa-miR-221, hsa-miR-483-3p, hsa-miR-548g,hsa-miR-28-3p, hsa-miR-335, hsa-miR-138-1*, hsa-miR-127-5p, hsa-miR-452,hsa-miR-16-2*, hsa-miR-520a-3p, hsa-miR-142-5p, hsa-miR-335*,hsa-miR-449a, hsa-miR-519c-3p, hsa-miR-19b, hsa-miR-302e, hsa-miR-1825,hsa-miR-128, hsa-miR-519a, hsa-miR-508-5p, hsa-miR-130b, hsa-miR-216b,hsa-miR-148a, hsa-miR-576-5p, hsa-miR-582-5p, hsa-miR-301b,hsa-miR-449b, hsa-miR-618, hsa-miR-33a*, hsa-miR-302c, hsa-miR-218-2*,hsa-miR-641, hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-494, hsa-miR-30a*,hsa-miR-548o, hsa-miR-373, hsa-miR-130a, hsa-miR-148b, hsa-miR-573,hsa-miR-302d, hsa-miR-532-5p, hsa-miR-34a, hsa-miR-643, hsa-miR-193a-3p,hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-18b, hsa-miR-1262,hsa-miR-1323, hsa-miR-505*, hsa-miR-302a, hsa-miR-30d*, hsa-miR-30e*,hsa-miR-21*, hsa-miR-517*, hsa-miR-222, hsa-miR-136*, hsa-miR-125a-3p,hsa-miR-512-3p, hsa-miR-520d-3p, hsa-miR-450b-5p, hsa-miR-664*,hsa-miR-520e, hsa-miR-200a, hsa-miR-193b, hsa-miR-1206, hsa-miR-942,hsa-miR-152, hsa-miR-33b*, hsa-miR-139-5p, hsa-miR-301a, hsa-miR-141,hsa-miR-889, hsa-miR-571, hsa-miR-381, hsa-miR-519e*, hsa-miR-361-3p,hsa-let-7f-1*, hsa-miR-432*, hsa-miR-583, hsa-miR-501-5p,hsa-miR-342-5p, hsa-miR-493, hsa-miR-18a, hsa-miR-1284, hsa-miR-527,hsa-miR-1321, hsa-miR-519e, hsa-miR-522, hsa-miR-548c-3p, hsa-miR-135a*,hsa-miR-196a*, hsa-miR-454, hsa-miR-548l, hsa-miR-302b, hsa-miR-137,hsa-miR-488*, hsa-miR-19a, hsa-miR-300, hsa-miR-627, hsa-miR-455-3p,hsa-let-7a*, hsa-miR-338-3p, hsa-miR-515-3p, hsa-miR-296-3p,hsa-let-7f-2*, hsa-miR-218, hsa-miR-372, hsa-miR-505, hsa-miR-595,hsa-miR-154*, hsa-miR-671-5p.

Myeloid cell leukemia sequence 1—MCL1—Variant 1 and Variant2—NM_(—)021960 and NM_(—)182763—hsa-miR-124*, hsa-miR-510, hsa-miR-877,hsa-miR-520b, hsa-miR-32, hsa-miR-645, hsa-miR-448, hsa-miR-493*,hsa-miR-130b*, hsa-miR-133a, hsa-miR-222*, hsa-miR-101*,hsa-miR-125a-5p, hsa-miR-204, hsa-let-7g*, hsa-miR-1289, hsa-miR-668,hsa-miR-214, hsa-miR-532-3p, hsa-miR-890, hsa-miR-548a-5p, hsa-miR-559,hsa-miR-27a, hsa-miR-92a-2*, hsa-miR-127-5p, hsa-miR-548b-5p,hsa-miR-575, hsa-miR-496, hsa-miR-320c, hsa-miR-520a-3p, hsa-miR-15b*,hsa-miR-513a-3p, hsa-miR-142-5p, hsa-miR-29b-1*, hsa-miR-561,hsa-miR-943, hsa-miR-548n, hsa-miR-217, hsa-miR-1288, hsa-miR-885-5p,hsa-miR-302e, hsa-miR-548c-5p, hsa-miR-603, hsa-miR-128, hsa-miR-92b,hsa-miR-1303, hsa-miR-1207-5p, hsa-miR-623, hsa-miR-339-3p,hsa-miR-1252, hsa-miR-600, hsa-miR-367, hsa-miR-582-5p, hsa-miR-524-5p,hsa-miR-34a*, hsa-miR-25, hsa-miR-374a*, hsa-miR-186, hsa-miR-1236,hsa-miR-618, hsa-miR-337-3p, hsa-miR-302c, hsa-miR-491-5p, hsa-miR-548i,hsa-miR-548d-3p, hsa-let-7b*, hsa-miR-146a*, hsa-miR-153,hsa-miR-582-3p, hsa-miR-622, hsa-miR-324-3p, hsa-miR-373,hsa-miR-362-5p, hsa-miR-26b, hsa-miR-573, hsa-miR-302d, hsa-miR-624,hsa-miR-296-5p, hsa-miR-1324, hsa-miR-320d, hsa-miR-617, hsa-miR-495,hsa-miR-29c, hsa-miR-1297, hsa-miR-939, hsa-miR-589*, hsa-miR-26b*,hsa-miR-1200, hsa-miR-29b, hsa-miR-193a-3p, hsa-miR-361-5p,hsa-miR-520f, hsa-miR-768-5p, hsa-miR-1243, hsa-miR-186*,hsa-miR-520c-3p, hsa-miR-518a-5p, hsa-miR-125b, hsa-miR-302a,hsa-miR-888, hsa-miR-596, hsa-miR-29a, hsa-miR-488, hsa-miR-517*,hsa-miR-940, hsa-miR-548d-5p, hsa-miR-588, hsa-miR-432, hsa-miR-520d-3p,hsa-miR-519d, hsa-miR-935, hsa-miR-514, hsa-miR-27b, hsa-miR-664*,hsa-miR-548j, hsa-miR-607, hsa-miR-520e, hsa-miR-578, hsa-miR-93,hsa-miR-192*, hsa-miR-193b, hsa-miR-1260, hsa-miR-942, hsa-miR-101,hsa-miR-545*, hsa-miR-133b, hsa-miR-149*, hsa-miR-139-5p, hsa-miR-526b*,hsa-miR-22*, hsa-miR-548h, hsa-miR-92a, hsa-miR-597, hsa-miR-1185,hsa-miR-211, hsa-let-7f-1*, hsa-miR-760, hsa-miR-1284, hsa-miR-221*,hsa-miR-527, hsa-miR-20b, hsa-miR-1321, hsa-miR-1224-3p, hsa-miR-106a,hsa-miR-320a, hsa-miR-17, hsa-miR-320b, hsa-miR-1264, hsa-miR-548k,hsa-miR-548l, hsa-miR-302b, hsa-miR-626, hsa-miR-1251, hsa-miR-1278,hsa-miR-556-3p, hsa-miR-20a, hsa-miR-876-3p, hsa-miR-455-3p,hsa-miR-363, hsa-let-7a*, hsa-miR-767-5p, hsa-miR-944, hsa-miR-193b*,hsa-miR-106b, hsa-miR-372, hsa-miR-10a*, hsa-miR-497*, hsa-miR-26a,hsa-miR-520d-5p.

GLI-Kruppel family member GLI2—GLI2—NM_(—)005270—hsa-miR-124*,hsa-miR-376b, hsa-miR-502-3p, hsa-miR-637, hsa-miR-877, hsa-miR-448,hsa-miR-138, hsa-miR-19b-2*, hsa-miR-766, hsa-miR-221, hsa-miR-483-3p,hsa-miR-193a-5p, hsa-miR-1179, hsa-miR-923, hsa-miR-890,hsa-miR-548a-5p, hsa-miR-490-3p, hsa-miR-559, hsa-miR-27a,hsa-miR-92a-2*, hsa-miR-363*, hsa-miR-548b-5p, hsa-miR-575,hsa-miR-15b*, hsa-miR-544, hsa-miR-335*, hsa-let-7c*, hsa-miR-769-5p,hsa-miR-548c-5p, hsa-miR-19a*, hsa-miR-298, hsa-miR-619, hsa-miR-1303,hsa-miR-875-3p, hsa-miR-1252, hsa-miR-1203, hsa-miR-19b-1*, hsa-miR-30b,hsa-miR-1236, hsa-miR-491-5p, hsa-miR-548i, hsa-miR-202, hsa-miR-371-5p,hsa-miR-30a, hsa-miR-376a, hsa-miR-1207-3p, hsa-let-7i*, hsa-miR-664,hsa-miR-484, hsa-miR-624, hsa-miR-296-5p, hsa-miR-29c, hsa-miR-1291,hsa-miR-1200, hsa-miR-885-3p, hsa-miR-29b, hsa-miR-579, hsa-miR-220b,hsa-miR-29a, hsa-miR-488, hsa-miR-105, hsa-miR-548d-5p, hsa-miR-222,hsa-miR-593, hsa-miR-1285, hsa-miR-512-3p, hsa-miR-452*, hsa-miR-612,hsa-miR-27b, hsa-miR-548j, hsa-miR-200a, hsa-miR-30d, hsa-miR-10b*,hsa-miR-518c*, hsa-miR-942, hsa-miR-33b, hsa-miR-516b, hsa-miR-567,hsa-miR-330-5p, hsa-miR-139-5p, hsa-miR-141, hsa-miR-548h, hsa-miR-1185,hsa-miR-432*, hsa-miR-30c, hsa-miR-760, hsa-miR-501-5p, hsa-miR-877*,hsa-miR-202*, hsa-miR-182, hsa-miR-1264, hsa-miR-485-5p, hsa-miR-892a,hsa-miR-33a, hsa-miR-455-3p, hsa-miR-501-3p, hsa-miR-218, hsa-miR-326,hsa-miR-1275, hsa-miR-891b, hsa-miR-512-5p, hsa-miR-30e.

Interleukin 4—IL4—Variant 1 and Variant 2—NM_(—)000589 andNM_(—)172348—hsa-miR-9*, hsa-miR-1272.

The miRNAs predicted to target CSC-related genes are particularly usefultargets for therapeutic intervention in prostate and other cancersthrough manipulation of their expression levels.

Example 4 MiRNAs Differentially Expressed in CD44⁺ Cancer Stem Cell fromFreshly Isolated Human Prostate Tumor Samples

The CD44-expressing subset in human prostate xenografts is highlyenriched in cells that have greater tumorigenic and metastaticpotential. CD44⁺ cells also preferentially express self-renewal genessuch as Smoothened, Oct-3/4, Bmi, and β-catenin that are aberrantlyregulated in a variety of cancers (Patrawala et al., 2006). In acutemyeloid leukemia (AML) and liver cancer, targeting the CD44⁺ cancer stemcells effectively eradicates the cancer cells highlighting thefunctional importance of this population in driving tumor growth (Jin etal., 2006; Xie et al., 2007).

We have shown that CD44⁺ cells obtained from LAPC4, LAPC9, and Du145prostate cancer xenografts differentially express miRNAs compared withCD44⁻ cells (Table 1). To investigate the expression of some of thedifferentially regulated miRNAs in clinical specimen, we obtainedsixteen, freshly isolated, human prostate tumor samples and immediatelydissociated them as follows: tumor tissue was minced in RPMI+10% FBS andincubated 12-14 hours in 200 U/ml Collagenase I solution (Cat. No.C-0310, Sigma-Aldrich, St. Louis, Mo.) to degrade the extracellularmatrix. To break up the organoids, the sample was incubated with 2.5%trypsin (cat. no. 17-160E; Biowhittaker Inc., Walkersville, Md., USA)for 15 minutes. The dissociated cells were then passed through an 80 μMnylon mesh to obtain a single cell suspension. Contaminatinghematopoietic and stromal cells were removed using the MACS Lineage CellDepletion kit (Cat. No. 130-092-211; Miltenyi Biotec, Inc.; Auburn,Calif., USA). The cell suspension was stained for 15 minutes at 4° C.first with a fluorescein isothiocyanate (FITC)-conjugated antibodyagainst CD44 (BD Biosciences, San Jose, Calif., USA) and next withanti-FITC microbeads (Cat. No. 130-048-701; Miltenyi Biotec, Inc). Thecells were sorted by passing through a MACS column (Cat. No.130-042-201; Miltenyi Biotec, Inc.), which binds to CD44⁺ cells leavingthe CD44⁻ cells in the effluent. The purity of the CD44⁺ fraction thusobtained ranged from 60-95%.

Total RNA was extracted using the mirVana™ miRNA Isolation kit (cat. no.AM1561; Ambion, Inc.; Austin, Tex., USA) according to the manufacturer'srecommended protocol. Expression of miR-34a, let-7b, miR-106a, miR-141,miR-301, miR-24, and miR-103 was determined in duplicate by quantitativereal-time PCR using (1) RNA from cells derived from prostate cancercells carrying the CD44 epitope (CD44⁺) and (2) RNA from the populationof tumor cells recovered after CSC removal from the respective tumors.Quantitative real-time PCR assays employed TaqMan® MicroRNA Assayreagents (Applied Biosystems, Foster City, Calif., USA). Raw Ct valuesfrom CSCs were normalized to those of the housekeeping miRNAs miR-24,miR-26a, and miR-191 and expressed relative to the normalized valuesgenerated in the CSC-depleted prostate tumor cell population (FIG. 1).All five of the therapeutic miRNAs tested showed the same expressiontrend as in the CD44⁺ CSCs obtained from xenografts (FIG. 1 and Table1). Four of the miRNAs, hsa-miR-34a, let-7b, miR-106a, and hsa-miR-141,were down-regulated overall. miR-301 was upregulated in CSCs frompatient samples as well as from xenografts.

miR-141, let-7b, miR-106a, and miR-34a are downregulated in CSCs derivedfrom clinical prostate tumor specimens and in CSCs purified fromprostate cancer xenografts, suggesting that they have an anti-oncogenicfunction. Replacement of these miRNAs can provide a potentialtherapeutic benefit in prostate cancer and in other cancers.Overexpression of miR-301 in CSCs indicates an oncogenic role, making ita potential target for cancer therapy using a miRNA antagonist.

Example 5 HSA-MIR-34A Inhibits Cancer Stem Cell Growth in Vitro and inVivo

Anchorage-independent growth, also known as clonogenicity, is a hallmarkof stem cells and CSCs from solid tumors. In brain and breast tissue,neurosphere and mammosphere assays are used to enrich for normal stemcells as well as cancer stem cells, as most differentiated cells perishin non-adherent culture conditions (Reynolds et al., 1992; Singh et al.,2003; Dontu et al., 2003; Liu et al., 2006). Prostaspheres are sphericalgroups of cells generated from anchorage-independent growth of prostatecancer cells that maintain higher levels of CD133 expression and thatare capable of undergoing differentiation with an appropriate stimulus(Miki et al., 2007). CD44⁺ cells from LAPC4 and LAPC9 prostatexenografts are 10-100 fold enriched in sphere-forming capacity, andcomprise a spectrum of differentiated and undifferentiated cellsindicating that the cell of origin is a CSC (Patrawala et al., 2006).Clonogenic assays, therefore, are an important tool for measuring thefrequency of CSCs in a bulk population.

Hsa-miR-34a was downregulated in all the CSC fractions analyzed (Tables1 and 2 above), suggesting that this miRNA may play a critical role inantagonizing CSC properties. The inventors therefore investigatedwhether re-expressing miR-34a in prostate cancer cells would have adeleterious effect on the CSC population as measured by efficiency ofsphere formation (EOS). LAPC4 cells (1.25×10³) were transfected with 5μg (1.6 μM) miR-34a (Pre-miR™-hsa-miR-34a, cat. no. 17100; Ambion) or asequence-scrambled negative control miRNA (Pre-miR™ MicroRNA PrecursorMolecule-Negative Control #2, cat. no. 17111; Ambion) by electroporationand seeded in triplicate into 60% Matrigel (Becton, Dickinson and Co.;Franklin Lakes, N.J., USA). After approximately 1 week, spheres with aclearly-defined three-dimensional structure consisting of >50 cells werequantified and used to calculate EOS. hsa-miR-34a treatment causes a 40%reduction in the clonogenic capacity of LAPC4 cells (Table 6) suggestingthat hsa-miR-34a downregulation is important for CSC growth and thathsa-miR-34a has therapeutic benefit for the treatment of prostatecancer.

TABLE 6 hsa-miR-34a inhibits in vitro sphere-formation in LAPC4 prostatetumor cells. average number miRNA of spheres SD EOS miR-NC 110 18.38100% miR-34a 66 15.56  60% Sphere formation of cells transfected withnegative control miRNA was set at 100%. Abbreviations: EOS, efficiencyof sphere formation; SD, standard deviation; miR-NC, negative controlmiRNA

Example 6 HSA-MIR-34A Inhibits Cancer Stem Cell Tumor Initiation in Vivo

CSCs with the cell surface marker CD44 are more efficient thannon-cancer stem cells in initiating tumors when transplanted intoimmunodeficient mice (Patrawala et al., 2005; 2006; 2007). Sincehsa-miR-34a suppressed the in vitro clonogenic potential of the LAPC4prostate cancer xenograft (Table 6 above), the inventors proceeded todetermine if miR-34a could also interfere with CSC tumor-initiation invivo. CD44+ Du145 prostate cancer cells cells were infected with acontrol lentivirus vector (lenti-ctl) or a lentivirus vector harboringpre-miR-34a (lenti-miR-34a) (Systems Biosciences Inc., Mountain View,Calif., USA), both at a multiplicity of infection (MOI) of 10. At 24 hrpost infection, 10⁴ cells were mixed 1:1 with BD Matrigel (BDBiosciences)and implanted subcutaneuosly into the into the dorsalprostate of NOD/SCID mice (JAX® Mice and Services, Bar Harbor, Me.,USA). One group of ten mice was injected with lenti-ctl-infected cells,and a separate group of ten animals was injected withlenti-mir-34a-infected cells. The mice were monitored for tumor growthfor 90 days before sacrifice and assessment of tumor development. Tumorsdeveloped in all ten mice injected with cells that had been infectedwith lenti-ctl (ctl, FIG. 2). In contrast, none of the ten mice injectedwith cells that had been infected with lenti-miR-34a (miR-34a, FIG. 2)developed tumors during the experiment. Since the tumor incidence in theanimal correlated with the presence of CD44⁺ cancer stem cells(Patrawala et al., 2006; Oncogene, 1696-708), this result demonstratedthat hsa-miR-34a negatively impacted the CSCs' ability to generatetumors and that the miRNA can be used to treat the CSC component oftumors.

Example 7 Inhibition of HSA-MIR-34A Promotes Tumor Growth in Vivo

The inventors determined the effect of miR-34a inhibition on tumorinitiation and tumor size in LAPC9 cells. Cells were transfected usingLipofectamine™ 2000 (Life Technologies;) with 33 nM of anti-miR-34a(Thermo Fisher Scientific Inc.; Lafayette, Colo., USA) or a negativecontrol miRNA hairpin inhibitor negative control (Thermo FisherScientific Inc.), mixed 1:1 with BD Matrigel™, (BD Biosciences), andimplanted into the dorsal prostate of intact male NOD/SCID mice (JAX®Mice and Services,). One group of seven mice was injected withanti-miR-34a -treated LAPC9 cells, and a separate group of seven animalswas injected with LAPC9 cells (10⁵ cells) treated with negative controlmiRNA. After 48 days, animals were sacrificed and tumors were dissected,weighed, and imaged. Five of seven animals in each group developedtumors. A single administration of anti-miR-34a to LAPC9 prostate cancercells, prior to tumor initiation in vivo, resulted in a 2 fold increasein average tumor weight compared with the anti-miR negativecontrol-treated LAPC9 cells (FIG. 3). Similar results were obtained inexperiments with LAPC4 cells. This supports the observation that cancercells with lower miR-34a activity are more highly tumorigenic.

Example 8 Synthetic Mimics of MiRNAs Down Regulated in Cancer Stem CellsInhibit Proliferation of Human Prostate Cancer Cells

The inventors assessed the anti-proliferative activity of multiplemiRNAs (hsa-let-7b, hsa-miR-34a, hsa-miR-15a, hsa-miR-126, hsa-miR-16,hsa-miR-hsa-101, and hsa-miR-124a) that were down-regulated in at leastone of the cancer stem cell populations that were used for expressionanalysis. Three individual human prostate cancer cell lines; PPC-1,derived from a bone metastasis; Du145, derived from a brain metastasis;and LNCaP, derived from a lymph node metastasis (Bello et al., 1997;Pretlow et al., 1993; Stone et al., 1978; Brothman et al., 1991;Horoszewicz et al., 1980). PPC-1 and Du145 cells lack expression of theprostate-specific antigen (PSA) and are independent of androgen receptor(AR) signaling. In contrast, LNCaP cells test positive for PSA and AR.Cells were transfected with synthetic miRNAs (Pre-miR™ miRNA PrecursorMolecule; Life Technologies/Ambion, Austin, Tex., USA) or negativecontrol miRNA (NC; Pre-miR™ miRNA Precursor Molecule-Negative Control#2; Ambion cat. no. AM17111) in a 96-well format using a lipid-basedtransfection reagent. Lipid-based reverse transfections were carried outin triplicate according to a published protocol (Ovcharenko et al.,2005) and the following parameters; (6,000-7,000 cells per each well ofa 96 well plate), 0.1-0.2 μl Lipofectamine™ 2000 (cat. no. 11668-019,Life Technologies/Invitrogen Corp., Carlsbad, Calif., USA) in 20 μlOptiMEM (Life Technologies/Invitrogen), 30 nM final concentration ofmiRNA in 100 μl. Proliferation was assessed 4-7 days post-transfectionusing Alamar Blue™ (Life Technologies/Invitrogen) following themanufacturer's instructions. Fluorescent light units (FLU) were measuredafter 3 hours, normalized to the control, and plotted as percent changein proliferation. Percent proliferation of the miRNA-treated cellsrelative to cells treated with negative control miRNA (100%) is shown inTable 7.

TABLE 7 Percent (%) proliferation of human prostate cancer cell linestreated with indicated miRNAs vs negative control miRNA (NC). PPC-1LNCaP C4-2 Du145 % Proliferation miRNA Avg SD Avg SD Avg SD let-7b 90.11.9 90.2 0.1 84.5 13.1  34a 24.6 0.6 49.4 7.1 55.4 4.2 124a 45.9 4.372.4 7.4 69.2 6.5 126 71.9 2.8 80.6 14.6 68.2 3.0  15a 64.0 7.0 84.1 7.580.0 1.0  16 63.1 7.0 97.8 5.8 70.0 2.0 101 47.5 5.3 109.8 6.5 30.0 1.2Values are normalized to values obtained from cells transfected withnegative control miRNA (100% proliferation). NC, negative control miRNA;Avg, average; SD, standard deviation.

Delivery of each synthetic miRNAs significantly inhibited cellularproliferation of human prostate cancer cells PPC-1, Du145, and LNCaP(Table 7). These results suggest that mimics of any of the miRNAs thatare down-regulated in cancer stem cells might function as therapeuticsfor patients with prostate cancer and other malignancies.

Example 9 Repeated Dosing of Human Prostate Cancer Cells with SyntheticHSA-MIR-34A Inhibits Proliferation

To evaluate the therapeutic activity of hsa-miR-34a over an extendedperiod of time, growth curve experiments in the presence of miRNA for upto 22 days were conducted. Since in vitro transfections of nakedinterfering RNAs, such as synthetic miRNA, are transient by nature andcompromised by the dilution of the oligo during ongoing cell divisions,miRNA was administered at multiple time points (Bartlett et al. 2006;Bartlett et al. 2007). To accommodate miRNA delivery into a largequantity of cells, the inventors employed the electroporation method todeliver hsa-miR-34a or negative control miRNA into PPC-1, PC3, and Du145human prostate cancer cells. Briefly, 1×10⁶ PPC-1 or PC3 cells, or0.5×10⁶ Du145 cells were electroporated with 1.6 μM hsa-miR-34a ornegative control using the BioRad Gene Pulser Xcell™ instrument (BioRadLaboratories Inc., Hercules, Calif., USA), seeded and propagated inregular growth medium. Experiments with PC3 and Du145 cells were carriedout in triplicates. When the control cells reached confluence (days 4and 11 for PPC-1; days 7 and 14 for PC3 and Du145), cells wereharvested, counted and electroporated again with the respective miRNAs.To ensure similar treatment of both conditions as well as to accommodateexponential growth, the cell numbers used for the second and thirdelectroporation were titrated down to the lowest count. The populationdoubling was calculated from these electroporation events using theformula PD=ln(Nf/N0)/ln 2 and adjusting for the fact that approximately72% of newly seeded cells adhere to the plate. Cell counts wereextrapolated and plotted on a linear scale (FIG. 4). Arrows representelectroporation days. Standard deviations are included in the graphs.

Repeated administration of hsa-miR-34a robustly inhibited proliferationof human prostate cancer cells (FIG. 4, white squares). In contrast,cells treated with negative control miRNA showed normal exponentialgrowth (FIG. 4, black diamonds). hsa-miR-34a treatment resulted in 97.2%inhibition of PC3 cell growth on day 21 (2.8% cells relative to cellselectroporated with negative control miRNA), and 93.1% inhibition ofDu145 cell growth on day 19 (6.9% cells relative to cells electroporatedwith negative control miRNA) relative to the proliferation of controlcells (100%). All PPC-1 cells electroporated with hsa-miR-34a wereeliminated by day 22.

The data indicate that hsa-miR-34a provides a useful therapeutic tool inthe treatment of human prostate cancer cells.

Example 10 Synthetic HSA-MIR-34A Inhibits Tumor Growth of Human ProstateCancer Xenografts in Mice

The therapeutic potential of synthetic hsa-miR-34a miRNA was evaluatedin the animal using the PPC-1 human prostate cancer xenograft. 5×10⁶PPC-1 cells per animal were electroporated with 1.6 μM synthetichsa-miR-34a or negative control miRNA (Pre-miR™-hsa-miR-34a, Ambion cat.no. AM17100; NC, Pre-miR™ microRNA Precursor Molecule-Negative Control#2, Ambion cat. no. AM17111), mixed with BD Matrigel™, (BD Biosciences;San Jose, Calif., USA; cat. no. 356237) in a 1:1 ratio and implantedsubcutaneously into the lower back of NOD/SCID mice (Charles RiverLaboratories, Inc.; Wilmington, Mass., USA). A group of 7 mice wasinjected with hsa-miR-34a treated PPC-1 cells, and a group of 7 animalswas injected with PPC-1 cells treated with negative control miRNA. Tomaintain steady levels of miRNA, 6.25 μg of each hsa-miR-34a or negativecontrol miRNA conjugated with the lipid-based siPORT™ amine deliveryagent (Ambion, Austin, Tex.; cat. no. AM4502) were repeatedlyadministered on days 7, 13, 20, and 25 via intra-tumoral injections.Given an average mouse weight of 20 g, this dose equals 0.3125 mg/kg.Tumor growth was monitored by taking caliper measurements every 1-2 daysfor 32 days. Tumor volumes were calculated using the formula,Volume=length×width×width/2, in which the length is greater than thewidth, and plotted over time (FIG. 5). Standard deviations are shown inthe graph. All data points had p values <0.01. p values were as low as1.86×10⁻⁹ for data obtained on day 22, indicating statisticalsignificance.

Repeated dosing with hsa-miR-34a blocked tumor growth of the human PPC-1prostate cancer xenograft (FIG. 5, white squares). The average volume oftumors that received hsa-miR-34a was 151 mm³ on day 32. Volumes of newlyimplanted tumors ranged between 111 and 155 mm³ (days 4-7) and thus,PPC-1 tumors failed to develop in response to hsa-miR-34a treatment. Incontrast, tumors locally treated with negative control miRNA wereunaffected and continued to grow at a steady pace (FIG. 5, blackdiamonds). The average volume of tumors treated with negative controlmiRNA was 437 mm³ on day 32. Of note, each single administration withhsa-miR-34a resulted in an acute regression of tumor volumes. Thiseffect was not induced with negative control miRNA, indicating that theanti-tumor activity of hsa-miR-34a is specific.

A histological analysis revealed that PPC-1 tumors treated with negativecontrol miRNA were densely packed with healthy, viable prostate cancercells (FIG. 6). In contrast, hsa-miR-34a-treated tumors consisted mostlyof matrigel with cellular debris and sparsely distributed cells, as wellas occasional pockets with seemingly viable cells (FIG. 6, arrow). Togain further insight into the biological status of these cells,immunohistochemistry analyses specific for the proliferation markerKi-67, as well as caspase 3, an indicator of apoptosis were performed.As illustrated in FIG. 7, areas with viable cells in hsa-miR-34a-treatedtumors showed reduced levels of Ki-67 and increased levels of caspase 3.The data indicate that hsa-miR-34a inhibits tumor growth by ananti-proliferative and pro-apoptotic mechanism.

The data indicate that hsa-miR-34a provides a powerful therapeutic toolin the treatment of patients with prostate cancer.

In addition, the data demonstrated the therapeutic utility ofhsa-miR-34a in a lipid-based formulation.

Example 11 Delivery of Synthetic HSA-MIR-34A Decreases Metastasis andIncreases Survival in Mice with Prostatecancer

To evaluate the therapeutic benefit of treating cancer patients with amiRNA that is down-regulated in cancer stem cells, we injected mice thathad orthotopic prostate tumors with synthetic hsa-miR-34a at two dayintervals with a dose of 1 mg of miRNA/kg body weight. LAPC9-GFP cells(500,000) were orthotopically implanted in the DP of male NOD/SCID mice.Twenty-one days later, animals were divided into four groups (n=7 foreach group) and injected, via tail vein, with the indicated materials(PBS, vehicle control; miR-NC; and miR-34a) on day 0. Injections wererepeated on days 2, 4, 6, 8, and 10 and all animals were terminated onday 13. Animals were tracked for survival before being sacrificed foranalysis. As shown in FIG. 8, all of the control mice had died by day 13of the experiment and none of the miR-34a treated animals died. Lungimaging revealed significantly reduced lung metastases in the miR-34atreated group compared to the NC group.

These data indicate that hsa-miR-34a can significantly enhance thesurvival of cancer patients by limiting metastasis.

Example 12 Synthetic MiRNAs Inhibit Proliferation of Human Lung CancerCells

miRNAs with therapeutic value in prostate cancer and prostate cancerstem cells may also be of therapeutic value in other cancer types.Therefore, the inventors assessed the therapeutic effect of severalmiRNAs, down-regulated in CSCs, for lung cancer by using four individuallung cancer cell lines. To measure cellular proliferation of lung cancercells, the following non-small cell lung cancer (NSCLC) cells were used;cells derived from lung adenocarcinoma (A549, Calu-3, HCC2935) and cellsderived from lung large cell carcinoma (H460). Synthetic miRNAs(Pre-miR™, Life Technologies/Ambion) or negative control (NC) miRNA(Pre-miR™ miRNA Precursor Molecule-Negative Control #2; Ambion cat. no.AM17111) was delivered via lipid-based transfection into A549, Calu-3,HCC2935, and H460 cells.

Lipid-based reverse transfections were carried out in triplicateaccording to a published protocol (Ovcharenko et al., 2005) and thefollowing parameters: cells (5,000-12,000 per each well of 96 wellplate), 0.1-0.2 μl Lipofectamine™ 2000 (cat. no. 11668-019, InvitrogenCorp., Carlsbad, Calif., USA) in 20 μl OptiMEM (Invitrogen), 30 nM finalconcentration of miRNA in 100 μl. All cells except for Calu-3 cells wereharvested 72 hours post transfection or electroporation for assessmentof cellular proliferation. Calu-3 cells were harvested 10 days posttransfection. Proliferation assays were performed using Alamar Blue(Invitrogen) following the manufacturer's instructions. Percent (%)proliferation values from the Alamar Blue assay were normalized tovalues from cells treated with negative control miRNA. Percentproliferation of miRNA-treated cells relative to cells treated withnegative control miRNA (100%) is shown in Table 8.

TABLE 8 Percent (%) proliferation of lung cancer cell lines treated withmimics of miRNAs down-regulated in cancer stem cells. A549 H460 Calu-3HCC2935 % Proliferation miRNA Avg SD Avg SD Avg SD Avg S D let-7b 68 1132 3 71 4 80 3 miR-126 84 4 33 3 66 4 68 7 miR-124a 70 12 18 4 28 5 76 7miR-34a 76 6 47 8 32 8 74 6 Values are normalized to values obtainedfrom cells transfected with negative control miRNA (100% proliferation).Avg, average; SD, standard deviation.

To evaluate the therapeutic activity of hsa-miR-34a over an extendedperiod of time, the inventors conducted growth curve experiments in thepresence of miRNA for up to 31 days in H226 lung cancer cells. Since invitro transfections of naked interfering RNAs, such as synthetic miRNA,are transient by nature and compromised by the dilution of the miRNAduring ongoing cell divisions, miRNA was administered at multiple timepoints (Bartlett et al., 2006; Bartlett et al., 2007). To accommodatemiRNA delivery into a large quantity of cells, hsa-miR-34a or negativecontrol miRNA were delivered by the electroporation method. Briefly,1×10⁶ H226 were electroporated in triplicate with 1.6 μM hsa-miR-34a ornegative control using the BioRad Gene Pulser Xcell™ instrument (BioRadLaboratories Inc., Hercules, Calif., USA), seeded and propagated inregular growth medium. When the control cells reached confluence (days6, 17, and 25), cells were harvested, counted and electroporated againwith the respective miRNAs. To ensure similar treatment of bothconditions as well as to accommodate exponential growth, the cellnumbers used for the second and third electroporation were titrated downto the lowest count. The population doubling was calculated from theseelectroporation events using the formula PD=ln(Nf/NO)/ln 2 and adjustingfor the fact that approximately 72% of newly seeded cells adhere to theplate. Cell counts were extrapolated and plotted on a linear scale (FIG.9). Arrows represent electroporation days. Standard deviations areincluded in the graphs.

Repeated administration of hsa-miR-34a robustly inhibited proliferationof human lung cancer cells (FIG. 9). In contrast, cells treated withnegative control miRNA showed normal exponential growth. hsa-miR-34atreatment resulted in 94.9% inhibition of H226 cell growth on day 31(5.1% remaining cells) relative to the proliferation of control cells(100%).

The data indicate that miRNAs that are down-regulated cancer stem cellscan be used as therapeutics to treat additional cancers including lungcancer.

Example 13 Synthetic HSA-MIR-34A Inhibits Tumor Growth of Human LungCancer Xenografts in Mice

The inventors assessed the growth-inhibitory activity of hsa-miR-34a inhuman lung cancer xenografts grown in immunodeficient mice. Each 3×10⁶human H460 non-small cell lung cancer cells were mixed with BDMatrigel™, (BD Biosciences; San Jose, Calif., USA; cat. no. 356237) in a1:1 ratio and subcutaneously injected into the lower back of 23 NOD/SCIDmice (Charles River Laboratories, Inc.; Wilmington, Mass., USA). Onceanimals developed palpable tumors (day 11 post xenograft implantation),a group of six animals received intratumoral injections of each 6.25 μghsa-miR-34a (Dharmacon, Lafayette, Colo.) formulated with thelipid-based siPORT™ amine delivery agent (Life Technologies/Ambion; cat.no. AM4502) on days 11, 14, and 17. A control group of six animalsreceived intratumoral injections of each 6.25 μg negative control miRNA(NC; Dharmacon, Lafayette, Colo.), following the same injection schedulethat was used for hsa-miR-34a. Given an average mouse weight of 20 g,this dose equals 0.3125 mg/kg. In addition, a group of six H460tumor-bearing mice received intratumoral injections of the siPORT™ aminedelivery formulation lacking any oligonucleotide, and a group of fiveanimals received intratumoral injections of phosphate-buffered saline(PBS). Caliper measurements were taken every 1-2 days, and tumor volumeswere calculated using the formula, Volume=length×width×width/2, in whichthe length is greater than the width. Average tumor volumes, standarddeviations and p-values were calculated and plotted over time (FIG. 10).

As shown in FIG. 10, three doses of hsa-miR-34a robustly inhibitedgrowth of established H460 lung tumors (white squares). On day 19, theaverage volume of tumors treated with hsa-miR-34a was 196 mm³. Incontrast, tumors treated with negative control miRNA (black diamonds)grew at a steady pace and yielded tumors with an average size of 421 mm³on day 19. Negative control tumors developed as quickly as tumorstreated with either PBS or the siPORT amine only control, indicatingthat the therapeutic activity of hsa-miR-34a is specific.

The data indicate that hsa-miR-34a represents a particularly usefulcandidate in the treatment of patients with lung cancer. The data alsoindicate that hsa-miR-34a provides universal therapeutic activityagainst a broad spectrum of cancer types and cancer stem cells. Thetherapeutic activity of hsa-miR-34a is highlighted by the fact thathsa-miR-34a inhibited growth of tumors that had developed prior totreatment.

In addition, the data demonstrate the therapeutic utility of hsa-miR-34ain a lipid-based formulation.

Example 14 Elivery of Synthetic HSA-MIR-126 Inhibits Tumor Growth ofHuman Prostate Cancer Xenografts in Mice

The in vitro studies demonstrated the therapeutic activity ofhsa-miR-126 in cultured human prostate cancer cells. Therefore,hsa-miR-126 is likely to interfere with prostate tumor growth in theanimal. To explore this, the therapeutic potential of synthetichsa-miR-126 miRNA was evaluated in mice using the PPC-1 human prostatecancer xenograft. PPC-1 cells, 5×10⁶ per animal, were electroporatedwith 1.6 μM synthetic hsa-miR-126 or negative control miRNA(Pre-miR™-hsa-miR-126, Ambion cat. no. AM17100; NC, Pre-miR™ miRNAPrecursor Molecule-Negative Control #2, Ambion cat. no. AM17111), mixedwith BD Matrigel™, (BD Biosciences; cat. no. 356237) in a 1:1 ratio andimplanted subcutaneously into the lower back of NOD/SCID mice (CharlesRiver Laboratories, Inc.; Wilmington, Mass., USA). A group of 7 mice wasinjected with hsa-miR-126 treated PPC-1 cells, and a group of 7 mice wasinjected with PPC-1 cells treated with negative control miRNA. Tomaintain steady levels of miRNA, 6.25 μg of hsa-miR-126 or negativecontrol miRNA conjugated with the lipid-based siPORT™ amine deliveryagent (Ambion; cat. no. AM4502) were repeatedly administered on days 7,13 and 20 via intra-tumoral injections. Given an average mouse weight of20 g, this dose equals 0.3125 mg/kg. Tumor growth was monitored bytaking caliper measurements every 1-2 days for 22 days. Tumor volumeswere calculated using the formula, Volume=length×width×width/2, in whichthe length is greater than the width, and plotted over time (FIG. 11).Standard deviations and data points with p values <0.01, indicatingstatistical significance, are shown in the graph.

Repeated dosing with hsa-miR-126 blocked tumor growth of the human PPC-1prostate cancer xenograft (FIG. 11). The average volume of tumors thatreceived hsa-miR-126 was 157 mm³ on day 22. In contrast, tumors locallytreated with negative control miRNA were unaffected and continued togrow at a steady pace. The average volume of tumors treated withnegative control miRNA was 250 mm³ on day 22. Of note, each singleadministration with hsa-miR-126 resulted in an acute regression of tumorvolumes. This effect was not induced with negative control miRNA,indicating that the anti-tumor activity of hsa-miR-126 is specific. Inresponse to hsa-miR-126 treatments on days 7 and 13, tumor volumesdiminished to approximately 130 mm³, a size that is comparable withnewly implanted and hardly detectable tumors (day 4).

The data suggest that hsa-miR-126 provides a powerful therapeutic toolin the treatment of patients with prostate cancer. In addition, the datademonstrated the therapeutic utility of hsa-miR-126 in a lipid-basedformulation.

Example 15 Delivery of Synthetic HSA-MIR-126 Inhibits Tumor Growth ofHuman Lung Cancer Xenografts in Mice

Delivery of hsa-miR-126 inhibited the growth of cultured human lungcancer cells. These results demonstrated the anti-oncogenic activity ofhsa-miR-126 and suggested that hsa-miR-126 may also provide a powerfultherapeutic tool to treat established lung tumors in the animal. Toexplore this possibility, each 3×10⁶ human H460 non-small lung cancercells were mixed with BD Matrigel™, (BD Biosciences; San Jose, Calif.,USA; cat. no. 356237) in a 1:1 ratio and subcutaneously injected intothe lower back of 23 NOD/SCID mice (Charles River Laboratories, Inc).Once animals developed palpable tumors (day 11 post xenograftimplantation), a group of six animals received intratumoral injectionsof each 6.25 μg hsa-miR-126 (Dharmacon, Inc., Lafayette, Colo., USA)formulated with the lipid-based siPORT™ amine delivery agent (Ambion,Austin, Tex.; cat. no. AM4502) on days 11, 14 and 17. A control group ofsix animals received intratumoral injections of each 6.25 μg negativecontrol miRNA (NC; Dharmacon, Lafayette, Colo., USA), following the sameinjection schedule that was used for hsa-miR-126. Given an average mouseweight of 20 g, this dose equals 0.3125 mg/kg. In addition, a group ofsix H460 tumor-bearing mice received intratumoral injections of thesiPORT™ amine delivery formulation lacking any oligonucleotide, and agroup of five animals received intratumoral injections ofphosphate-buffered saline (PBS). Caliper measurements were taken every1-2 days, and tumor volumes were calculated using the formula,Volume=length×width×width/2, in which the length is greater than thewidth.

As shown in FIG. 12, three doses of hsa-miR-126 robustly inhibitedgrowth of established H460 lung tumors. In contrast, tumors treated withnegative control miRNA grew at a steady pace and yielded tumors with anaverage size of 420 mm³ on day 19. Negative control tumors developed asquickly as tumors treated with either PBS or the siPORT amine onlycontrol, indicating that the therapeutic activity of hsa-miR-126 isspecific.

The data suggest that hsa-miR-126 represents a particularly usefulcandidate in the treatment of patients with lung cancer. The data alsoindicated that hsa-miR-126 provides universal therapeutic activityagainst a broad spectrum of cancer types and cancer stem cells. Thetherapeutic activity of hsa-miR-126 is highlighted by the fact thathsa-miR-126 inhibited tumor growth of tumors that had developed prior totreatment. In addition, the data demonstrated the therapeutic utility ofhsa-miR-126 in a lipid-based formulation.

Example 16 Delivery of Synthetic HSA-LET-7 Inhibits Tumor Growth ofHuman Lung Cancer Xenografts in Mice

Delivery of hsa-miR-let-7 inhibited the growth of cultured human lungcancer cells. These results demonstrated the anti-oncogenic activity ofhsa-let-7 and suggest that hsa-let-7 may also provide a powerfultherapeutic tool to treat established lung tumors in the animal. Toexplore this possibility, each 3×10⁶ human H460 non-small lung cancercells were mixed with BD Matrigel™, (BD Biosciences; cat. no. 356237) ina 1:1 ratio and subcutaneously injected into the lower back of 23NOD/SCID mice (Charles River Laboratories, Inc.). Once animals developedpalpable tumors (day 11 post xenograft implantation), a group of sixanimals received intratumoral injections of each 6.25 μg hsa-let-7b(Dharmacon, Inc.) formulated with the lipid-based siPORT™ amine deliveryagent (Ambion; cat. no. AM4502) on days 11, 14 and 17. A control groupof six animals received intratumoral injections of each 6.25 μg negativecontrol miRNA (NC; Dharmacon, Lafayette, Colo.), following the sameinjection schedule that was used for hsa-let-7b. Given an average mouseweight of 20 g, this dose equals 0.3125 mg/kg. In addition, a group ofsix H460 tumor-bearing mice received intratumoral injections of thesiPORT™ amine delivery formulation lacking any oligonucleotide, and agroup of five animals received intratumoral injections ofphosphate-buffered saline (PBS). Caliper measurements were taken every1-2 days, and tumor volumes were calculated using the formula,Volume=length×width×width/2, in which the length is greater than thewidth.

As shown in FIG. 13, three doses of hsa-let-7b robustly inhibited growthof established H460 lung tumors. In contrast, tumors treated withnegative control miRNA grew at a steady pace and yielded tumors with anaverage size of 420 mm³ on day 19. Negative control tumors developed asquickly as tumors treated with either PBS or the siPORT amine onlycontrol, indicating that the therapeutic activity of hsa-let-7b isspecific.

The data suggest that hsa-let-7b represents a particularly usefulcandidate in the treatment of patients with lung cancer. The therapeuticactivity of hsa-let-7b is highlighted by the fact that hsa-let-7binhibited growth of tumors that had developed prior to treatment. Inaddition, the data demonstrated the therapeutic utility of hsa-let-7b ina lipid-based formulation.

Hsa-miR-34a, hsa-miR-126, and hsa-let-7 are among the miRNAs that aredownregulated in prostate cancer stem cells. Reintroduction of thesemiRNAs provides a therapeutic response in multiple models of humancancer, such as prostate and lung cancer. The data indicate that miRNAsdownregulated in prostate cancer stem cells have therapeutic valueagainst a broad spectrum of cancer types and cancer stem cells.

REFERENCES

The following references, to the extent that they provide exemplaryprocedural or other details supplementary to those set forth herein, arespecifically incorporated herein by reference.

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1. A method of treating cancer comprising administering to a subject inneed of such therapy an effective amount of: (a) an inhibitor ofhsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-miR-100, hsa-miR-101,hsa-miR-105, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a, hsa-miR-125a,hsa-miR-125b, hsa-miR-127, hsa-miR-133a, hsa-miR-133b, hsa-miR-140,hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-145, hsa-miR-146a, hsa-miR-146b,hsa-miR-147, hsa-miR-148a, hsa-miR-148b, hsa-miR-15b, hsa-miR-16,hsa-miR-181a, hsa-miR-181d, hsa-miR-183, hsa-miR-18a, hsa-miR-190,hsa-miR-192, hsa-miR-193b, hsa-miR-195, hsa-miR-196a, hsa-miR-196b,hsa-miR-19a, hsa-miR-19b, hsa-miR-203, hsa-miR-205, hsa-miR-21,hsa-miR-214, hsa-miR-218, hsa-miR-22, hsa-miR-221, hsa-miR-222,hsa-miR-223, hsa-miR-24, hsa-miR-25, hsa-miR-26b, hsa-miR-27a,hsa-miR-27b, hsa-miR-28, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c,hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c,hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32, hsa-miR-320, hsa-miR-324-3p,hsa-miR-324-5p, hsa-miR-328, hsa-miR-33, hsa-miR-331, hsa-miR-338,hsa-miR-339, hsa-miR-345, hsa-miR-361, hsa-miR-374, hsa-miR-378,hsa-miR-422a, hsa-miR-422b, hsa-miR-423, hsa-miR-425, hsa-miR-433,hsa-miR-451, hsa-miR-452, hsa-miR-500, hsa-miR-501, hsa-miR-9, and/orhsa-miR-96; or (b) a molecule having hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7e, hsa-let-7f, hsa-let-7i, hsa-miR-101, hsa-miR-103,hsa-miR-106a, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a, hsa-miR-125a,hsa-miR-126, hsa-miR-132, hsa-miR-133a, hsa-miR-141, hsa-miR-146a,hsa-miR-146b, hsa-miR-148a, hsa-miR-148b, hsa-miR-149, hsa-miR-151,hsa-miR-152, hsa-miR-15a, hsa-miR-15b, hsa-miR-181b, hsa-miR-182,hsa-miR-183, hsa-miR-18a, hsa-miR-191, hsa-miR-193b, hsa-miR-195,hsa-miR-196a, hsa-miR-196b, hsa-miR-199a, hsa-miR-200a, hsa-miR-200c,hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218,hsa-miR-22, hsa-miR-222, hsa-miR-24, hsa-miR-25, hsa-miR-26a,hsa-miR-27a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30a-3p, hsa-miR-30a-5p,hsa-miR-30d, hsa-miR-320, hsa-miR-324-5p, hsa-miR-328, hsa-miR-331,hsa-miR-335, hsa-miR-340, hsa-miR-342, hsa-miR-345, hsa-miR-34a,hsa-miR-362, hsa-miR-365, hsa-miR-375, hsa-miR-378, hsa-miR-422a,hsa-miR-422b, hsa-miR-425, hsa-miR-429, hsa-miR-500, hsa-miR-7,hsa-miR-9*, hsa-miR-92, hsa-miR-93, hsa-miR-98, and/or hsa-miR-99bactivity.
 2. The method of claim 1, wherein the nucleic acid inhibitoris an inhibitor of hsa-miR-125b, hsa-miR-133b, hsa-miR-142-3p,hsa-miR-181a, hsa-miR-181d, hsa-miR-205, hsa-miR-221, hsa-miR-222,hsa-miR-223, hsa-miR-29a, hsa-miR-29c, hsa-miR-301, hsa-miR-328,hsa-miR-33, hsa-miR-338, hsa-miR-374, hsa-miR-378, hsa-miR-451,hsa-miR-452, and/or hsa-miR-501.
 3. The method of claim 1, wherein thenucleic acid has an activity of one or more hsa-let-7c, hsa-miR-126,hsa-miR-15a, hsa-miR-15b, hsa-miR-182, hsa-miR-183, hsa-miR-191,hsa-miR-200a, hsa-miR-200c, hsa-miR-203, hsa-miR-218, hsa-miR-27a,hsa-miR-29b, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-335, hsa-miR-340,hsa-miR-34a, hsa-miR-365, hsa-miR-375, hsa-miR-422a, hsa-miR-425,hsa-miR-92, and/or hsa-miR-93.
 4. The method of claim 1, wherein anucleic acid has an activity of a hsa-let-7b, hsa-miR-34a, hsa-miR-126,hsa-miR-141, hsa-miR-335, hsa-miR-365, and/or hsa-miR-375.
 5. The methodof claim 1, wherein a nucleic acid inhibitor is an inhibitor ofhsa-miR-142-3p, hsa-miR-33, hsa-miR-301, hsa-miR-451, and/orhsa-miR-452.
 6. The method of claim 1, wherein a hsa-miR-34a,hsa-miR-126 and/or hsa-let-7b nucleic acid is administered. 7.(canceled)
 8. The method of claim 1, wherein the subject is suspected ofhaving or at risk of developing brain, breast, bone, colorectal,pancreatic, ovarian, prostate, testicular, hepatic, kidney, or lungcancer.
 9. The method of claim 8, wherein the subject is suspected of orat risk of developing prostate cancer.
 10. (canceled)
 11. (canceled) 12.(canceled)
 13. (canceled)
 14. (canceled)
 15. (canceled)
 16. The methodof claim 1, wherein the therapeutic nucleic acid is a synthetic nucleicacid.
 17. The method of claim 16, wherein the nucleic acid isadministered at a dose of 0.01 μg/kg of body weight to 10 mg/kg of bodyweight.
 18. (canceled)
 19. (canceled)
 20. (canceled)
 21. (canceled) 22.(canceled)
 23. The method of claim 1, further comprising administering2, 3, 4, 5, 6, or more therapeutic nucleic acids.
 24. (canceled)
 25. Themethod of claim 1, wherein proliferation of the cancer is reduced. 26.The method of claim 1, wherein metastasis of the cancer is reduced. 27.The method of claim 1, wherein the cancer is a metastasized cancer. 28.(canceled)
 29. (canceled)
 30. (canceled)
 31. A method of treating apatient diagnosed with or suspected of having or at risk of developingprostate cancer comprising the step of administering to the patient aneffective amount of: (a) an inhibitor of one or more of hsa-let-7b,hsa-let-7c, hsa-let-7e, hsa-miR-100, hsa-miR-101, hsa-miR-105,hsa-miR-10a, hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-125b,hsa-miR-127, hsa-miR-133a, hsa-miR-133b, hsa-miR-140, hsa-miR-142-3p,hsa-miR-142-5p, hsa-miR-145, hsa-miR-146a, hsa-miR-146b, hsa-miR-147,hsa-miR-148a, hsa-miR-148b, hsa-miR-15b, hsa-miR-16, hsa-miR-181a,hsa-miR-181d, hsa-miR-183, hsa-miR-18a, hsa-miR-190, hsa-miR-192,hsa-miR-193b, hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-19a,hsa-miR-19b, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-223,hsa-miR-24, hsa-miR-25, hsa-miR-26b, hsa-miR-27a, hsa-miR-27b,hsa-miR-28, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-301,hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d,hsa-miR-30e-5p, hsa-miR-32, hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p,hsa-miR-328, hsa-miR-33, hsa-miR-331, hsa-miR-338, hsa-miR-339,hsa-miR-345, hsa-miR-361, hsa-miR-374, hsa-miR-378, hsa-miR-422a,hsa-miR-422b, hsa-miR-423, hsa-miR-425, hsa-miR-433, hsa-miR-451,hsa-miR-452, hsa-miR-500, hsa-miR-501, hsa-miR-9, and/or hsa-miR-96;and/or (b) a molecule having an activity of one or more of hsa-let-7a,hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-let-7i, hsa-miR-101,hsa-miR-103, hsa-miR-106a, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a,hsa-miR-125a, hsa-miR-126, hsa-miR-132, hsa-miR-133a, hsa-miR-141,hsa-miR-146a, hsa-miR-146b, hsa-miR-148a, hsa-miR-148b, hsa-miR-149,hsa-miR-151, hsa-miR-152, hsa-miR-15a, hsa-miR-15b, hsa-miR-181b,hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-191, hsa-miR-193b,hsa-miR-195, hsa-miR-196a, hsa-miR-196b, hsa-miR-199a, hsa-miR-200a,hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-222, hsa-miR-24, hsa-miR-25,hsa-miR-26a, hsa-miR-27a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30a-3p,hsa-miR-30a-5p, hsa-miR-30d, hsa-miR-320, hsa-miR-324-5p, hsa-miR-328,hsa-miR-331, hsa-miR-335, hsa-miR-340, hsa-miR-342, hsa-miR-345,hsa-miR-34a, hsa-miR-362, hsa-miR-365, hsa-miR-375, hsa-miR-378,hsa-miR-422a, hsa-miR-422b, hsa-miR-425, hsa-miR-429, hsa-miR-500,hsa-miR-7, hsa-miR-9*, hsa-miR-92, hsa-miR-93, hsa-miR-98, and/orhsa-miR-99b activity.
 32. (canceled)
 33. (canceled)
 34. (canceled) 35.(canceled)
 36. (canceled)
 37. (canceled)
 38. The method of claim 31,wherein the therapeutic nucleic acid is a synthetic nucleic acid. 39.The method of claim 38, wherein the nucleic acid is administered at adose of 0.01 μg/kg of body weight to 10 mg/kg of body weight. 40.(canceled)
 41. (canceled)
 42. (canceled)
 43. (canceled)
 44. (canceled)45. (canceled)
 46. (canceled)
 47. The method of claim 31, whereinproliferation of the cancer is reduced.
 48. The method of claim 31,wherein metastasis of the cancer is reduced.
 49. (canceled) 50.(canceled)
 51. (canceled)
 52. (canceled)
 53. (canceled)
 54. A method ofdetecting cancer stem cells in a biological sample comprising evaluatingexpression levels of hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e,hsa-let-7f, hsa-let-7i, hsa-miR-100, hsa-miR-101, hsa-miR-103,hsa-miR-105, hsa-miR-106a, hsa-miR-10a, hsa-miR-10b, hsa-miR-124a,hsa-miR-125a, hsa-miR-125b, hsa-miR-126, hsa-miR-127, hsa-miR-132,hsa-miR-133a, hsa-miR-133b, hsa-miR-140, hsa-miR-141, hsa-miR-142-3p,hsa-miR-142-5p, hsa-miR-145, hsa-miR-146a, hsa-miR-146b, hsa-miR-147,hsa-miR-148a, hsa-miR-148b, hsa-miR-149, hsa-miR-151, hsa-miR-152,hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-181a, hsa-miR-181b,hsa-miR-181d, hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-190,hsa-miR-191, hsa-miR-192, hsa-miR-193b, hsa-miR-195, hsa-miR-196a,hsa-miR-196b, hsa-miR-199a, hsa-miR-19a, hsa-miR-19b, hsa-miR-200a,hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-21, hsa-miR-214,hsa-miR-218, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-223,hsa-miR-24, hsa-miR-25, hsa-miR-26a, hsa-miR-26b, hsa-miR-27a,hsa-miR-27b, hsa-miR-28, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c,hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c,hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32, hsa-miR-320, hsa-miR-324-3p,hsa-miR-324-5p, hsa-miR-328, hsa-miR-33, hsa-miR-331, hsa-miR-335,hsa-miR-338, hsa-miR-339, hsa-miR-340, hsa-miR-342, hsa-miR-345,hsa-miR-34a, hsa-miR-361, hsa-miR-362, hsa-miR-365, hsa-miR-374,hsa-miR-375, hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-423,hsa-miR-425, hsa-miR-429, hsa-miR-433, hsa-miR-451, hsa-miR-452,hsa-miR-500, hsa-miR-501, hsa-miR-7, hsa-miR-9, hsa-miR-9*, hsa-miR-92,hsa-miR-93, hsa-miR-96, hsa-miR-98, hsa-miR-99b, or combinationsthereof.
 55. (canceled)
 56. The method of claim 54, wherein an increasein the level of one or more of hsa-let-7b, hsa-let-7c, hsa-let-7e,hsa-miR-100, hsa-miR-101, hsa-miR-105, hsa-miR-10a, hsa-miR-10b,hsa-miR-124a, hsa-miR-125a, hsa-miR-125b, hsa-miR-127, hsa-miR-133a,hsa-miR-133b, hsa-miR-140, hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-145,hsa-miR-146a, hsa-miR-146b, hsa-miR-147, hsa-miR-148a, hsa-miR-148b,hsa-miR-15b, hsa-miR-16, hsa-miR-181a, hsa-miR-181d, hsa-miR-183,hsa-miR-18a, hsa-miR-190, hsa-miR-192, hsa-miR-193b, hsa-miR-195,hsa-miR-196a, hsa-miR-196b, hsa-miR-19a, hsa-miR-19b, hsa-miR-203,hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22,hsa-miR-221, hsa-miR-222, hsa-miR-223, hsa-miR-24, hsa-miR-25,hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-28, hsa-miR-29a,hsa-miR-29b, hsa-miR-29c, hsa-miR-301, hsa-miR-30a-3p, hsa-miR-30a-5p,hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e-5p, hsa-miR-32,hsa-miR-320, hsa-miR-324-3p, hsa-miR-324-5p, hsa-miR-328, hsa-miR-33,hsa-miR-331, hsa-miR-338, hsa-miR-339, hsa-miR-345, hsa-miR-361,hsa-miR-374, hsa-miR-378, hsa-miR-422a, hsa-miR-422b, hsa-miR-423,hsa-miR-425, hsa-miR-433, hsa-miR-451, hsa-miR-452, hsa-miR-500,hsa-miR-501, hsa-miR-9, and/or hsa-miR-96 is indicative of a cancer stemcell.
 57. The method of claim 54, wherein an decrease in the level ofone or more of hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e,hsa-let-7f, hsa-let-7i, hsa-miR-101, hsa-miR-103, hsa-miR-106a,hsa-miR-10a, hsa-miR-10b, hsa-miR-124a, hsa-miR-125a, hsa-miR-126,hsa-miR-132, hsa-miR-133a, hsa-miR-141, hsa-miR-146a, hsa-miR-146b,hsa-miR-148a, hsa-miR-148b, hsa-miR-149, hsa-miR-151, hsa-miR-152,hsa-miR-15a, hsa-miR-15b, hsa-miR-181b, hsa-miR-182, hsa-miR-183,hsa-miR-18a, hsa-miR-191, hsa-miR-193b, hsa-miR-195, hsa-miR-196a,hsa-miR-196b, hsa-miR-199a, hsa-miR-200a, hsa-miR-200c, hsa-miR-203,hsa-miR-205, hsa-miR-21, hsa-miR-214, hsa-miR-218, hsa-miR-22,hsa-miR-222, hsa-miR-24, hsa-miR-25, hsa-miR-26a, hsa-miR-27a,hsa-miR-29b, hsa-miR-29c, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30d,hsa-miR-320, hsa-miR-324-5p, hsa-miR-328, hsa-miR-331, hsa-miR-335,hsa-miR-340, hsa-miR-342, hsa-miR-345, hsa-miR-34a, hsa-miR-362,hsa-miR-365, hsa-miR-375, hsa-miR-378, hsa-miR-422a, hsa-miR-422b,hsa-miR-425, hsa-miR-429, hsa-miR-500, hsa-miR-7, hsa-miR-9*,hsa-miR-92, hsa-miR-93, hsa-miR-98, and/or hsa-miR-99b is indicative ofa cancer stem cell.